Gene FCGR1A - ENSG00000150337 | NCBI Gene ID: 2209

Details for: FCGR1A

Gene ID: 2209

Symbol: FCGR1A

Ensembl ID: ENSG00000150337

Description: Fc gamma receptor Ia

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen processing-cross presentation
(R-HSA-1236975)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cross-presentation of soluble exogenous antigens (endosomes)
(R-HSA-1236978)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr activation
(R-HSA-2029481)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Parasitic infection pathways
(R-HSA-9824443)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Antibody-dependent cellular cytotoxicity
(GO:0001788)
Antigen processing and presentation of exogenous peptide antigen via mhc class i
(GO:0042590)
Cell surface receptor signaling pathway
(GO:0007166)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Defense response to bacterium
(GO:0042742)
Early endosome membrane
(GO:0031901)
External side of plasma membrane
(GO:0009897)
Fc-gamma receptor signaling pathway
(GO:0038094)
High-affinity igg receptor activity
(GO:0019771)
Igg binding
(GO:0019864)
Igg receptor activity
(GO:0019770)
Immune response
(GO:0006955)
Innate immune response
(GO:0045087)
Phagocytosis, engulfment
(GO:0006911)
Phagocytosis, recognition
(GO:0006910)
Plasma membrane
(GO:0005886)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of protein tyrosine kinase activity
(GO:0061098)
Positive regulation of type iia hypersensitivity
(GO:0001798)
Positive regulation of type iii hypersensitivity
(GO:0001805)
Protein binding
(GO:0005515)
Receptor-mediated endocytosis
(GO:0006898)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 3.34
Marker Score: 2357
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.13
Marker Score: 1173
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.98
Marker Score: 807
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.7
Marker Score: 43437
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.66
Marker Score: 92614
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.61
Marker Score: 582
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.22
Marker Score: 5048
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7685
Cell Name: blood cell (CL0000081)
Fold Change: 1.15
Marker Score: 13356
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.1
Marker Score: 1118
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.09
Marker Score: 456
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 796
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.01
Marker Score: 1013
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.01
Marker Score: 1219
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71822
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48046
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.98
Marker Score: 1906
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2426
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5352
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2739
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5288
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.87
Marker Score: 5296
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.84
Marker Score: 559.5
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.82
Marker Score: 283
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.81
Marker Score: 2020
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.8
Marker Score: 484
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 709
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.74
Marker Score: 1179
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.72
Marker Score: 827
Cell Name: promonocyte (CL0000559)
Fold Change: 0.72
Marker Score: 464
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179.5
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.63
Marker Score: 1645
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 467
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.57
Marker Score: 359
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.54
Marker Score: 1108
Cell Name: neutrophil (CL0000775)
Fold Change: 0.52
Marker Score: 315
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.51
Marker Score: 265
Cell Name: macrophage (CL0000235)
Fold Change: 0.44
Marker Score: 486
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.42
Marker Score: 112
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.38
Marker Score: 375
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.33
Marker Score: 320.5
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.33
Marker Score: 332
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.32
Marker Score: 112
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.32
Marker Score: 159
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.32
Marker Score: 763
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.31
Marker Score: 498
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.3
Marker Score: 231
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.29
Marker Score: 81
Cell Name: monocyte (CL0000576)
Fold Change: 0.29
Marker Score: 371
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.28
Marker Score: 526
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.26
Marker Score: 592
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.25
Marker Score: 737
Cell Name: leukocyte (CL0000738)
Fold Change: 0.25
Marker Score: 142
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.24
Marker Score: 143
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.24
Marker Score: 118
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.23
Marker Score: 58
Cell Name: microglial cell (CL0000129)
Fold Change: 0.23
Marker Score: 421
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.23
Marker Score: 128
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.22
Marker Score: 151
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.22
Marker Score: 3435
Cell Name: myelocyte (CL0002193)
Fold Change: 0.22
Marker Score: 93
Cell Name: B cell (CL0000236)
Fold Change: 0.21
Marker Score: 201
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.21
Marker Score: 427
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.2
Marker Score: 138
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.19
Marker Score: 154
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.18
Marker Score: 195
Cell Name: phagocyte (CL0000234)
Fold Change: 0.18
Marker Score: 60
Cell Name: Unknown (CL0000003)
Fold Change: 0.18
Marker Score: 555.5
Cell Name: mature T cell (CL0002419)
Fold Change: 0.18
Marker Score: 1777
Cell Name: mast cell (CL0000097)
Fold Change: 0.18
Marker Score: 103
Cell Name: plasma cell (CL0000786)
Fold Change: 0.17
Marker Score: 191
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.17
Marker Score: 55
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.16
Marker Score: 88
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.16
Marker Score: 97
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.16
Marker Score: 110
Cell Name: Langerhans cell (CL0000453)
Fold Change: 0.16
Marker Score: 48
Cell Name: granulocyte (CL0000094)
Fold Change: 0.16
Marker Score: 71
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.16
Marker Score: 157.5
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.16
Marker Score: 296
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.15
Marker Score: 73
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.15
Marker Score: 194
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.15
Marker Score: 46
Cell Name: basophil (CL0000767)
Fold Change: 0.15
Marker Score: 69
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.14
Marker Score: 68
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.14
Marker Score: 50
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.13
Marker Score: 29
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.13
Marker Score: 87
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.13
Marker Score: 54
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.13
Marker Score: 45
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.13
Marker Score: 138
Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.12
Marker Score: 36
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.12
Marker Score: 82
Cell Name: glial cell (CL0000125)
Fold Change: 0.12
Marker Score: 132
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.12
Marker Score: 108
Cell Name: oocyte (CL0000023)
Fold Change: 0.12
Marker Score: 29
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.11
Marker Score: 29
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.11
Marker Score: 81

Hover over a box to see details here...

**Key characteristics:** * The FCGR1A gene is located on chromosome 17q21. * It is a member of the immunoglobulin superfamily. * The protein is a type I receptor, meaning it is a transmembrane protein that binds to carbohydrates on the surface of immune cells. * FCGR1A is expressed on the surface of macrophages, dendritic cells, and lymphocytes. * It is a key regulator of the adaptive immune response to infection. **Pathways and functions:** * FCGR1A is involved in the activation of macrophages and dendritic cells. * It is a key regulator of the inflammatory response to infection. * It is involved in the cross-presentation of antigens to cytotoxic T cells. * It is also involved in the regulation of the innate immune response to infection. **Clinical significance:** * Mutations in the FCGR1A gene have been linked to a variety of diseases, including leishmaniasis. * FCGR1A is a target for immunotherapy in leishmaniasis. * Targeting FCGR1A can inhibit the inflammatory response and prevent leishmaniasis. **Additional information:** * The FCGR1A gene is also known as CD112. * It is a highly conserved protein, with similar sequences found in mammals, birds, and reptiles. * FCGR1A is a key molecule in the regulation of the adaptive immune response to infection.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

High affinity immunoglobulin gamma Fc receptor I

Genular Protein ID: 536282682

Symbol: FCGR1_HUMAN

Name: High affinity immunoglobulin gamma Fc receptor I

UniProtKB Accession Codes:

P12314 P12315 Q5QNW7 Q92495 Q92663

Database IDs:

Citations:

PubMed ID: 2974947

Title: Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI).

PubMed ID: 2974947

DOI: 10.1093/nar/16.24.11824

PubMed ID: 2911749

Title: Isolation and expression of functional high-affinity Fc receptor complementary DNAs.

PubMed ID: 2911749

DOI: 10.1126/science.2911749

PubMed ID: 1430234

Title: Novel Fc gamma receptor I family gene products in human mononuclear cells.

PubMed ID: 1430234

DOI: 10.1172/jci116094

PubMed ID: 1402657

Title: Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure.

PubMed ID: 1402657

DOI: 10.1084/jem.176.4.1115

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 1379234

Title: Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products.

PubMed ID: 1379234

DOI: 10.1016/s0021-9258(19)49591-4

PubMed ID: 8064233

Title: Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.

PubMed ID: 8064233

DOI: 10.1084/jem.180.3.1165

PubMed ID: 8611682

Title: FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.

PubMed ID: 8611682

PubMed ID: 9881690

Title: Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts.

PubMed ID: 9881690

DOI: 10.1016/s0161-5890(98)00079-0

PubMed ID: 10397749

Title: The FcgammaRIa (CD64) ligand binding chain triggers major histocompatibility complex class II antigen presentation independently of its associated FcR gamma-chain.

PubMed ID: 10397749

PubMed ID: 10514529

Title: The cytoplasmic domain of human FcgammaRIa alters the functional properties of the FcgammaRI.gamma-chain receptor complex.

PubMed ID: 10514529

DOI: 10.1074/jbc.274.42.30328

PubMed ID: 10781611

Title: The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells.

PubMed ID: 10781611

DOI: 10.1074/jbc.m909462199

PubMed ID: 11711607

Title: Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1.

PubMed ID: 11711607

DOI: 10.1128/jvi.75.24.12161-12168.2001

PubMed ID: 12756162

Title: Fcgamma receptor transmembrane domains: role in cell surface expression, gamma chain interaction, and phagocytosis.

PubMed ID: 12756162

DOI: 10.1182/blood.v101.11.4479

PubMed ID: 15229321

Title: Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity.

PubMed ID: 15229321

DOI: 10.1073/pnas.0401217101

PubMed ID: 18322202

Title: Filamin A stabilizes FcgammaRI surface expression and prevents its lysosomal routing.

PubMed ID: 18322202

DOI: 10.4049/jimmunol.180.6.3938

PubMed ID: 18023480

Title: Protein 4.1G binds to a unique motif within the FcgammaRI cytoplasmic tail.

PubMed ID: 18023480

DOI: 10.1016/j.molimm.2007.10.024

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21965667

Title: Crystal structure of Fcgamma receptor I and its implication in high affinity gamma-immunoglobulin binding.

PubMed ID: 21965667

DOI: 10.1074/jbc.m111.257550

Sequence Information:

Length: 374
Mass: 42632
Checksum: D33D59398CEEA699
Sequence:

MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG SSSTQWFLNG 
TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI HRGWLLLQVS SRVFTEGEPL 
ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN SNLTILKTNI SHNGTYHCSG MGKHRYTSAG 
ISVTVKELFP APVLNASVTS PLLEGNLVTL SCETKLLLQR PGLQLYFSFY MGSKTLRGRN 
TSSEYQILTA RREDSGLYWC EAATEDGNVL KRSPELELQV LGLQLPTPVW FHVLFYLAVG 
IMFLVNTVLW VTIRKELKRK KKWDLEISLD SGHEKKVISS LQEDRHLEEE LKCQEQKEEQ 
LQEGVHRKEP QGAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FCGR1A

Associated with

Cells (max top 100)

Other Information

Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI). PubMed ID: 2974947

Isolation and expression of functional high-affinity Fc receptor complementary DNAs. PubMed ID: 2911749

Novel Fc gamma receptor I family gene products in human mononuclear cells. PubMed ID: 1430234

Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure. PubMed ID: 1402657

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. PubMed ID: 1379234

Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. PubMed ID: 8064233

FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo. PubMed ID: 8611682

Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts. PubMed ID: 9881690

The FcgammaRIa (CD64) ligand binding chain triggers major histocompatibility complex class II antigen presentation independently of its associated FcR gamma-chain. PubMed ID: 10397749

The cytoplasmic domain of human FcgammaRIa alters the functional properties of the FcgammaRI.gamma-chain receptor complex. PubMed ID: 10514529

The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells. PubMed ID: 10781611

Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1. PubMed ID: 11711607

Fcgamma receptor transmembrane domains: role in cell surface expression, gamma chain interaction, and phagocytosis. PubMed ID: 12756162

Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity. PubMed ID: 15229321

Filamin A stabilizes FcgammaRI surface expression and prevents its lysosomal routing. PubMed ID: 18322202

Protein 4.1G binds to a unique motif within the FcgammaRI cytoplasmic tail. PubMed ID: 18023480

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Crystal structure of Fcgamma receptor I and its implication in high affinity gamma-immunoglobulin binding. PubMed ID: 21965667