Details for: EPHB1

Gene ID: 2047

Symbol: EPHB1

Ensembl ID: ENSG00000154928

Description: EPH receptor B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 244.3019
    Cell Significance Index: -38.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 149.8955
    Cell Significance Index: -38.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8896
    Cell Significance Index: -12.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 4.5262
    Cell Significance Index: 657.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 4.4010
    Cell Significance Index: 75.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.0005
    Cell Significance Index: 151.4900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 3.2388
    Cell Significance Index: 45.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.1997
    Cell Significance Index: 141.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.8000
    Cell Significance Index: 61.3100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.9440
    Cell Significance Index: 20.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.6561
    Cell Significance Index: 42.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.5318
    Cell Significance Index: 49.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3071
    Cell Significance Index: 262.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8585
    Cell Significance Index: 38.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7824
    Cell Significance Index: 148.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7462
    Cell Significance Index: 267.6700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6555
    Cell Significance Index: 8.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5422
    Cell Significance Index: 41.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5421
    Cell Significance Index: 33.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5238
    Cell Significance Index: 35.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4877
    Cell Significance Index: 337.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3838
    Cell Significance Index: 346.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3052
    Cell Significance Index: 30.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1864
    Cell Significance Index: 4.4700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1524
    Cell Significance Index: 2.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1363
    Cell Significance Index: 22.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1010
    Cell Significance Index: 1.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0825
    Cell Significance Index: 155.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0809
    Cell Significance Index: 2.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0693
    Cell Significance Index: 13.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0454
    Cell Significance Index: 69.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0388
    Cell Significance Index: 0.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0344
    Cell Significance Index: 1.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0321
    Cell Significance Index: 14.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0310
    Cell Significance Index: 3.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0282
    Cell Significance Index: 38.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0264
    Cell Significance Index: 48.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0181
    Cell Significance Index: 11.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0007
    Cell Significance Index: -0.3100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0152
    Cell Significance Index: -0.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0290
    Cell Significance Index: -1.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0317
    Cell Significance Index: -17.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0458
    Cell Significance Index: -33.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0538
    Cell Significance Index: -39.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0707
    Cell Significance Index: -44.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0717
    Cell Significance Index: -40.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1046
    Cell Significance Index: -18.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1084
    Cell Significance Index: -31.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1330
    Cell Significance Index: -2.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1463
    Cell Significance Index: -2.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2009
    Cell Significance Index: -12.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2075
    Cell Significance Index: -43.7000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2182
    Cell Significance Index: -3.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2189
    Cell Significance Index: -26.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2280
    Cell Significance Index: -4.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2309
    Cell Significance Index: -15.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2412
    Cell Significance Index: -41.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2463
    Cell Significance Index: -31.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2619
    Cell Significance Index: -8.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2680
    Cell Significance Index: -36.8100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2765
    Cell Significance Index: -3.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2868
    Cell Significance Index: -37.0500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3139
    Cell Significance Index: -4.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3197
    Cell Significance Index: -22.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3216
    Cell Significance Index: -32.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3226
    Cell Significance Index: -33.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3320
    Cell Significance Index: -39.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3389
    Cell Significance Index: -39.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3478
    Cell Significance Index: -7.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3709
    Cell Significance Index: -5.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3753
    Cell Significance Index: -43.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3868
    Cell Significance Index: -10.8100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4028
    Cell Significance Index: -5.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4107
    Cell Significance Index: -11.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4171
    Cell Significance Index: -25.5700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4476
    Cell Significance Index: -5.7400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4569
    Cell Significance Index: -5.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4811
    Cell Significance Index: -10.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5022
    Cell Significance Index: -37.4300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5158
    Cell Significance Index: -5.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5342
    Cell Significance Index: -17.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5560
    Cell Significance Index: -28.9600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5813
    Cell Significance Index: -5.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5829
    Cell Significance Index: -36.7400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.6123
    Cell Significance Index: -9.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6431
    Cell Significance Index: -22.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6682
    Cell Significance Index: -31.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6872
    Cell Significance Index: -36.0800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.6886
    Cell Significance Index: -4.4800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6977
    Cell Significance Index: -13.8000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7160
    Cell Significance Index: -10.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7466
    Cell Significance Index: -34.8100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.7851
    Cell Significance Index: -4.9300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7918
    Cell Significance Index: -16.9300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8250
    Cell Significance Index: -20.1300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.8816
    Cell Significance Index: -10.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8944
    Cell Significance Index: -22.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9286
    Cell Significance Index: -32.2700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9770
    Cell Significance Index: -20.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.0020
    Cell Significance Index: -24.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane receptor**: EPHB1 is a type-B receptor, characterized by its seven transmembrane domains and a cytoplasmic domain that undergoes autophosphorylation upon ligand binding. 2. **High expression in various tissues**: EPHB1 is significantly expressed in the nervous system, immune cells, vascular endothelium, and other tissues, indicating its involvement in multiple biological processes. 3. **Receptor activity**: EPHB1 exhibits receptor activity, mediating forward signaling upon binding to its ligands, ephrins. 4. **Signaling pathways**: EPHB1 is involved in various signaling pathways, including the regulation of Erk1/2 and JNK cascades, which play crucial roles in cell proliferation, differentiation, and survival. **Pathways and Functions:** 1. **Angiogenesis**: EPHB1 regulates angiogenesis, the process of new blood vessel formation, by modulating endothelial cell migration and proliferation. 2. **Neurogenesis**: EPHB1 is involved in the regulation of neural precursor cell proliferation and neurogenesis, the process of generating new neurons. 3. **Immune cell function**: EPHB1 plays a crucial role in the regulation of immune cell functions, including the activation and proliferation of T cells and the migration of innate lymphoid cells. 4. **Skeletal muscle development**: EPHB1 is involved in the regulation of skeletal muscle satellite cell proliferation and activation. 5. **Neurotransmission**: EPHB1 modulates the assembly of glutamatergic synapses, which are critical for neuronal communication. **Clinical Significance:** 1. **Cancer**: EPHB1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role as a tumor suppressor. 2. **Neurological disorders**: EPHB1 is involved in the regulation of neurogenesis and neuronal migration, which are disrupted in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. 3. **Immune-mediated diseases**: EPHB1 is involved in the regulation of immune cell functions, which are dysregulated in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. 4. **Vascular diseases**: EPHB1 regulates angiogenesis, which is impaired in vascular diseases such as atherosclerosis and stroke. In conclusion, the EPHB1 gene plays a crucial role in various biological processes, including cell migration, adhesion, and differentiation, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the complexities of EPHB1 and its potential therapeutic applications.

Genular Protein ID: 1247109369

Symbol: EPHB1_HUMAN

Name: Ephrin type-B receptor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8666391

Title: cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain.

PubMed ID: 8666391

DOI: 10.1006/geno.1995.9985

PubMed ID: 9430661

Title: Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.

PubMed ID: 9430661

DOI: 10.1074/jbc.273.3.1303

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 8798570

Title: Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.

PubMed ID: 8798570

DOI: 10.1074/jbc.271.38.23588

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 9499402

Title: Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.

PubMed ID: 9499402

DOI: 10.1101/gad.12.5.667

PubMed ID: 11713248

Title: The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1.

PubMed ID: 11713248

DOI: 10.1074/jbc.m108011200

PubMed ID: 12223469

Title: EphB1 associates with Grb7 and regulates cell migration.

PubMed ID: 12223469

DOI: 10.1074/jbc.m203165200

PubMed ID: 12925710

Title: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.

PubMed ID: 12925710

DOI: 10.1083/jcb.200302073

PubMed ID: 18034775

Title: Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.

PubMed ID: 18034775

DOI: 10.1111/j.1600-0854.2007.00679.x

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 984
  • Mass: 109885
  • Checksum: 8044160E24E93A92
  • Sequence:
  • MALDYLLLLL LASAVAAMEE TLMDTRTATA ELGWTANPAS GWEEVSGYDE NLNTIRTYQV 
    CNVFEPNQNN WLLTTFINRR GAHRIYTEMR FTVRDCSSLP NVPGSCKETF NLYYYETDSV 
    IATKKSAFWS EAPYLKVDTI AADESFSQVD FGGRLMKVNT EVRSFGPLTR NGFYLAFQDY 
    GACMSLLSVR VFFKKCPSIV QNFAVFPETM TGAESTSLVI ARGTCIPNAE EVDVPIKLYC 
    NGDGEWMVPI GRCTCKPGYE PENSVACKAC PAGTFKASQE AEGCSHCPSN SRSPAEASPI 
    CTCRTGYYRA DFDPPEVACT SVPSGPRNVI SIVNETSIIL EWHPPRETGG RDDVTYNIIC 
    KKCRADRRSC SRCDDNVEFV PRQLGLTECR VSISSLWAHT PYTFDIQAIN GVSSKSPFPP 
    QHVSVNITTN QAAPSTVPIM HQVSATMRSI TLSWPQPEQP NGIILDYEIR YYEKEHNEFN 
    SSMARSQTNT ARIDGLRPGM VYVVQVRART VAGYGKFSGK MCFQTLTDDD YKSELREQLP 
    LIAGSAAAGV VFVVSLVAIS IVCSRKRAYS KEAVYSDKLQ HYSTGRGSPG MKIYIDPFTY 
    EDPNEAVREF AKEIDVSFVK IEEVIGAGEF GEVYKGRLKL PGKREIYVAI KTLKAGYSEK 
    QRRDFLSEAS IMGQFDHPNI IRLEGVVTKS RPVMIITEFM ENGALDSFLR QNDGQFTVIQ 
    LVGMLRGIAA GMKYLAEMNY VHRDLAARNI LVNSNLVCKV SDFGLSRYLQ DDTSDPTYTS 
    SLGGKIPVRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSF GERPYWDMSN QDVINAIEQD 
    YRLPPPMDCP AALHQLMLDC WQKDRNSRPR FAEIVNTLDK MIRNPASLKT VATITAVPSQ 
    PLLDRSIPDF TAFTTVDDWL SAIKMVQYRD SFLTAGFTSL QLVTQMTSED LLRIGITLAG 
    HQKKILNSIH SMRVQISQSP TAMA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.