Details for: F5

Gene ID: 2153

Symbol: F5

Ensembl ID: ENSG00000198734

Description: coagulation factor V

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.5600
    Cell Significance Index: -6.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.4545
    Cell Significance Index: -6.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.5012
    Cell Significance Index: -7.1100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 13.3503
    Cell Significance Index: 220.0000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 10.0573
    Cell Significance Index: 169.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.3854
    Cell Significance Index: -6.6400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 3.4492
    Cell Significance Index: 2.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.8625
    Cell Significance Index: 568.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1823
    Cell Significance Index: 58.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.6865
    Cell Significance Index: -5.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.5051
    Cell Significance Index: 25.3200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.3032
    Cell Significance Index: 7.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.1371
    Cell Significance Index: 722.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7107
    Cell Significance Index: 10.4900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6638
    Cell Significance Index: 10.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5520
    Cell Significance Index: 11.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5089
    Cell Significance Index: 13.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3896
    Cell Significance Index: 23.3900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3850
    Cell Significance Index: 1.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3558
    Cell Significance Index: 11.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2932
    Cell Significance Index: 22.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2578
    Cell Significance Index: 11.4100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2531
    Cell Significance Index: 3.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2432
    Cell Significance Index: 9.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2348
    Cell Significance Index: 25.5400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2235
    Cell Significance Index: 7.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2182
    Cell Significance Index: 197.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1837
    Cell Significance Index: 36.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1780
    Cell Significance Index: 17.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1693
    Cell Significance Index: 3.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1692
    Cell Significance Index: 4.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1406
    Cell Significance Index: 9.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1211
    Cell Significance Index: 3.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1201
    Cell Significance Index: 19.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1078
    Cell Significance Index: 31.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1032
    Cell Significance Index: 194.4000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0794
    Cell Significance Index: 0.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0728
    Cell Significance Index: 3.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0407
    Cell Significance Index: 5.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0205
    Cell Significance Index: 0.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0190
    Cell Significance Index: 2.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0154
    Cell Significance Index: 1.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0112
    Cell Significance Index: 0.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0060
    Cell Significance Index: 0.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0058
    Cell Significance Index: 4.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0048
    Cell Significance Index: 0.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0036
    Cell Significance Index: 1.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0029
    Cell Significance Index: 3.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0008
    Cell Significance Index: 1.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0007
    Cell Significance Index: -0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0015
    Cell Significance Index: -0.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0023
    Cell Significance Index: -1.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0028
    Cell Significance Index: -4.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0042
    Cell Significance Index: -2.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0068
    Cell Significance Index: -0.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0093
    Cell Significance Index: -7.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0113
    Cell Significance Index: -0.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0120
    Cell Significance Index: -6.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0124
    Cell Significance Index: -2.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0153
    Cell Significance Index: -0.2300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0165
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0197
    Cell Significance Index: -3.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0262
    Cell Significance Index: -3.0500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0274
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0336
    Cell Significance Index: -3.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0352
    Cell Significance Index: -4.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0461
    Cell Significance Index: -4.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0465
    Cell Significance Index: -3.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0511
    Cell Significance Index: -7.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0634
    Cell Significance Index: -1.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0635
    Cell Significance Index: -0.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0646
    Cell Significance Index: -8.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0680
    Cell Significance Index: -1.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0693
    Cell Significance Index: -8.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0707
    Cell Significance Index: -7.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0744
    Cell Significance Index: -1.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0791
    Cell Significance Index: -4.8600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0819
    Cell Significance Index: -1.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0833
    Cell Significance Index: -4.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0973
    Cell Significance Index: -5.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1099
    Cell Significance Index: -3.8500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1109
    Cell Significance Index: -1.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1130
    Cell Significance Index: -4.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1139
    Cell Significance Index: -8.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1188
    Cell Significance Index: -3.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1232
    Cell Significance Index: -2.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1244
    Cell Significance Index: -7.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1274
    Cell Significance Index: -6.6900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1316
    Cell Significance Index: -3.2100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1337
    Cell Significance Index: -2.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1347
    Cell Significance Index: -4.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1379
    Cell Significance Index: -6.4300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1401
    Cell Significance Index: -0.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1404
    Cell Significance Index: -4.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1648
    Cell Significance Index: -7.7500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1669
    Cell Significance Index: -0.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1754
    Cell Significance Index: -6.4400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1759
    Cell Significance Index: -2.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure and Function**: Factor V is a vitamin K-dependent glycoprotein, consisting of a large coagulation factor V protein domain, a light chain, and a gamma-carboxyglutamic acid (Gla) domain. The Gla domain is essential for the protein's interaction with phospholipid surfaces, facilitating the assembly of coagulation complexes. 2. **Expression and Regulation**: Factor V is expressed in various tissues, including the liver, placenta, and endothelial cells. Its expression is tightly regulated by vitamin K-dependent carboxylation, which modifies the protein's Gla domain and enables it to bind to phospholipid surfaces. 3. **Subcellular Localization**: Factor V is primarily synthesized in the endoplasmic reticulum (ER) and transported to the Golgi apparatus for modification and glycosylation. It is then secreted into the bloodstream, where it plays a central role in the coagulation cascade. **Pathways and Functions** Factor V is integral to the coagulation pathway, participating in the following processes: 1. **Blood Coagulation**: Factor V is a cofactor for the prothrombinase complex, which activates prothrombin (factor II) to thrombin (factor IIa). Thrombin then converts fibrinogen (factor I) to fibrin, forming a stable clot. 2. **Fibrin Clot Formation**: Factor V is essential for the assembly of coagulation complexes, including the prothrombinase complex, tenase complex, and fibrinogen complex. 3. **Vitamin K-Dependent Regulation**: The carboxylation of Factor V by vitamin K-dependent carboxylases ensures its proper functioning in the coagulation cascade. **Clinical Significance** Dysregulation of Factor V has been implicated in various clinical conditions, including: 1. **Thrombophilia**: Elevated levels of Factor V have been linked to an increased risk of thrombosis, including deep vein thrombosis and pulmonary embolism. 2. **Hemophilia C**: Mutations in the F5 gene have been associated with hemophilia C, a rare bleeding disorder characterized by impaired Factor V activity. 3. **Cancer**: Aberrant expression of Factor V has been observed in various cancers, including colorectal, breast, and lung cancer, suggesting its potential role in tumor progression and metastasis. 4. **Infectious Diseases**: Factor V has been implicated in the pathogenesis of infectious diseases, such as sepsis and meningitis, where it plays a role in the inflammatory response and coagulation cascade. In conclusion, Coagulation Factor V is a vital protein involved in the blood coagulation cascade, and its dysregulation has significant clinical implications. Further research is needed to fully elucidate the role of Factor V in various diseases and to develop targeted therapies for the treatment of thrombophilic disorders and other conditions associated with Factor V dysregulation.

Genular Protein ID: 3902758543

Symbol: FA5_HUMAN

Name: Coagulation factor V

UniProtKB Accession Codes:

P12259 A8K6E8 Q14285 Q2EHR5 Q5R346 Q5R347 Q6UPU6 Q8WWQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 EMBL 32 EMDB 14 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 11 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PIRSF 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3110773

Title: Complete cDNA and derived amino acid sequence of human factor V.

PubMed ID: 3110773

DOI: 10.1073/pnas.84.14.4846

PubMed ID: 1567832

Title: Structure of the gene for human coagulation factor V.

PubMed ID: 1567832

DOI: 10.1021/bi00130a007

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 2827731

Title: Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats.

PubMed ID: 2827731

DOI: 10.1021/bi00394a033

PubMed ID: 11758222

Title: Studies on hereditary deficiency of coagulation factor V.

PubMed ID: 11758222

PubMed ID: 3092220

Title: Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin.

PubMed ID: 3092220

DOI: 10.1073/pnas.83.18.6800

PubMed ID: 8454869

Title: The serine protease cofactor factor V is synthesized by lymphocytes.

PubMed ID: 8454869

PubMed ID: 6323392

Title: Mechanism of inhibition of activated protein C by protein C inhibitor.

PubMed ID: 6323392

DOI: 10.1093/oxfordjournals.jbchem.a134583

PubMed ID: 6490642

Title: Coagulation Factor V contains copper ion.

PubMed ID: 6490642

DOI: 10.1016/s0021-9258(18)90637-x

PubMed ID: 2844223

Title: Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor.

PubMed ID: 2844223

DOI: 10.1021/bi00412a005

PubMed ID: 8204629

Title: Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity.

PubMed ID: 8204629

DOI: 10.1021/bi00188a026

PubMed ID: 2168225

Title: Sulfation of tyrosine residues in coagulation factor V.

PubMed ID: 2168225

PubMed ID: 7989361

Title: The mechanism of inactivation of human factor V and human factor Va by activated protein C.

PubMed ID: 7989361

DOI: 10.1016/s0021-9258(18)31776-9

PubMed ID: 8665956

Title: Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor.

PubMed ID: 8665956

DOI: 10.1111/j.1432-1033.1996.0088q.x

PubMed ID: 9556620

Title: Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles.

PubMed ID: 9556620

DOI: 10.1074/jbc.273.18.11281

PubMed ID: 11018168

Title: Mutations in coagulation factors in women with unexplained late fetal loss.

PubMed ID: 11018168

DOI: 10.1056/nejm200010053431405

PubMed ID: 15140131

Title: Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions.

PubMed ID: 15140131

DOI: 10.1111/j.1538-7836.2004.00733.x

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 38237698

Title: Analysis of the Healthy Platelet Proteome Identifies a New Form of Domain-Specific O-Fucosylation.

PubMed ID: 38237698

DOI: 10.1016/j.mcpro.2024.100717

PubMed ID: 10586886

Title: Crystal structures of the membrane-binding C2 domain of human coagulation factor V.

PubMed ID: 10586886

DOI: 10.1038/46594

PubMed ID: 7874144

Title: A polymorphism in the human coagulation factor V gene.

PubMed ID: 7874144

PubMed ID: 8164741

Title: Mutation in blood coagulation factor V associated with resistance to activated protein C.

PubMed ID: 8164741

DOI: 10.1038/369064a0

PubMed ID: 8713778

Title: Detection of new polymorphic markers in the factor V gene: association with factor V levels in plasma.

PubMed ID: 8713778

PubMed ID: 9245936

Title: Prevalence of the factor V Leiden mutation in hepatic and portal vein thrombosis.

PubMed ID: 9245936

DOI: 10.1136/gut.40.6.798

PubMed ID: 9454741

Title: A novel mutation of Arg306 of factor V gene in Hong Kong Chinese.

PubMed ID: 9454741

PubMed ID: 9454742

Title: Factor V Cambridge: a new mutation (Arg306-to-Thr) associated with resistance to activated protein C.

PubMed ID: 9454742

PubMed ID: 9746807

Title: Clinical significance of Arg306 mutations of factor V gene.

PubMed ID: 9746807

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10942390

Title: Combinations of 4 mutations (FV R506Q, FV H1299R, FV Y1702C, PT 20210G/A) affecting the prothrombinase complex in a thrombophilic family.

PubMed ID: 10942390

PubMed ID: 11435304

Title: Five novel mutations in the gene for human blood coagulation factor V associated with type I factor V deficiency.

PubMed ID: 11435304

DOI: 10.1182/blood.v98.2.358

PubMed ID: 11858490

Title: Novel factor V C2-domain mutation (R2074H) in two families with factor V deficiency and bleeding.

PubMed ID: 11858490

PubMed ID: 12393490

Title: Arg2074Cys missense mutation in the C2 domain of factor V causing moderately severe factor V deficiency: molecular characterization by expression of the recombinant protein.

PubMed ID: 12393490

DOI: 10.1182/blood-2002-06-1928

PubMed ID: 14617013

Title: Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C.

PubMed ID: 14617013

DOI: 10.1046/j.1365-2141.2003.04624.x

PubMed ID: 15534175

Title: Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.

PubMed ID: 15534175

DOI: 10.1001/archneur.61.11.1652

PubMed ID: 14695241

Title: Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis.

PubMed ID: 14695241

DOI: 10.1182/blood-2003-06-2092

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 2224
  • Mass: 251703
  • Checksum: 24AEF3FEA7332E37
  • Sequence:
    • MFPGCPRLWV LVVLGTSWVG WGSQGTEAAQ LRQFYVAAQG ISWSYRPEPT NSSLNLSVTS 
FKKIVYREYE PYFKKEKPQS TISGLLGPTL YAEVGDIIKV HFKNKADKPL SIHPQGIRYS 
KLSEGASYLD HTFPAEKMDD AVAPGREYTY EWSISEDSGP THDDPPCLTH IYYSHENLIE 
DFNSGLIGPL LICKKGTLTE GGTQKTFDKQ IVLLFAVFDE SKSWSQSSSL MYTVNGYVNG 
TMPDITVCAH DHISWHLLGM SSGPELFSIH FNGQVLEQNH HKVSAITLVS ATSTTANMTV 
GPEGKWIISS LTPKHLQAGM QAYIDIKNCP KKTRNLKKIT REQRRHMKRW EYFIAAEEVI 
WDYAPVIPAN MDKKYRSQHL DNFSNQIGKH YKKVMYTQYE DESFTKHTVN PNMKEDGILG 
PIIRAQVRDT LKIVFKNMAS RPYSIYPHGV TFSPYEDEVN SSFTSGRNNT MIRAVQPGET 
YTYKWNILEF DEPTENDAQC LTRPYYSDVD IMRDIASGLI GLLLICKSRS LDRRGIQRAA 
DIEQQAVFAV FDENKSWYLE DNINKFCENP DEVKRDDPKF YESNIMSTIN GYVPESITTL 
GFCFDDTVQW HFCSVGTQNE ILTIHFTGHS FIYGKRHEDT LTLFPMRGES VTVTMDNVGT 
WMLTSMNSSP RSKKLRLKFR DVKCIPDDDE DSYEIFEPPE STVMATRKMH DRLEPEDEES 
DADYDYQNRL AAALGIRSFR NSSLNQEEEE FNLTALALEN GTEFVSSNTD IIVGSNYSSP 
SNISKFTVNN LAEPQKAPSH QQATTAGSPL RHLIGKNSVL NSSTAEHSSP YSEDPIEDPL 
QPDVTGIRLL SLGAGEFKSQ EHAKHKGPKV ERDQAAKHRF SWMKLLAHKV GRHLSQDTGS 
PSGMRPWEDL PSQDTGSPSR MRPWKDPPSD LLLLKQSNSS KILVGRWHLA SEKGSYEIIQ 
DTDEDTAVNN WLISPQNASR AWGESTPLAN KPGKQSGHPK FPRVRHKSLQ VRQDGGKSRL 
KKSQFLIKTR KKKKEKHTHH APLSPRTFHP LRSEAYNTFS ERRLKHSLVL HKSNETSLPT 
DLNQTLPSMD FGWIASLPDH NQNSSNDTGQ ASCPPGLYQT VPPEEHYQTF PIQDPDQMHS 
TSDPSHRSSS PELSEMLEYD RSHKSFPTDI SQMSPSSEHE VWQTVISPDL SQVTLSPELS 
QTNLSPDLSH TTLSPELIQR NLSPALGQMP ISPDLSHTTL SPDLSHTTLS LDLSQTNLSP 
ELSQTNLSPA LGQMPLSPDL SHTTLSLDFS QTNLSPELSH MTLSPELSQT NLSPALGQMP 
ISPDLSHTTL SLDFSQTNLS PELSQTNLSP ALGQMPLSPD PSHTTLSLDL SQTNLSPELS 
QTNLSPDLSE MPLFADLSQI PLTPDLDQMT LSPDLGETDL SPNFGQMSLS PDLSQVTLSP 
DISDTTLLPD LSQISPPPDL DQIFYPSESS QSLLLQEFNE SFPYPDLGQM PSPSSPTLND 
TFLSKEFNPL VIVGLSKDGT DYIEIIPKEE VQSSEDDYAE IDYVPYDDPY KTDVRTNINS 
SRDPDNIAAW YLRSNNGNRR NYYIAAEEIS WDYSEFVQRE TDIEDSDDIP EDTTYKKVVF 
RKYLDSTFTK RDPRGEYEEH LGILGPIIRA EVDDVIQVRF KNLASRPYSL HAHGLSYEKS 
SEGKTYEDDS PEWFKEDNAV QPNSSYTYVW HATERSGPES PGSACRAWAY YSAVNPEKDI 
HSGLIGPLLI CQKGILHKDS NMPMDMREFV LLFMTFDEKK SWYYEKKSRS SWRLTSSEMK 
KSHEFHAING MIYSLPGLKM YEQEWVRLHL LNIGGSQDIH VVHFHGQTLL ENGNKQHQLG 
VWPLLPGSFK TLEMKASKPG WWLLNTEVGE NQRAGMQTPF LIMDRDCRMP MGLSTGIISD 
SQIKASEFLG YWEPRLARLN NGGSYNAWSV EKLAAEFASK PWIQVDMQKE VIITGIQTQG 
AKHYLKSCYT TEFYVAYSSN QINWQIFKGN STRNVMYFNG NSDASTIKEN QFDPPIVARY 
IRISPTRAYN RPTLRLELQG CEVNGCSTPL GMENGKIENK QITASSFKKS WWGDYWEPFR 
ARLNAQGRVN AWQAKANNNK QWLEIDLLKI KKITAIITQG CKSLSSEMYV KSYTIHYSEQ 
GVEWKPYRLK SSMVDKIFEG NTNTKGHVKN FFNPPIISRF IRVIPKTWNQ SIALRLELFG 
CDIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.