Gene FDX1 - ENSG00000137714 | NCBI Gene ID: 2230

Details for: FDX1

Gene ID: 2230

Symbol: FDX1

Ensembl ID: ENSG00000137714

Description: ferredoxin 1

Associated with

Biological oxidations
(R-HSA-211859)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Defective cyp11a1 causes aicsr
(R-HSA-5579026)
Disease
(R-HSA-1643685)
Diseases of metabolism
(R-HSA-5668914)
Electron transport from nadph to ferredoxin
(R-HSA-2395516)
Endogenous sterols
(R-HSA-211976)
Metabolic disorders of biological oxidation enzymes
(R-HSA-5579029)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroid hormones
(R-HSA-196071)
Metabolism of steroids
(R-HSA-8957322)
Mitochondrial iron-sulfur cluster biogenesis
(R-HSA-1362409)
Phase i - functionalization of compounds
(R-HSA-211945)
Pregnenolone biosynthesis
(R-HSA-196108)
2 iron, 2 sulfur cluster binding
(GO:0051537)
Cellular response to camp
(GO:0071320)
Cellular response to forskolin
(GO:1904322)
Cholesterol metabolic process
(GO:0008203)
Electron transfer activity
(GO:0009055)
Electron transport chain
(GO:0022900)
Hormone biosynthetic process
(GO:0042446)
Iron ion binding
(GO:0005506)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
P450-containing electron transport chain
(GO:0140647)
Steroid biosynthetic process
(GO:0006694)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 11.52
Marker Score: 204488.5
Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.6
Marker Score: 3654
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.13
Marker Score: 5376
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.1
Marker Score: 2972
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.02
Marker Score: 2147
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.95
Marker Score: 49846
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.83
Marker Score: 7172
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.71
Marker Score: 2835
Cell Name: enterocyte (CL0000584)
Fold Change: 1.69
Marker Score: 8103
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.65
Marker Score: 2337
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.63
Marker Score: 5797
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.63
Marker Score: 537
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.63
Marker Score: 2585
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.61
Marker Score: 7933
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.6
Marker Score: 1263
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.59
Marker Score: 2338
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.55
Marker Score: 4156
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.54
Marker Score: 4832
Cell Name: peptic cell (CL0000155)
Fold Change: 1.52
Marker Score: 638
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.52
Marker Score: 13089
Cell Name: basophil (CL0000767)
Fold Change: 1.52
Marker Score: 720
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.51
Marker Score: 1622
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.48
Marker Score: 50489
Cell Name: stem cell (CL0000034)
Fold Change: 1.46
Marker Score: 3467
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.41
Marker Score: 2274
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.41
Marker Score: 11027
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.4
Marker Score: 403
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.39
Marker Score: 5148.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.37
Marker Score: 3354
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.34
Marker Score: 8571
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.34
Marker Score: 843.5
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.33
Marker Score: 13518
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.31
Marker Score: 8555
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.29
Marker Score: 3510
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.29
Marker Score: 1339
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.28
Marker Score: 483
Cell Name: mature T cell (CL0002419)
Fold Change: 1.28
Marker Score: 12676
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.28
Marker Score: 1284
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.27
Marker Score: 5192
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.26
Marker Score: 9415.5
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.26
Marker Score: 862
Cell Name: Unknown (CL0000548)
Fold Change: 1.25
Marker Score: 909
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.25
Marker Score: 317
Cell Name: decidual cell (CL2000002)
Fold Change: 1.24
Marker Score: 5362
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.23
Marker Score: 1902
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.23
Marker Score: 294
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.23
Marker Score: 2790.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.22
Marker Score: 2123
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.21
Marker Score: 2747
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.2
Marker Score: 663
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.19
Marker Score: 414
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.18
Marker Score: 413.5
Cell Name: secretory cell (CL0000151)
Fold Change: 1.18
Marker Score: 2152
Cell Name: granulocyte (CL0000094)
Fold Change: 1.18
Marker Score: 527
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.18
Marker Score: 549
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.16
Marker Score: 289.5
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.16
Marker Score: 1239
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.16
Marker Score: 1235
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.15
Marker Score: 289.5
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.15
Marker Score: 7310
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.14
Marker Score: 1077
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.14
Marker Score: 1070
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.14
Marker Score: 1020
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.14
Marker Score: 2407
Cell Name: basal cell (CL0000646)
Fold Change: 1.13
Marker Score: 1465
Cell Name: precursor cell (CL0011115)
Fold Change: 1.13
Marker Score: 275
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.13
Marker Score: 3074.5
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.13
Marker Score: 460
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.13
Marker Score: 1186
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.13
Marker Score: 3109
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.12
Marker Score: 388
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.12
Marker Score: 1840
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.11
Marker Score: 9568.5
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.11
Marker Score: 38567
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.11
Marker Score: 1123
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.11
Marker Score: 462
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.1
Marker Score: 1697
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.09
Marker Score: 6612
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.09
Marker Score: 243
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.09
Marker Score: 953
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.08
Marker Score: 4157.5
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.08
Marker Score: 11123
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.07
Marker Score: 65882
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 1.07
Marker Score: 304
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.07
Marker Score: 39467
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.06
Marker Score: 1002.5
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 1.06
Marker Score: 281
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.06
Marker Score: 1172
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.06
Marker Score: 1153
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.06
Marker Score: 767.5
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.06
Marker Score: 232
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.06
Marker Score: 522
Cell Name: serous secreting cell (CL0000313)
Fold Change: 1.05
Marker Score: 419.5
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.05
Marker Score: 1049.5
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.05
Marker Score: 276
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 1.05
Marker Score: 295
Cell Name: epidermal cell (CL0000362)
Fold Change: 1.05
Marker Score: 294
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.05
Marker Score: 669.5
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.04
Marker Score: 5474.5
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.04
Marker Score: 221.5

Hover over a box to see details here...

**Key characteristics:** - Gene name: FDX1 - Ensembl ID: ENSG00000137714 - Pathway: 2 iron, 2 sulfur cluster binding, Biological oxidations, Cytochrome p450 - arranged by substrate type - Disease: Defective cyp11a1 causes aicsr (adrenoisomerase-induced cell death syndrome) **Pathways and functions:** - Electron transport chain reactions in the mitochondria - Generation of ATP through oxidative phosphorylation - Participation in the detoxification of reactive oxygen species - Maintenance of cellular redox balance - Regulation of cell growth and differentiation **Clinical significance:** - Mutations in the FDX1 gene have been linked to several human diseases, including aicsr and related disorders. - Mutations in FDX1 can cause a decrease in the activity of ferredoxin 1, leading to impaired electron transport chain reactions and increased susceptibility to oxidative stress. - Understanding the role of FDX1 in human health and disease is important for the development of novel therapeutic strategies for these disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Adrenodoxin, mitochondrial

Genular Protein ID: 2479906196

Symbol: ADX_HUMAN

Name: Adrenodoxin, mitochondrial

UniProtKB Accession Codes:

P10109 B0YJ14 Q53YD6

Database IDs:

Citations:

PubMed ID: 3229285

Title: Cloning and structure of the human adrenodoxin gene.

PubMed ID: 3229285

DOI: 10.1089/dna.1988.7.609

PubMed ID: 3343244

Title: Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells.

PubMed ID: 3343244

DOI: 10.1016/s0021-9258(18)69061-1

PubMed ID: 2969697

Title: Molecular cloning and sequence analysis of human placental ferredoxin.

PubMed ID: 2969697

DOI: 10.1016/0003-9861(88)90303-7

PubMed ID: 2340092

Title: Structure, sequence, chromosomal location, and evolution of the human ferredoxin gene family.

PubMed ID: 2340092

DOI: 10.1089/dna.1990.9.205

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12699818

Title: Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode.

PubMed ID: 12699818

DOI: 10.1016/s1567-5394(02)00188-3

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20547883

Title: Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis.

PubMed ID: 20547883

DOI: 10.1073/pnas.1004250107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1909889

Title: 1H NMR spectra of vertebrate [2Fe-2S] ferredoxins. Hyperfine resonances suggest different electron delocalization patterns from plant ferredoxins.

PubMed ID: 1909889

DOI: 10.1021/bi00101a024

PubMed ID: 21636783

Title: Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.

PubMed ID: 21636783

DOI: 10.1073/pnas.1019441108

Sequence Information:

Length: 184
Mass: 19393
Checksum: A234EC601136C85F
Sequence:

MAAAGGARLL RAASAVLGGP AGRWLHHAGS RAGSSGLLRN RGPGGSAEAS RSLSVSARAR 
SSSEDKITVH FINRDGETLT TKGKVGDSLL DVVVENNLDI DGFGACEGTL ACSTCHLIFE 
DHIYEKLDAI TDEENDMLDL AYGLTDRSRL GCQICLTKSM DNMTVRVPET VADARQSIDV 
GKTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FDX1

Associated with

Cells (max top 100)

Other Information

Cloning and structure of the human adrenodoxin gene. PubMed ID: 3229285

Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells. PubMed ID: 3343244

Molecular cloning and sequence analysis of human placental ferredoxin. PubMed ID: 2969697

Structure, sequence, chromosomal location, and evolution of the human ferredoxin gene family. PubMed ID: 2340092

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode. PubMed ID: 12699818

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis. PubMed ID: 20547883

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

1H NMR spectra of vertebrate [2Fe-2S] ferredoxins. Hyperfine resonances suggest different electron delocalization patterns from plant ferredoxins. PubMed ID: 1909889

Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. PubMed ID: 21636783