Details for: FAAH

Gene ID: 2166

Symbol: FAAH

Ensembl ID: ENSG00000117480

Description: fatty acid amide hydrolase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 96.4993
    Cell Significance Index: -15.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.0092
    Cell Significance Index: -14.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.0549
    Cell Significance Index: -12.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 21.4822
    Cell Significance Index: -14.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.7731
    Cell Significance Index: -12.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.3362
    Cell Significance Index: -15.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4874
    Cell Significance Index: -14.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8722
    Cell Significance Index: -15.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0254
    Cell Significance Index: 329.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9967
    Cell Significance Index: -4.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7872
    Cell Significance Index: 38.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7522
    Cell Significance Index: 79.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6601
    Cell Significance Index: 47.8300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3247
    Cell Significance Index: 19.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3002
    Cell Significance Index: 141.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2601
    Cell Significance Index: 75.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1371
    Cell Significance Index: 59.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9440
    Cell Significance Index: 12.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8307
    Cell Significance Index: 22.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7128
    Cell Significance Index: 19.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7041
    Cell Significance Index: 48.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6295
    Cell Significance Index: 126.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6123
    Cell Significance Index: 28.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5826
    Cell Significance Index: 67.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5042
    Cell Significance Index: 31.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4192
    Cell Significance Index: 3.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4157
    Cell Significance Index: 74.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4135
    Cell Significance Index: 11.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4059
    Cell Significance Index: 13.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3830
    Cell Significance Index: 47.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3728
    Cell Significance Index: 24.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3703
    Cell Significance Index: 16.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3601
    Cell Significance Index: 26.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3356
    Cell Significance Index: 12.7100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3314
    Cell Significance Index: 3.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2666
    Cell Significance Index: 50.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2548
    Cell Significance Index: 91.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2527
    Cell Significance Index: 16.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2398
    Cell Significance Index: 5.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2265
    Cell Significance Index: 22.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1705
    Cell Significance Index: 5.9900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1686
    Cell Significance Index: 0.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1557
    Cell Significance Index: 30.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1435
    Cell Significance Index: 78.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1254
    Cell Significance Index: 2.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1204
    Cell Significance Index: 185.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1193
    Cell Significance Index: 107.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1181
    Cell Significance Index: 3.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0974
    Cell Significance Index: 2.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0847
    Cell Significance Index: 37.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0795
    Cell Significance Index: 108.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0753
    Cell Significance Index: 138.7900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0736
    Cell Significance Index: 0.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0378
    Cell Significance Index: 6.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0280
    Cell Significance Index: 0.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0108
    Cell Significance Index: 1.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -2.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0029
    Cell Significance Index: -1.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0044
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0119
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0182
    Cell Significance Index: -13.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0192
    Cell Significance Index: -2.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0200
    Cell Significance Index: -2.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0241
    Cell Significance Index: -13.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0249
    Cell Significance Index: -11.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0251
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0270
    Cell Significance Index: -16.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0305
    Cell Significance Index: -3.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0432
    Cell Significance Index: -5.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0446
    Cell Significance Index: -12.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0505
    Cell Significance Index: -0.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0645
    Cell Significance Index: -3.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0781
    Cell Significance Index: -16.4500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0909
    Cell Significance Index: -1.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0947
    Cell Significance Index: -9.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1002
    Cell Significance Index: -11.8200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1112
    Cell Significance Index: -0.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1152
    Cell Significance Index: -2.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1341
    Cell Significance Index: -7.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1361
    Cell Significance Index: -3.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1372
    Cell Significance Index: -6.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1448
    Cell Significance Index: -3.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1451
    Cell Significance Index: -11.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1569
    Cell Significance Index: -9.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1629
    Cell Significance Index: -12.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1702
    Cell Significance Index: -3.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1748
    Cell Significance Index: -2.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1824
    Cell Significance Index: -6.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1918
    Cell Significance Index: -1.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1985
    Cell Significance Index: -11.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2013
    Cell Significance Index: -2.4000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2129
    Cell Significance Index: -2.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2644
    Cell Significance Index: -7.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2756
    Cell Significance Index: -6.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2805
    Cell Significance Index: -6.0000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2977
    Cell Significance Index: -4.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3130
    Cell Significance Index: -9.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3164
    Cell Significance Index: -9.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Serine Hydrolase Activity**: FAAH possesses serine hydrolase activity, which allows it to hydrolyze ester bonds in fatty acid amides, such as endocannabinoids. 2. **Endocannabinoid Hydrolysis**: FAAH is specifically responsible for the hydrolysis of anandamide and 2-AG, terminating their signaling activity and regulating their levels in the body. 3. **Tissue Expression**: FAAH is widely expressed in various tissues, including the brain, kidney, immune cells, and lens epithelial cells, indicating its diverse physiological roles. 4. **Regulation of Lipid Homeostasis**: FAAH plays a critical role in regulating lipid homeostasis by controlling the levels of endocannabinoids and other fatty acid amides. **Pathways and Functions** 1. **Endocannabinoid Signaling**: FAAH regulates endocannabinoid signaling by hydrolyzing anandamide and 2-AG, thereby terminating their signaling activity and modulating their levels in the body. 2. **Fatty Acid Metabolism**: FAAH is involved in the regulation of fatty acid metabolism by controlling the levels of fatty acid amides and other lipids. 3. **Lipid Homeostasis**: FAAH maintains lipid homeostasis by regulating the levels of endocannabinoids and other fatty acid amides, which is essential for various physiological processes. 4. **Immune Function**: FAAH is expressed in immune cells and plays a role in regulating immune function by controlling the levels of endocannabinoids and other fatty acid amides. **Clinical Significance** 1. **Pain Modulation**: FAAH has been implicated in pain modulation, and its dysregulation has been linked to various pain disorders, such as chronic pain and neuropathic pain. 2. **Neuroprotection**: FAAH has been shown to have neuroprotective effects, and its dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Psychiatric Disorders**: FAAH has been implicated in psychiatric disorders, such as anxiety and depression, and its dysregulation has been linked to these conditions. 4. **Cancer**: FAAH has been shown to have anti-tumor effects, and its dysregulation has been linked to cancer progression and metastasis. In conclusion, FAAH is a critical enzyme involved in the regulation of endocannabinoid signaling, fatty acid metabolism, and lipid homeostasis. Its dysregulation has been linked to various physiological and pathological processes, including pain modulation, neuroprotection, psychiatric disorders, and cancer. Further research is necessary to fully elucidate the role of FAAH in human health and disease.

Genular Protein ID: 4105601799

Symbol: FAAH1_HUMAN

Name: Fatty-acid amide hydrolase 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9122178

Title: Molecular characterization of human and mouse fatty acid amide hydrolases.

PubMed ID: 9122178

DOI: 10.1073/pnas.94.6.2238

PubMed ID: 9878243

Title: Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation.

PubMed ID: 9878243

DOI: 10.1006/geno.1998.5597

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 17015445

Title: A second fatty acid amide hydrolase with variable distribution among placental mammals.

PubMed ID: 17015445

DOI: 10.1074/jbc.m606646200

PubMed ID: 21049984

Title: Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2.

PubMed ID: 21049984

DOI: 10.1021/tx1002194

PubMed ID: 19926788

Title: Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2.

PubMed ID: 19926788

DOI: 10.1074/jbc.m109.058461

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12060782

Title: A missense mutation in human fatty acid amide hydrolase associated with problem drug use.

PubMed ID: 12060782

DOI: 10.1073/pnas.082235799

PubMed ID: 15254019

Title: Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use.

PubMed ID: 15254019

DOI: 10.1093/hmg/ddh216

PubMed ID: 16972078

Title: The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction.

PubMed ID: 16972078

DOI: 10.1007/s00439-006-0250-x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23556448

Title: Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.

PubMed ID: 23556448

DOI: 10.2217/pgs.13.25

Sequence Information:

  • Length: 579
  • Mass: 63066
  • Checksum: 633A92DC36940C18
  • Sequence:
  • MVQYELWAAL PGASGVALAC CFVAAAVALR WSGRRTARGA VVRARQRQRA GLENMDRAAQ 
    RFRLQNPDLD SEALLALPLP QLVQKLHSRE LAPEAVLFTY VGKAWEVNKG TNCVTSYLAD 
    CETQLSQAPR QGLLYGVPVS LKECFTYKGQ DSTLGLSLNE GVPAECDSVV VHVLKLQGAV 
    PFVHTNVPQS MFSYDCSNPL FGQTVNPWKS SKSPGGSSGG EGALIGSGGS PLGLGTDIGG 
    SIRFPSSFCG ICGLKPTGNR LSKSGLKGCV YGQEAVRLSV GPMARDVESL ALCLRALLCE 
    DMFRLDPTVP PLPFREEVYT SSQPLRVGYY ETDNYTMPSP AMRRAVLETK QSLEAAGHTL 
    VPFLPSNIPH ALETLSTGGL FSDGGHTFLQ NFKGDFVDPC LGDLVSILKL PQWLKGLLAF 
    LVKPLLPRLS AFLSNMKSRS AGKLWELQHE IEVYRKTVIA QWRALDLDVV LTPMLAPALD 
    LNAPGRATGA VSYTMLYNCL DFPAGVVPVT TVTAEDEAQM EHYRGYFGDI WDKMLQKGMK 
    KSVGLPVAVQ CVALPWQEEL CLRFMREVER LMTPEKQSS

Genular Protein ID: 3791554701

Symbol: Q9UG55_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 151
  • Mass: 16894
  • Checksum: D16F7383BADA4B4D
  • Sequence:
  • RRQHPLPLLL LRHLRPQAHR EPPQVYTSSQ PLRVGYYETD NYTMPSPAMR RAVLETKQSL 
    EAAGHTLVPF LPSNIPHALE TLSTGGLFSD GGHTFLQNFK GDFVDPCLGD LVSILKLPQW 
    LKGLLAFLVK PLLPRLSAFL SNMKSRCTAK P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.