Details for: EPHB1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 244.3019
Cell Significance Index: -38.0000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 149.8955
Cell Significance Index: -38.0200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.8896
Cell Significance Index: -12.8900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 4.5262
Cell Significance Index: 657.9400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 4.4010
Cell Significance Index: 75.4200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 4.0005
Cell Significance Index: 151.4900 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 3.2388
Cell Significance Index: 45.2900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 3.1997
Cell Significance Index: 141.5300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.8000
Cell Significance Index: 61.3100 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 1.9440
Cell Significance Index: 20.2500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.6561
Cell Significance Index: 42.5700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.5318
Cell Significance Index: 49.0600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3071
Cell Significance Index: 262.2000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8585
Cell Significance Index: 38.9200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7824
Cell Significance Index: 148.9000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7462
Cell Significance Index: 267.6700 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.6555
Cell Significance Index: 8.1300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5422
Cell Significance Index: 41.6100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5421
Cell Significance Index: 33.3200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.5238
Cell Significance Index: 35.2200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4877
Cell Significance Index: 337.3000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3838
Cell Significance Index: 346.5200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3052
Cell Significance Index: 30.1900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.1864
Cell Significance Index: 4.4700 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.1524
Cell Significance Index: 2.6400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1363
Cell Significance Index: 22.1600 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.1010
Cell Significance Index: 1.2600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0825
Cell Significance Index: 155.2700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0809
Cell Significance Index: 2.3300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0693
Cell Significance Index: 13.7600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0454
Cell Significance Index: 69.9400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0388
Cell Significance Index: 0.9700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0344
Cell Significance Index: 1.9300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0321
Cell Significance Index: 14.1800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0310
Cell Significance Index: 3.3700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0282
Cell Significance Index: 38.2900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0264
Cell Significance Index: 48.6100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0181
Cell Significance Index: 11.5100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0007
Cell Significance Index: -0.3100 - Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0152
Cell Significance Index: -0.0900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0290
Cell Significance Index: -1.0200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0317
Cell Significance Index: -17.3200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0458
Cell Significance Index: -33.5700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0538
Cell Significance Index: -39.8500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0707
Cell Significance Index: -44.1800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0717
Cell Significance Index: -40.4300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1046
Cell Significance Index: -18.8500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1084
Cell Significance Index: -31.1900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1330
Cell Significance Index: -2.6700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1463
Cell Significance Index: -2.1000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.2009
Cell Significance Index: -12.0600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2075
Cell Significance Index: -43.7000 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.2182
Cell Significance Index: -3.3200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.2189
Cell Significance Index: -26.9200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2280
Cell Significance Index: -4.9400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2309
Cell Significance Index: -15.9700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2412
Cell Significance Index: -41.1900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2463
Cell Significance Index: -31.5800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2619
Cell Significance Index: -8.3400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2680
Cell Significance Index: -36.8100 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.2765
Cell Significance Index: -3.4900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2868
Cell Significance Index: -37.0500 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.3139
Cell Significance Index: -4.4000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3197
Cell Significance Index: -22.6100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.3216
Cell Significance Index: -32.8500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3226
Cell Significance Index: -33.5900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3320
Cell Significance Index: -39.1500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3389
Cell Significance Index: -39.5000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3478
Cell Significance Index: -7.2200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3709
Cell Significance Index: -5.5900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3753
Cell Significance Index: -43.0000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3868
Cell Significance Index: -10.8100 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.4028
Cell Significance Index: -5.6500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4107
Cell Significance Index: -11.7200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4171
Cell Significance Index: -25.5700 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.4476
Cell Significance Index: -5.7400 - Cell Name: neural cell (CL0002319)
Fold Change: -0.4569
Cell Significance Index: -5.3300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4811
Cell Significance Index: -10.2100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5022
Cell Significance Index: -37.4300 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.5158
Cell Significance Index: -5.6200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5342
Cell Significance Index: -17.4900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5560
Cell Significance Index: -28.9600 - Cell Name: neuron (CL0000540)
Fold Change: -0.5813
Cell Significance Index: -5.5100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5829
Cell Significance Index: -36.7400 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.6123
Cell Significance Index: -9.3000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6431
Cell Significance Index: -22.5300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.6682
Cell Significance Index: -31.4100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6872
Cell Significance Index: -36.0800 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.6886
Cell Significance Index: -4.4800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.6977
Cell Significance Index: -13.8000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.7160
Cell Significance Index: -10.5700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.7466
Cell Significance Index: -34.8100 - Cell Name: glioblast (CL0000030)
Fold Change: -0.7851
Cell Significance Index: -4.9300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.7918
Cell Significance Index: -16.9300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.8250
Cell Significance Index: -20.1300 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.8816
Cell Significance Index: -10.0900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.8944
Cell Significance Index: -22.3100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.9286
Cell Significance Index: -32.2700 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.9770
Cell Significance Index: -20.3900 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -1.0020
Cell Significance Index: -24.2700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1247109369
Symbol: EPHB1_HUMAN
Name: Ephrin type-B receptor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8666391
Title: cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain.
PubMed ID: 8666391
PubMed ID: 9430661
Title: Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.
PubMed ID: 9430661
PubMed ID: 18593464
Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
PubMed ID: 18593464
DOI: 10.1186/ar2447
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15340161
Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.
PubMed ID: 15340161
DOI: 10.1110/ps.04682504
PubMed ID: 8798570
Title: Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.
PubMed ID: 8798570
PubMed ID: 9267020
Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.
PubMed ID: 9267020
PubMed ID: 9499402
Title: Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.
PubMed ID: 9499402
DOI: 10.1101/gad.12.5.667
PubMed ID: 11713248
Title: The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1.
PubMed ID: 11713248
PubMed ID: 12223469
Title: EphB1 associates with Grb7 and regulates cell migration.
PubMed ID: 12223469
PubMed ID: 12925710
Title: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.
PubMed ID: 12925710
PubMed ID: 18034775
Title: Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.
PubMed ID: 18034775
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 984
- Mass: 109885
- Checksum: 8044160E24E93A92
- Sequence:
MALDYLLLLL LASAVAAMEE TLMDTRTATA ELGWTANPAS GWEEVSGYDE NLNTIRTYQV CNVFEPNQNN WLLTTFINRR GAHRIYTEMR FTVRDCSSLP NVPGSCKETF NLYYYETDSV IATKKSAFWS EAPYLKVDTI AADESFSQVD FGGRLMKVNT EVRSFGPLTR NGFYLAFQDY GACMSLLSVR VFFKKCPSIV QNFAVFPETM TGAESTSLVI ARGTCIPNAE EVDVPIKLYC NGDGEWMVPI GRCTCKPGYE PENSVACKAC PAGTFKASQE AEGCSHCPSN SRSPAEASPI CTCRTGYYRA DFDPPEVACT SVPSGPRNVI SIVNETSIIL EWHPPRETGG RDDVTYNIIC KKCRADRRSC SRCDDNVEFV PRQLGLTECR VSISSLWAHT PYTFDIQAIN GVSSKSPFPP QHVSVNITTN QAAPSTVPIM HQVSATMRSI TLSWPQPEQP NGIILDYEIR YYEKEHNEFN SSMARSQTNT ARIDGLRPGM VYVVQVRART VAGYGKFSGK MCFQTLTDDD YKSELREQLP LIAGSAAAGV VFVVSLVAIS IVCSRKRAYS KEAVYSDKLQ HYSTGRGSPG MKIYIDPFTY EDPNEAVREF AKEIDVSFVK IEEVIGAGEF GEVYKGRLKL PGKREIYVAI KTLKAGYSEK QRRDFLSEAS IMGQFDHPNI IRLEGVVTKS RPVMIITEFM ENGALDSFLR QNDGQFTVIQ LVGMLRGIAA GMKYLAEMNY VHRDLAARNI LVNSNLVCKV SDFGLSRYLQ DDTSDPTYTS SLGGKIPVRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSF GERPYWDMSN QDVINAIEQD YRLPPPMDCP AALHQLMLDC WQKDRNSRPR FAEIVNTLDK MIRNPASLKT VATITAVPSQ PLLDRSIPDF TAFTTVDDWL SAIKMVQYRD SFLTAGFTSL QLVTQMTSED LLRIGITLAG HQKKILNSIH SMRVQISQSP TAMA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.