Details for: EPHA4

Gene ID: 2043

Symbol: EPHA4

Ensembl ID: ENSG00000116106

Description: EPH receptor A4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.44
    Marker Score: 116143
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.43
    Marker Score: 12195
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.38
    Marker Score: 3994
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.37
    Marker Score: 42071
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.28
    Marker Score: 1362.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.24
    Marker Score: 6399
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.04
    Marker Score: 125632
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.96
    Marker Score: 74438
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.94
    Marker Score: 18229
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.87
    Marker Score: 17810
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.8
    Marker Score: 7470
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.67
    Marker Score: 12801
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.6
    Marker Score: 2463
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.57
    Marker Score: 33490
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.5
    Marker Score: 630
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.48
    Marker Score: 837
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168704
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.45
    Marker Score: 453
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.39
    Marker Score: 5660
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.35
    Marker Score: 1686
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 851
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.3
    Marker Score: 1440
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.29
    Marker Score: 353
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.25
    Marker Score: 749
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.24
    Marker Score: 356
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.23
    Marker Score: 18459
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19185
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.17
    Marker Score: 10073.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.14
    Marker Score: 2677
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.13
    Marker Score: 4712
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.05
    Marker Score: 4065
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.05
    Marker Score: 3882
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1
    Marker Score: 1052
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71784
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48009
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.99
    Marker Score: 1445
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.98
    Marker Score: 1060
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.95
    Marker Score: 3957.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.93
    Marker Score: 295
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.9
    Marker Score: 217
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5090
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.87
    Marker Score: 32253
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5271
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.87
    Marker Score: 504
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.86
    Marker Score: 1896
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.86
    Marker Score: 278
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.84
    Marker Score: 473
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.83
    Marker Score: 545
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.81
    Marker Score: 16141
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.81
    Marker Score: 8188
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.8
    Marker Score: 384
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.8
    Marker Score: 221
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.8
    Marker Score: 687
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 603
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.79
    Marker Score: 682
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.78
    Marker Score: 182
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.77
    Marker Score: 447
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1245
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3178.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.72
    Marker Score: 482
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.71
    Marker Score: 922
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.7
    Marker Score: 178
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.7
    Marker Score: 1874
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.68
    Marker Score: 1120.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.67
    Marker Score: 14978
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.66
    Marker Score: 8719
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.65
    Marker Score: 783.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.63
    Marker Score: 135
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.63
    Marker Score: 567
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.62
    Marker Score: 625
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.61
    Marker Score: 9851
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.61
    Marker Score: 227
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.6
    Marker Score: 202
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.6
    Marker Score: 1195
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.57
    Marker Score: 294
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.56
    Marker Score: 258
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 146
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.53
    Marker Score: 2065
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.52
    Marker Score: 237
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.52
    Marker Score: 3865
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.52
    Marker Score: 471
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.51
    Marker Score: 193
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.51
    Marker Score: 5117.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.51
    Marker Score: 176
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 211
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.5
    Marker Score: 209
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.5
    Marker Score: 186
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.5
    Marker Score: 178
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.5
    Marker Score: 571

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Other Information

**Key characteristics:** * EPHA4 is a transmembrane protein with a single extracellular domain and four intracellular domains. * It is a cell surface receptor that binds to Eph receptors on neighboring cells. * EPHA4 signaling is involved in a variety of cellular processes, including cell adhesion, migration, and survival. **Pathways and functions:** * EPHA4 is a key receptor for the Eph-ephrin signaling pathway. * It is involved in the formation of paraxial mesoderm, which is a tissue that forms the inner lining of the brain and spinal cord. * EPHA4 also plays a role in gastrulation, the process by which the embryo forms a body. * It is involved in the regulation of neuronal migration and differentiation. * EPHA4 is also involved in the development of the cardiovascular system, the nervous system, and the kidney. **Clinical significance:** * Mutations in EPHA4 have been linked to a number of human diseases, including autism, schizophrenia, and cardiovascular disease. * EPHA4 is a potential target for therapeutic interventions in these diseases. **Additional information:** * EPHA4 is a highly conserved protein, with a similar sequence found in mammals, birds, and fish. * It is expressed in high levels in the brain and spinal cord. * It is a key regulator of neural development and function.

Genular Protein ID: 1531986221

Symbol: EPHA4_HUMAN

Name: Ephrin type-A receptor 4

UniProtKB Accession Codes:

P54764 A8K2P1 B2R601 B7Z6Q8 Q2M380

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTAC 3 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 74 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 19 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 16 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 8 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 Rhea 3 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7898931

Title: cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.

PubMed ID: 7898931

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 18094260

Title: The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.

PubMed ID: 18094260

DOI: 10.1523/jneurosci.2746-07.2007

PubMed ID: 17143272

Title: Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.

PubMed ID: 17143272

DOI: 10.1038/nn1811

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 18708347

Title: Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor.

PubMed ID: 18708347

DOI: 10.1074/jbc.m804114200

PubMed ID: 19836338

Title: Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling.

PubMed ID: 19836338

DOI: 10.1016/j.str.2009.07.018

PubMed ID: 19875447

Title: Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity.

PubMed ID: 19875447

DOI: 10.1074/jbc.m109.064824

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 986
  • Mass: 109860
  • Checksum: 0C39C1152EDDD46F
  • Sequence:
    • MAGIFYFALF SCLFGICDAV TGSRVYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM 
DEKNTPIRTY QVCNVMEPSQ NNWLRTDWIT REGAQRVYIE IKFTLRDCNS LPGVMGTCKE 
TFNLYYYESD NDKERFIREN QFVKIDTIAA DESFTQVDIG DRIMKLNTEI RDVGPLSKKG 
FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG ADTSSLVEVR GSCVNNSEEK 
DVPKMYCGAD GEWLVPIGNC LCNAGHEERS GECQACKIGY YKALSTDATC AKCPPHSYSV 
WEGATSCTCD RGFFRADNDA ASMPCTRPPS APLNLISNVN ETSVNLEWSS PQNTGGRQDI 
SYNVVCKKCG AGDPSKCRPC GSGVHYTPQQ NGLKTTKVSI TDLLAHTNYT FEIWAVNGVS 
KYNPNPDQSV SVTVTTNQAA PSSIALVQAK EVTRYSVALA WLEPDRPNGV ILEYEVKYYE 
KDQNERSYRI VRTAARNTDI KGLNPLTSYV FHVRARTAAG YGDFSEPLEV TTNTVPSRII 
GDGANSTVLL VSVSGSVVLV VILIAAFVIS RRRSKYSKAK QEADEEKHLN QGVRTYVDPF 
TYEDPNQAVR EFAKEIDASC IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT 
DKQRRDFLSE ASIMGQFDHP NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV 
IQLVGMLRGI GSGMKYLSDM SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT 
TRGGKIPIRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG 
YRLPPPMDCP IALHQLMLDC WQKERSDRPK FGQIVNMLDK LIRNPNSLKR TGTESSRPNT 
ALLDPSSPEF SAVVSVGDWL QAIKMDRYKD NFTAAGYTTL EAVVHVNQED LARIGITAIT 
HQNKILSSVQ AMRTQMQQMH GRMVPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.