Details for: EPHB1

Gene ID: 2047

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: EPHB1

Ensembl ID: ENSG00000154928

Description: EPH receptor B1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cerebellar granule cell CL0001031
    CSI 24.38
    rCSI 35.84%
    PRS 83.47
  • VIP GABAergic cortical interneuron CL4023016
    CSI 19.48
    rCSI 23.27%
    PRS 75.12
  • astrocyte of the cerebral cortex CL0002605
    CSI 15.01
    rCSI 33.65%
    PRS 75.59
  • progenitor cell CL0011026
    CSI 14.94
    rCSI 31.77%
    PRS 83.01
  • sncg GABAergic cortical interneuron CL4023015
    CSI 14.72
    rCSI 23.67%
    PRS 76.19
  • plasmacytoid dendritic cell, human CL0001058
    CSI 9.15
    rCSI 6.39%
    PRS 92.09
  • retinal ganglion cell CL0000740
    CSI 9.06
    rCSI 20.02%
    PRS 77.81
  • dendritic cell CL0000451
    CSI 8.22
    rCSI 10.13%
    PRS 88.94
  • interneuron CL0000099
    CSI 8.14
    rCSI 16.34%
    PRS 82.36
  • GABAergic amacrine cell CL4030027
    CSI 7.63
    rCSI 26.12%
    PRS 76.14
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 7.59
    rCSI 18.45%
    PRS 72.77
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 7.03
    rCSI 25.29%
    PRS 73
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 6.37
    rCSI 8.17%
    PRS 85.56
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 5.93
    rCSI 7.37%
    PRS 72.82
  • cerebral cortex endothelial cell CL1001602
    CSI 5.85
    rCSI 10.12%
    PRS 83.17
  • glioblast CL0000030
    CSI 5.76
    rCSI 9.19%
    PRS 81.35
  • amacrine cell CL0000561
    CSI 5.55
    rCSI 16.08%
    PRS 80.15
  • neural crest cell CL0011012
    CSI 5.52
    rCSI 4.37%
    PRS 81.27
  • radial glial cell CL0000681
    CSI 5.37
    rCSI 7.46%
    PRS 87.48
  • cardiac muscle cell CL0000746
    CSI 5.33
    rCSI 7.65%
    PRS 80.87
  • inhibitory interneuron CL0000498
    CSI 5.09
    rCSI 11.75%
    PRS 79.49
  • melanocyte CL0000148
    CSI 5.05
    rCSI 3.74%
    PRS 84.92
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 4.94
    rCSI 5.71%
    PRS 81.8
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 4.75
    rCSI 27.99%
    PRS 75.54
  • Mueller cell CL0000636
    CSI 4.69
    rCSI 10.71%
    PRS 82.01
  • sst GABAergic cortical interneuron CL4023017
    CSI 4.58
    rCSI 5.91%
    PRS 76.18
  • blood vessel endothelial cell CL0000071
    CSI 4.5
    rCSI 9.34%
    PRS 87.13
  • neural cell CL0002319
    CSI 4.49
    rCSI 16.96%
    PRS 73.56
  • renal interstitial pericyte CL1001318
    CSI 4.36
    rCSI 12.02%
    PRS 85.91
  • glial cell CL0000125
    CSI 4.09
    rCSI 15.58%
    PRS 82.03
  • neuron CL0000540
    CSI 3.9
    rCSI 10.39%
    PRS 76.97
  • adipocyte CL0000136
    CSI 3.73
    rCSI 4.79%
    PRS 80.45
  • central nervous system neuron CL2000029
    CSI 3.52
    rCSI 25.89%
    PRS 79.81
  • mature astrocyte CL0002627
    CSI 3.48
    rCSI 14.79%
    PRS 81.99
  • ON parasol ganglion cell CL4033052
    CSI 3.42
    rCSI 48.51%
    PRS 81.16
  • neural progenitor cell CL0011020
    CSI 3.31
    rCSI 14.58%
    PRS 78.16
  • medium spiny neuron CL1001474
    CSI 3.25
    rCSI 28.02%
    PRS 80.31
  • retinal cone cell CL0000573
    CSI 2.96
    rCSI 4.76%
    PRS 80.9
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 2.88
    rCSI 6.88%
    PRS 77.96
  • chondrocyte CL0000138
    CSI 2.81
    rCSI 4.46%
    PRS 83.93
  • myoepithelial cell CL0000185
    CSI 2.66
    rCSI 6.74%
    PRS 91.78
  • forebrain radial glial cell CL0013000
    CSI 2.65
    rCSI 8.51%
    PRS 88.92
  • glutamatergic neuron CL0000679
    CSI 2.63
    rCSI 5.4%
    PRS 77.16
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.54
    rCSI 6.45%
    PRS 82.11
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 2.48
    rCSI 7.74%
    PRS 78.29
  • lung neuroendocrine cell CL1000223
    CSI 2.43
    rCSI 3.6%
    PRS 90.97
  • retinal pigment epithelial cell CL0002586
    CSI 2.34
    rCSI 4.64%
    PRS 85.3
  • macroglial cell CL0000126
    CSI 2.32
    rCSI 5.97%
    PRS 85.03
  • serotonergic neuron CL0000850
    CSI 2.23
    rCSI 9.96%
    PRS 74.68
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.23
    rCSI 4.04%
    PRS 82.25
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 2.18
    rCSI 3.66%
    PRS 75.03
  • glycinergic amacrine cell CL4030028
    CSI 2.14
    rCSI 5.58%
    PRS 83.04
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 2.11
    rCSI 4.58%
    PRS 77.7
  • direct pathway medium spiny neuron CL4023026
    CSI 2.1
    rCSI 50.35%
    PRS 72.74
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.08
    rCSI 50.19%
    PRS 73.05
  • ON midget ganglion cell CL4033046
    CSI 2.08
    rCSI 42.31%
    PRS 80
  • OFF midget ganglion cell CL4033047
    CSI 2.02
    rCSI 41.1%
    PRS 80.86
  • GABAergic neuron CL0000617
    CSI 2.02
    rCSI 6.75%
    PRS 75.11
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2
    rCSI 3.54%
    PRS 74.53
  • regular atrial cardiac myocyte CL0002129
    CSI 1.54
    rCSI 4.96%
    PRS 85.69
  • L6b glutamatergic cortical neuron CL4023038
    CSI 1.41
    rCSI 4.41%
    PRS 76.43
  • cerebellar neuron CL1001611
    CSI 1.36
    rCSI 11.93%
    PRS 77.1
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 1.32
    rCSI 4.32%
    PRS 76.99
  • dopaminergic neuron CL0000700
    CSI 1.31
    rCSI 7.4%
    PRS 78.01
  • diffuse bipolar 1 cell CL4033027
    CSI 1.21
    rCSI 9.11%
    PRS 78.93
  • basal cell CL0000646
    CSI 1.18
    rCSI 1.58%
    PRS 86.36
  • diffuse bipolar 3b cell CL4033030
    CSI 1.06
    rCSI 7.06%
    PRS 83.05
  • midbrain dopaminergic neuron CL2000097
    CSI 0.99
    rCSI 6.33%
    PRS 83.74
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.88
    rCSI 5.47%
    PRS 82.41
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.82
    rCSI 3.09%
    PRS 75.29
  • H2 horizontal cell CL0004218
    CSI 0.72
    rCSI 3.57%
    PRS 83.36
  • flat midget bipolar cell CL4033033
    CSI 0.62
    rCSI 4.46%
    PRS 79.61
  • GABAergic interneuron CL0011005
    CSI 0.58
    rCSI 9.1%
    PRS 89.46
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.57
    rCSI 6.05%
    PRS 85.05

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [EPHB1](/details-gene/2047) (Ephrin type-B receptor 1) is a protein-coding gene located on chromosome 3q22.2 that encodes a member of the Eph receptor family, the largest subgroup of receptor protein-tyrosine kinases. Functionally, [EPHB1](/details-gene/2047) is a transmembrane receptor that plays a crucial role in developmental processes, particularly in the nervous system, through its involvement in pathways like `Axon guidance` ([R-HSA-422475](https://reactome.org/content/detail/R-HSA-422475)) and `Nervous system development` ([R-HSA-9675108](https://reactome.org/content/detail/R-HSA-9675108)). Its expression profile reflects this role, showing high significance in a wide array of neuronal and glial cell types, most notably in the [cerebellar granule cell](/details-cell/CL0001031), various [cortical interneurons](/details-cell/CL4023016), and [astrocytes](/details-cell/CL0002605). The receptor's function is initiated by binding to its ephrin-B ligands, which triggers bidirectional signaling that modulates cell adhesion, migration, and morphology. A potential clinical link is noted in OMIM ([600600](https://omim.org/entry/600600)). ## Cellular Roles and Expression Landscape The expression profile of [EPHB1](/details-gene/2047) strongly indicates a primary function within the central nervous system. **Overall**, the gene shows its highest significance in [cerebellar granule cell](/details-cell/CL0001031) (CSI: 24.38), suggesting a defining role in this abundant neuronal population. This is further supported by its high significance in multiple subtypes of cortical neurons, including [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 19.48), [sncg GABAergic cortical interneuron](/details-cell/CL4023015) (CSI: 14.72), and various glutamatergic neurons ([L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) and [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041)). Beyond mature neurons, [EPHB1](/details-gene/2047) is also highly significant in neural [progenitor cell](/details-cell/CL0011026) (CSI: 14.94) and [neuroblast (sensu Vertebrata)](/details-cell/CL0000031) (CSI: 6.37), consistent with its established role in neurogenesis and development. Its significance in glial cells, specifically [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: 15.01), points towards a function in neuron-glia communication and brain homeostasis. Interestingly, [EPHB1](/details-gene/2047) also shows notable significance in specific immune cell populations, particularly [plasmacytoid dendritic cell, human](/details-cell/CL0001058) (CSI: 9.15) and the broader [dendritic cell](/details-cell/CL0000451) category (CSI: 8.22). This suggests a secondary role for [EPHB1](/details-gene/2047) at the neuro-immune interface, potentially mediating crosstalk between the nervous and immune systems. ## Pathways and Molecular Function [EPHB1](/details-gene/2047) functions as a `transmembrane-ephrin receptor activity` ([GO:0005005](https://www.ebi.ac.uk/QuickGO/term/GO:0005005)) that involves `ATP binding` ([GO:0005524](https://www.ebi.ac.uk/QuickGO/term/GO:0005524)) and subsequent `protein autophosphorylation` ([GO:0046777](https://www.ebi.ac.uk/QuickGO/term/GO:0046777)). This kinase activity initiates downstream signaling cascades, including the `regulation of erk1 and erk2 cascade` ([GO:0070372](https://www.ebi.ac.uk/QuickGO/term/GO:0070372)) and `regulation of jnk cascade` ([GO:0046328](https://www.ebi.ac.uk/QuickGO/term/GO:0046328)), as reported in literature ([Link](https://doi.org/10.1074/jbc.273.3.1303), [Link](https://doi.org/10.1083/jcb.200302073)). The predominant biological processes associated with [EPHB1](/details-gene/2047) relate to cell-cell communication and guidance, particularly during development. It is a key component of the `Ephrin receptor signaling pathway` ([GO:0048013](https://www.ebi.ac.uk/QuickGO/term/GO:0048013)) and the broader `Eph-ephrin signaling` pathway ([R-HSA-2682334](https://reactome.org/content/detail/R-HSA-2682334)). These pathways are fundamental to `Axon guidance` ([GO:0007411](https://www.ebi.ac.uk/QuickGO/term/GO:0007411)) and `retinal ganglion cell axon guidance` ([GO:0031290](https://www.ebi.ac.uk/QuickGO/term/GO:0031290)), which is consistent with its high expression in [retinal ganglion cell](/details-cell/CL0000740). Its role extends to synaptic development, as shown by its involvement in `dendritic spine morphogenesis` ([GO:0060997](https://www.ebi.ac.uk/QuickGO/term/GO:0060997)) and `positive regulation of synapse assembly` ([GO:0051965](https://www.ebi.ac.uk/QuickGO/term/GO:0051965)). The expression of [EPHB1](/details-gene/2047) in dendritic cells is functionally supported by its role in `Immunological synapse formation` ([GO:0001771](https://www.ebi.ac.uk/QuickGO/term/GO:0001771)), suggesting it contributes to the physical and signaling interface between antigen-presenting cells and T cells. Furthermore, its participation in processes like `Angiogenesis` ([GO:0001525](https://www.ebi.ac.uk/QuickGO/term/GO:0001525)) aligns with its expression in [cerebral cortex endothelial cell](/details-cell/CL1001602). ## Research Directions The dual expression of [EPHB1](/details-gene/2047) in both the nervous system and immune cells, coupled with its known signaling functions, suggests it may act as a critical mediator of neuro-immune interactions in health and disease. **Proposed Hypotheses:** 1. **[EPHB1](/details-gene/2047) mediates pain sensitization through dendritic cell-neuron crosstalk.** Given its role in `detection of temperature stimulus involved in sensory perception of pain` ([GO:0050965](https://www.ebi.ac.uk/QuickGO/term/GO:0050965)) and its expression in [dendritic cell](/details-cell/CL0000451)s, we hypothesize that ephrin-B/EphB1 signaling between peripheral sensory neurons and resident dendritic cells contributes to the neuro-inflammatory cascade that lowers pain thresholds during inflammation or injury. 2. **[EPHB1](/details-gene/2047) signaling regulates the fate of neural progenitor cells in the adult brain.** The high significance of [EPHB1](/details-gene/2047) in both [progenitor cell](/details-cell/CL0011026)s and mature neurons suggests it may act as a molecular switch. We hypothesize that the level of ephrin-B ligand in the neurogenic niche determines whether [EPHB1](/details-gene/2047)-expressing progenitor cells remain quiescent, proliferate, or commit to neuronal differentiation. **Key Experimental Approach:** To test the hypothesis regarding pain sensitization (Hypothesis 1), a co-culture system could be established using primary dorsal root ganglion (DRG) neurons and bone marrow-derived dendritic cells. Dendritic cells could be treated with an shRNA targeting [EPHB1](/details-gene/2047) or a control. Following co-culture and stimulation with an inflammatory agent (e.g., LPS), neuronal excitability could be measured via patch-clamp electrophysiology or calcium imaging. A reduction in neuronal hyperexcitability in the [EPHB1](/details-gene/2047)-knockdown condition would support the hypothesis that dendritic cell-expressed [EPHB1](/details-gene/2047) is pro-nociceptive. **Therapeutic Potential:** As a cell surface receptor tyrosine kinase, [EPHB1](/details-gene/2047) is a druggable target. Its roles in cell migration, axon guidance, and angiogenesis are frequently dysregulated in cancer and inflammatory diseases. Indeed, splice variants have been investigated as potential therapeutics for rheumatoid arthritis ([Link](https://doi.org/10.1186/ar2447)). Therapeutic strategies would likely focus on **inhibition**. Soluble decoy receptors (EphB1-Fc fusion proteins) could be used to sequester ephrin-B ligands, disrupting pathological signaling in contexts like tumor angiogenesis or chronic inflammatory pain. Small molecule kinase inhibitors targeting the intracellular domain of [EPHB1](/details-gene/2047) could also be developed to block its downstream effects on MAPK/ERK and JNK pathways.

Genular Protein ID: 1247109369

Symbol: EPHB1_HUMAN

Name: Ephrin type-B receptor 1

UniProtKB Accession Codes:

P54762 A8K593 B3KTB2 B5A969 O43569 O95142 O95143 Q0VG87

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 14 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 40 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 20 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIRSF 1 PRINTS 2 PRO 1 PROSITE 9 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 1 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8666391

Title: cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain.

PubMed ID: 8666391

DOI: 10.1006/geno.1995.9985

PubMed ID: 9430661

Title: Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.

PubMed ID: 9430661

DOI: 10.1074/jbc.273.3.1303

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 8798570

Title: Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.

PubMed ID: 8798570

DOI: 10.1074/jbc.271.38.23588

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 9499402

Title: Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.

PubMed ID: 9499402

DOI: 10.1101/gad.12.5.667

PubMed ID: 11713248

Title: The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1.

PubMed ID: 11713248

DOI: 10.1074/jbc.m108011200

PubMed ID: 12223469

Title: EphB1 associates with Grb7 and regulates cell migration.

PubMed ID: 12223469

DOI: 10.1074/jbc.m203165200

PubMed ID: 12925710

Title: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.

PubMed ID: 12925710

DOI: 10.1083/jcb.200302073

PubMed ID: 18034775

Title: Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.

PubMed ID: 18034775

DOI: 10.1111/j.1600-0854.2007.00679.x

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 984
  • Mass: 109885
  • Checksum: 8044160E24E93A92
  • Sequence:
    • MALDYLLLLL LASAVAAMEE TLMDTRTATA ELGWTANPAS GWEEVSGYDE NLNTIRTYQV 
CNVFEPNQNN WLLTTFINRR GAHRIYTEMR FTVRDCSSLP NVPGSCKETF NLYYYETDSV 
IATKKSAFWS EAPYLKVDTI AADESFSQVD FGGRLMKVNT EVRSFGPLTR NGFYLAFQDY 
GACMSLLSVR VFFKKCPSIV QNFAVFPETM TGAESTSLVI ARGTCIPNAE EVDVPIKLYC 
NGDGEWMVPI GRCTCKPGYE PENSVACKAC PAGTFKASQE AEGCSHCPSN SRSPAEASPI 
CTCRTGYYRA DFDPPEVACT SVPSGPRNVI SIVNETSIIL EWHPPRETGG RDDVTYNIIC 
KKCRADRRSC SRCDDNVEFV PRQLGLTECR VSISSLWAHT PYTFDIQAIN GVSSKSPFPP 
QHVSVNITTN QAAPSTVPIM HQVSATMRSI TLSWPQPEQP NGIILDYEIR YYEKEHNEFN 
SSMARSQTNT ARIDGLRPGM VYVVQVRART VAGYGKFSGK MCFQTLTDDD YKSELREQLP 
LIAGSAAAGV VFVVSLVAIS IVCSRKRAYS KEAVYSDKLQ HYSTGRGSPG MKIYIDPFTY 
EDPNEAVREF AKEIDVSFVK IEEVIGAGEF GEVYKGRLKL PGKREIYVAI KTLKAGYSEK 
QRRDFLSEAS IMGQFDHPNI IRLEGVVTKS RPVMIITEFM ENGALDSFLR QNDGQFTVIQ 
LVGMLRGIAA GMKYLAEMNY VHRDLAARNI LVNSNLVCKV SDFGLSRYLQ DDTSDPTYTS 
SLGGKIPVRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSF GERPYWDMSN QDVINAIEQD 
YRLPPPMDCP AALHQLMLDC WQKDRNSRPR FAEIVNTLDK MIRNPASLKT VATITAVPSQ 
PLLDRSIPDF TAFTTVDDWL SAIKMVQYRD SFLTAGFTSL QLVTQMTSED LLRIGITLAG 
HQKKILNSIH SMRVQISQSP TAMA