Gene F5 - ENSG00000198734 | NCBI Gene ID: 2153

Details for: F5

Gene ID: 2153

Symbol: F5

Ensembl ID: ENSG00000198734

Description: coagulation factor V

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Common pathway of fibrin clot formation
(R-HSA-140875)
Copii-mediated vesicle transport
(R-HSA-204005)
Er to golgi anterograde transport
(R-HSA-199977)
Formation of fibrin clot (clotting cascade)
(R-HSA-140877)
Hemostasis
(R-HSA-109582)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Blood circulation
(GO:0008015)
Blood coagulation
(GO:0007596)
Copii-coated er to golgi transport vesicle
(GO:0030134)
Copper ion binding
(GO:0005507)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extracellular vesicle
(GO:1903561)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
Platelet alpha granule
(GO:0031091)
Platelet alpha granule lumen
(GO:0031093)
Protein binding
(GO:0005515)
Response to vitamin k
(GO:0032571)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.87
Marker Score: 838
Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.39
Marker Score: 6859
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 2.35
Marker Score: 2251
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.29
Marker Score: 7510
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.93
Marker Score: 1586
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.73
Marker Score: 9299
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.69
Marker Score: 10881
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.66
Marker Score: 7167
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1166
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 1.54
Marker Score: 1009
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 1.48
Marker Score: 4388
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169115
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.28
Marker Score: 405
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 852
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.19
Marker Score: 4663
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 485
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 1.14
Marker Score: 9649
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.1
Marker Score: 415
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 501
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251801
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71820
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48044
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 460
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5343
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 372
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2737
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.9
Marker Score: 3787.5
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.87
Marker Score: 596
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.82
Marker Score: 12774
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 613.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1260
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.77
Marker Score: 1468
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 699
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3118.5
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 460
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.7
Marker Score: 255
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.69
Marker Score: 1402
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.66
Marker Score: 2727
Cell Name: serous secreting cell (CL0000313)
Fold Change: 0.66
Marker Score: 262
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.65
Marker Score: 694
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.63
Marker Score: 1563
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.62
Marker Score: 34889
Cell Name: podocyte (CL0000653)
Fold Change: 0.62
Marker Score: 228
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 440
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 146
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.55
Marker Score: 490
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 172
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.54
Marker Score: 224
Cell Name: osteoclast (CL0000092)
Fold Change: 0.53
Marker Score: 265
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.51
Marker Score: 780
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.5
Marker Score: 11270
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 0.46
Marker Score: 161
Cell Name: blood cell (CL0000081)
Fold Change: 0.44
Marker Score: 5100
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.43
Marker Score: 260
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.43
Marker Score: 281
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.42
Marker Score: 1490
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.4
Marker Score: 182
Cell Name: neutrophil (CL0000775)
Fold Change: 0.39
Marker Score: 238
Cell Name: tracheobronchial serous cell (CL0019001)
Fold Change: 0.39
Marker Score: 141
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.38
Marker Score: 380
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.38
Marker Score: 119
Cell Name: mast cell (CL0000097)
Fold Change: 0.37
Marker Score: 212
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.36
Marker Score: 135
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.36
Marker Score: 156
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.36
Marker Score: 89
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.34
Marker Score: 21020
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.34
Marker Score: 105.5
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.34
Marker Score: 2156
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.34
Marker Score: 160
Cell Name: melanocyte (CL0000148)
Fold Change: 0.32
Marker Score: 130
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.32
Marker Score: 219
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.31
Marker Score: 734
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.3
Marker Score: 193
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.3
Marker Score: 97
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.3
Marker Score: 333
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.3
Marker Score: 300
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.29
Marker Score: 99
Cell Name: fat cell (CL0000136)
Fold Change: 0.29
Marker Score: 160
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.28
Marker Score: 704
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.28
Marker Score: 84
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.27
Marker Score: 86
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.27
Marker Score: 131
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.27
Marker Score: 2297
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.26
Marker Score: 69
Cell Name: astrocyte (CL0000127)
Fold Change: 0.24
Marker Score: 211
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.24
Marker Score: 1531
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.24
Marker Score: 672
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.23
Marker Score: 242
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.23
Marker Score: 139
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.23
Marker Score: 212.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.23
Marker Score: 563
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.23
Marker Score: 67
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.23
Marker Score: 78

Hover over a box to see details here...

**Key characteristics:** * F5 is a glycoprotein with a molecular weight of approximately 150 kDa. * It is produced by a single gene, F5. * It is expressed in high levels in the liver and other tissues with high vascularization, such as the retina and blood. * It is a key regulator of blood coagulation and is involved in the formation of fibrin clots. **Pathways and functions:** * F5 is involved in the coagulation cascade, a complex pathway that is responsible for the formation of blood clots. * It is a key factor in the initial stages of clot formation, where it is produced by endothelial cells and deposited onto the surface of blood platelets. * It also plays a role in the regulation of platelet aggregation and degranulation. * It is involved in the transport of proteins and molecules between the endoplasmic reticulum (ER) and the Golgi apparatus. * It is also involved in the regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps). **Clinical significance:** * Mutations in the F5 gene have been linked to several human diseases, including hemophilia A and von Willebrand disease. * In hemophilia A, mutations in F5 lead to a severe deficiency of the coagulation factor, resulting in a significant increase in bleeding time. * In von Willebrand disease, mutations in F5 result in a reduced expression of the factor, which can lead to a decreased ability to form blood clots and an increased risk of bleeding disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Coagulation factor V

Genular Protein ID: 3902758543

Symbol: FA5_HUMAN

Name: Coagulation factor V

UniProtKB Accession Codes:

P12259 A8K6E8 Q14285 Q2EHR5 Q5R346 Q5R347 Q6UPU6 Q8WWQ6

Database IDs:

Citations:

PubMed ID: 3110773

Title: Complete cDNA and derived amino acid sequence of human factor V.

PubMed ID: 3110773

DOI: 10.1073/pnas.84.14.4846

PubMed ID: 1567832

Title: Structure of the gene for human coagulation factor V.

PubMed ID: 1567832

DOI: 10.1021/bi00130a007

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 2827731

Title: Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats.

PubMed ID: 2827731

DOI: 10.1021/bi00394a033

PubMed ID: 11758222

Title: Studies on hereditary deficiency of coagulation factor V.

PubMed ID: 11758222

PubMed ID: 3092220

Title: Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin.

PubMed ID: 3092220

DOI: 10.1073/pnas.83.18.6800

PubMed ID: 8454869

Title: The serine protease cofactor factor V is synthesized by lymphocytes.

PubMed ID: 8454869

PubMed ID: 6323392

Title: Mechanism of inhibition of activated protein C by protein C inhibitor.

PubMed ID: 6323392

DOI: 10.1093/oxfordjournals.jbchem.a134583

PubMed ID: 6490642

Title: Coagulation Factor V contains copper ion.

PubMed ID: 6490642

DOI: 10.1016/s0021-9258(18)90637-x

PubMed ID: 2844223

Title: Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor.

PubMed ID: 2844223

DOI: 10.1021/bi00412a005

PubMed ID: 8204629

Title: Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity.

PubMed ID: 8204629

DOI: 10.1021/bi00188a026

PubMed ID: 2168225

Title: Sulfation of tyrosine residues in coagulation factor V.

PubMed ID: 2168225

PubMed ID: 7989361

Title: The mechanism of inactivation of human factor V and human factor Va by activated protein C.

PubMed ID: 7989361

DOI: 10.1016/s0021-9258(18)31776-9

PubMed ID: 8665956

Title: Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor.

PubMed ID: 8665956

DOI: 10.1111/j.1432-1033.1996.0088q.x

PubMed ID: 9556620

Title: Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles.

PubMed ID: 9556620

DOI: 10.1074/jbc.273.18.11281

PubMed ID: 11018168

Title: Mutations in coagulation factors in women with unexplained late fetal loss.

PubMed ID: 11018168

DOI: 10.1056/nejm200010053431405

PubMed ID: 15140131

Title: Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions.

PubMed ID: 15140131

DOI: 10.1111/j.1538-7836.2004.00733.x

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 10586886

Title: Crystal structures of the membrane-binding C2 domain of human coagulation factor V.

PubMed ID: 10586886

DOI: 10.1038/46594

PubMed ID: 7874144

Title: A polymorphism in the human coagulation factor V gene.

PubMed ID: 7874144

PubMed ID: 8164741

Title: Mutation in blood coagulation factor V associated with resistance to activated protein C.

PubMed ID: 8164741

DOI: 10.1038/369064a0

PubMed ID: 8713778

Title: Detection of new polymorphic markers in the factor V gene: association with factor V levels in plasma.

PubMed ID: 8713778

PubMed ID: 9245936

Title: Prevalence of the factor V Leiden mutation in hepatic and portal vein thrombosis.

PubMed ID: 9245936

DOI: 10.1136/gut.40.6.798

PubMed ID: 9454741

Title: A novel mutation of Arg306 of factor V gene in Hong Kong Chinese.

PubMed ID: 9454741

PubMed ID: 9454742

Title: Factor V Cambridge: a new mutation (Arg306-to-Thr) associated with resistance to activated protein C.

PubMed ID: 9454742

PubMed ID: 9746807

Title: Clinical significance of Arg306 mutations of factor V gene.

PubMed ID: 9746807

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10942390

Title: Combinations of 4 mutations (FV R506Q, FV H1299R, FV Y1702C, PT 20210G/A) affecting the prothrombinase complex in a thrombophilic family.

PubMed ID: 10942390

PubMed ID: 11435304

Title: Five novel mutations in the gene for human blood coagulation factor V associated with type I factor V deficiency.

PubMed ID: 11435304

DOI: 10.1182/blood.v98.2.358

PubMed ID: 11858490

Title: Novel factor V C2-domain mutation (R2074H) in two families with factor V deficiency and bleeding.

PubMed ID: 11858490

PubMed ID: 12393490

Title: Arg2074Cys missense mutation in the C2 domain of factor V causing moderately severe factor V deficiency: molecular characterization by expression of the recombinant protein.

PubMed ID: 12393490

DOI: 10.1182/blood-2002-06-1928

PubMed ID: 14617013

Title: Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C.

PubMed ID: 14617013

DOI: 10.1046/j.1365-2141.2003.04624.x

PubMed ID: 15534175

Title: Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.

PubMed ID: 15534175

DOI: 10.1001/archneur.61.11.1652

PubMed ID: 14695241

Title: Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis.

PubMed ID: 14695241

DOI: 10.1182/blood-2003-06-2092

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 2224
Mass: 251703
Checksum: 24AEF3FEA7332E37
Sequence:

MFPGCPRLWV LVVLGTSWVG WGSQGTEAAQ LRQFYVAAQG ISWSYRPEPT NSSLNLSVTS 
FKKIVYREYE PYFKKEKPQS TISGLLGPTL YAEVGDIIKV HFKNKADKPL SIHPQGIRYS 
KLSEGASYLD HTFPAEKMDD AVAPGREYTY EWSISEDSGP THDDPPCLTH IYYSHENLIE 
DFNSGLIGPL LICKKGTLTE GGTQKTFDKQ IVLLFAVFDE SKSWSQSSSL MYTVNGYVNG 
TMPDITVCAH DHISWHLLGM SSGPELFSIH FNGQVLEQNH HKVSAITLVS ATSTTANMTV 
GPEGKWIISS LTPKHLQAGM QAYIDIKNCP KKTRNLKKIT REQRRHMKRW EYFIAAEEVI 
WDYAPVIPAN MDKKYRSQHL DNFSNQIGKH YKKVMYTQYE DESFTKHTVN PNMKEDGILG 
PIIRAQVRDT LKIVFKNMAS RPYSIYPHGV TFSPYEDEVN SSFTSGRNNT MIRAVQPGET 
YTYKWNILEF DEPTENDAQC LTRPYYSDVD IMRDIASGLI GLLLICKSRS LDRRGIQRAA 
DIEQQAVFAV FDENKSWYLE DNINKFCENP DEVKRDDPKF YESNIMSTIN GYVPESITTL 
GFCFDDTVQW HFCSVGTQNE ILTIHFTGHS FIYGKRHEDT LTLFPMRGES VTVTMDNVGT 
WMLTSMNSSP RSKKLRLKFR DVKCIPDDDE DSYEIFEPPE STVMATRKMH DRLEPEDEES 
DADYDYQNRL AAALGIRSFR NSSLNQEEEE FNLTALALEN GTEFVSSNTD IIVGSNYSSP 
SNISKFTVNN LAEPQKAPSH QQATTAGSPL RHLIGKNSVL NSSTAEHSSP YSEDPIEDPL 
QPDVTGIRLL SLGAGEFKSQ EHAKHKGPKV ERDQAAKHRF SWMKLLAHKV GRHLSQDTGS 
PSGMRPWEDL PSQDTGSPSR MRPWKDPPSD LLLLKQSNSS KILVGRWHLA SEKGSYEIIQ 
DTDEDTAVNN WLISPQNASR AWGESTPLAN KPGKQSGHPK FPRVRHKSLQ VRQDGGKSRL 
KKSQFLIKTR KKKKEKHTHH APLSPRTFHP LRSEAYNTFS ERRLKHSLVL HKSNETSLPT 
DLNQTLPSMD FGWIASLPDH NQNSSNDTGQ ASCPPGLYQT VPPEEHYQTF PIQDPDQMHS 
TSDPSHRSSS PELSEMLEYD RSHKSFPTDI SQMSPSSEHE VWQTVISPDL SQVTLSPELS 
QTNLSPDLSH TTLSPELIQR NLSPALGQMP ISPDLSHTTL SPDLSHTTLS LDLSQTNLSP 
ELSQTNLSPA LGQMPLSPDL SHTTLSLDFS QTNLSPELSH MTLSPELSQT NLSPALGQMP 
ISPDLSHTTL SLDFSQTNLS PELSQTNLSP ALGQMPLSPD PSHTTLSLDL SQTNLSPELS 
QTNLSPDLSE MPLFADLSQI PLTPDLDQMT LSPDLGETDL SPNFGQMSLS PDLSQVTLSP 
DISDTTLLPD LSQISPPPDL DQIFYPSESS QSLLLQEFNE SFPYPDLGQM PSPSSPTLND 
TFLSKEFNPL VIVGLSKDGT DYIEIIPKEE VQSSEDDYAE IDYVPYDDPY KTDVRTNINS 
SRDPDNIAAW YLRSNNGNRR NYYIAAEEIS WDYSEFVQRE TDIEDSDDIP EDTTYKKVVF 
RKYLDSTFTK RDPRGEYEEH LGILGPIIRA EVDDVIQVRF KNLASRPYSL HAHGLSYEKS 
SEGKTYEDDS PEWFKEDNAV QPNSSYTYVW HATERSGPES PGSACRAWAY YSAVNPEKDI 
HSGLIGPLLI CQKGILHKDS NMPMDMREFV LLFMTFDEKK SWYYEKKSRS SWRLTSSEMK 
KSHEFHAING MIYSLPGLKM YEQEWVRLHL LNIGGSQDIH VVHFHGQTLL ENGNKQHQLG 
VWPLLPGSFK TLEMKASKPG WWLLNTEVGE NQRAGMQTPF LIMDRDCRMP MGLSTGIISD 
SQIKASEFLG YWEPRLARLN NGGSYNAWSV EKLAAEFASK PWIQVDMQKE VIITGIQTQG 
AKHYLKSCYT TEFYVAYSSN QINWQIFKGN STRNVMYFNG NSDASTIKEN QFDPPIVARY 
IRISPTRAYN RPTLRLELQG CEVNGCSTPL GMENGKIENK QITASSFKKS WWGDYWEPFR 
ARLNAQGRVN AWQAKANNNK QWLEIDLLKI KKITAIITQG CKSLSSEMYV KSYTIHYSEQ 
GVEWKPYRLK SSMVDKIFEG NTNTKGHVKN FFNPPIISRF IRVIPKTWNQ SIALRLELFG 
CDIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: F5

Associated with

Cells (max top 100)

Other Information

Complete cDNA and derived amino acid sequence of human factor V. PubMed ID: 3110773

Structure of the gene for human coagulation factor V. PubMed ID: 1567832

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats. PubMed ID: 2827731

Studies on hereditary deficiency of coagulation factor V. PubMed ID: 11758222

Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin. PubMed ID: 3092220

The serine protease cofactor factor V is synthesized by lymphocytes. PubMed ID: 8454869

Mechanism of inhibition of activated protein C by protein C inhibitor. PubMed ID: 6323392

Coagulation Factor V contains copper ion. PubMed ID: 6490642

Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor. PubMed ID: 2844223

Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity. PubMed ID: 8204629

Sulfation of tyrosine residues in coagulation factor V. PubMed ID: 2168225

The mechanism of inactivation of human factor V and human factor Va by activated protein C. PubMed ID: 7989361

Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. PubMed ID: 8665956

Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles. PubMed ID: 9556620

Mutations in coagulation factors in women with unexplained late fetal loss. PubMed ID: 11018168

Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions. PubMed ID: 15140131

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. PubMed ID: 16263699

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039

Crystal structures of the membrane-binding C2 domain of human coagulation factor V. PubMed ID: 10586886

A polymorphism in the human coagulation factor V gene. PubMed ID: 7874144

Mutation in blood coagulation factor V associated with resistance to activated protein C. PubMed ID: 8164741

Detection of new polymorphic markers in the factor V gene: association with factor V levels in plasma. PubMed ID: 8713778

Prevalence of the factor V Leiden mutation in hepatic and portal vein thrombosis. PubMed ID: 9245936

A novel mutation of Arg306 of factor V gene in Hong Kong Chinese. PubMed ID: 9454741

Factor V Cambridge: a new mutation (Arg306-to-Thr) associated with resistance to activated protein C. PubMed ID: 9454742

Clinical significance of Arg306 mutations of factor V gene. PubMed ID: 9746807

Characterization of single-nucleotide polymorphisms in coding regions of human genes. PubMed ID: 10391209

Combinations of 4 mutations (FV R506Q, FV H1299R, FV Y1702C, PT 20210G/A) affecting the prothrombinase complex in a thrombophilic family. PubMed ID: 10942390

Five novel mutations in the gene for human blood coagulation factor V associated with type I factor V deficiency. PubMed ID: 11435304

Novel factor V C2-domain mutation (R2074H) in two families with factor V deficiency and bleeding. PubMed ID: 11858490

Arg2074Cys missense mutation in the C2 domain of factor V causing moderately severe factor V deficiency: molecular characterization by expression of the recombinant protein. PubMed ID: 12393490

Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C. PubMed ID: 14617013

Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. PubMed ID: 15534175

Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis. PubMed ID: 14695241

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974