Details for: FECH

Gene ID: 2235

Symbol: FECH

Ensembl ID: ENSG00000066926

Description: ferrochelatase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.7369
    Cell Significance Index: -13.6300
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 34.4967
    Cell Significance Index: 15.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.8702
    Cell Significance Index: -13.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2560
    Cell Significance Index: -14.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9989
    Cell Significance Index: -15.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2435
    Cell Significance Index: -4.9100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.7932
    Cell Significance Index: 29.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1111
    Cell Significance Index: 76.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0755
    Cell Significance Index: 22.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0256
    Cell Significance Index: 205.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7337
    Cell Significance Index: 10.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6157
    Cell Significance Index: 555.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5650
    Cell Significance Index: 61.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4623
    Cell Significance Index: 75.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3673
    Cell Significance Index: 131.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3141
    Cell Significance Index: 11.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3075
    Cell Significance Index: 8.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3006
    Cell Significance Index: 13.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2637
    Cell Significance Index: 7.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2576
    Cell Significance Index: 51.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2575
    Cell Significance Index: 178.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2349
    Cell Significance Index: 27.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1580
    Cell Significance Index: 15.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1489
    Cell Significance Index: 10.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1329
    Cell Significance Index: 6.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1246
    Cell Significance Index: 22.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1174
    Cell Significance Index: 16.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1139
    Cell Significance Index: 21.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1116
    Cell Significance Index: 2.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0846
    Cell Significance Index: 37.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0823
    Cell Significance Index: 44.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0810
    Cell Significance Index: 1.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0757
    Cell Significance Index: 9.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0667
    Cell Significance Index: 48.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0611
    Cell Significance Index: 3.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0586
    Cell Significance Index: 2.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0505
    Cell Significance Index: 4.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0476
    Cell Significance Index: 3.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0312
    Cell Significance Index: 0.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0236
    Cell Significance Index: 1.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0140
    Cell Significance Index: 0.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0046
    Cell Significance Index: 8.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0042
    Cell Significance Index: 2.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -5.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0036
    Cell Significance Index: -0.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0051
    Cell Significance Index: -0.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0095
    Cell Significance Index: -1.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0111
    Cell Significance Index: -5.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0146
    Cell Significance Index: -11.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0154
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0167
    Cell Significance Index: -12.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0227
    Cell Significance Index: -0.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0243
    Cell Significance Index: -13.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0285
    Cell Significance Index: -17.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0288
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0293
    Cell Significance Index: -5.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0306
    Cell Significance Index: -4.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0329
    Cell Significance Index: -3.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0351
    Cell Significance Index: -1.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0442
    Cell Significance Index: -12.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0495
    Cell Significance Index: -5.6700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0557
    Cell Significance Index: -0.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0598
    Cell Significance Index: -4.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0642
    Cell Significance Index: -1.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0718
    Cell Significance Index: -1.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0759
    Cell Significance Index: -1.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0767
    Cell Significance Index: -9.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0818
    Cell Significance Index: -17.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0933
    Cell Significance Index: -3.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0979
    Cell Significance Index: -2.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1070
    Cell Significance Index: -2.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1111
    Cell Significance Index: -7.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1115
    Cell Significance Index: -6.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1132
    Cell Significance Index: -3.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1287
    Cell Significance Index: -6.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1298
    Cell Significance Index: -4.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1327
    Cell Significance Index: -4.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1416
    Cell Significance Index: -14.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1441
    Cell Significance Index: -7.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1605
    Cell Significance Index: -2.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1661
    Cell Significance Index: -8.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1716
    Cell Significance Index: -10.5200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1950
    Cell Significance Index: -1.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2264
    Cell Significance Index: -5.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2396
    Cell Significance Index: -12.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2397
    Cell Significance Index: -7.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2452
    Cell Significance Index: -7.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2485
    Cell Significance Index: -5.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2637
    Cell Significance Index: -5.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2695
    Cell Significance Index: -5.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2734
    Cell Significance Index: -8.9500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3013
    Cell Significance Index: -2.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3032
    Cell Significance Index: -6.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3187
    Cell Significance Index: -6.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3266
    Cell Significance Index: -11.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3399
    Cell Significance Index: -6.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3419
    Cell Significance Index: -12.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Ferrochelatase is a ferrous iron-dependent enzyme that exhibits high specificity for the iron ion. It is a mitochondrial protein, primarily localized to the inner membrane, where it plays a critical role in the regulation of iron homeostasis. The FECH gene is highly expressed in cells involved in heme biosynthesis, such as erythroid progenitor cells and proerythroblasts. Ferrochelatase also exhibits tissue-specific expression, with significant levels found in the kidney loop of Henle and choroid plexus epithelial cells. **Pathways and Functions** Ferrochelatase is integral to the heme biosynthetic pathway, which involves the sequential conversion of succinyl-CoA, glycine, and succinate into heme. This pathway is crucial for the production of hemoglobin, myoglobin, and other hemoproteins, which play vital roles in oxygen transport, energy storage, and cellular protection. Ferrochelatase's activity is also linked to various cellular processes, including: 1. Iron homeostasis: Ferrochelatase helps regulate the availability of iron ions within the cell, which is essential for various cellular functions. 2. Erythropoiesis: Ferrochelatase is critical for the production of hemoglobin, which is essential for erythropoiesis, the process of red blood cell formation. 3. Neuroprotection: Heme, a product of ferrochelatase activity, has been shown to have neuroprotective properties, making ferrochelatase a potential therapeutic target for neurodegenerative disorders. **Clinical Significance** Dysregulation of ferrochelatase has been implicated in various diseases, including: 1. Anemia: Mutations in the FECH gene have been associated with anemia, particularly beta-thalassemia major. 2. Cancer: Elevated ferrochelatase activity has been observed in some types of cancer, including leukemia and lymphoma. 3. Neurodegenerative disorders: Ferrochelatase has been implicated in the pathogenesis of neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease. 4. Iron overload: Ferrochelatase activity can be affected by iron overload, which can lead to oxidative stress and tissue damage. In conclusion, ferrochelatase is a critical enzyme involved in the biosynthesis of heme, and its dysregulation has significant implications for human health. Further research is needed to fully understand the role of ferrochelatase in various diseases and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 1997659158

Symbol: HEMH_HUMAN

Name: Ferrochelatase, mitochondrial

UniProtKB Accession Codes:

P22830 A8KA72 Q8IXN1 Q8NAN0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2260980

Title: Molecular cloning and sequence analysis of cDNA encoding human ferrochelatase.

PubMed ID: 2260980

DOI: 10.1016/s0006-291x(05)80099-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7983009

Title: A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene.

PubMed ID: 7983009

DOI: 10.1016/s0021-9258(18)47351-6

PubMed ID: 8276824

Title: Mammalian ferrochelatase. Expression and characterization of normal and two human protoporphyric ferrochelatases.

PubMed ID: 8276824

DOI: 10.1016/s0021-9258(17)42362-3

PubMed ID: 8973195

Title: Site-directed mutagenesis and spectroscopic characterization of human ferrochelatase: identification of residues coordinating the [2Fe-2S] cluster.

PubMed ID: 8973195

DOI: 10.1021/bi9620114

PubMed ID: 9712849

Title: Evidence that the fourth ligand to the 2Fe-2S cluster in animal ferrochelatase is a cysteine. Characterization of the enzyme from Drosophila melanogaster.

PubMed ID: 9712849

DOI: 10.1074/jbc.273.35.22311

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27599036

Title: A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase.

PubMed ID: 27599036

DOI: 10.1021/acs.biochem.6b00756

PubMed ID: 30765471

Title: Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.

PubMed ID: 30765471

DOI: 10.3324/haematol.2018.214320

PubMed ID: 11175906

Title: The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis.

PubMed ID: 11175906

DOI: 10.1038/84152

PubMed ID: 17261801

Title: Substrate interactions with human ferrochelatase.

PubMed ID: 17261801

DOI: 10.1073/pnas.0606144104

PubMed ID: 9211198

Title: Erythropoietic protoporphyria.

PubMed ID: 9211198

DOI: 10.1023/a:1005317124985

PubMed ID: 1755842

Title: Human erythropoietic protoporphyria: two point mutations in the ferrochelatase gene.

PubMed ID: 1755842

DOI: 10.1016/0006-291x(91)91231-z

PubMed ID: 1376018

Title: A molecular defect in human protoporphyria.

PubMed ID: 1376018

PubMed ID: 7910885

Title: Recessive inheritance of erythropoietic protoporphyria with liver failure.

PubMed ID: 7910885

DOI: 10.1016/s0140-6736(94)92525-9

PubMed ID: 8757534

Title: A novel mutation in the ferrochelatase gene associated with erythropoietic protoporphyria.

PubMed ID: 8757534

DOI: 10.1046/j.1365-2141.1996.d01-1771.x

PubMed ID: 9585598

Title: Systematic analysis of molecular defects in the ferrochelatase gene from patients with erythropoietic protoporphyria.

PubMed ID: 9585598

DOI: 10.1086/301870

PubMed ID: 9740232

Title: Mutations in the ferrochelatase gene of four Spanish patients with erythropoietic protoporphyria.

PubMed ID: 9740232

DOI: 10.1046/j.1523-1747.1998.00327.x

PubMed ID: 10942404

Title: Mutations in the iron-sulfur cluster ligands of the human ferrochelatase lead to erythropoietic protoporphyria.

PubMed ID: 10942404

PubMed ID: 11375302

Title: New missense mutation in the human ferrochelatase gene in a family with erythropoietic protoporphyria: functional studies and correlation of genotype and phenotype.

PubMed ID: 11375302

PubMed ID: 12063482

Title: Erythropoietic protoporphyria: altered phenotype after bone marrow transplantation for myelogenous leukemia in a patient heteroallelic for ferrochelatase gene mutations.

PubMed ID: 12063482

DOI: 10.1067/mjd.2002.120460

PubMed ID: 12601550

Title: Novel mutations and phenotypic effect of the splice site modulator IVS3-48C in nine Swedish families with erythropoietic protoporphyria.

PubMed ID: 12601550

DOI: 10.1007/s100380300009

PubMed ID: 15286165

Title: Autosomal recessive erythropoietic protoporphyria in the United Kingdom: prevalence and relationship to liver disease.

PubMed ID: 15286165

DOI: 10.1136/jmg.2003.016121

PubMed ID: 17196862

Title: Heterogeneity of mutations in the ferrochelatase gene in Italian patients with erythropoietic protoporphyria.

PubMed ID: 17196862

DOI: 10.1016/j.ymgme.2006.10.012

Sequence Information:

  • Length: 423
  • Mass: 47862
  • Checksum: 3FD50965E8DEABCE
  • Sequence:
    • MRSLGANMAA ALRAAGVLLR DPLASSSWRV CQPWRWKSGA AAAAVTTETA QHAQGAKPQV 
QPQKRKPKTG ILMLNMGGPE TLGDVHDFLL RLFLDRDLMT LPIQNKLAPF IAKRRTPKIQ 
EQYRRIGGGS PIKIWTSKQG EGMVKLLDEL SPNTAPHKYY IGFRYVHPLT EEAIEEMERD 
GLERAIAFTQ YPQYSCSTTG SSLNAIYRYY NQVGRKPTMK WSTIDRWPTH HLLIQCFADH 
ILKELDHFPL EKRSEVVILF SAHSLPMSVV NRGDPYPQEV SATVQKVMER LEYCNPYRLV 
WQSKVGPMPW LGPQTDESIK GLCERGRKNI LLVPIAFTSD HIETLYELDI EYSQVLAKEC 
GVENIRRAES LNGNPLFSKA LADLVHSHIQ SNELCSKQLT LSCPLCVNPV CRETKSFFTS 
QQL

Genular Protein ID: 1125924969

Symbol: Q7KZA3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7KZA3

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 3 Gene3D 1 HAMAP 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 Rhea 1 RuleBase 1 SMR 1 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 416
  • Mass: 47132
  • Checksum: 4CC6E64E061042D7
  • Sequence:
    • MAAALRAAGV LLRDPLASSS WRVCQPWRWK SGAAAAAVTT ETAQHAQGAK PQVQPQKRKP 
KTGILMLNMG GPETLGDVHD FLLRLFLDRD LMTLPIQNKL APFIAKRRTP KIQEQYRRIG 
GGSPIKIWTS KQGEGMVKLL DELSPNTAPH KYYIGFRYVH PLTEEAIEEM ERDGLERAIA 
FTQYPQYSCS TTGSSLNAIY RYYNQVGRKP TMKWSTIDRW PTHHLLIQCF ADHILKELDH 
FPLEKRSEVV ILFSAHSLPM SVVNRGDPYP QEVSATVQKV MERLEYCNPY RLVWQSKVGP 
MPWLGPQTDE SIKGLCERGR KNILLVPIAF TSDHIETLYE LDIEYSQVLA KECGVENIRR 
AESLNGNPLF SKALADLVHS HIQSNELCSK QLTLSCPLCV NPVCRETKSF FTSQQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.