Details for: EPHB3

Gene ID: 2049

Symbol: EPHB3

Ensembl ID: ENSG00000182580

Description: EPH receptor B3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.26
    Marker Score: 6747
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.58
    Marker Score: 1319.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.52
    Marker Score: 3095
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18796
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.18
    Marker Score: 2684
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.14
    Marker Score: 361
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2096
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48032
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.95
    Marker Score: 1044
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.93
    Marker Score: 632
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.9
    Marker Score: 282
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.9
    Marker Score: 289
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5111
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.89
    Marker Score: 425
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2062
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.84
    Marker Score: 11024.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.83
    Marker Score: 878
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.82
    Marker Score: 344
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.82
    Marker Score: 878
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.8
    Marker Score: 439
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 581
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.75
    Marker Score: 709
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 296
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 671
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.69
    Marker Score: 258
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.67
    Marker Score: 405
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.67
    Marker Score: 355
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.67
    Marker Score: 1583
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.66
    Marker Score: 292
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2755.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.64
    Marker Score: 150
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.64
    Marker Score: 352
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.62
    Marker Score: 247
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.61
    Marker Score: 652
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.61
    Marker Score: 5263
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.58
    Marker Score: 1566
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.58
    Marker Score: 185
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.57
    Marker Score: 7630
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.55
    Marker Score: 4089
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.55
    Marker Score: 4279.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.55
    Marker Score: 381
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.51
    Marker Score: 190
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.51
    Marker Score: 263
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.5
    Marker Score: 312
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.49
    Marker Score: 586
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.48
    Marker Score: 3098
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.47
    Marker Score: 121
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.46
    Marker Score: 161
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.46
    Marker Score: 1038
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.45
    Marker Score: 696
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.45
    Marker Score: 1654
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.44
    Marker Score: 421
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.44
    Marker Score: 346
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.43
    Marker Score: 2556
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.42
    Marker Score: 287
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.42
    Marker Score: 643
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.41
    Marker Score: 150
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.4
    Marker Score: 515
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 383
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.38
    Marker Score: 224
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.38
    Marker Score: 470
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.38
    Marker Score: 1567
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.35
    Marker Score: 165
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.34
    Marker Score: 800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.33
    Marker Score: 214
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.33
    Marker Score: 12320
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.33
    Marker Score: 95
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.32
    Marker Score: 117
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.32
    Marker Score: 93
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.32
    Marker Score: 90
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.32
    Marker Score: 1248
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.31
    Marker Score: 2965
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.31
    Marker Score: 1969
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.31
    Marker Score: 311
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.31
    Marker Score: 295
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3
    Marker Score: 301
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.3
    Marker Score: 541
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3
    Marker Score: 627
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.29
    Marker Score: 195
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.29
    Marker Score: 133
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.29
    Marker Score: 397
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.29
    Marker Score: 1191
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.28
    Marker Score: 348
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.28
    Marker Score: 240
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.27
    Marker Score: 93
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.27
    Marker Score: 308

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Other Information

## Summary EPHB3 is a cell surface protein that plays a crucial role in various physiological and pathological processes in the human body. It is a member of the EPH family of cell surface receptors, which are known for their ability to regulate cell migration, proliferation, and survival. ## Key characteristics * EPHB3 is a transmembrane protein with a extracellular domain and a cytoplasmic domain. * It is expressed on various cell types, including endothelial cells, epithelial cells, and immune cells. * EPHB3 is a key regulator of angiogenesis, as it is highly expressed in blood vessels and is involved in the formation of new blood vessels. * It is also involved in axon guidance, axonal fasciculation, and axonal guidance receptor activity. * EPHB3 is a key regulator of cell migration, as it is expressed on neurons and is involved in the formation of new blood vessels and the growth of new neurons. * It is also involved in the development of the central nervous system and the corpus callosum, a structure that connects the two hemispheres of the brain. ## Pathways and functions * EPHB3 is a key regulator of angiogenesis. It is expressed in high levels in blood vessels and is involved in the formation of new blood vessels by promoting the migration and proliferation of endothelial cells. * It is also involved in axon guidance, axonal fasciculation, and axonal guidance receptor activity. * EPHB3 is a key regulator of cell migration, as it is expressed on neurons and is involved in the formation of new blood vessels and the growth of new neurons. * It is also involved in the development of the central nervous system and the corpus callosum, a structure that connects the two hemispheres of the brain. ## Clinical significance EPHB3 is a promising target for cancer immunotherapy. Mutations in EPHB3 have been linked to several human cancers, including breast cancer, lung cancer, and colon cancer. Targeting EPHB3 with antibodies or small molecules is a promising strategy for treating these cancers.

Genular Protein ID: 3417221612

Symbol: EPHB3_HUMAN

Name: Ephrin type-B receptor 3

UniProtKB Accession Codes:

P54753 Q7Z740

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 28 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 8 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8397371

Title: PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2.

PubMed ID: 8397371

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 9674711

Title: Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.

PubMed ID: 9674711

DOI: 10.1038/sj.onc.1201907

PubMed ID: 15536074

Title: Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases.

PubMed ID: 15536074

DOI: 10.1074/jbc.m411383200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 33280498

Title: RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.

PubMed ID: 33280498

DOI: 10.1080/15548627.2020.1851496

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 998
  • Mass: 110330
  • Checksum: 9B65A4EF58B27407
  • Sequence:
    • MARARPPPPP SPPPGLLPLL PPLLLLPLLL LPAGCRALEE TLMDTKWVTS ELAWTSHPES 
GWEEVSGYDE AMNPIRTYQV CNVRESSQNN WLRTGFIWRR DVQRVYVELK FTVRDCNSIP 
NIPGSCKETF NLFYYEADSD VASASSPFWM ENPYVKVDTI APDESFSRLD AGRVNTKVRS 
FGPLSKAGFY LAFQDQGACM SLISVRAFYK KCASTTAGFA LFPETLTGAE PTSLVIAPGT 
CIPNAVEVSV PLKLYCNGDG EWMVPVGACT CATGHEPAAK ESQCRPCPPG SYKAKQGEGP 
CLPCPPNSRT TSPAASICTC HNNFYRADSD SADSACTTVP SPPRGVISNV NETSLILEWS 
EPRDLGGRDD LLYNVICKKC HGAGGASACS RCDDNVEFVP RQLGLTERRV HISHLLAHTR 
YTFEVQAVNG VSGKSPLPPR YAAVNITTNQ AAPSEVPTLR LHSSSGSSLT LSWAPPERPN 
GVILDYEMKY FEKSEGIAST VTSQMNSVQL DGLRPDARYV VQVRARTVAG YGQYSRPAEF 
ETTSERGSGA QQLQEQLPLI VGSATAGLVF VVAVVVIAIV CLRKQRHGSD SEYTEKLQQY 
IAPGMKVYID PFTYEDPNEA VREFAKEIDV SCVKIEEVIG AGEFGEVCRG RLKQPGRREV 
FVAIKTLKVG YTERQRRDFL SEASIMGQFD HPNIIRLEGV VTKSRPVMIL TEFMENCALD 
SFLRLNDGQF TVIQLVGMLR GIAAGMKYLS EMNYVHRDLA ARNILVNSNL VCKVSDFGLS 
RFLEDDPSDP TYTSSLGGKI PIRWTAPEAI AYRKFTSASD VWSYGIVMWE VMSYGERPYW 
DMSNQDVINA VEQDYRLPPP MDCPTALHQL MLDCWVRDRN LRPKFSQIVN TLDKLIRNAA 
SLKVIASAQS GMSQPLLDRT VPDYTTFTTV GDWLDAIKMG RYKESFVSAG FASFDLVAQM 
TAEDLLRIGV TLAGHQKKIL SSIQDMRLQM NQTLPVQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.