EPHA4 | ENSG00000116106 | NCBI 2043

Details for: EPHA4

Gene ID: 2043

Symbol: EPHA4

Ensembl ID: ENSG00000116106

Description: EPH receptor A4

Associated with

Developmental biology
(R-HSA-1266738)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Epha-mediated growth cone collapse
(R-HSA-3928663)
Formation of paraxial mesoderm
(R-HSA-9793380)
Gastrulation
(R-HSA-9758941)
Nervous system development
(R-HSA-9675108)
Somitogenesis
(R-HSA-9824272)
Adherens junction
(GO:0005912)
Adherens junction organization
(GO:0034332)
Adult walking behavior
(GO:0007628)
Amyloid-beta binding
(GO:0001540)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Axonal growth cone
(GO:0044295)
Axon guidance
(GO:0007411)
Axon terminus
(GO:0043679)
Cell adhesion
(GO:0007155)
Cell surface
(GO:0009986)
Cellular response to amyloid-beta
(GO:1904646)
Cochlea development
(GO:0090102)
Corticospinal tract morphogenesis
(GO:0021957)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Dendritic shaft
(GO:0043198)
Dendritic spine
(GO:0043197)
Dh domain binding
(GO:0097161)
Early endosome membrane
(GO:0031901)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Fasciculation of motor neuron axon
(GO:0097156)
Fasciculation of sensory neuron axon
(GO:0097155)
Filopodium
(GO:0030175)
Glial cell migration
(GO:0008347)
Glutamatergic synapse
(GO:0098978)
Gpi-linked ephrin receptor activity
(GO:0005004)
Identical protein binding
(GO:0042802)
Innervation
(GO:0060384)
Kinase activity
(GO:0016301)
Mitochondrial outer membrane
(GO:0005741)
Motor neuron axon guidance
(GO:0008045)
Negative regulation of axon regeneration
(GO:0048681)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cellular response to hypoxia
(GO:1900038)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of long-term synaptic potentiation
(GO:1900272)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of proteolysis involved in protein catabolic process
(GO:1903051)
Negative regulation of translation
(GO:0017148)
Nephric duct morphogenesis
(GO:0072178)
Neuromuscular junction
(GO:0031594)
Neuron projection fasciculation
(GO:0106030)
Neuron projection guidance
(GO:0097485)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Perikaryon
(GO:0043204)
Ph domain binding
(GO:0042731)
Plasma membrane
(GO:0005886)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
(GO:1902961)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of protein tyrosine kinase activity
(GO:0061098)
Positive regulation of rho guanyl-nucleotide exchange factor activity
(GO:2001108)
Postsynaptic density membrane
(GO:0098839)
Presynaptic membrane
(GO:0042734)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein stabilization
(GO:0050821)
Protein tyrosine kinase activity
(GO:0004713)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of astrocyte differentiation
(GO:0048710)
Regulation of axonogenesis
(GO:0050770)
Regulation of dendritic spine morphogenesis
(GO:0061001)
Regulation of gtpase activity
(GO:0043087)
Regulation of modification of synaptic structure
(GO:1905244)
Regulation of synapse pruning
(GO:1905806)
Schaffer collateral - ca1 synapse
(GO:0098685)
Synapse pruning
(GO:0098883)
Transmembrane-ephrin receptor activity
(GO:0005005)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 231.9583
Cell Significance Index: -36.0800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 29.2711
Cell Significance Index: -36.0900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 26.9078
Cell Significance Index: -25.6900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.1813
Cell Significance Index: -36.2300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.0600
Cell Significance Index: -17.6400
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 5.1894
Cell Significance Index: 148.0900
Cell Name: Purkinje cell (CL0000121)
Fold Change: 3.7988
Cell Significance Index: 83.1800
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 3.0794
Cell Significance Index: 44.2900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.9970
Cell Significance Index: 201.5200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.9480
Cell Significance Index: 591.3600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.6546
Cell Significance Index: 71.1300
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.2751
Cell Significance Index: 17.4500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.9308
Cell Significance Index: 367.4500
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 1.6680
Cell Significance Index: 22.2500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.2953
Cell Significance Index: 895.8500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1431
Cell Significance Index: 1032.1200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.9898
Cell Significance Index: 37.4800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.8678
Cell Significance Index: 38.3900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.8537
Cell Significance Index: 65.5100
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.7420
Cell Significance Index: 17.8000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6795
Cell Significance Index: 110.5200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6598
Cell Significance Index: 236.6700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5450
Cell Significance Index: 67.0200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5362
Cell Significance Index: 237.0800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5346
Cell Significance Index: 96.3700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5170
Cell Significance Index: 56.2300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4512
Cell Significance Index: 20.4500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4443
Cell Significance Index: 27.3100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4088
Cell Significance Index: 22.9400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2977
Cell Significance Index: 6.3400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.2579
Cell Significance Index: 6.6300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2227
Cell Significance Index: 15.4000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1484
Cell Significance Index: 8.9100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1449
Cell Significance Index: 14.3300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1431
Cell Significance Index: 78.1400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0953
Cell Significance Index: 2.7500
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.0788
Cell Significance Index: 0.7500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0655
Cell Significance Index: 2.3000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0376
Cell Significance Index: 17.0700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0020
Cell Significance Index: 0.2300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0011
Cell Significance Index: -1.7000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0062
Cell Significance Index: -11.7500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0104
Cell Significance Index: -19.1600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0189
Cell Significance Index: -13.8800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0207
Cell Significance Index: -28.1700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0351
Cell Significance Index: -22.3000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0390
Cell Significance Index: -7.7400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0419
Cell Significance Index: -31.7300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0476
Cell Significance Index: -35.2700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0621
Cell Significance Index: -38.7800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0664
Cell Significance Index: -37.4500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1008
Cell Significance Index: -2.1100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1055
Cell Significance Index: -30.3500
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.1138
Cell Significance Index: -1.2400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1261
Cell Significance Index: -1.7200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1341
Cell Significance Index: -18.4200
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1355
Cell Significance Index: -2.0000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1542
Cell Significance Index: -1.4200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1694
Cell Significance Index: -3.6700
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.1718
Cell Significance Index: -1.7900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1772
Cell Significance Index: -22.7200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1864
Cell Significance Index: -39.2600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1867
Cell Significance Index: -27.1400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1985
Cell Significance Index: -10.3100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2122
Cell Significance Index: -22.0900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2234
Cell Significance Index: -38.1400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2358
Cell Significance Index: -27.8100
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2369
Cell Significance Index: -3.5700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2427
Cell Significance Index: -31.3600
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2456
Cell Significance Index: -4.9300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2484
Cell Significance Index: -6.2100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2562
Cell Significance Index: -8.1600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2856
Cell Significance Index: -29.1700
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.2879
Cell Significance Index: -3.5900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3102
Cell Significance Index: -16.1600
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.3225
Cell Significance Index: -4.5100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3259
Cell Significance Index: -6.7600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3342
Cell Significance Index: -17.5500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3350
Cell Significance Index: -38.3800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3509
Cell Significance Index: -27.7900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3543
Cell Significance Index: -16.5200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3600
Cell Significance Index: -25.4600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3747
Cell Significance Index: -12.0000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3975
Cell Significance Index: -11.1100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4376
Cell Significance Index: -20.5700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4465
Cell Significance Index: -33.2800
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.4548
Cell Significance Index: -5.7400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4681
Cell Significance Index: -28.7000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5029
Cell Significance Index: -32.4500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5229
Cell Significance Index: -17.1200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5659
Cell Significance Index: -14.8800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5666
Cell Significance Index: -9.7100
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.5739
Cell Significance Index: -12.4000
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.5815
Cell Significance Index: -4.8000
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: -0.5918
Cell Significance Index: -6.1300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6197
Cell Significance Index: -39.0600
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.6346
Cell Significance Index: -15.8300
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6426
Cell Significance Index: -22.5100
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.6963
Cell Significance Index: -12.0400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.7049
Cell Significance Index: -24.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** EPHA4 is a transmembrane receptor tyrosine kinase that belongs to the Eph family of receptors. It is characterized by its unique structure, which includes a characteristic immunoglobulin-like domain, seven transmembrane helices, and a tyrosine kinase domain. EPHA4 is primarily expressed in the nervous system, with notable expression in Purkinje cells, pyramidal neurons, and other brain-derived cells. **Pathways and Functions:** EPHA4 is involved in a wide range of signaling pathways, including: 1. **Axon guidance and fasciculation**: EPHA4 plays a crucial role in regulating axon growth, guidance, and fasciculation, particularly in the development of the nervous system. 2. **Cell adhesion and migration**: EPHA4-mediated signaling regulates cell adhesion, migration, and proliferation, influencing tissue development and homeostasis. 3. **Neurotransmission and synapse formation**: EPHA4 is involved in regulating neurotransmitter release, synaptic plasticity, and synapse formation. 4. **Immune responses**: EPHA4 has been implicated in modulating immune responses, including regulation of dendritic cell migration and T-cell activation. **Clinical Significance:** EPHA4 has significant implications in various immunological and neurological disorders, including: 1. **Multiple sclerosis**: EPHA4 has been shown to play a role in regulating axonal damage and repair in multiple sclerosis, a chronic autoimmune disease affecting the central nervous system. 2. **Neurodegenerative diseases**: EPHA4 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer**: EPHA4 has been linked to cancer progression and metastasis, particularly in brain and neuroendocrine tumors. 4. **Autoimmune disorders**: EPHA4 has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and lupus. **Conclusion:** EPHA4 is a complex receptor tyrosine kinase that plays a multifaceted role in regulating various physiological and pathological processes. Its involvement in axon guidance, cell adhesion, neurotransmission, and immune responses makes it an attractive target for immunological research and therapeutic interventions. Further studies are needed to fully elucidate the mechanisms underlying EPHA4-mediated signaling and its implications in immunological disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ephrin type-A receptor 4

Genular Protein ID: 1531986221

Symbol: EPHA4_HUMAN

Name: Ephrin type-A receptor 4

UniProtKB Accession Codes:

P54764 A8K2P1 B2R601 B7Z6Q8 Q2M380

Database IDs:

Citations:

PubMed ID: 7898931

Title: cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.

PubMed ID: 7898931

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 18094260

Title: The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.

PubMed ID: 18094260

DOI: 10.1523/jneurosci.2746-07.2007

PubMed ID: 17143272

Title: Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.

PubMed ID: 17143272

DOI: 10.1038/nn1811

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 18708347

Title: Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor.

PubMed ID: 18708347

DOI: 10.1074/jbc.m804114200

PubMed ID: 19836338

Title: Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling.

PubMed ID: 19836338

DOI: 10.1016/j.str.2009.07.018

PubMed ID: 19875447

Title: Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity.

PubMed ID: 19875447

DOI: 10.1074/jbc.m109.064824

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 986
Mass: 109860
Checksum: 0C39C1152EDDD46F
Sequence:

MAGIFYFALF SCLFGICDAV TGSRVYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM 
DEKNTPIRTY QVCNVMEPSQ NNWLRTDWIT REGAQRVYIE IKFTLRDCNS LPGVMGTCKE 
TFNLYYYESD NDKERFIREN QFVKIDTIAA DESFTQVDIG DRIMKLNTEI RDVGPLSKKG 
FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG ADTSSLVEVR GSCVNNSEEK 
DVPKMYCGAD GEWLVPIGNC LCNAGHEERS GECQACKIGY YKALSTDATC AKCPPHSYSV 
WEGATSCTCD RGFFRADNDA ASMPCTRPPS APLNLISNVN ETSVNLEWSS PQNTGGRQDI 
SYNVVCKKCG AGDPSKCRPC GSGVHYTPQQ NGLKTTKVSI TDLLAHTNYT FEIWAVNGVS 
KYNPNPDQSV SVTVTTNQAA PSSIALVQAK EVTRYSVALA WLEPDRPNGV ILEYEVKYYE 
KDQNERSYRI VRTAARNTDI KGLNPLTSYV FHVRARTAAG YGDFSEPLEV TTNTVPSRII 
GDGANSTVLL VSVSGSVVLV VILIAAFVIS RRRSKYSKAK QEADEEKHLN QGVRTYVDPF 
TYEDPNQAVR EFAKEIDASC IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT 
DKQRRDFLSE ASIMGQFDHP NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV 
IQLVGMLRGI GSGMKYLSDM SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT 
TRGGKIPIRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG 
YRLPPPMDCP IALHQLMLDC WQKERSDRPK FGQIVNMLDK LIRNPNSLKR TGTESSRPNT 
ALLDPSSPEF SAVVSVGDWL QAIKMDRYKD NFTAAGYTTL EAVVHVNQED LARIGITAIT 
HQNKILSSVQ AMRTQMQQMH GRMVPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EPHA4

Associated with

Cells (max top 100)

Other Information

cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. PubMed ID: 7898931

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Unified nomenclature for Eph family receptors and their ligands, the ephrins. PubMed ID: 9267020

The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. PubMed ID: 18094260

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. PubMed ID: 17143272

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor. PubMed ID: 18708347

Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling. PubMed ID: 19836338

Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. PubMed ID: 19875447

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846