Details for: FCGR1A

Gene ID: 2209

Symbol: FCGR1A

Ensembl ID: ENSG00000150337

Description: Fc gamma receptor Ia

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 63.5506
    Cell Significance Index: -9.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.5975
    Cell Significance Index: -9.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 19.2852
    Cell Significance Index: -9.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.1997
    Cell Significance Index: -7.8000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 15.1340
    Cell Significance Index: 219.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.0011
    Cell Significance Index: -9.8700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.5982
    Cell Significance Index: 55.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5088
    Cell Significance Index: -9.9000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.8350
    Cell Significance Index: 33.9200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3292
    Cell Significance Index: 1.3700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2568
    Cell Significance Index: 2.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1815
    Cell Significance Index: 4.8600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0116
    Cell Significance Index: 0.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0064
    Cell Significance Index: 0.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0050
    Cell Significance Index: -9.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0118
    Cell Significance Index: -8.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0123
    Cell Significance Index: -9.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0127
    Cell Significance Index: -19.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0140
    Cell Significance Index: -8.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0141
    Cell Significance Index: -19.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0155
    Cell Significance Index: -8.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0159
    Cell Significance Index: -9.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0175
    Cell Significance Index: -9.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0235
    Cell Significance Index: -8.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0246
    Cell Significance Index: -11.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0298
    Cell Significance Index: -1.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0312
    Cell Significance Index: -1.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0362
    Cell Significance Index: -7.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0412
    Cell Significance Index: -7.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0443
    Cell Significance Index: -0.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0467
    Cell Significance Index: -9.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0470
    Cell Significance Index: -9.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0547
    Cell Significance Index: -1.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0587
    Cell Significance Index: -1.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0599
    Cell Significance Index: -8.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0634
    Cell Significance Index: -8.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0637
    Cell Significance Index: -10.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0650
    Cell Significance Index: -7.9900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0662
    Cell Significance Index: -0.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0817
    Cell Significance Index: -10.4700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0901
    Cell Significance Index: -1.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0964
    Cell Significance Index: -5.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0976
    Cell Significance Index: -11.1800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1127
    Cell Significance Index: -4.9000
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.1154
    Cell Significance Index: -1.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1157
    Cell Significance Index: -9.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1159
    Cell Significance Index: -5.4500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1161
    Cell Significance Index: -1.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1295
    Cell Significance Index: -16.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1298
    Cell Significance Index: -7.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1338
    Cell Significance Index: -1.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1339
    Cell Significance Index: -8.6400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1350
    Cell Significance Index: -1.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1395
    Cell Significance Index: -10.7000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1420
    Cell Significance Index: -1.2000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1510
    Cell Significance Index: -1.3300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1560
    Cell Significance Index: -3.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1618
    Cell Significance Index: -10.8800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1685
    Cell Significance Index: -2.3700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1704
    Cell Significance Index: -1.4900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1900
    Cell Significance Index: -1.9400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1986
    Cell Significance Index: -1.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2041
    Cell Significance Index: -10.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2085
    Cell Significance Index: -11.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2160
    Cell Significance Index: -9.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2247
    Cell Significance Index: -16.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2299
    Cell Significance Index: -12.0700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2367
    Cell Significance Index: -3.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2446
    Cell Significance Index: -8.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2465
    Cell Significance Index: -2.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2492
    Cell Significance Index: -6.6600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2717
    Cell Significance Index: -2.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2781
    Cell Significance Index: -12.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2828
    Cell Significance Index: -6.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2938
    Cell Significance Index: -9.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3033
    Cell Significance Index: -9.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3040
    Cell Significance Index: -19.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3046
    Cell Significance Index: -11.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3114
    Cell Significance Index: -14.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3178
    Cell Significance Index: -9.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3248
    Cell Significance Index: -12.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3287
    Cell Significance Index: -11.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3445
    Cell Significance Index: -8.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3507
    Cell Significance Index: -8.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3617
    Cell Significance Index: -9.5100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.3794
    Cell Significance Index: -3.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3795
    Cell Significance Index: -10.8300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3943
    Cell Significance Index: -10.0500
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3956
    Cell Significance Index: -3.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4016
    Cell Significance Index: -11.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4050
    Cell Significance Index: -10.1000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4108
    Cell Significance Index: -4.8300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4176
    Cell Significance Index: -10.4300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4438
    Cell Significance Index: -9.0300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4466
    Cell Significance Index: -9.6500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4537
    Cell Significance Index: -9.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4572
    Cell Significance Index: -9.5700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.4628
    Cell Significance Index: -5.4700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4629
    Cell Significance Index: -9.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The FCGR1A is a type I transmembrane receptor that belongs to the Fc gamma receptor (FcγR) family. It is characterized by its high affinity for IgG antibodies, particularly IgG1 and IgG3 subclasses, and its ability to undergo rapid internalization and recycling upon binding. The FCGR1A is also known for its ability to modulate immune responses through the production of cytokines, such as IL-10, and its involvement in various signaling pathways, including the JAK/STAT and PI3K/AKT pathways. **Pathways and Functions:** The FCGR1A is involved in several key immune pathways, including: 1. **Phagocytosis:** The FCGR1A plays a crucial role in the phagocytosis of pathogens, including bacteria and parasites, by binding to IgG antibodies that are deposited on the surface of these microorganisms. 2. **Antigen Presentation:** The FCGR1A is involved in the presentation of antigens to T-cells, which is mediated by the processing and loading of antigens onto major histocompatibility complex (MHC) class II molecules. 3. **Cytokine Production:** The FCGR1A is capable of producing cytokines, such as IL-10, which modulate immune responses and promote tolerance. 4. **Antibody-Dependent Cellular Cytotoxicity (ADCC):** The FCGR1A is involved in ADCC, a process in which immune cells, such as natural killer (NK) cells and macrophages, release cytotoxic granules that kill target cells that have been opsonized by IgG antibodies. **Clinical Significance:** Dysregulation of the FCGR1A has been implicated in various disease states, including: 1. **Leishmaniasis:** The FCGR1A plays a critical role in the immune response to Leishmania parasites, and its dysregulation has been linked to the development of cutaneous leishmaniasis. 2. **Autoimmune Diseases:** The FCGR1A has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where it is thought to contribute to the production of autoantibodies. 3. **Cancer:** The FCGR1A has been studied as a potential target for cancer immunotherapy, where its ability to recognize and bind to IgG antibodies can be exploited to enhance anti-tumor immune responses. In conclusion, the FCGR1A is a critical component of the immune system's effector arm, and its dysregulation has been implicated in various disease states. Further research is needed to fully understand the mechanisms by which the FCGR1A regulates immune responses and to explore its potential as a therapeutic target.

Genular Protein ID: 536282682

Symbol: FCGR1_HUMAN

Name: High affinity immunoglobulin gamma Fc receptor I

UniProtKB Accession Codes:

P12314 P12315 Q5QNW7 Q92495 Q92663

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 14 DrugCentral 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2974947

Title: Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI).

PubMed ID: 2974947

DOI: 10.1093/nar/16.24.11824

PubMed ID: 2911749

Title: Isolation and expression of functional high-affinity Fc receptor complementary DNAs.

PubMed ID: 2911749

DOI: 10.1126/science.2911749

PubMed ID: 1430234

Title: Novel Fc gamma receptor I family gene products in human mononuclear cells.

PubMed ID: 1430234

DOI: 10.1172/jci116094

PubMed ID: 1402657

Title: Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure.

PubMed ID: 1402657

DOI: 10.1084/jem.176.4.1115

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 1379234

Title: Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products.

PubMed ID: 1379234

DOI: 10.1016/s0021-9258(19)49591-4

PubMed ID: 8064233

Title: Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.

PubMed ID: 8064233

DOI: 10.1084/jem.180.3.1165

PubMed ID: 8611682

Title: FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.

PubMed ID: 8611682

PubMed ID: 9881690

Title: Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts.

PubMed ID: 9881690

DOI: 10.1016/s0161-5890(98)00079-0

PubMed ID: 10397749

Title: The FcgammaRIa (CD64) ligand binding chain triggers major histocompatibility complex class II antigen presentation independently of its associated FcR gamma-chain.

PubMed ID: 10397749

PubMed ID: 10514529

Title: The cytoplasmic domain of human FcgammaRIa alters the functional properties of the FcgammaRI.gamma-chain receptor complex.

PubMed ID: 10514529

DOI: 10.1074/jbc.274.42.30328

PubMed ID: 10781611

Title: The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells.

PubMed ID: 10781611

DOI: 10.1074/jbc.m909462199

PubMed ID: 11711607

Title: Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1.

PubMed ID: 11711607

DOI: 10.1128/jvi.75.24.12161-12168.2001

PubMed ID: 12756162

Title: Fcgamma receptor transmembrane domains: role in cell surface expression, gamma chain interaction, and phagocytosis.

PubMed ID: 12756162

DOI: 10.1182/blood.v101.11.4479

PubMed ID: 15229321

Title: Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity.

PubMed ID: 15229321

DOI: 10.1073/pnas.0401217101

PubMed ID: 18322202

Title: Filamin A stabilizes FcgammaRI surface expression and prevents its lysosomal routing.

PubMed ID: 18322202

DOI: 10.4049/jimmunol.180.6.3938

PubMed ID: 18023480

Title: Protein 4.1G binds to a unique motif within the FcgammaRI cytoplasmic tail.

PubMed ID: 18023480

DOI: 10.1016/j.molimm.2007.10.024

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21965667

Title: Crystal structure of Fcgamma receptor I and its implication in high affinity gamma-immunoglobulin binding.

PubMed ID: 21965667

DOI: 10.1074/jbc.m111.257550

Sequence Information:

  • Length: 374
  • Mass: 42632
  • Checksum: D33D59398CEEA699
  • Sequence:
    • MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG SSSTQWFLNG 
TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI HRGWLLLQVS SRVFTEGEPL 
ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN SNLTILKTNI SHNGTYHCSG MGKHRYTSAG 
ISVTVKELFP APVLNASVTS PLLEGNLVTL SCETKLLLQR PGLQLYFSFY MGSKTLRGRN 
TSSEYQILTA RREDSGLYWC EAATEDGNVL KRSPELELQV LGLQLPTPVW FHVLFYLAVG 
IMFLVNTVLW VTIRKELKRK KKWDLEISLD SGHEKKVISS LQEDRHLEEE LKCQEQKEEQ 
LQEGVHRKEP QGAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.