Details for: FDX1

Gene ID: 2230

Symbol: FDX1

Ensembl ID: ENSG00000137714

Description: ferredoxin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 242.5983
    Cell Significance Index: -37.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 134.0070
    Cell Significance Index: -33.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.9824
    Cell Significance Index: -39.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.7238
    Cell Significance Index: -39.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 59.2082
    Cell Significance Index: -39.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.2744
    Cell Significance Index: -38.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 18.5796
    Cell Significance Index: 497.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9365
    Cell Significance Index: -39.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6478
    Cell Significance Index: -25.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1048
    Cell Significance Index: -27.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.1090
    Cell Significance Index: -13.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 5.6997
    Cell Significance Index: 152.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.9310
    Cell Significance Index: 107.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.8730
    Cell Significance Index: 172.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2699
    Cell Significance Index: 30.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8118
    Cell Significance Index: 294.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0451
    Cell Significance Index: 128.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0273
    Cell Significance Index: 66.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9079
    Cell Significance Index: 42.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8798
    Cell Significance Index: 176.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8686
    Cell Significance Index: 156.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8495
    Cell Significance Index: 24.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7695
    Cell Significance Index: 35.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7560
    Cell Significance Index: 39.2700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7493
    Cell Significance Index: 12.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7348
    Cell Significance Index: 51.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6883
    Cell Significance Index: 19.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6821
    Cell Significance Index: 372.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6004
    Cell Significance Index: 265.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5945
    Cell Significance Index: 5.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5460
    Cell Significance Index: 40.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5286
    Cell Significance Index: 72.5900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5263
    Cell Significance Index: 3.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5030
    Cell Significance Index: 59.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4984
    Cell Significance Index: 94.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4457
    Cell Significance Index: 88.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4158
    Cell Significance Index: 21.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4128
    Cell Significance Index: 53.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4016
    Cell Significance Index: 68.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3230
    Cell Significance Index: 115.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2715
    Cell Significance Index: 7.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2236
    Cell Significance Index: 28.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1948
    Cell Significance Index: 6.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1905
    Cell Significance Index: 8.6300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.1675
    Cell Significance Index: 1.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1528
    Cell Significance Index: 15.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1479
    Cell Significance Index: 11.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0565
    Cell Significance Index: 106.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0560
    Cell Significance Index: 42.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0299
    Cell Significance Index: 21.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0279
    Cell Significance Index: 0.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0065
    Cell Significance Index: 2.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0055
    Cell Significance Index: 10.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0030
    Cell Significance Index: 4.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0089
    Cell Significance Index: -5.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0117
    Cell Significance Index: -15.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0292
    Cell Significance Index: -18.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0323
    Cell Significance Index: -0.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0339
    Cell Significance Index: -3.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0422
    Cell Significance Index: -2.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0433
    Cell Significance Index: -1.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0487
    Cell Significance Index: -27.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0515
    Cell Significance Index: -7.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0821
    Cell Significance Index: -9.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0963
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0980
    Cell Significance Index: -20.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1009
    Cell Significance Index: -29.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1089
    Cell Significance Index: -2.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1188
    Cell Significance Index: -3.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1261
    Cell Significance Index: -4.0400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1449
    Cell Significance Index: -2.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1879
    Cell Significance Index: -11.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1885
    Cell Significance Index: -12.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1897
    Cell Significance Index: -22.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1915
    Cell Significance Index: -12.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1933
    Cell Significance Index: -13.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2018
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2053
    Cell Significance Index: -23.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2081
    Cell Significance Index: -16.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2088
    Cell Significance Index: -9.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2704
    Cell Significance Index: -10.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2737
    Cell Significance Index: -5.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2936
    Cell Significance Index: -4.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3376
    Cell Significance Index: -8.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3407
    Cell Significance Index: -35.4800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3706
    Cell Significance Index: -3.5200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4512
    Cell Significance Index: -6.6600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4850
    Cell Significance Index: -2.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5072
    Cell Significance Index: -31.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5734
    Cell Significance Index: -16.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5806
    Cell Significance Index: -14.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6861
    Cell Significance Index: -34.6800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6984
    Cell Significance Index: -7.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7230
    Cell Significance Index: -14.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7292
    Cell Significance Index: -10.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8104
    Cell Significance Index: -17.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8498
    Cell Significance Index: -29.7700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8517
    Cell Significance Index: -10.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization:** FDX1 is predominantly found in the mitochondrial matrix, where it participates in the electron transport chain and iron-sulfur cluster biogenesis. 2. **Iron-sulfur cluster binding:** FDX1 binds to iron-sulfur clusters, which are essential for electron transfer reactions in the mitochondrial electron transport chain. 3. **Electron transfer activity:** FDX1 facilitates the transfer of electrons from NADPH to ferredoxin, generating ATP and reducing hydrogen peroxide. 4. **Expression in various tissues:** FDX1 is expressed in cortical cells of the adrenal gland, chromaffin cells, kidney collecting duct principal cells, and other cell types, highlighting its importance in different tissues. **Pathways and Functions:** FDX1 is involved in the following pathways: 1. **Electron transport chain:** FDX1 participates in the electron transport chain, facilitating the transfer of electrons from NADPH to ferredoxin. 2. **Iron-sulfur cluster biogenesis:** FDX1 is involved in the assembly of iron-sulfur clusters, which are essential for various cellular functions. 3. **Hormone biosynthesis:** FDX1 is required for the biosynthesis of steroid hormones, such as cortisol and aldosterone. 4. **Metabolic disorders:** Defects in FDX1 have been implicated in metabolic disorders, including defects in the electron transport chain and iron-sulfur cluster biogenesis. **Clinical Significance:** Defects in FDX1 have been associated with various metabolic disorders, including: 1. **Adrenal insufficiency:** Defects in FDX1 have been implicated in adrenal insufficiency, which is characterized by impaired production of steroid hormones. 2. **Mitochondrial disorders:** FDX1 is involved in the electron transport chain and iron-sulfur cluster biogenesis, making it a crucial component of mitochondrial function. Defects in FDX1 can lead to mitochondrial disorders, including Kearns-Sayre syndrome and MERRF syndrome. 3. **Metabolic disorders:** FDX1 is involved in the metabolism of steroids and lipids, making it a potential target for the treatment of metabolic disorders. In conclusion, FDX1 is a crucial component of the mitochondrial electron transport chain and iron-sulfur cluster biogenesis pathway. Defects in FDX1 have been implicated in various metabolic disorders, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is needed to fully understand the role of FDX1 in human disease and to develop effective therapeutic strategies for the treatment of metabolic disorders.

Genular Protein ID: 2479906196

Symbol: ADX_HUMAN

Name: Adrenodoxin, mitochondrial

UniProtKB Accession Codes:

P10109 B0YJ14 Q53YD6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 12 Ensembl 1 EvolutionaryTrace 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3229285

Title: Cloning and structure of the human adrenodoxin gene.

PubMed ID: 3229285

DOI: 10.1089/dna.1988.7.609

PubMed ID: 3343244

Title: Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells.

PubMed ID: 3343244

DOI: 10.1016/s0021-9258(18)69061-1

PubMed ID: 2969697

Title: Molecular cloning and sequence analysis of human placental ferredoxin.

PubMed ID: 2969697

DOI: 10.1016/0003-9861(88)90303-7

PubMed ID: 2340092

Title: Structure, sequence, chromosomal location, and evolution of the human ferredoxin gene family.

PubMed ID: 2340092

DOI: 10.1089/dna.1990.9.205

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12699818

Title: Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode.

PubMed ID: 12699818

DOI: 10.1016/s1567-5394(02)00188-3

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20547883

Title: Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis.

PubMed ID: 20547883

DOI: 10.1073/pnas.1004250107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1909889

Title: 1H NMR spectra of vertebrate [2Fe-2S] ferredoxins. Hyperfine resonances suggest different electron delocalization patterns from plant ferredoxins.

PubMed ID: 1909889

DOI: 10.1021/bi00101a024

PubMed ID: 21636783

Title: Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.

PubMed ID: 21636783

DOI: 10.1073/pnas.1019441108

Sequence Information:

  • Length: 184
  • Mass: 19393
  • Checksum: A234EC601136C85F
  • Sequence:
    • MAAAGGARLL RAASAVLGGP AGRWLHHAGS RAGSSGLLRN RGPGGSAEAS RSLSVSARAR 
SSSEDKITVH FINRDGETLT TKGKVGDSLL DVVVENNLDI DGFGACEGTL ACSTCHLIFE 
DHIYEKLDAI TDEENDMLDL AYGLTDRSRL GCQICLTKSM DNMTVRVPET VADARQSIDV 
GKTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.