Details for: EPHB1

Gene ID: 2047

Symbol: EPHB1

Ensembl ID: ENSG00000154928

Description: EPH receptor B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.75
    Marker Score: 126677
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.73
    Marker Score: 14681
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.69
    Marker Score: 5103
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.58
    Marker Score: 55117
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.38
    Marker Score: 917
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.06
    Marker Score: 1154
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.06
    Marker Score: 1354
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.9
    Marker Score: 2371
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.84
    Marker Score: 69772
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.77
    Marker Score: 3606
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.74
    Marker Score: 1011
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.7
    Marker Score: 8941
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.7
    Marker Score: 714
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.61
    Marker Score: 722
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.59
    Marker Score: 12200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.59
    Marker Score: 15078
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5
    Marker Score: 1496
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5
    Marker Score: 92158
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.49
    Marker Score: 11241
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.49
    Marker Score: 15375
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.48
    Marker Score: 6014
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168721
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2243
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.43
    Marker Score: 5921
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.42
    Marker Score: 31661
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.38
    Marker Score: 51051
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.37
    Marker Score: 657
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.36
    Marker Score: 3215
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.36
    Marker Score: 12780
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.33
    Marker Score: 20864
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.31
    Marker Score: 785
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.27
    Marker Score: 348
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.27
    Marker Score: 384
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.23
    Marker Score: 717
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.23
    Marker Score: 4133
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.22
    Marker Score: 382
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.22
    Marker Score: 7213.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.21
    Marker Score: 24149
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.2
    Marker Score: 3417
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.2
    Marker Score: 10276
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.17
    Marker Score: 399
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.11
    Marker Score: 4302
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.06
    Marker Score: 671.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1
    Marker Score: 1208
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1
    Marker Score: 4626
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1
    Marker Score: 674
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.96
    Marker Score: 560
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.95
    Marker Score: 246
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.94
    Marker Score: 3919
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.93
    Marker Score: 13910
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5264
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.91
    Marker Score: 787
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.9
    Marker Score: 1113
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9
    Marker Score: 412
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.89
    Marker Score: 425
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.84
    Marker Score: 2098
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.83
    Marker Score: 1908
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 624
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.82
    Marker Score: 987
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.79
    Marker Score: 1333
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3327.5
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.76
    Marker Score: 2952
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.76
    Marker Score: 1658.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 688
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4179
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.69
    Marker Score: 1649
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.67
    Marker Score: 306
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.66
    Marker Score: 238
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.63
    Marker Score: 278
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.61
    Marker Score: 264
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.61
    Marker Score: 530
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.61
    Marker Score: 819
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.58
    Marker Score: 252
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.58
    Marker Score: 2488
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.56
    Marker Score: 2006
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.56
    Marker Score: 766.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.53
    Marker Score: 150
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.53
    Marker Score: 213
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.52
    Marker Score: 5305
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.5
    Marker Score: 158
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.48
    Marker Score: 139

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Other Information

**Key characteristics:** - EPHB1 is a transmembrane protein with a single extracellular domain and a single intracellular domain. - It is expressed on a variety of cell types, including neurons, astrocytes, and endothelial cells. - It is a key regulator of neuronal migration and survival. **Pathways and functions:** - EPHB1 is involved in the regulation of angiogenesis. It is expressed in endothelial cells, which are responsible for the formation of new blood vessels. When EPHB1 is bound by its ligand, EPHB4, it inhibits the activation of the angiogenic factor VEGFR2, which is essential for the formation of new blood vessels. - EPHB1 is also involved in axon guidance. It is expressed on neurons and is important for the guidance of axons during development. - EPHB1 is a key regulator of the migration of retinal ganglion cells, which are neurons that are responsible for sending visual information to the brain. - In addition to its roles in angiogenesis, axon guidance, and neuronal migration, EPHB1 is also involved in the regulation of synaptic plasticity, learning and memory. **Clinical significance:** - Mutations in EPHB1 have been linked to a number of neurodevelopmental disorders, including autism, schizophrenia, and epilepsy. - These mutations can lead to a loss of function of EPHB1, which can result in the formation of abnormal blood vessels, abnormal axon guidance, and neuronal migration defects. - Targeting EPHB1 with drugs is a promising new therapy for a variety of neurodevelopmental disorders.

Genular Protein ID: 1247109369

Symbol: EPHB1_HUMAN

Name: Ephrin type-B receptor 1

UniProtKB Accession Codes:

P54762 A8K593 B3KTB2 B5A969 O43569 O95142 O95143 Q0VG87

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 14 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 40 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 19 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 8 PIRSF 1 PRINTS 2 PRO 1 PROSITE 9 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 1 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8666391

Title: cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain.

PubMed ID: 8666391

DOI: 10.1006/geno.1995.9985

PubMed ID: 9430661

Title: Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.

PubMed ID: 9430661

DOI: 10.1074/jbc.273.3.1303

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 8798570

Title: Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.

PubMed ID: 8798570

DOI: 10.1074/jbc.271.38.23588

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 9499402

Title: Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.

PubMed ID: 9499402

DOI: 10.1101/gad.12.5.667

PubMed ID: 11713248

Title: The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1.

PubMed ID: 11713248

DOI: 10.1074/jbc.m108011200

PubMed ID: 12223469

Title: EphB1 associates with Grb7 and regulates cell migration.

PubMed ID: 12223469

DOI: 10.1074/jbc.m203165200

PubMed ID: 12925710

Title: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.

PubMed ID: 12925710

DOI: 10.1083/jcb.200302073

PubMed ID: 18034775

Title: Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.

PubMed ID: 18034775

DOI: 10.1111/j.1600-0854.2007.00679.x

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 984
  • Mass: 109885
  • Checksum: 8044160E24E93A92
  • Sequence:
    • MALDYLLLLL LASAVAAMEE TLMDTRTATA ELGWTANPAS GWEEVSGYDE NLNTIRTYQV 
CNVFEPNQNN WLLTTFINRR GAHRIYTEMR FTVRDCSSLP NVPGSCKETF NLYYYETDSV 
IATKKSAFWS EAPYLKVDTI AADESFSQVD FGGRLMKVNT EVRSFGPLTR NGFYLAFQDY 
GACMSLLSVR VFFKKCPSIV QNFAVFPETM TGAESTSLVI ARGTCIPNAE EVDVPIKLYC 
NGDGEWMVPI GRCTCKPGYE PENSVACKAC PAGTFKASQE AEGCSHCPSN SRSPAEASPI 
CTCRTGYYRA DFDPPEVACT SVPSGPRNVI SIVNETSIIL EWHPPRETGG RDDVTYNIIC 
KKCRADRRSC SRCDDNVEFV PRQLGLTECR VSISSLWAHT PYTFDIQAIN GVSSKSPFPP 
QHVSVNITTN QAAPSTVPIM HQVSATMRSI TLSWPQPEQP NGIILDYEIR YYEKEHNEFN 
SSMARSQTNT ARIDGLRPGM VYVVQVRART VAGYGKFSGK MCFQTLTDDD YKSELREQLP 
LIAGSAAAGV VFVVSLVAIS IVCSRKRAYS KEAVYSDKLQ HYSTGRGSPG MKIYIDPFTY 
EDPNEAVREF AKEIDVSFVK IEEVIGAGEF GEVYKGRLKL PGKREIYVAI KTLKAGYSEK 
QRRDFLSEAS IMGQFDHPNI IRLEGVVTKS RPVMIITEFM ENGALDSFLR QNDGQFTVIQ 
LVGMLRGIAA GMKYLAEMNY VHRDLAARNI LVNSNLVCKV SDFGLSRYLQ DDTSDPTYTS 
SLGGKIPVRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSF GERPYWDMSN QDVINAIEQD 
YRLPPPMDCP AALHQLMLDC WQKDRNSRPR FAEIVNTLDK MIRNPASLKT VATITAVPSQ 
PLLDRSIPDF TAFTTVDDWL SAIKMVQYRD SFLTAGFTSL QLVTQMTSED LLRIGITLAG 
HQKKILNSIH SMRVQISQSP TAMA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.