Details for: FAAH

Gene ID: 2166

Symbol: FAAH

Ensembl ID: ENSG00000117480

Description: fatty acid amide hydrolase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.57
    Marker Score: 918
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.44
    Marker Score: 1744
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.29
    Marker Score: 2255
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.1
    Marker Score: 1474
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.01
    Marker Score: 2375
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.99
    Marker Score: 2015
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.99
    Marker Score: 9363
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5310
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.92
    Marker Score: 2203
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.91
    Marker Score: 1409
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.9
    Marker Score: 1517
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.88
    Marker Score: 512
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.88
    Marker Score: 911
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5276
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.86
    Marker Score: 4139
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13483
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.86
    Marker Score: 3038
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.83
    Marker Score: 7142
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.83
    Marker Score: 1962
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 605
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1275
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.75
    Marker Score: 283
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.75
    Marker Score: 2341
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.75
    Marker Score: 1148.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.72
    Marker Score: 905
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 657
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.72
    Marker Score: 716
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.7
    Marker Score: 2849
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.69
    Marker Score: 42464
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.68
    Marker Score: 1291.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.68
    Marker Score: 4345
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2756
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.65
    Marker Score: 158
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.64
    Marker Score: 2459
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.64
    Marker Score: 4060
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.64
    Marker Score: 24126
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.63
    Marker Score: 200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.63
    Marker Score: 925
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.62
    Marker Score: 751
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.61
    Marker Score: 12180
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.61
    Marker Score: 193
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.61
    Marker Score: 4507
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.6
    Marker Score: 5643
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.6
    Marker Score: 2581
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6
    Marker Score: 2309
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6
    Marker Score: 6158
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.59
    Marker Score: 1347
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.58
    Marker Score: 3121
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.58
    Marker Score: 144
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.58
    Marker Score: 565
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.57
    Marker Score: 238
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.55
    Marker Score: 209
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.55
    Marker Score: 20266
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.55
    Marker Score: 1565
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 347
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.54
    Marker Score: 612
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.53
    Marker Score: 4088
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.53
    Marker Score: 5347
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.53
    Marker Score: 836
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.52
    Marker Score: 7830
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.51
    Marker Score: 490
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.51
    Marker Score: 1163
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5
    Marker Score: 1221
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5
    Marker Score: 1956
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.5
    Marker Score: 1353
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.5
    Marker Score: 1327
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.48
    Marker Score: 468
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.47
    Marker Score: 786
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.47
    Marker Score: 996.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.47
    Marker Score: 1183
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.46
    Marker Score: 193
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.45
    Marker Score: 279
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.44
    Marker Score: 3843
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.44
    Marker Score: 164
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.44
    Marker Score: 163
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.42
    Marker Score: 121
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.42
    Marker Score: 134
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.41
    Marker Score: 113
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.41
    Marker Score: 411
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.41
    Marker Score: 272
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.4
    Marker Score: 408
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.4
    Marker Score: 425
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.4
    Marker Score: 2104
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.4
    Marker Score: 179
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.4
    Marker Score: 186
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4
    Marker Score: 6393
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.39
    Marker Score: 424

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Other Information

## Summary The FAAH gene encodes a protein called FAAH1 that is involved in the metabolism of fatty acids. It is expressed in a variety of cell types, including the secondary lens fiber, lens epithelial cell, germ cell, anterior lens cell, kidney proximal straight tubule epithelial cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, and immature innate lymphoid cell. ## Key characteristics * The FAAH gene is located on chromosome 19q21.1. * It is a large gene with a length of approximately 2.6 kb. * The protein encoded by FAAH is a transmembrane protein with a molecular weight of approximately 120 kDa. * FAAH is a member of the FAB family of enzymes, which are involved in the hydrolysis of fatty acids. * The FAAH protein is expressed in high levels in the lens and surrounding tissues. * It is also expressed in low levels in the liver and other tissues. ## Pathways and functions The FAAH gene is involved in a variety of metabolic pathways, including: * Acylglycerol lipase activity * Amidase activity * Arachidonic acid metabolic process * Arachidonic acid metabolism * Cytoskeleton * Endoplasmic reticulum membrane * Fatty acid amide hydrolase activity * Fatty acid catabolic process * Fatty acid metabolism * Identical protein binding * Metabolism * Metabolism of lipids * Monoacylglycerol catabolic process * Organelle membrane * Phospholipid binding * Positive regulation of vasoconstriction ## Clinical significance Mutations in the FAAH gene have been linked to a number of eye diseases, including: * Cataracts * Diabetic retinopathy * Macular degeneration * Retinoblastoma The FAAH protein is a key regulator of fatty acid metabolism in the eye. Mutations in the FAAH gene can lead to the accumulation of fatty acids in the eye, which can damage the lens and lead to the development of eye diseases.

Genular Protein ID: 4105601799

Symbol: FAAH1_HUMAN

Name: Fatty-acid amide hydrolase 1

UniProtKB Accession Codes:

O00519 D3DQ19 Q52M86 Q5TDF8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EC 2 EMBL 18 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 58 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9122178

Title: Molecular characterization of human and mouse fatty acid amide hydrolases.

PubMed ID: 9122178

DOI: 10.1073/pnas.94.6.2238

PubMed ID: 9878243

Title: Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation.

PubMed ID: 9878243

DOI: 10.1006/geno.1998.5597

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 17015445

Title: A second fatty acid amide hydrolase with variable distribution among placental mammals.

PubMed ID: 17015445

DOI: 10.1074/jbc.m606646200

PubMed ID: 21049984

Title: Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2.

PubMed ID: 21049984

DOI: 10.1021/tx1002194

PubMed ID: 19926788

Title: Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2.

PubMed ID: 19926788

DOI: 10.1074/jbc.m109.058461

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12060782

Title: A missense mutation in human fatty acid amide hydrolase associated with problem drug use.

PubMed ID: 12060782

DOI: 10.1073/pnas.082235799

PubMed ID: 15254019

Title: Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use.

PubMed ID: 15254019

DOI: 10.1093/hmg/ddh216

PubMed ID: 16972078

Title: The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction.

PubMed ID: 16972078

DOI: 10.1007/s00439-006-0250-x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23556448

Title: Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.

PubMed ID: 23556448

DOI: 10.2217/pgs.13.25

Sequence Information:

  • Length: 579
  • Mass: 63066
  • Checksum: 633A92DC36940C18
  • Sequence:
    • MVQYELWAAL PGASGVALAC CFVAAAVALR WSGRRTARGA VVRARQRQRA GLENMDRAAQ 
RFRLQNPDLD SEALLALPLP QLVQKLHSRE LAPEAVLFTY VGKAWEVNKG TNCVTSYLAD 
CETQLSQAPR QGLLYGVPVS LKECFTYKGQ DSTLGLSLNE GVPAECDSVV VHVLKLQGAV 
PFVHTNVPQS MFSYDCSNPL FGQTVNPWKS SKSPGGSSGG EGALIGSGGS PLGLGTDIGG 
SIRFPSSFCG ICGLKPTGNR LSKSGLKGCV YGQEAVRLSV GPMARDVESL ALCLRALLCE 
DMFRLDPTVP PLPFREEVYT SSQPLRVGYY ETDNYTMPSP AMRRAVLETK QSLEAAGHTL 
VPFLPSNIPH ALETLSTGGL FSDGGHTFLQ NFKGDFVDPC LGDLVSILKL PQWLKGLLAF 
LVKPLLPRLS AFLSNMKSRS AGKLWELQHE IEVYRKTVIA QWRALDLDVV LTPMLAPALD 
LNAPGRATGA VSYTMLYNCL DFPAGVVPVT TVTAEDEAQM EHYRGYFGDI WDKMLQKGMK 
KSVGLPVAVQ CVALPWQEEL CLRFMREVER LMTPEKQSS

Genular Protein ID: 3791554701

Symbol: Q9UG55_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UG55

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 151
  • Mass: 16894
  • Checksum: D16F7383BADA4B4D
  • Sequence:
    • RRQHPLPLLL LRHLRPQAHR EPPQVYTSSQ PLRVGYYETD NYTMPSPAMR RAVLETKQSL 
EAAGHTLVPF LPSNIPHALE TLSTGGLFSD GGHTFLQNFK GDFVDPCLGD LVSILKLPQW 
LKGLLAFLVK PLLPRLSAFL SNMKSRCTAK P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.