Details for: EVPL

Gene ID: 2125

Symbol: EVPL

Ensembl ID: ENSG00000167880

Description: envoplakin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.0339
    Cell Significance Index: -4.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.2289
    Cell Significance Index: -4.3700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 4.4977
    Cell Significance Index: 10.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.5484
    Cell Significance Index: -4.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 3.2286
    Cell Significance Index: 45.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.0354
    Cell Significance Index: 157.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.6937
    Cell Significance Index: 24.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5980
    Cell Significance Index: 44.6600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.3510
    Cell Significance Index: 15.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2430
    Cell Significance Index: 122.9600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.2042
    Cell Significance Index: 10.2400
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.9152
    Cell Significance Index: 6.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9146
    Cell Significance Index: 54.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8359
    Cell Significance Index: 90.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6779
    Cell Significance Index: 110.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5683
    Cell Significance Index: 66.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5305
    Cell Significance Index: 15.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5059
    Cell Significance Index: 22.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4862
    Cell Significance Index: 87.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4824
    Cell Significance Index: 10.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4671
    Cell Significance Index: 32.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4592
    Cell Significance Index: 56.4700
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.3471
    Cell Significance Index: 2.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3329
    Cell Significance Index: 63.3500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.3246
    Cell Significance Index: 5.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2717
    Cell Significance Index: 245.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2716
    Cell Significance Index: 6.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2678
    Cell Significance Index: 118.4000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2514
    Cell Significance Index: 2.1600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1803
    Cell Significance Index: 1.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1533
    Cell Significance Index: 83.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1249
    Cell Significance Index: 3.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1166
    Cell Significance Index: 3.0700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0922
    Cell Significance Index: 1.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0721
    Cell Significance Index: 5.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0658
    Cell Significance Index: 3.0700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0631
    Cell Significance Index: 0.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0615
    Cell Significance Index: 1.3100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0546
    Cell Significance Index: 0.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0428
    Cell Significance Index: 8.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0296
    Cell Significance Index: 1.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0226
    Cell Significance Index: 41.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0175
    Cell Significance Index: 26.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0174
    Cell Significance Index: 0.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0169
    Cell Significance Index: 0.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0149
    Cell Significance Index: 1.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0113
    Cell Significance Index: 7.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0109
    Cell Significance Index: 8.2600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0091
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0062
    Cell Significance Index: 0.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0043
    Cell Significance Index: 3.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0003
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0015
    Cell Significance Index: -0.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0057
    Cell Significance Index: -0.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0057
    Cell Significance Index: -2.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0059
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0069
    Cell Significance Index: -4.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0094
    Cell Significance Index: -2.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0111
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0135
    Cell Significance Index: -2.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0150
    Cell Significance Index: -2.1800
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.0167
    Cell Significance Index: -0.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0205
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0217
    Cell Significance Index: -4.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0294
    Cell Significance Index: -0.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0310
    Cell Significance Index: -4.2600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0311
    Cell Significance Index: -0.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0346
    Cell Significance Index: -2.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0363
    Cell Significance Index: -0.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0407
    Cell Significance Index: -1.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0429
    Cell Significance Index: -4.4700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0437
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0438
    Cell Significance Index: -0.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0481
    Cell Significance Index: -2.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0490
    Cell Significance Index: -3.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0593
    Cell Significance Index: -3.9900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0633
    Cell Significance Index: -0.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0663
    Cell Significance Index: -0.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0670
    Cell Significance Index: -5.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0676
    Cell Significance Index: -3.4100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0714
    Cell Significance Index: -0.9200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0717
    Cell Significance Index: -1.7900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0720
    Cell Significance Index: -0.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0734
    Cell Significance Index: -3.8200
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0756
    Cell Significance Index: -0.6500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0810
    Cell Significance Index: -0.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0860
    Cell Significance Index: -3.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0861
    Cell Significance Index: -4.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0866
    Cell Significance Index: -2.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0958
    Cell Significance Index: -5.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0990
    Cell Significance Index: -2.5300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1002
    Cell Significance Index: -1.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1022
    Cell Significance Index: -3.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1053
    Cell Significance Index: -3.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Envoplakin is a cytoplasmic protein that belongs to the plakin family of proteins, which are known for their ability to bind multiple partners and regulate various cellular functions. The EVPL gene is highly expressed in stratified epithelial cells, including corneal epithelial cells, squamous epithelial cells, and bladder urothelial cells. Envoplakin is characterized by its ability to: 1. Bind keratin filaments, contributing to the organization of intermediate filaments. 2. Interact with desmosomal adhesion proteins, such as cadherins, to maintain desmosomal integrity. 3. Cross-link peptides, which is essential for maintaining the structural integrity of desmosomes. 4. Regulate cell signaling pathways, including those involved in keratinization and cell differentiation. **Pathways and Functions** Envoplakin is involved in various cellular pathways, including: 1. **Desmosome formation and maintenance**: Envoplakin interacts with desmosomal adhesion proteins to maintain the integrity of desmosomes, which are essential for maintaining tissue structure and function. 2. **Keratinization**: Envoplakin regulates the organization of keratin filaments, which is essential for maintaining the structural integrity of epithelial cells during keratinization. 3. **Cell differentiation**: Envoplakin is involved in regulating cell differentiation, particularly in stratified epithelial cells, where it helps to maintain the integrity of the epithelial layer. 4. **Wound healing**: Envoplakin plays a role in regulating the healing process by maintaining the integrity of desmosomes and promoting the organization of intermediate filaments. 5. **Signaling pathways**: Envoplakin interacts with various signaling pathways, including those involved in cell proliferation, differentiation, and survival. **Clinical Significance** Dysregulation of envoplakin has been implicated in several diseases, including: 1. **Skin disorders**: Envoplakin mutations have been associated with epidermolysis bullosa simplex, a rare genetic disorder characterized by blistering skin lesions. 2. **Cancers**: Envoplakin has been implicated in the development and progression of various cancers, including breast cancer, ovarian cancer, and lung cancer. 3. **Neuropathies**: Envoplakin mutations have been associated with certain neuropathies, including Charcot-Marie-Tooth disease, a disorder characterized by peripheral nerve degeneration. 4. **Neurological disorders**: Envoplakin has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In conclusion, envoplakin is a multifunctional protein that plays a crucial role in maintaining the structural integrity and function of desmosomes, regulating keratinization, and participating in various signaling pathways. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the mechanisms of envoplakin function and its role in human disease.

Genular Protein ID: 2225273369

Symbol: EVPL_HUMAN

Name: Envoplakin

UniProtKB Accession Codes:

Q92817 A0AUV5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8707850

Title: Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin.

PubMed ID: 8707850

DOI: 10.1083/jcb.134.3.715

PubMed ID: 10409435

Title: Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25.

PubMed ID: 10409435

DOI: 10.1006/geno.1999.5857

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 2033
  • Mass: 231604
  • Checksum: 0A994627703393E0
  • Sequence:
    • MFKGLSKGSQ GKGSPKGSPA KGSPKGSPSR HSRAATQELA LLISRMQANA DQVERDILET 
QKRLQQDRLN SEQSQALQHQ QETGRSLKEA EVLLKDLFLD VDKARRLKHP QAEEIEKDIK 
QLHERVTQEC AEYRALYEKM VLPPDVGPRV DWARVLEQKQ KQVCAGQYGP GMAELEQQIA 
EHNILQKEID AYGQQLRSLV GPDAATIRSQ YRDLLKAASW RGQSLGSLYT HLQGCTRQLS 
ALAEQQRRIL QQDWSDLMAD PAGVRREYEH FKQHELLSQE QSVNQLEDDG ERMVELRHPA 
VGPIQAHQEA LKMEWQNFLN LCICQETQLQ HVEDYRRFQE EADSVSQTLA KLNSNLDAKY 
SPAPGGPPGA PTELLQQLEA EEKRLAVTER ATGDLQRRSR DVAPLPQRRN PPQQPLHVDS 
ICDWDSGEVQ LLQGERYKLV DNTDPHAWVV QGPGGETKRA PAACFCIPAP DPDAVARASR 
LASELQALKQ KLATVQSRLK ASAVESLRPS QQAPSGSDLA NPQAQKLLTQ MTRLDGDLGQ 
IERQVLAWAR APLSRPTPLE DLEGRIHSHE GTAQRLQSLG TEKETAQKEC EAFLSTRPVG 
PAALQLPVAL NSVKNKFSDV QVLCSLYGEK AKAALDLERQ IQDADRVIRG FEATLVQEAP 
IPAEPGALQE RVSELQRQRR ELLEQQTCVL RLHRALKASE HACAALQNNF QEFCQDLPRQ 
QRQVRALTDR YHAVGDQLDL REKVVQDAAL TYQQFKNCKD NLSSWLEHLP RSQVRPSDGP 
SQIAYKLQAQ KRLTQEIQSR ERDRATASHL SQALQAALQD YELQADTYRC SLEPTLAVSA 
PKRPRVAPLQ ESIQAQEKNL AKAYTEVAAA QQQLLQQLEF ARKMLEKKEL SEDIRRTHDA 
KQGSESPAQA GRESEALKAQ LEEERKRVAR VQHELEAQRS QLLQLRTQRP LERLEEKEVV 
EFYRDPQLEG SLSRVKAQVE EEGKRRAGLQ ADLEVAAQKV VQLESKRKTM QPHLLTKEVT 
QVERDPGLDS QAAQLRIQIQ QLRGEDAVIS ARLEGLKKEL LALEKREVDV KEKVVVKEVV 
KVEKNLEMVK AAQALRLQME EDAARRKQAE EAVAKLQARI EDLERAISSV EPKVIVKEVK 
KVEQDPGLLQ ESSRLRSLLE EERTKNATLA RELSDLHSKY SVVEKQRPKV QLQERVHEIF 
QVDPETEQEI TRLKAKLQEM AGKRSGVEKE VEKLLPDLEV LRAQKPTVEY KEVTQEVVRH 
ERSPEVLREI DRLKAQLNEL VNSHGRSQEQ LIRLQGERDE WRRERAKVET KTVSKEVVRH 
EKDPVLEKEA ERLRQEVREA AQKRRAAEDA VYELQSKRLL LERRKPEEKV VVQEVVVTQK 
DPKLREEHSR LSGSLDEEVG RRRQLELEVQ QLRAGVEEQE GLLSFQEDRS KKLAVERELR 
QLTLRIQELE KRPPTVQEKI IMEEVVKLEK DPDLEKSTEA LRWDLDQEKT QVTELNRECK 
NLQVQIDVLQ KAKSQEKTIY KEVIRVQKDR VLEDERARVW EMLNRERTAR QAREEEARRL 
RERIDRAETL GRTWSREESE LQRARDQADQ ECGRLQQELR ALERQKQQQT LQLQEESKLL 
SQKTESERQK AAQRGQELSR LEAAILREKD QIYEKERTLR DLHAKVSREE LSQETQTRET 
NLSTKISILE PETGKDMSPY EAYKRGIIDR GQYLQLQELE CDWEEVTTSG PCGEESVLLD 
RKSGKQYSIE AALRCRRISK EEYHLYKDGH LPISEFALLV AGETKPSSSL SIGSIISKSP 
LASPAPQSTS FFSPSFSLGL GDDSFPIAGI YDTTTDNKCS IKTAVAKNML DPITGQKLLE 
AQAATGGIVD LLSRERYSVH KAMERGLIEN TSTQRLLNAQ KAFTGIEDPV TKKRLSVGEA 
VQKGWMPRES VLPHLQVQHL TGGLIDPKRT GRIPIQQALL SGMISEELAQ LLQDESSYEK 
DLTDPISKER LSYKEAMGRC RKDPLSGLLL LPAALEGYRC YRSASPTVPR SLR

Genular Protein ID: 3775239690

Symbol: B7ZLH8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLH8

Database IDs:

ARBA 4 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 4 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 2055
  • Mass: 233821
  • Checksum: 88E727275A804307
  • Sequence:
    • MFKGLSKGSQ GKGSPKGSPA KGSPKGSPSR HSRAATQELA LLISRMQANA DQVERDILET 
QKRLQQDRLN SEQSQALQHQ QETGRSLKEA EVLLKDLFLD VDKARRLKHP QAEEIEKDIK 
QLHERVTQEC AEYRALYEKM VLPPDVGPRV DWARVLEQKQ KQVCAGQYGP GMAELEQQIA 
EHNILQKEID AYGQQLRSLV GPDAATIRSQ YRDLLKAASW RGQSLGSLYT HLQGCTRQLS 
ALAEQQRRIL QQDWSDLMAD PAGVRREYEH FKQHELLSQE QSVNQLEDDG ERMVELRHPA 
VGPIQAHQEA LKMEWQNFLN LCICQETQLQ HVEDYRRFQE EADSVSQTLA KLNSNLDAKY 
SPAPGGPPGA PTELLQQLEA EEKRLAVTER ATGDLQRRSR DVAPLPQRRN PPQQPLHVDS 
ICDWDSGEVQ LLQGERYKLV DNTDPHAWVV QGPGGETKRA PAACFCIPAP DPDAVARASR 
LASELQALKQ KLATVQSRLK ASAVESLRPS QQGTQGGPGR GGCGARRSRF RLPTAPSGSD 
LANPQAQKLL TQMTRLDGDL GQIERQVLAW ARAPLSRPTP LEDLEGRIHS HEGTAQRLQS 
LGTEKETAQK ECEAFLSTRP VGPAALQLPV ALNSVKNKFS DVQVLCSLYG EKAKAALDLE 
RQIQDADRVI RGFEATLVQE APIPAEPGAL QERVSELQRQ RRELLEQQTC VLRLHRALKA 
SEHACAALQN NFQEFCQDLP RQQRQVRALT DRYHAVGDQL DLREKVVQDA ALTYQQFKNC 
KDNLSSWLEH LPRSQVRPSD GPSQIAYKLQ AQKRLTQEIQ SRERDRATAS HLSQALQAAL 
QDYELQADTY RCSLEPTLAV SAPKRPRVAP LQESIQAQEK NLAKAYTEVA AAQQQLLQQL 
EFARKMLEKK ELSEDIRRTH DAKQGSESPA QAGRESEALK AQLEEERKRV ARVQHELEAQ 
RSQLLQLRTQ RPLERLEEKE VVEFYRDPQL EGSLSRVKAQ VEEEGKRRAG LQADLEVAAQ 
KVVQLESKRK TMQPHLLTKE VTQVERDPGL DSQAAQLRIQ IQQLRGEDAV ISARLEGLKK 
ELLALEKREV DVKEKVVVKE VVKVEKNLEM VKAAQALRLQ MEEDAARRKQ AEEAVAKLQA 
RIEDLERAIS SVEPKVIVKE VKKVEQDPGL LQESSRLRSL LEEERTKNAT LARELSDLHS 
KYSVVEKQRP KVQLQERVHE IFQVDPETEQ EITRLKAKLQ EMAGKRSGVE KEVEKLLPDL 
EVLRAQKPTV EYKEVTQEVV RHERSPEVLR EIDRLKAQLN ELVNSHGRSQ EQLIRLQGER 
DEWRRERAKV ETKTVSKEVV RHEKDPVLEK EAERLRQEVR EAAQKRRAAE DAVYELQSKR 
LLLERRKPEE KVVVQEVVVT QKDPKLREEH SRLSGSLDEE VGRRRQLELE VQQLRAGVEE 
QEGLLSFQED RSKKLAVERE LRQLTLRIQE LEKRPPTVQE KIIMEEVVKL EKDPDLEKST 
EALRWDLDQE KTQVTELNRE CKNLQVQIDV LQKAKSQEKT IYKEVIRVQK DRVLEDERAR 
VWEMLNRERT ARQAREEEAR RLRERIDRAE TLGRTWSREE SELQRARDQA DQECGRLQQE 
LRALERQKQQ QTLQLQEESK LLSQKTESER QKAAQRGQEL SRLEAAILRE KDQIYEKERT 
LRDLHAKVSR EELSQETQTR ETNLSTKISI LEPETGKDMS PYEAYKRGII DRGQYLQLQE 
LECDWEEVTT SGPCGEESVL LDRKSGKQYS IEAALRCRRI SKEEYHLYKD GHLPISEFAL 
LVAGETKPSS SLSIGSIISK SPLASPAPQS TSFFSSSFSL GLGDDSFPIA GIYDTTTDNK 
CSIKTAVAKN MLDPITGQKL LEAQAATGGI VDLLSRERYS VHKAMERGLI ENTSTQRLLN 
AQKAFTGIED PVTKKRLSVG EAVQKGWMPR ESVLPHLQVQ HLTGGLIDPK RTGRIPIQQA 
LLSGMISEEL AQLLQDESSY EKDLTDPISK ERLSYKEAMG RCRKDPLSGL LLLPAALEGY 
RCYRSASPTV PRSLR

Genular Protein ID: 1078045613

Symbol: K7EKI0_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7EKI0

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 4 GeneTree 1 HGNC 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 2055
  • Mass: 233831
  • Checksum: A4C5E50BBB7D6FE7
  • Sequence:
    • MFKGLSKGSQ GKGSPKGSPA KGSPKGSPSR HSRAATQELA LLISRMQANA DQVERDILET 
QKRLQQDRLN SEQSQALQHQ QETGRSLKEA EVLLKDLFLD VDKARRLKHP QAEEIEKDIK 
QLHERVTQEC AEYRALYEKM VLPPDVGPRV DWARVLEQKQ KQVCAGQYGP GMAELEQQIA 
EHNILQKEID AYGQQLRSLV GPDAATIRSQ YRDLLKAASW RGQSLGSLYT HLQGCTRQLS 
ALAEQQRRIL QQDWSDLMAD PAGVRREYEH FKQHELLSQE QSVNQLEDDG ERMVELRHPA 
VGPIQAHQEA LKMEWQNFLN LCICQETQLQ HVEDYRRFQE EADSVSQTLA KLNSNLDAKY 
SPAPGGPPGA PTELLQQLEA EEKRLAVTER ATGDLQRRSR DVAPLPQRRN PPQQPLHVDS 
ICDWDSGEVQ LLQGERYKLV DNTDPHAWVV QGPGGETKRA PAACFCIPAP DPDAVARASR 
LASELQALKQ KLATVQSRLK ASAVESLRPS QQGTQGGPGR GGCGARRSRF RLPTAPSGSD 
LANPQAQKLL TQMTRLDGDL GQIERQVLAW ARAPLSRPTP LEDLEGRIHS HEGTAQRLQS 
LGTEKETAQK ECEAFLSTRP VGPAALQLPV ALNSVKNKFS DVQVLCSLYG EKAKAALDLE 
RQIQDADRVI RGFEATLVQE APIPAEPGAL QERVSELQRQ RRELLEQQTC VLRLHRALKA 
SEHACAALQN NFQEFCQDLP RQQRQVRALT DRYHAVGDQL DLREKVVQDA ALTYQQFKNC 
KDNLSSWLEH LPRSQVRPSD GPSQIAYKLQ AQKRLTQEIQ SRERDRATAS HLSQALQAAL 
QDYELQADTY RCSLEPTLAV SAPKRPRVAP LQESIQAQEK NLAKAYTEVA AAQQQLLQQL 
EFARKMLEKK ELSEDIRRTH DAKQGSESPA QAGRESEALK AQLEEERKRV ARVQHELEAQ 
RSQLLQLRTQ RPLERLEEKE VVEFYRDPQL EGSLSRVKAQ VEEEGKRRAG LQADLEVAAQ 
KVVQLESKRK TMQPHLLTKE VTQVERDPGL DSQAAQLRIQ IQQLRGEDAV ISARLEGLKK 
ELLALEKREV DVKEKVVVKE VVKVEKNLEM VKAAQALRLQ MEEDAARRKQ AEEAVAKLQA 
RIEDLERAIS SVEPKVIVKE VKKVEQDPGL LQESSRLRSL LEEERTKNAT LARELSDLHS 
KYSVVEKQRP KVQLQERVHE IFQVDPETEQ EITRLKAKLQ EMAGKRSGVE KEVEKLLPDL 
EVLRAQKPTV EYKEVTQEVV RHERSPEVLR EIDRLKAQLN ELVNSHGRSQ EQLIRLQGER 
DEWRRERAKV ETKTVSKEVV RHEKDPVLEK EAERLRQEVR EAAQKRRAAE DAVYELQSKR 
LLLERRKPEE KVVVQEVVVT QKDPKLREEH SRLSGSLDEE VGRRRQLELE VQQLRAGVEE 
QEGLLSFQED RSKKLAVERE LRQLTLRIQE LEKRPPTVQE KIIMEEVVKL EKDPDLEKST 
EALRWDLDQE KTQVTELNRE CKNLQVQIDV LQKAKSQEKT IYKEVIRVQK DRVLEDERAR 
VWEMLNRERT ARQAREEEAR RLRERIDRAE TLGRTWSREE SELQRARDQA DQECGRLQQE 
LRALERQKQQ QTLQLQEESK LLSQKTESER QKAAQRGQEL SRLEAAILRE KDQIYEKERT 
LRDLHAKVSR EELSQETQTR ETNLSTKISI LEPETGKDMS PYEAYKRGII DRGQYLQLQE 
LECDWEEVTT SGPCGEESVL LDRKSGKQYS IEAALRCRRI SKEEYHLYKD GHLPISEFAL 
LVAGETKPSS SLSIGSIISK SPLASPAPQS TSFFSPSFSL GLGDDSFPIA GIYDTTTDNK 
CSIKTAVAKN MLDPITGQKL LEAQAATGGI VDLLSRERYS VHKAMERGLI ENTSTQRLLN 
AQKAFTGIED PVTKKRLSVG EAVQKGWMPR ESVLPHLQVQ HLTGGLIDPK RTGRIPIQQA 
LLSGMISEEL AQLLQDESSY EKDLTDPISK ERLSYKEAMG RCRKDPLSGL LLLPAALEGY 
RCYRSASPTV PRSLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.