Details for: AKT1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 201.5491
Cell Significance Index: -31.3500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 123.3228
Cell Significance Index: -31.2800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 63.7281
Cell Significance Index: -25.8900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 62.3657
Cell Significance Index: -32.0800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 27.4943
Cell Significance Index: -26.2500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 26.2540
Cell Significance Index: -32.3700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.8222
Cell Significance Index: -31.6700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.2817
Cell Significance Index: -32.6800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.2679
Cell Significance Index: -16.1800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.5646
Cell Significance Index: -9.9900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.7768
Cell Significance Index: 323.6000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.8221
Cell Significance Index: 24.8600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.2973
Cell Significance Index: 77.8800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.0790
Cell Significance Index: 50.3100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.9149
Cell Significance Index: 59.0300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.8232
Cell Significance Index: 42.8800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6825
Cell Significance Index: 47.2000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5748
Cell Significance Index: 29.8600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5735
Cell Significance Index: 16.5300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5674
Cell Significance Index: 77.9300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5400
Cell Significance Index: 11.7000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5365
Cell Significance Index: 24.3200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5048
Cell Significance Index: 82.1000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5022
Cell Significance Index: 453.4200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4954
Cell Significance Index: 60.9100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4797
Cell Significance Index: 261.9900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4779
Cell Significance Index: 47.2700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4703
Cell Significance Index: 89.5000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4353
Cell Significance Index: 20.4600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4279
Cell Significance Index: 77.1400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4162
Cell Significance Index: 184.0300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4136
Cell Significance Index: 11.5600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4006
Cell Significance Index: 79.5100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3760
Cell Significance Index: 64.2100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3200
Cell Significance Index: 64.2000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2743
Cell Significance Index: 19.4000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.2710
Cell Significance Index: 31.0500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2700
Cell Significance Index: 7.3500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2314
Cell Significance Index: 8.1300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1774
Cell Significance Index: 63.6500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1585
Cell Significance Index: 109.5900 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1087
Cell Significance Index: 13.9400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0973
Cell Significance Index: 7.2500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.0691
Cell Significance Index: 1.9800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0563
Cell Significance Index: 1.2000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0356
Cell Significance Index: 0.8900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0347
Cell Significance Index: 0.7200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0105
Cell Significance Index: 1.2400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0083
Cell Significance Index: 6.3100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0063
Cell Significance Index: 11.8700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0053
Cell Significance Index: -9.8200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0074
Cell Significance Index: -5.4900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0091
Cell Significance Index: -14.0700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0099
Cell Significance Index: -6.2100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0101
Cell Significance Index: -0.2700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0104
Cell Significance Index: -7.5900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0151
Cell Significance Index: -1.9500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0161
Cell Significance Index: -0.2700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0171
Cell Significance Index: -10.8900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0216
Cell Significance Index: -29.3200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0275
Cell Significance Index: -15.5000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0347
Cell Significance Index: -0.9300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0389
Cell Significance Index: -17.6500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0419
Cell Significance Index: -4.2800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0735
Cell Significance Index: -5.6400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0814
Cell Significance Index: -23.4300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0823
Cell Significance Index: -17.3300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1414
Cell Significance Index: -8.9100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1420
Cell Significance Index: -20.6400 - Cell Name: peg cell (CL4033014)
Fold Change: -0.1718
Cell Significance Index: -3.9700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2271
Cell Significance Index: -6.0800 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2274
Cell Significance Index: -1.9100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2432
Cell Significance Index: -27.7600 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.2454
Cell Significance Index: -1.6000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2539
Cell Significance Index: -2.0700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2938
Cell Significance Index: -30.5900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3051
Cell Significance Index: -17.1200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3078
Cell Significance Index: -24.3800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3153
Cell Significance Index: -6.6000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3250
Cell Significance Index: -10.4100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3294
Cell Significance Index: -22.1500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3503
Cell Significance Index: -3.9800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3588
Cell Significance Index: -9.4400 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.4081
Cell Significance Index: -6.1200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4129
Cell Significance Index: -21.6800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4468
Cell Significance Index: -27.3900 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.4541
Cell Significance Index: -3.8600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5567
Cell Significance Index: -34.2200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5573
Cell Significance Index: -24.6500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.5607
Cell Significance Index: -9.4400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5723
Cell Significance Index: -14.7100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5735
Cell Significance Index: -10.6000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.5893
Cell Significance Index: -6.1000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5943
Cell Significance Index: -20.6500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.6119
Cell Significance Index: -5.6400 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.6485
Cell Significance Index: -9.0900 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.6638
Cell Significance Index: -4.0900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6668
Cell Significance Index: -19.6400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6848
Cell Significance Index: -25.9300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6874
Cell Significance Index: -24.0800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Key Characteristics
- Serine/threonine kinase: AKT1 is a serine/threonine kinase that phosphorylates and regulates various substrates, including proteins and lipids.
- PI3K/AKT signaling pathway: AKT1 is a key component of the PI3K/AKT signaling pathway, which is involved in the regulation of multiple cellular functions, including cell growth, differentiation, and apoptosis.
- Cell survival and proliferation: AKT1 promotes cell survival and proliferation by inhibiting pro-apoptotic proteins and activating anti-apoptotic proteins.
- Metabolism regulation: AKT1 regulates metabolism by phosphorylating and activating key enzymes involved in glucose and lipid metabolism.
- Signaling cross-talk: AKT1 interacts with other signaling pathways, including the MAPK/ERK pathway, the NF-κB pathway, and the Wnt/β-catenin pathway.
Pathways and Functions
- Activation of bad and translocation to mitochondria: AKT1 activates the pro-apoptotic protein bad, which translocates to the mitochondria and promotes apoptosis.
- Activation of bh3-only proteins: AKT1 activates the BH3-only protein bax, which promotes apoptosis.
- Adaptive immune system: AKT1 is involved in the regulation of the adaptive immune system, including the activation of T cells and B cells.
- Akt-mediated inactivation of foxo1a: AKT1 phosphorylates and inactivates the transcription factor foxo1a, which regulates glucose and lipid metabolism.
- Phosphorylation of targets in the cytosol and nucleus: AKT1 phosphorylates and regulates various targets in the cytosol and nucleus, including proteins and lipids.
Clinical Significance
- Cancer: AKT1 is overexpressed in many types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis and resistance to therapy.
- Diabetes: AKT1 is involved in the regulation of glucose metabolism and is overexpressed in type 2 diabetes.
- Cardiovascular diseases: AKT1 is involved in the regulation of cardiovascular function and is overexpressed in cardiovascular diseases, including atherosclerosis and heart failure.
- Neurological disorders: AKT1 is involved in the regulation of neuronal function and is overexpressed in neurological disorders, including Alzheimer’s disease and Parkinson’s disease.
- Immunological disorders: AKT1 is involved in the regulation of the immune system and is overexpressed in immunological disorders, including autoimmune diseases and allergies.
In conclusion, AKT1 is a crucial component of the PI3K/AKT signaling pathway, which plays a pivotal role in the regulation of various cellular processes, including cell survival, proliferation, and metabolism. Abnormal expression or activation of AKT1 has been implicated in several diseases, including cancer, diabetes, and cardiovascular diseases. Further research is needed to fully understand the role of AKT1 in human diseases and to develop effective therapeutic strategies to target AKT1 for the treatment of these diseases.
Genular Protein ID: 831704053
Symbol: AKT1_HUMAN
Name: RAC-alpha serine/threonine-protein kinase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1851997
Title: Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.
PubMed ID: 1851997
PubMed ID: 11508278
Title: Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes.
PubMed ID: 11508278
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 19054851
Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
PubMed ID: 19054851
DOI: 10.1038/nmeth.1273
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1718748
Title: Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.
PubMed ID: 1718748
PubMed ID: 1533586
Title:
PubMed ID: 1533586
PubMed ID: 9829964
Title: CREB is a regulatory target for the protein kinase Akt/PKB.
PubMed ID: 9829964
PubMed ID: 9736715
Title: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.
PubMed ID: 9736715
PubMed ID: 8978681
Title: Mechanism of activation of protein kinase B by insulin and IGF-1.
PubMed ID: 8978681
PubMed ID: 9512493
Title: Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
PubMed ID: 9512493
DOI: 10.1042/bj3310299
PubMed ID: 10358075
Title: Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
PubMed ID: 10358075
PubMed ID: 10576742
Title: Phosphorylation and regulation of Raf by Akt (protein kinase B).
PubMed ID: 10576742
PubMed ID: 10926925
Title: Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage.
PubMed ID: 10926925
PubMed ID: 10983986
Title: The protooncogene TCL1 is an Akt kinase coactivator.
PubMed ID: 10983986
PubMed ID: 10716693
Title: Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.
PubMed ID: 10716693
PubMed ID: 11154276
Title: Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.
PubMed ID: 11154276
PubMed ID: 11598301
Title: Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.
PubMed ID: 11598301
PubMed ID: 11994271
Title: A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.
PubMed ID: 11994271
PubMed ID: 12042314
Title: Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
PubMed ID: 12042314
PubMed ID: 12149249
Title: Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.
PubMed ID: 12149249
PubMed ID: 12150915
Title: Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
PubMed ID: 12150915
PubMed ID: 11839817
Title: Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1.
PubMed ID: 11839817
PubMed ID: 12172553
Title: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
PubMed ID: 12172553
DOI: 10.1038/ncb839
PubMed ID: 12244301
Title: PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
PubMed ID: 12244301
DOI: 10.1038/nm759
PubMed ID: 12878163
Title: Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.
PubMed ID: 12878163
PubMed ID: 14761976
Title: PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion.
PubMed ID: 14761976
PubMed ID: 15047712
Title: LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway.
PubMed ID: 15047712
PubMed ID: 14749367
Title: Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.
PubMed ID: 14749367
PubMed ID: 15118108
Title: PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.
PubMed ID: 15118108
PubMed ID: 16266983
Title: Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.
PubMed ID: 16266983
PubMed ID: 16139227
Title: Akt/PKB regulates actin organization and cell motility via Girdin/APE.
PubMed ID: 16139227
PubMed ID: 15861136
Title: The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.
PubMed ID: 15861136
PubMed ID: 15718470
Title: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
PubMed ID: 15718470
PubMed ID: 17013611
Title: Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias.
PubMed ID: 17013611
PubMed ID: 16792529
Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.
PubMed ID: 16792529
DOI: 10.1042/bj20060511
PubMed ID: 16417524
Title: Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha.
PubMed ID: 16417524
DOI: 10.1042/bj20051794
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16540465
PubMed ID: 16982699
Title: Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.
PubMed ID: 16982699
DOI: 10.1128/mcb.00201-06
PubMed ID: 17932490
Title: The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.
PubMed ID: 17932490
PubMed ID: 17726016
Title: Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation.
PubMed ID: 17726016
PubMed ID: 18507042
Title: Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells.
PubMed ID: 18507042
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20059950
Title: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.
PubMed ID: 20059950
PubMed ID: 19592491
Title: Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.
PubMed ID: 19592491
PubMed ID: 19934221
Title: The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration.
PubMed ID: 19934221
DOI: 10.1242/jcs.053728
PubMed ID: 19713527
Title: The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
PubMed ID: 19713527
PubMed ID: 20086174
Title: Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt.
PubMed ID: 20086174
PubMed ID: 19940129
Title: Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120.
PubMed ID: 19940129
PubMed ID: 27825096
PubMed ID: 20682768
Title: Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation.
PubMed ID: 20682768
PubMed ID: 20471940
Title: The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.
PubMed ID: 20471940
PubMed ID: 20231902
Title: Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway.
PubMed ID: 20231902
PubMed ID: 20333297
Title: Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
PubMed ID: 20333297
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21333377
Title: Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2.
PubMed ID: 21333377
PubMed ID: 21329884
Title: Clk2 and B56-beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt.
PubMed ID: 21329884
PubMed ID: 23251525
Title: Microarray-assisted pathway analysis identifies MT1X & NFkappaB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.
PubMed ID: 23251525
PubMed ID: 23152800
Title: OGDHL is a modifier of AKT-dependent signaling and NF-kappaB function.
PubMed ID: 23152800
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23676467
Title: FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies.
PubMed ID: 23676467
PubMed ID: 15526160
Title: Signal transduction via the stem cell factor receptor/c-Kit.
PubMed ID: 15526160
PubMed ID: 11882383
Title: The protein kinase B/Akt signalling pathway in human malignancy.
PubMed ID: 11882383
PubMed ID: 20978158
Title: A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.
PubMed ID: 20978158
PubMed ID: 21620960
PubMed ID: 21432781
PubMed ID: 21464307
Title: IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
PubMed ID: 21464307
PubMed ID: 21775285
Title: The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.
PubMed ID: 21775285
PubMed ID: 22410793
Title: Akt is negatively regulated by the MULAN E3 ligase.
PubMed ID: 22410793
DOI: 10.1038/cr.2012.38
PubMed ID: 22629392
Title: Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling.
PubMed ID: 22629392
PubMed ID: 23799035
Title: CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site.
PubMed ID: 23799035
PubMed ID: 23431171
Title: MOZ increases p53 acetylation and premature senescence through its complex formation with PML.
PubMed ID: 23431171
PubMed ID: 23300339
Title: BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
PubMed ID: 23300339
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26440888
Title: Akt kinase-mediated checkpoint of cGAS DNA sensing pathway.
PubMed ID: 26440888
PubMed ID: 24784001
Title: KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.
PubMed ID: 24784001
PubMed ID: 28147277
Title: Regulation of serine-threonine kinase Akt activation by NAD+-dependent deacetylase SIRT7.
PubMed ID: 28147277
PubMed ID: 30504268
Title: Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth.
PubMed ID: 30504268
PubMed ID: 31204173
Title: Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.
PubMed ID: 31204173
PubMed ID: 31548394
Title: Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.
PubMed ID: 31548394
PubMed ID: 32322062
Title: The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
PubMed ID: 32322062
PubMed ID: 32228865
Title: Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175.
PubMed ID: 32228865
DOI: 10.7554/elife.53430
PubMed ID: 33594058
Title: RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
PubMed ID: 33594058
PubMed ID: 12176338
Title: High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate.
PubMed ID: 12176338
PubMed ID: 12964941
Title: Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.
PubMed ID: 12964941
DOI: 10.1042/bj20031229
PubMed ID: 18456494
Title: Synthesis and structure based optimization of novel Akt inhibitors.
PubMed ID: 18456494
PubMed ID: 20810279
Title: Discovery of pyrrolopyrimidine inhibitors of Akt.
PubMed ID: 20810279
PubMed ID: 20481595
Title: Design of selective, ATP-competitive inhibitors of Akt.
PubMed ID: 20481595
DOI: 10.1021/jm1003842
PubMed ID: 20886116
Title: Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition.
PubMed ID: 20886116
PubMed ID: 21392984
Title: Discovery and SAR of spirochromane Akt inhibitors.
PubMed ID: 21392984
PubMed ID: 17611497
Title: A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
PubMed ID: 17611497
DOI: 10.1038/nature05933
PubMed ID: 18954143
Title: Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain.
PubMed ID: 18954143
DOI: 10.1021/bi801683k
PubMed ID: 21793738
Title: A mosaic activating mutation in AKT1 associated with the Proteus syndrome.
PubMed ID: 21793738
PubMed ID: 23246288
Title: Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.
PubMed ID: 23246288
Sequence Information:
- Length: 480
- Mass: 55686
- Checksum: 6EAFF4F8AD436714
- Sequence:
MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA PLNNFSVAQC QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KKQEEEEMDF RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEEIRFPR TLGPEAKSLL SGLLKKDPKQ RLGGGSEDAK EIMQHRFFAG IVWQHVYEKK LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA
Genular Protein ID: 3107120840
Symbol: B3KVH4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 480
- Mass: 55629
- Checksum: 6FA7CCFCA94BBD68
- Sequence:
MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA PLNNFSVAQC QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KKQEEEEMDF RSGSPSDNSG AEEMEVSLAK PKHRVTMSEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEEIRFPR TLGPEAKSLL SGLLKKDPKQ RLGGGSEDAK EIMQHRFFAG IVWQHVYEKK LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSTEC VDSERRPHFP QFSYSASGTA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.