Details for: AKT1

Gene ID: 207

Symbol: AKT1

Ensembl ID: ENSG00000142208

Description: AKT serine/threonine kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 201.5491
    Cell Significance Index: -31.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 123.3228
    Cell Significance Index: -31.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.7281
    Cell Significance Index: -25.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.3657
    Cell Significance Index: -32.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.4943
    Cell Significance Index: -26.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.2540
    Cell Significance Index: -32.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.8222
    Cell Significance Index: -31.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2817
    Cell Significance Index: -32.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2679
    Cell Significance Index: -16.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.5646
    Cell Significance Index: -9.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.7768
    Cell Significance Index: 323.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8221
    Cell Significance Index: 24.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2973
    Cell Significance Index: 77.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0790
    Cell Significance Index: 50.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9149
    Cell Significance Index: 59.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8232
    Cell Significance Index: 42.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6825
    Cell Significance Index: 47.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5748
    Cell Significance Index: 29.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5735
    Cell Significance Index: 16.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5674
    Cell Significance Index: 77.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5400
    Cell Significance Index: 11.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5365
    Cell Significance Index: 24.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5048
    Cell Significance Index: 82.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5022
    Cell Significance Index: 453.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4954
    Cell Significance Index: 60.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4797
    Cell Significance Index: 261.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4779
    Cell Significance Index: 47.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4703
    Cell Significance Index: 89.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4353
    Cell Significance Index: 20.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4279
    Cell Significance Index: 77.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4162
    Cell Significance Index: 184.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4136
    Cell Significance Index: 11.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4006
    Cell Significance Index: 79.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3760
    Cell Significance Index: 64.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3200
    Cell Significance Index: 64.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2743
    Cell Significance Index: 19.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2710
    Cell Significance Index: 31.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2700
    Cell Significance Index: 7.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2314
    Cell Significance Index: 8.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1774
    Cell Significance Index: 63.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1585
    Cell Significance Index: 109.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1087
    Cell Significance Index: 13.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0973
    Cell Significance Index: 7.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0691
    Cell Significance Index: 1.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0563
    Cell Significance Index: 1.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0356
    Cell Significance Index: 0.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0347
    Cell Significance Index: 0.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0105
    Cell Significance Index: 1.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0083
    Cell Significance Index: 6.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0063
    Cell Significance Index: 11.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0074
    Cell Significance Index: -5.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -14.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0099
    Cell Significance Index: -6.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0101
    Cell Significance Index: -0.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0104
    Cell Significance Index: -7.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0151
    Cell Significance Index: -1.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0161
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0171
    Cell Significance Index: -10.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0216
    Cell Significance Index: -29.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0275
    Cell Significance Index: -15.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0347
    Cell Significance Index: -0.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0389
    Cell Significance Index: -17.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0419
    Cell Significance Index: -4.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0735
    Cell Significance Index: -5.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0814
    Cell Significance Index: -23.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0823
    Cell Significance Index: -17.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1414
    Cell Significance Index: -8.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1420
    Cell Significance Index: -20.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1718
    Cell Significance Index: -3.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2271
    Cell Significance Index: -6.0800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2274
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2432
    Cell Significance Index: -27.7600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2454
    Cell Significance Index: -1.6000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2539
    Cell Significance Index: -2.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2938
    Cell Significance Index: -30.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3051
    Cell Significance Index: -17.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3078
    Cell Significance Index: -24.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3153
    Cell Significance Index: -6.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3250
    Cell Significance Index: -10.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3294
    Cell Significance Index: -22.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3503
    Cell Significance Index: -3.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3588
    Cell Significance Index: -9.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4081
    Cell Significance Index: -6.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4129
    Cell Significance Index: -21.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4468
    Cell Significance Index: -27.3900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4541
    Cell Significance Index: -3.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5567
    Cell Significance Index: -34.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5573
    Cell Significance Index: -24.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5607
    Cell Significance Index: -9.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5723
    Cell Significance Index: -14.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5735
    Cell Significance Index: -10.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5893
    Cell Significance Index: -6.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5943
    Cell Significance Index: -20.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6119
    Cell Significance Index: -5.6400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.6485
    Cell Significance Index: -9.0900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6638
    Cell Significance Index: -4.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6668
    Cell Significance Index: -19.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6848
    Cell Significance Index: -25.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6874
    Cell Significance Index: -24.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Key Characteristics

  1. Serine/threonine kinase: AKT1 is a serine/threonine kinase that phosphorylates and regulates various substrates, including proteins and lipids.
  2. PI3K/AKT signaling pathway: AKT1 is a key component of the PI3K/AKT signaling pathway, which is involved in the regulation of multiple cellular functions, including cell growth, differentiation, and apoptosis.
  3. Cell survival and proliferation: AKT1 promotes cell survival and proliferation by inhibiting pro-apoptotic proteins and activating anti-apoptotic proteins.
  4. Metabolism regulation: AKT1 regulates metabolism by phosphorylating and activating key enzymes involved in glucose and lipid metabolism.
  5. Signaling cross-talk: AKT1 interacts with other signaling pathways, including the MAPK/ERK pathway, the NF-κB pathway, and the Wnt/β-catenin pathway.

Pathways and Functions

  1. Activation of bad and translocation to mitochondria: AKT1 activates the pro-apoptotic protein bad, which translocates to the mitochondria and promotes apoptosis.
  2. Activation of bh3-only proteins: AKT1 activates the BH3-only protein bax, which promotes apoptosis.
  3. Adaptive immune system: AKT1 is involved in the regulation of the adaptive immune system, including the activation of T cells and B cells.
  4. Akt-mediated inactivation of foxo1a: AKT1 phosphorylates and inactivates the transcription factor foxo1a, which regulates glucose and lipid metabolism.
  5. Phosphorylation of targets in the cytosol and nucleus: AKT1 phosphorylates and regulates various targets in the cytosol and nucleus, including proteins and lipids.

Clinical Significance

  1. Cancer: AKT1 is overexpressed in many types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis and resistance to therapy.
  2. Diabetes: AKT1 is involved in the regulation of glucose metabolism and is overexpressed in type 2 diabetes.
  3. Cardiovascular diseases: AKT1 is involved in the regulation of cardiovascular function and is overexpressed in cardiovascular diseases, including atherosclerosis and heart failure.
  4. Neurological disorders: AKT1 is involved in the regulation of neuronal function and is overexpressed in neurological disorders, including Alzheimer’s disease and Parkinson’s disease.
  5. Immunological disorders: AKT1 is involved in the regulation of the immune system and is overexpressed in immunological disorders, including autoimmune diseases and allergies.

In conclusion, AKT1 is a crucial component of the PI3K/AKT signaling pathway, which plays a pivotal role in the regulation of various cellular processes, including cell survival, proliferation, and metabolism. Abnormal expression or activation of AKT1 has been implicated in several diseases, including cancer, diabetes, and cardiovascular diseases. Further research is needed to fully understand the role of AKT1 in human diseases and to develop effective therapeutic strategies to target AKT1 for the treatment of these diseases.

Genular Protein ID: 831704053

Symbol: AKT1_HUMAN

Name: RAC-alpha serine/threonine-protein kinase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1851997

Title: Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

PubMed ID: 1851997

DOI: 10.1073/pnas.88.10.4171

PubMed ID: 11508278

Title: Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes.

PubMed ID: 11508278

DOI: 10.1007/s001250100577

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1718748

Title: Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.

PubMed ID: 1718748

DOI: 10.1111/j.1432-1033.1991.tb16305.x

PubMed ID: 1533586

Title:

PubMed ID: 1533586

PubMed ID: 9829964

Title: CREB is a regulatory target for the protein kinase Akt/PKB.

PubMed ID: 9829964

DOI: 10.1074/jbc.273.49.32377

PubMed ID: 9736715

Title: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

PubMed ID: 9736715

DOI: 10.1073/pnas.95.19.11211

PubMed ID: 8978681

Title: Mechanism of activation of protein kinase B by insulin and IGF-1.

PubMed ID: 8978681

DOI: 10.1002/j.1460-2075.1996.tb01045.x

PubMed ID: 9512493

Title: Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.

PubMed ID: 9512493

DOI: 10.1042/bj3310299

PubMed ID: 10358075

Title: Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.

PubMed ID: 10358075

DOI: 10.1074/jbc.274.24.17179

PubMed ID: 10576742

Title: Phosphorylation and regulation of Raf by Akt (protein kinase B).

PubMed ID: 10576742

DOI: 10.1126/science.286.5445.1741

PubMed ID: 10926925

Title: Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage.

PubMed ID: 10926925

DOI: 10.1074/jbc.m001753200

PubMed ID: 10983986

Title: The protooncogene TCL1 is an Akt kinase coactivator.

PubMed ID: 10983986

DOI: 10.1016/s1097-2765(00)00039-3

PubMed ID: 10716693

Title: Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.

PubMed ID: 10716693

DOI: 10.1073/pnas.97.7.3028

PubMed ID: 11154276

Title: Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.

PubMed ID: 11154276

DOI: 10.1128/mcb.21.3.893-901.2001

PubMed ID: 11598301

Title: Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.

PubMed ID: 11598301

DOI: 10.1126/science.1062030

PubMed ID: 11994271

Title: A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.

PubMed ID: 11994271

DOI: 10.1074/jbc.c200198200

PubMed ID: 12042314

Title: Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.

PubMed ID: 12042314

DOI: 10.1074/jbc.m203668200

PubMed ID: 12149249

Title: Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.

PubMed ID: 12149249

DOI: 10.1074/jbc.m203387200

PubMed ID: 12150915

Title: Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

PubMed ID: 12150915

DOI: 10.1016/s1097-2765(02)00568-3

PubMed ID: 11839817

Title: Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1.

PubMed ID: 11839817

DOI: 10.1128/mcb.22.5.1513-1525.2002

PubMed ID: 12172553

Title: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.

PubMed ID: 12172553

DOI: 10.1038/ncb839

PubMed ID: 12244301

Title: PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.

PubMed ID: 12244301

DOI: 10.1038/nm759

PubMed ID: 12878163

Title: Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.

PubMed ID: 12878163

DOI: 10.1016/s0014-4827(03)00206-4

PubMed ID: 14761976

Title: PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion.

PubMed ID: 14761976

DOI: 10.1074/jbc.m312175200

PubMed ID: 15047712

Title: LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway.

PubMed ID: 15047712

DOI: 10.1074/jbc.m314192200

PubMed ID: 14749367

Title: Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.

PubMed ID: 14749367

DOI: 10.1128/mcb.24.4.1493-1504.2004

PubMed ID: 15118108

Title: PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.

PubMed ID: 15118108

DOI: 10.1073/pnas.0400921101

PubMed ID: 16266983

Title: Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.

PubMed ID: 16266983

DOI: 10.1158/0008-5472.can-05-0422

PubMed ID: 16139227

Title: Akt/PKB regulates actin organization and cell motility via Girdin/APE.

PubMed ID: 16139227

DOI: 10.1016/j.devcel.2005.08.001

PubMed ID: 15861136

Title: The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.

PubMed ID: 15861136

DOI: 10.1038/sj.emboj.7600648

PubMed ID: 15718470

Title: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

PubMed ID: 15718470

DOI: 10.1126/science.1106148

PubMed ID: 17013611

Title: Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias.

PubMed ID: 17013611

DOI: 10.1007/s00401-006-0128-y

PubMed ID: 16792529

Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

PubMed ID: 16792529

DOI: 10.1042/bj20060511

PubMed ID: 16417524

Title: Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha.

PubMed ID: 16417524

DOI: 10.1042/bj20051794

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16540465

Title: Kinetic mechanism of AKT/PKB enzyme family.

PubMed ID: 16540465

DOI: 10.1074/jbc.m601384200

PubMed ID: 16982699

Title: Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.

PubMed ID: 16982699

DOI: 10.1128/mcb.00201-06

PubMed ID: 17932490

Title: The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.

PubMed ID: 17932490

DOI: 10.1038/sj.emboj.7601872

PubMed ID: 17726016

Title: Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation.

PubMed ID: 17726016

DOI: 10.1074/jbc.m704542200

PubMed ID: 18507042

Title: Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells.

PubMed ID: 18507042

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20059950

Title: The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.

PubMed ID: 20059950

DOI: 10.1016/j.devcel.2009.09.007

PubMed ID: 19592491

Title: Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.

PubMed ID: 19592491

DOI: 10.1074/jbc.m109.026237

PubMed ID: 19934221

Title: The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration.

PubMed ID: 19934221

DOI: 10.1242/jcs.053728

PubMed ID: 19713527

Title: The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

PubMed ID: 19713527

DOI: 10.1126/science.1175065

PubMed ID: 20086174

Title: Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt.

PubMed ID: 20086174

DOI: 10.1158/0008-5472.can-09-3147

PubMed ID: 19940129

Title: Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120.

PubMed ID: 19940129

DOI: 10.1074/jbc.m109.059675

PubMed ID: 27825096

Title:

PubMed ID: 27825096

DOI: 10.1074/jbc.a109.059675

PubMed ID: 20682768

Title: Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation.

PubMed ID: 20682768

DOI: 10.1074/jbc.m110.122044

PubMed ID: 20471940

Title: The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.

PubMed ID: 20471940

DOI: 10.1016/j.molcel.2010.02.031

PubMed ID: 20231902

Title: Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway.

PubMed ID: 20231902

DOI: 10.1371/journal.pone.0009616

PubMed ID: 20333297

Title: Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.

PubMed ID: 20333297

DOI: 10.1371/journal.pone.0009646

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21333377

Title: Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2.

PubMed ID: 21333377

DOI: 10.1016/j.ejcb.2010.12.001

PubMed ID: 21329884

Title: Clk2 and B56-beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt.

PubMed ID: 21329884

DOI: 10.1016/j.molcel.2011.02.007

PubMed ID: 23251525

Title: Microarray-assisted pathway analysis identifies MT1X & NFkappaB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma.

PubMed ID: 23251525

DOI: 10.1371/journal.pone.0051413

PubMed ID: 23152800

Title: OGDHL is a modifier of AKT-dependent signaling and NF-kappaB function.

PubMed ID: 23152800

DOI: 10.1371/journal.pone.0048770

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23676467

Title: FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies.

PubMed ID: 23676467

DOI: 10.18632/oncotarget.1027

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 11882383

Title: The protein kinase B/Akt signalling pathway in human malignancy.

PubMed ID: 11882383

DOI: 10.1016/s0898-6568(01)00271-6

PubMed ID: 20978158

Title: A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.

PubMed ID: 20978158

DOI: 10.1158/1535-7163.mct-10-0730

PubMed ID: 21620960

Title: Akt signalling in health and disease.

PubMed ID: 21620960

DOI: 10.1016/j.cellsig.2011.05.004

PubMed ID: 21432781

Title: Akt1 and Akt2: differentiating the aktion.

PubMed ID: 21432781

DOI: 10.14670/hh-26.651

PubMed ID: 21464307

Title: IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

PubMed ID: 21464307

DOI: 10.1073/pnas.1016132108

PubMed ID: 21775285

Title: The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.

PubMed ID: 21775285

DOI: 10.1126/scisignal.2001465

PubMed ID: 22410793

Title: Akt is negatively regulated by the MULAN E3 ligase.

PubMed ID: 22410793

DOI: 10.1038/cr.2012.38

PubMed ID: 22629392

Title: Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling.

PubMed ID: 22629392

DOI: 10.1371/journal.pone.0037427

PubMed ID: 23799035

Title: CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site.

PubMed ID: 23799035

DOI: 10.1371/journal.pone.0065679

PubMed ID: 23431171

Title: MOZ increases p53 acetylation and premature senescence through its complex formation with PML.

PubMed ID: 23431171

DOI: 10.1073/pnas.1300490110

PubMed ID: 23300339

Title: BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.

PubMed ID: 23300339

DOI: 10.1126/scisignal.2003295

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26440888

Title: Akt kinase-mediated checkpoint of cGAS DNA sensing pathway.

PubMed ID: 26440888

DOI: 10.1016/j.celrep.2015.09.007

PubMed ID: 24784001

Title: KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.

PubMed ID: 24784001

DOI: 10.1016/j.neo.2014.03.008

PubMed ID: 28147277

Title: Regulation of serine-threonine kinase Akt activation by NAD+-dependent deacetylase SIRT7.

PubMed ID: 28147277

DOI: 10.1016/j.celrep.2017.01.009

PubMed ID: 30504268

Title: Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth.

PubMed ID: 30504268

DOI: 10.15252/embj.201899435

PubMed ID: 31204173

Title: Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.

PubMed ID: 31204173

DOI: 10.1016/j.devcel.2019.05.022

PubMed ID: 31548394

Title: Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.

PubMed ID: 31548394

DOI: 10.1073/pnas.1904774116

PubMed ID: 32322062

Title: The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.

PubMed ID: 32322062

DOI: 10.1038/s41586-020-2183-2

PubMed ID: 32228865

Title: Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175.

PubMed ID: 32228865

DOI: 10.7554/elife.53430

PubMed ID: 33594058

Title: RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.

PubMed ID: 33594058

DOI: 10.1038/s41467-021-21206-3

PubMed ID: 12176338

Title: High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate.

PubMed ID: 12176338

DOI: 10.1016/s0960-9822(02)00972-7

PubMed ID: 12964941

Title: Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.

PubMed ID: 12964941

DOI: 10.1042/bj20031229

PubMed ID: 18456494

Title: Synthesis and structure based optimization of novel Akt inhibitors.

PubMed ID: 18456494

DOI: 10.1016/j.bmcl.2008.04.034

PubMed ID: 20810279

Title: Discovery of pyrrolopyrimidine inhibitors of Akt.

PubMed ID: 20810279

DOI: 10.1016/j.bmcl.2010.08.053

PubMed ID: 20481595

Title: Design of selective, ATP-competitive inhibitors of Akt.

PubMed ID: 20481595

DOI: 10.1021/jm1003842

PubMed ID: 20886116

Title: Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition.

PubMed ID: 20886116

DOI: 10.1371/journal.pone.0012913

PubMed ID: 21392984

Title: Discovery and SAR of spirochromane Akt inhibitors.

PubMed ID: 21392984

DOI: 10.1016/j.bmcl.2011.02.073

PubMed ID: 17611497

Title: A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.

PubMed ID: 17611497

DOI: 10.1038/nature05933

PubMed ID: 18954143

Title: Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain.

PubMed ID: 18954143

DOI: 10.1021/bi801683k

PubMed ID: 21793738

Title: A mosaic activating mutation in AKT1 associated with the Proteus syndrome.

PubMed ID: 21793738

DOI: 10.1056/nejmoa1104017

PubMed ID: 23246288

Title: Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.

PubMed ID: 23246288

DOI: 10.1016/j.ajhg.2012.10.021

Sequence Information:

  • Length: 480
  • Mass: 55686
  • Checksum: 6EAFF4F8AD436714
  • Sequence:
  • MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA PLNNFSVAQC 
    QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KKQEEEEMDF 
    RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI 
    LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS 
    RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI 
    KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL 
    ILMEEIRFPR TLGPEAKSLL SGLLKKDPKQ RLGGGSEDAK EIMQHRFFAG IVWQHVYEKK 
    LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA

Genular Protein ID: 3107120840

Symbol: B3KVH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 480
  • Mass: 55629
  • Checksum: 6FA7CCFCA94BBD68
  • Sequence:
  • MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA PLNNFSVAQC 
    QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KKQEEEEMDF 
    RSGSPSDNSG AEEMEVSLAK PKHRVTMSEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI 
    LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS 
    RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI 
    KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL 
    ILMEEIRFPR TLGPEAKSLL SGLLKKDPKQ RLGGGSEDAK EIMQHRFFAG IVWQHVYEKK 
    LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSTEC VDSERRPHFP QFSYSASGTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.