Details for: FGF8

Gene ID: 2253

Symbol: FGF8

Ensembl ID: ENSG00000107831

Description: fibroblast growth factor 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.2
    Marker Score: 2212
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.55
    Marker Score: 3202
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.53
    Marker Score: 1978
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.37
    Marker Score: 799
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.28
    Marker Score: 1216
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7694
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.06
    Marker Score: 585.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.01
    Marker Score: 1910
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.92
    Marker Score: 1024
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.9
    Marker Score: 959
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12239
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.75
    Marker Score: 1521
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.64
    Marker Score: 1033
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 503
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 329
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.52
    Marker Score: 503
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.49
    Marker Score: 325
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.49
    Marker Score: 257
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.45
    Marker Score: 144
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 257
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.42
    Marker Score: 820
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.41
    Marker Score: 977
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.38
    Marker Score: 21161
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 163
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.32
    Marker Score: 555
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.32
    Marker Score: 168
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.29
    Marker Score: 227
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.23
    Marker Score: 12146
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.22
    Marker Score: 228
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.21
    Marker Score: 77
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.21
    Marker Score: 656
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.2
    Marker Score: 93
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 168
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 84
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.09
    Marker Score: 144
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.09
    Marker Score: 153
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.09
    Marker Score: 102
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.08
    Marker Score: 56
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.08
    Marker Score: 168
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.08
    Marker Score: 98.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.06
    Marker Score: 258
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.06
    Marker Score: 340
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 49
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.05
    Marker Score: 55
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.05
    Marker Score: 64
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.04
    Marker Score: 60
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.03
    Marker Score: 47
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.03
    Marker Score: 257
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 80
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.03
    Marker Score: 51
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.03
    Marker Score: 1062
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 42
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.03
    Marker Score: 17.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.03
    Marker Score: 393
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 15

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Other Information

**Key characteristics:** * FGF8 is a secreted protein that belongs to the Fibroblast Growth Factor 8 (FGF) family of growth factors. * It is a transmembrane protein with a molecular weight of approximately 170 kDa. * FGF8 is a potent mitogen that promotes cell proliferation and survival. * It is essential for the development of the cardiovascular system, as it is expressed in high levels in blood vessel endothelial cells. * It is also involved in kidney development and function. **Pathways and functions:** * FGF8 signaling is mediated through its interaction with its receptor, FGFR1. * Binding of FGF8 to FGFR1 triggers the activation of the PI3K/AKT pathway. * This pathway is involved in cell growth, proliferation, and survival. * FGF8 also promotes angiogenesis, cell migration, and tissue remodeling. * It is essential for the formation of blood vessels, the growth of the cardiovascular system, and the development of the gastrointestinal tract. **Clinical significance:** * Mutations in FGF8 have been linked to several human diseases, including cancer, cardiovascular diseases, and kidney disease. * Overexpression of FGF8 has been observed in many cancers, where it promotes tumor growth and metastasis. * Inhibition of FGF8 signaling has shown to suppress cancer growth and metastasis. **Conclusion:** FGF8 is a critical growth factor that plays a crucial role in various cellular processes. Its overexpression and dysregulation have significant implications for human health and disease. Further understanding of FGF8 signaling could lead to the development of novel therapeutic strategies for cancer and other diseases.

Genular Protein ID: 1187425905

Symbol: FGF8_HUMAN

Name: Fibroblast growth factor 8

UniProtKB Accession Codes:

P55075 A1A514 Q14915 Q15766

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 31 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 79 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 8 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 39 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7737407

Title: Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties.

PubMed ID: 7737407

DOI: 10.1016/0014-5793(95)00324-3

PubMed ID: 8891346

Title: Molecular cloning and characterization of human FGF8 alternative messenger RNA forms.

PubMed ID: 8891346

PubMed ID: 8661131

Title: Structure and sequence of human FGF8.

PubMed ID: 8661131

DOI: 10.1006/geno.1996.0349

PubMed ID: 8700553

Title: The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells.

PubMed ID: 8700553

PubMed ID: 11341643

Title: A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma.

PubMed ID: 11341643

DOI: 10.1023/a:1010753826788

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 21576111

Title: Senataxin modulates neurite growth through fibroblast growth factor 8 signalling.

PubMed ID: 21576111

DOI: 10.1093/brain/awr084

PubMed ID: 34433009

Title: Position effects at the FGF8 locus are associated with femoral hypoplasia.

PubMed ID: 34433009

DOI: 10.1016/j.ajhg.2021.08.001

PubMed ID: 16384934

Title: Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain.

PubMed ID: 16384934

DOI: 10.1101/gad.1365406

PubMed ID: 18596921

Title: Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice.

PubMed ID: 18596921

DOI: 10.1172/jci34538

PubMed ID: 23643382

Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

PubMed ID: 23643382

DOI: 10.1016/j.ajhg.2013.04.008

Sequence Information:

  • Length: 233
  • Mass: 26525
  • Checksum: 4C1EAF932A3A211D
  • Sequence:
    • MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQHVREQSLV 
TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP FAKLIVETDT FGSRVRVRGA 
ETGLYICMNK KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA FTRKGRPRKG 
SKTRQHQREV HFMKRLPRGH HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR

Genular Protein ID: 2430662174

Symbol: A1A515_HUMAN

Name: N/A

UniProtKB Accession Codes:

A1A515

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 4 RuleBase 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 204
  • Mass: 23494
  • Checksum: 9A4CAB6524288A90
  • Sequence:
    • MGSPRSALSC LLLHLLVLCL QAQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK 
RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE 
IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE AHFMKRLPRG HHTTEQSLRF 
EFLNYPPFTR SLRGSQRTWA PEPR

Genular Protein ID: 3120431376

Symbol: A0A087X1S5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X1S5

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 140
  • Mass: 16255
  • Checksum: 52FEA2004965E454
  • Sequence:
    • MAEDGDPFAK LIVETDTFGS RVRVRGAETG LYICMNKKGK LIAKSNGKGK DCVFTEIVLE 
NNYTALQNAK YEGWYMAFTR KGRPRKGSKT RQHQREVHFM KRLPRGHHTT EQSLRFEFLN 
YPPFTRSLRG SQRTWAPEPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.