Details for: EPHB3

Gene ID: 2049

Symbol: EPHB3

Ensembl ID: ENSG00000182580

Description: EPH receptor B3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.5287
    Cell Significance Index: -11.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.4187
    Cell Significance Index: -12.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.2127
    Cell Significance Index: -11.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4538
    Cell Significance Index: -14.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9675
    Cell Significance Index: -11.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8214
    Cell Significance Index: 24.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1823
    Cell Significance Index: 70.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0740
    Cell Significance Index: 22.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0624
    Cell Significance Index: 172.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8569
    Cell Significance Index: 773.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8520
    Cell Significance Index: 38.6200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.6154
    Cell Significance Index: 8.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6027
    Cell Significance Index: 17.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5780
    Cell Significance Index: 26.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4830
    Cell Significance Index: 33.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4442
    Cell Significance Index: 43.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3661
    Cell Significance Index: 3.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3436
    Cell Significance Index: 8.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3037
    Cell Significance Index: 4.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2705
    Cell Significance Index: 5.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2696
    Cell Significance Index: 31.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2674
    Cell Significance Index: 50.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2669
    Cell Significance Index: 34.2200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2413
    Cell Significance Index: 3.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1636
    Cell Significance Index: 72.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1585
    Cell Significance Index: 5.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1360
    Cell Significance Index: 4.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1226
    Cell Significance Index: 2.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0896
    Cell Significance Index: 61.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0800
    Cell Significance Index: 3.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0667
    Cell Significance Index: 13.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0655
    Cell Significance Index: 35.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0552
    Cell Significance Index: 2.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0463
    Cell Significance Index: 0.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0394
    Cell Significance Index: 5.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0383
    Cell Significance Index: 1.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0345
    Cell Significance Index: 12.3600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0207
    Cell Significance Index: 0.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0088
    Cell Significance Index: 0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0003
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0049
    Cell Significance Index: -0.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0082
    Cell Significance Index: -11.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0092
    Cell Significance Index: -17.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0103
    Cell Significance Index: -15.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0111
    Cell Significance Index: -1.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0194
    Cell Significance Index: -12.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0208
    Cell Significance Index: -15.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0259
    Cell Significance Index: -7.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0267
    Cell Significance Index: -15.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0267
    Cell Significance Index: -16.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0277
    Cell Significance Index: -0.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0287
    Cell Significance Index: -5.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0294
    Cell Significance Index: -13.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0332
    Cell Significance Index: -4.2900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0376
    Cell Significance Index: -1.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0503
    Cell Significance Index: -0.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0671
    Cell Significance Index: -4.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0727
    Cell Significance Index: -15.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0817
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0872
    Cell Significance Index: -9.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0873
    Cell Significance Index: -12.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0878
    Cell Significance Index: -4.6100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0971
    Cell Significance Index: -0.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0981
    Cell Significance Index: -0.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1127
    Cell Significance Index: -7.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1134
    Cell Significance Index: -11.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1224
    Cell Significance Index: -12.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1225
    Cell Significance Index: -7.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1347
    Cell Significance Index: -7.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1370
    Cell Significance Index: -10.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1400
    Cell Significance Index: -8.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1404
    Cell Significance Index: -8.6300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1412
    Cell Significance Index: -2.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1491
    Cell Significance Index: -11.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1628
    Cell Significance Index: -12.8900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1738
    Cell Significance Index: -2.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1766
    Cell Significance Index: -9.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1779
    Cell Significance Index: -3.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1787
    Cell Significance Index: -5.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1808
    Cell Significance Index: -12.1600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1880
    Cell Significance Index: -3.9200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1933
    Cell Significance Index: -1.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2037
    Cell Significance Index: -4.2300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2125
    Cell Significance Index: -3.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2147
    Cell Significance Index: -7.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2389
    Cell Significance Index: -6.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2485
    Cell Significance Index: -6.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2544
    Cell Significance Index: -2.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2552
    Cell Significance Index: -6.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2634
    Cell Significance Index: -9.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2645
    Cell Significance Index: -6.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2778
    Cell Significance Index: -4.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2838
    Cell Significance Index: -9.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2850
    Cell Significance Index: -2.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2855
    Cell Significance Index: -12.6300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3024
    Cell Significance Index: -5.9800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3044
    Cell Significance Index: -3.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Receptor:** EPHB3 is a transmembrane receptor with an extracellular domain that binds to ephrin ligands, triggering a signaling cascade. 2. **Eph/ephrin Signaling System:** EPHB3 is part of the Eph/ephrin signaling system, a complex network of cell-cell interactions that regulate various biological processes. 3. **Regulation of Axon Guidance:** EPHB3 plays a critical role in regulating axon guidance, a process essential for the proper formation and maintenance of neural connections. 4. **Cell Migration and Adhesion:** EPHB3 also regulates cell migration and cell-cell adhesion, processes that are crucial for tissue morphogenesis and development. **Pathways and Functions:** EPHB3 is involved in various signaling pathways, including: 1. **Angiogenesis:** EPHB3 regulates angiogenesis, the formation of new blood vessels, by modulating endothelial cell migration and proliferation. 2. **Axonal Fasciculation:** EPHB3 plays a role in regulating axonal fasciculation, the process by which axons organize and align during neural development. 3. **Cell Migration:** EPHB3 regulates cell migration, a process essential for tissue morphogenesis and development. 4. **Cytoskeleton Organization:** EPHB3 interacts with the cytoskeleton, regulating the organization and dynamics of microtubules and actin filaments. 5. **Protein Phosphorylation:** EPHB3 triggers protein phosphorylation, a key step in the signaling cascade that regulates downstream effects. **Clinical Significance:** Dysregulation of the EPHB3 gene has been implicated in various neurological and developmental disorders, including: 1. **Autism Spectrum Disorder (ASD):** Abnormalities in the EPHB3 gene have been associated with ASD, a complex neurodevelopmental disorder characterized by social and communication deficits. 2. **Schizophrenia:** EPHB3 has been implicated in schizophrenia, a psychiatric disorder characterized by cognitive and emotional deficits. 3. **Neurodegenerative Diseases:** Abnormalities in the EPHB3 gene have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer:** EPHB3 has been implicated in cancer, a group of diseases characterized by uncontrolled cell growth and tumor formation. In conclusion, the EPHB3 gene plays a critical role in regulating neural development, cell migration, and signaling pathways. Abnormalities in this gene have been implicated in various neurological and developmental disorders, highlighting the importance of this gene in maintaining tissue homeostasis and function. Further research is needed to elucidate the mechanisms by which EPHB3 regulates biological processes and to identify potential therapeutic targets for the treatment of related disorders.

Genular Protein ID: 3417221612

Symbol: EPHB3_HUMAN

Name: Ephrin type-B receptor 3

UniProtKB Accession Codes:

P54753 Q7Z740

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 2 Ensembl 1 EvolutionaryTrace 1 GO 28 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 19 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 8 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8397371

Title: PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2.

PubMed ID: 8397371

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 9674711

Title: Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.

PubMed ID: 9674711

DOI: 10.1038/sj.onc.1201907

PubMed ID: 15536074

Title: Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases.

PubMed ID: 15536074

DOI: 10.1074/jbc.m411383200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 33280498

Title: RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.

PubMed ID: 33280498

DOI: 10.1080/15548627.2020.1851496

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 998
  • Mass: 110330
  • Checksum: 9B65A4EF58B27407
  • Sequence:
    • MARARPPPPP SPPPGLLPLL PPLLLLPLLL LPAGCRALEE TLMDTKWVTS ELAWTSHPES 
GWEEVSGYDE AMNPIRTYQV CNVRESSQNN WLRTGFIWRR DVQRVYVELK FTVRDCNSIP 
NIPGSCKETF NLFYYEADSD VASASSPFWM ENPYVKVDTI APDESFSRLD AGRVNTKVRS 
FGPLSKAGFY LAFQDQGACM SLISVRAFYK KCASTTAGFA LFPETLTGAE PTSLVIAPGT 
CIPNAVEVSV PLKLYCNGDG EWMVPVGACT CATGHEPAAK ESQCRPCPPG SYKAKQGEGP 
CLPCPPNSRT TSPAASICTC HNNFYRADSD SADSACTTVP SPPRGVISNV NETSLILEWS 
EPRDLGGRDD LLYNVICKKC HGAGGASACS RCDDNVEFVP RQLGLTERRV HISHLLAHTR 
YTFEVQAVNG VSGKSPLPPR YAAVNITTNQ AAPSEVPTLR LHSSSGSSLT LSWAPPERPN 
GVILDYEMKY FEKSEGIAST VTSQMNSVQL DGLRPDARYV VQVRARTVAG YGQYSRPAEF 
ETTSERGSGA QQLQEQLPLI VGSATAGLVF VVAVVVIAIV CLRKQRHGSD SEYTEKLQQY 
IAPGMKVYID PFTYEDPNEA VREFAKEIDV SCVKIEEVIG AGEFGEVCRG RLKQPGRREV 
FVAIKTLKVG YTERQRRDFL SEASIMGQFD HPNIIRLEGV VTKSRPVMIL TEFMENCALD 
SFLRLNDGQF TVIQLVGMLR GIAAGMKYLS EMNYVHRDLA ARNILVNSNL VCKVSDFGLS 
RFLEDDPSDP TYTSSLGGKI PIRWTAPEAI AYRKFTSASD VWSYGIVMWE VMSYGERPYW 
DMSNQDVINA VEQDYRLPPP MDCPTALHQL MLDCWVRDRN LRPKFSQIVN TLDKLIRNAA 
SLKVIASAQS GMSQPLLDRT VPDYTTFTTV GDWLDAIKMG RYKESFVSAG FASFDLVAQM 
TAEDLLRIGV TLAGHQKKIL SSIQDMRLQM NQTLPVQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.