Details for: EPHB6

Gene ID: 2051

Symbol: EPHB6

Ensembl ID: ENSG00000106123

Description: EPH receptor B6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.93
    Marker Score: 2005
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.9
    Marker Score: 2634
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.89
    Marker Score: 37679
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.64
    Marker Score: 100719
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1145
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.44
    Marker Score: 13666
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.42
    Marker Score: 2188
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.38
    Marker Score: 6377
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.37
    Marker Score: 50640
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.3
    Marker Score: 418
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.1
    Marker Score: 9483
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.06
    Marker Score: 2163
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251769
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.03
    Marker Score: 1514
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1
    Marker Score: 7441
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.98
    Marker Score: 7495
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 492
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 361
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5116
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.89
    Marker Score: 2046
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.87
    Marker Score: 1235.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5272
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.84
    Marker Score: 492
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.83
    Marker Score: 1555
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.76
    Marker Score: 330
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.74
    Marker Score: 6961
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.73
    Marker Score: 2984
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.73
    Marker Score: 167
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.72
    Marker Score: 10743
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2965
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.69
    Marker Score: 4086
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.66
    Marker Score: 7427
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.65
    Marker Score: 221
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.61
    Marker Score: 245
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.6
    Marker Score: 214
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6
    Marker Score: 632.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.58
    Marker Score: 603
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.56
    Marker Score: 1364
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.55
    Marker Score: 375
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.55
    Marker Score: 584
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 348
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.54
    Marker Score: 326
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.54
    Marker Score: 449
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 169
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.53
    Marker Score: 219
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.51
    Marker Score: 164
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.45
    Marker Score: 129
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.45
    Marker Score: 111
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.45
    Marker Score: 516
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.45
    Marker Score: 1648
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.43
    Marker Score: 713
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.43
    Marker Score: 3682
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.42
    Marker Score: 332
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.42
    Marker Score: 476
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.42
    Marker Score: 243
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.42
    Marker Score: 253
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.41
    Marker Score: 101
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.41
    Marker Score: 958
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.41
    Marker Score: 387
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4
    Marker Score: 696
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.4
    Marker Score: 1657
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.4
    Marker Score: 261
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4
    Marker Score: 2576
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.39
    Marker Score: 266
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.39
    Marker Score: 181
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.39
    Marker Score: 974
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.39
    Marker Score: 3875
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.38
    Marker Score: 795
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.37
    Marker Score: 95
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.37
    Marker Score: 207
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.37
    Marker Score: 129
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.37
    Marker Score: 19420
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.37
    Marker Score: 1490
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.36
    Marker Score: 136
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.36
    Marker Score: 358
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.36
    Marker Score: 258
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.36
    Marker Score: 81
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.36
    Marker Score: 126
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.36
    Marker Score: 300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.36
    Marker Score: 104
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.36
    Marker Score: 1483
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.35
    Marker Score: 207
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.35
    Marker Score: 176
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.35
    Marker Score: 331
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.35
    Marker Score: 357
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 232
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.35
    Marker Score: 70
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.34
    Marker Score: 104
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.34
    Marker Score: 1467
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.34
    Marker Score: 225

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Other Information

**Key characteristics:** * EPHB6 is a transmembrane protein that is composed of 13 extracellular repeats and 3 intracellular repeats. * It is expressed in high levels in the brain, particularly in areas such as the cerebral cortex, hippocampus, and cerebellum. * It is also expressed in lower levels in other tissues, such as the kidney, liver, and pancreas. **Pathways and functions:** * EPHB6 is a ligand for EPHB4, a transmembrane protein that is expressed in the brain. * The binding of EPHB6 to EPHB4 is thought to regulate the stability of a signaling complex that is involved in the development and maintenance of the nervous system. * EPHB6 is also a negative regulator of the EphB-mediated forward signaling pathway. * It is thought to play a role in the regulation of neuronal migration and differentiation. **Clinical significance:** * Mutations in EPHB6 have been linked to a number of neurodevelopmental disorders, including autism spectrum disorder, schizophrenia, and epilepsy. * In one study, mutations in EPHB6 were found to be associated with a significantly increased risk of autism in children. * This suggests that EPHB6 may be a promising target for the treatment of autism. **Additional information:** * EPHB6 is a relatively recently identified protein, and there is still much that is unknown about its function. * However, it is clear that EPHB6 plays an important role in the development and maintenance of the nervous system.

Genular Protein ID: 538486877

Symbol: EPHB6_HUMAN

Name: Ephrin type-B receptor 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9207182

Title: Expression of a kinase-defective Eph-like receptor in the normal human brain.

PubMed ID: 9207182

DOI: 10.1006/bbrc.1997.6812

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18425388

Title: Identification of EphB6 variant-derived epitope peptides recognized by cytotoxic T-lymphocytes from HLA-A24+ malignant glioma patients.

PubMed ID: 18425388

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11713248

Title: The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1.

PubMed ID: 11713248

DOI: 10.1074/jbc.m108011200

PubMed ID: 12517763

Title: The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses.

PubMed ID: 12517763

DOI: 10.1074/jbc.m208179200

PubMed ID: 15955811

Title: Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration.

PubMed ID: 15955811

DOI: 10.1074/jbc.m500010200

PubMed ID: 18754880

Title: Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients.

PubMed ID: 18754880

DOI: 10.1111/j.1349-7006.2008.00866.x

PubMed ID: 19234485

Title: EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells.

PubMed ID: 19234485

DOI: 10.1038/onc.2009.18

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1021
  • Mass: 110700
  • Checksum: BF1D4D9BE34358A5
  • Sequence:
  • MATEGAAQLG NRVAGMVCSL WVLLLVSSVL ALEEVLLDTT GETSEIGWLT YPPGGWDEVS 
    VLDDQRRLTR TFEACHVAGA PPGTGQDNWL QTHFVERRGA QRAHIRLHFS VRACSSLGVS 
    GGTCRETFTL YYRQAEEPDS PDSVSSWHLK RWTKVDTIAA DESFPSSSSS SSSSSSAAWA 
    VGPHGAGQRA GLQLNVKERS FGPLTQRGFY VAFQDTGACL ALVAVRLFSY TCPAVLRSFA 
    SFPETQASGA GGASLVAAVG TCVAHAEPEE DGVGGQAGGS PPRLHCNGEG KWMVAVGGCR 
    CQPGYQPARG DKACQACPRG LYKSSAGNAP CSPCPARSHA PNPAAPVCPC LEGFYRASSD 
    PPEAPCTGPP SAPQELWFEV QGSALMLHWR LPRELGGRGD LLFNVVCKEC EGRQEPASGG 
    GGTCHRCRDE VHFDPRQRGL TESRVLVGGL RAHVPYILEV QAVNGVSELS PDPPQAAAIN 
    VSTSHEVPSA VPVVHQVSRA SNSITVSWPQ PDQTNGNILD YQLRYYDQAE DESHSFTLTS 
    ETNTATVTQL SPGHIYGFQV RARTAAGHGP YGGKVYFQTL PQGELSSQLP ERLSLVIGSI 
    LGALAFLLLA AITVLAVVFQ RKRRGTGYTE QLQQYSSPGL GVKYYIDPST YEDPCQAIRE 
    LAREVDPAYI KIEEVIGTGS FGEVRQGRLQ PRGRREQTVA IQALWAGGAE SLQMTFLGRA 
    AVLGQFQHPN ILRLEGVVTK SRPLMVLTEF MELGPLDSFL RQREGQFSSL QLVAMQRGVA 
    AAMQYLSSFA FVHRSLSAHS VLVNSHLVCK VARLGHSPQG PSCLLRWAAP EVIAHGKHTT 
    SSDVWSFGIL MWEVMSYGER PYWDMSEQEV LNAIEQEFRL PPPPGCPPGL HLLMLDTWQK 
    DRARRPHFDQ LVAAFDKMIR KPDTLQAGGD PGERPSQALL TPVALDFPCL DSPQAWLSAI 
    GLECYQDNFS KFGLCTFSDV AQLSLEDLPA LGITLAGHQK KLLHHIQLLQ QHLRQQGSVE 
    V

Genular Protein ID: 3480164463

Symbol: J3KQU5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

Sequence Information:

  • Length: 729
  • Mass: 79768
  • Checksum: 9A6BD391485CDDA0
  • Sequence:
  • MVAVGGCRCQ PGYQPARGDK ACQACPRGLY KASAGNAPCS PCPARSHAPN PAAPVCPCLE 
    GFYRASSDPP EAPCTGPPSA PQELWFEVQG SALMLHWRLP RELGGRGDLL FNVVCKECEG 
    RQEPASGGGG TCHRCRDEVH FDPRQRGLTE SRVLVGGLRA HVPYILEVQA VNGVSELSPD 
    PPQAAAINVS TSHEVPSAVP VVHQVSRASN SITVSWPQPD QTNGNILDYQ LRYYDQAEDE 
    SHSFTLTSET NTATVTQLSP GHIYGFQVRA RTAAGHGPYG GKVYFQTLPQ GELSSQLPER 
    LSLVIGSILG ALAFLLLAAI TVLAVVFQRK RRGTGYTEQL QQYSSPGLGV KYYIDPSTYE 
    DPCQAIRELA REVDPAYIKI EEVIGTGSFG EVRQGRLQPR GRREQTVAIQ ALWAGGAESL 
    QMTFLGRAAV LGQFQHPNIL RLEGVVTKSR PLMVLTEFME LGPLDSFLRQ REGQFSSLQL 
    VAMQRGVAAA MQYLSSFAFV HRSLSAHSVL VNSHLVCKVA RLGHSPQGPS CLLRWAAPEV 
    IAHGKHTTSS DVWSFGILMW EVMSYGERPY WDMSEQEVLN AIEQEFRLPP PPGCPPGLHL 
    LMLDTWQKDR ARRPHFDQLV AAFDKMIRKP DTLQAGGDPG ERPSQALLTP VALDFPCLDS 
    PQAWLSAIGL ECYQDNFSKF GLCTFSDVAQ LSLEDLPALG ITLAGHQKKL LHHIQLLQQH 
    LRQQGSVEV

Genular Protein ID: 681707333

Symbol: F8WCM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

Sequence Information:

  • Length: 1022
  • Mass: 110771
  • Checksum: 5038EA11DEE6FFCE
  • Sequence:
  • MATEGAAQLG NRVAGMVCSL WVLLLVSSVL ALEEVLLDTT GETSEIGWLT YPPGGWDEVS 
    VLDDQRRLTR TFEACHVAGA PPGTGQDNWL QTHFVERRGA QRAHIRLHFS VRACSSLGVS 
    GGTCRETFTL YYRQAEEPDS PDSVSSWHLK RWTKVDTIAA DESFPSSSSS SSSSSSSAAW 
    AVGPHGAGQR AGLQLNVKER SFGPLTQRGF YVAFQDTGAC LALVAVRLFS YTCPAVLRSF 
    ASFPETQASG AGGASLVAAV GTCVAHAEPE EDGVGGQAGG SPPRLHCNGE GKWMVAVGGC 
    RCQPGYQPAR GDKACQACPR GLYKASAGNA PCSPCPARSH APNPAAPVCP CLEGFYRASS 
    DPPEAPCTGP PSAPQELWFE VQGSALMLHW RLPRELGGRG DLLFNVVCKE CEGRQEPASG 
    GGGTCHRCRD EVHFDPRQRG LTESRVLVGG LRAHVPYILE VQAVNGVSEL SPDPPQAAAI 
    NVSTSHEVPS AVPVVHQVSR ASNSITVSWP QPDQTNGNIL DYQLRYYDQA EDESHSFTLT 
    SETNTATVTQ LSPGHIYGFQ VRARTAAGHG PYGGKVYFQT LPQGELSSQL PERLSLVIGS 
    ILGALAFLLL AAITVLAVVF QRKRRGTGYT EQLQQYSSPG LGVKYYIDPS TYEDPCQAIR 
    ELAREVDPAY IKIEEVIGTG SFGEVRQGRL QPRGRREQTV AIQALWAGGA ESLQMTFLGR 
    AAVLGQFQHP NILRLEGVVT KSRPLMVLTE FMELGPLDSF LRQREGQFSS LQLVAMQRGV 
    AAAMQYLSSF AFVHRSLSAH SVLVNSHLVC KVARLGHSPQ GPSCLLRWAA PEVIAHGKHT 
    TSSDVWSFGI LMWEVMSYGE RPYWDMSEQE VLNAIEQEFR LPPPPGCPPG LHLLMLDTWQ 
    KDRARRPHFD QLVAAFDKMI RKPDTLQAGG DPGERPSQAL LTPVALDFPC LDSPQAWLSA 
    IGLECYQDNF SKFGLCTFSD VAQLSLEDLP ALGITLAGHQ KKLLHHIQLL QQHLRQQGSV 
    EV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.