FGF8 | ENSG00000107831 | NCBI 2253

Details for: FGF8

Gene ID: 2253

Symbol: FGF8

Ensembl ID: ENSG00000107831

Description: fibroblast growth factor 8

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Fgfr1c ligand binding and activation
(R-HSA-190373)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3b ligand binding and activation
(R-HSA-190371)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Fgfrl1 modulation of fgfr1 signaling
(R-HSA-5658623)
Formation of the posterior neural plate
(R-HSA-9832991)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
M-decay: degradation of maternal mrnas by maternally stored factors
(R-HSA-9820841)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr1
(R-HSA-1839122)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Blood vessel remodeling
(GO:0001974)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Chemoattractant activity
(GO:0042056)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Gastrulation
(GO:0007369)
Gonad development
(GO:0008406)
Growth factor activity
(GO:0008083)
Heart looping
(GO:0001947)
Mapk cascade
(GO:0000165)
Mesodermal cell migration
(GO:0008078)
Mesonephros development
(GO:0001823)
Metanephros development
(GO:0001656)
Motor neuron axon guidance
(GO:0008045)
Neural plate morphogenesis
(GO:0001839)
Organ induction
(GO:0001759)
Outflow tract septum morphogenesis
(GO:0003148)
Positive regulation of cell population proliferation
(GO:0008284)
Response to oxidative stress
(GO:0006979)
Signal transduction
(GO:0007165)
Type 1 fibroblast growth factor receptor binding
(GO:0005105)
Type 2 fibroblast growth factor receptor binding
(GO:0005111)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.5741
Cell Significance Index: 19.9500
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.5341
Cell Significance Index: 4.5400
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.4376
Cell Significance Index: 7.4800
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.3355
Cell Significance Index: 4.8100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1547
Cell Significance Index: 30.7000
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.1128
Cell Significance Index: 0.6200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.1046
Cell Significance Index: 3.0800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0873
Cell Significance Index: 4.9000
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.0500
Cell Significance Index: 1.2500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0108
Cell Significance Index: 2.1600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0064
Cell Significance Index: 2.3100
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0055
Cell Significance Index: 0.1400
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.0039
Cell Significance Index: 0.0300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0035
Cell Significance Index: 1.0000
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.0032
Cell Significance Index: 0.0400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0027
Cell Significance Index: 0.3200
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.0024
Cell Significance Index: 0.0400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0003
Cell Significance Index: 0.0200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0006
Cell Significance Index: -1.1500
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0008
Cell Significance Index: -0.0100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0008
Cell Significance Index: -1.5500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0010
Cell Significance Index: -0.5600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0012
Cell Significance Index: -1.6200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0014
Cell Significance Index: -1.0700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0016
Cell Significance Index: -1.1500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0020
Cell Significance Index: -1.2800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0021
Cell Significance Index: -1.1600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0028
Cell Significance Index: -1.2800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0042
Cell Significance Index: -0.7700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0050
Cell Significance Index: -0.8500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0057
Cell Significance Index: -0.6500
Cell Name: kidney cell (CL1000497)
Fold Change: -0.0063
Cell Significance Index: -0.0500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0086
Cell Significance Index: -1.2500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0090
Cell Significance Index: -1.1100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0090
Cell Significance Index: -0.4700
Cell Name: granulocyte (CL0000094)
Fold Change: -0.0091
Cell Significance Index: -0.1100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0095
Cell Significance Index: -1.3000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0119
Cell Significance Index: -0.2200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0122
Cell Significance Index: -1.4400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0128
Cell Significance Index: -0.8600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0128
Cell Significance Index: -0.9800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0151
Cell Significance Index: -0.6700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0161
Cell Significance Index: -0.4600
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.0176
Cell Significance Index: -0.1700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0185
Cell Significance Index: -0.5900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0185
Cell Significance Index: -0.7000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0191
Cell Significance Index: -0.9000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0198
Cell Significance Index: -0.7000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0202
Cell Significance Index: -1.3000
Cell Name: tendon cell (CL0000388)
Fold Change: -0.0206
Cell Significance Index: -0.2800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0212
Cell Significance Index: -1.3100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0223
Cell Significance Index: -0.7300
Cell Name: acinar cell (CL0000622)
Fold Change: -0.0231
Cell Significance Index: -0.2900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0234
Cell Significance Index: -0.4900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0251
Cell Significance Index: -1.3100
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0264
Cell Significance Index: -0.5700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0264
Cell Significance Index: -0.5600
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0269
Cell Significance Index: -0.5900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0270
Cell Significance Index: -1.4200
Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.0294
Cell Significance Index: -0.1800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0298
Cell Significance Index: -0.8100
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0301
Cell Significance Index: -0.7500
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0320
Cell Significance Index: -0.3100
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0327
Cell Significance Index: -0.4000
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0331
Cell Significance Index: -0.4700
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0344
Cell Significance Index: -0.6800
Cell Name: neuron (CL0000540)
Fold Change: -0.0348
Cell Significance Index: -0.3300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0366
Cell Significance Index: -0.9800
Cell Name: mesangial cell (CL0000650)
Fold Change: -0.0371
Cell Significance Index: -0.4700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0398
Cell Significance Index: -1.1400
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0408
Cell Significance Index: -0.8200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0415
Cell Significance Index: -1.4600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0422
Cell Significance Index: -1.5500
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0431
Cell Significance Index: -0.9000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0434
Cell Significance Index: -1.1600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0438
Cell Significance Index: -2.2100
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0455
Cell Significance Index: -0.6600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0464
Cell Significance Index: -1.1900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0471
Cell Significance Index: -1.1300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0472
Cell Significance Index: -1.3600
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0483
Cell Significance Index: -0.9500
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0487
Cell Significance Index: -1.2800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0490
Cell Significance Index: -0.8200
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0506
Cell Significance Index: -1.0100
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0515
Cell Significance Index: -1.3100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0520
Cell Significance Index: -1.2600
Cell Name: osteoblast (CL0000062)
Fold Change: -0.0526
Cell Significance Index: -0.5100
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0531
Cell Significance Index: -0.8600
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0553
Cell Significance Index: -0.8400
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0562
Cell Significance Index: -0.7800
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0584
Cell Significance Index: -1.0100
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0587
Cell Significance Index: -0.6400
Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.0588
Cell Significance Index: -0.7400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0593
Cell Significance Index: -1.2300
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0607
Cell Significance Index: -0.6600
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.0613
Cell Significance Index: -0.6400
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.0615
Cell Significance Index: -0.9200
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0615
Cell Significance Index: -1.2000
Cell Name: mast cell (CL0000097)
Fold Change: -0.0623
Cell Significance Index: -0.8200
Cell Name: peg cell (CL4033014)
Fold Change: -0.0623
Cell Significance Index: -1.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** FGF8 is a member of the fibroblast growth factor family, characterized by its ability to bind to specific receptors and initiate signaling cascades. It is primarily expressed in embryonic tissues, including the neural plate, heart, and blood vessels. FGF8 has been shown to be involved in various developmental processes, including gastrulation, organ induction, and cell migration. Its expression is also observed in adult tissues, such as the kidney and brain, where it plays a role in maintaining tissue homeostasis. **Pathways and Functions** FGF8 signaling is mediated through the binding of FGF8 to its specific receptors, FGFR1, FGFR2, and FGFR4. This interaction triggers a series of downstream signaling events, including the activation of the PI3K/AKT pathway, MAPK/ERK pathway, and the phospholipase C-mediated cascade. FGF8 has been shown to regulate various cellular processes, including cell proliferation, differentiation, and survival. It also plays a role in angiogenesis, the formation of new blood vessels, and in the development of the nervous system. FGF8 has been implicated in several diseases, including cancer, where it is often upregulated and contributes to tumor growth and metastasis. Additionally, FGF8 has been shown to play a role in cardiovascular diseases, such as atherosclerosis and heart failure. **Clinical Significance** FGF8 has been implicated in various diseases, including: 1. **Cancer**: FGF8 is often upregulated in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumor growth and metastasis. 2. **Cardiovascular diseases**: FGF8 has been shown to play a role in the development of atherosclerosis and heart failure. 3. **Neurological disorders**: FGF8 has been implicated in various neurological disorders, including autism, schizophrenia, and Alzheimer's disease. 4. **Kidney disease**: FGF8 has been shown to play a role in kidney development and disease, including polycystic kidney disease. In conclusion, FGF8 is a multifunctional protein involved in various biological processes, including embryonic development, cell proliferation, and angiogenesis. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular diseases, and neurological disorders. Further research is needed to fully understand the role of FGF8 in human disease and to explore its potential as a therapeutic target. **References** * [1] FGF8 (Fibroblast Growth Factor 8) - Human - RefSeq Gene * [2] FGF8 (Fibroblast Growth Factor 8) - Human - UniProt * [3] FGF8 (Fibroblast Growth Factor 8) - Human - GeneCards * [4] FGF8 (Fibroblast Growth Factor 8) - Human - PubMed Note: The references provided are for general information purposes only and are not intended to be a comprehensive list of all relevant literature on FGF8.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 1187425905

Symbol: FGF8_HUMAN

Name: Fibroblast growth factor 8

UniProtKB Accession Codes:

P55075 A1A514 Q14915 Q15766

Database IDs:

Citations:

PubMed ID: 7737407

Title: Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties.

PubMed ID: 7737407

DOI: 10.1016/0014-5793(95)00324-3

PubMed ID: 8891346

Title: Molecular cloning and characterization of human FGF8 alternative messenger RNA forms.

PubMed ID: 8891346

PubMed ID: 8661131

Title: Structure and sequence of human FGF8.

PubMed ID: 8661131

DOI: 10.1006/geno.1996.0349

PubMed ID: 8700553

Title: The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells.

PubMed ID: 8700553

PubMed ID: 11341643

Title: A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma.

PubMed ID: 11341643

DOI: 10.1023/a:1010753826788

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 21576111

Title: Senataxin modulates neurite growth through fibroblast growth factor 8 signalling.

PubMed ID: 21576111

DOI: 10.1093/brain/awr084

PubMed ID: 34433009

Title: Position effects at the FGF8 locus are associated with femoral hypoplasia.

PubMed ID: 34433009

DOI: 10.1016/j.ajhg.2021.08.001

PubMed ID: 16384934

Title: Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain.

PubMed ID: 16384934

DOI: 10.1101/gad.1365406

PubMed ID: 18596921

Title: Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice.

PubMed ID: 18596921

DOI: 10.1172/jci34538

PubMed ID: 23643382

Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

PubMed ID: 23643382

DOI: 10.1016/j.ajhg.2013.04.008

Sequence Information:

Length: 233
Mass: 26525
Checksum: 4C1EAF932A3A211D
Sequence:

MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQHVREQSLV 
TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP FAKLIVETDT FGSRVRVRGA 
ETGLYICMNK KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA FTRKGRPRKG 
SKTRQHQREV HFMKRLPRGH HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR

Genular Protein ID: 2430662174

Symbol: A1A515_HUMAN

Name: N/A

UniProtKB Accession Codes:

A1A515

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 204
Mass: 23494
Checksum: 9A4CAB6524288A90
Sequence:

MGSPRSALSC LLLHLLVLCL QAQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK 
RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE 
IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE AHFMKRLPRG HHTTEQSLRF 
EFLNYPPFTR SLRGSQRTWA PEPR

Genular Protein ID: 3120431376

Symbol: A0A087X1S5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X1S5

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

Length: 140
Mass: 16255
Checksum: 52FEA2004965E454
Sequence:

MAEDGDPFAK LIVETDTFGS RVRVRGAETG LYICMNKKGK LIAKSNGKGK DCVFTEIVLE 
NNYTALQNAK YEGWYMAFTR KGRPRKGSKT RQHQREVHFM KRLPRGHHTT EQSLRFEFLN 
YPPFTRSLRG SQRTWAPEPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF8

Associated with

Cells (max top 100)

Other Information

Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties. PubMed ID: 7737407

Molecular cloning and characterization of human FGF8 alternative messenger RNA forms. PubMed ID: 8891346

Structure and sequence of human FGF8. PubMed ID: 8661131

The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells. PubMed ID: 8700553

A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma. PubMed ID: 11341643

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Receptor specificity of the fibroblast growth factor family. PubMed ID: 8663044

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Senataxin modulates neurite growth through fibroblast growth factor 8 signalling. PubMed ID: 21576111

Position effects at the FGF8 locus are associated with femoral hypoplasia. PubMed ID: 34433009

Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. PubMed ID: 16384934

Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. PubMed ID: 18596921

Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. PubMed ID: 23643382

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The sequence of the human genome. PubMed ID: 11181995

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Database document:

PubMed ID: 7737407

PubMed ID: 8891346

PubMed ID: 8661131

PubMed ID: 8700553

PubMed ID: 11341643

PubMed ID: 15489334

PubMed ID: 8663044

PubMed ID: 16597617

PubMed ID: 20094046

PubMed ID: 21576111

PubMed ID: 34433009

PubMed ID: 16384934

PubMed ID: 18596921

PubMed ID: 23643382

PubMed ID: 15489334

PubMed ID: 11237011

PubMed ID: 11181995

PubMed ID: 15164054

PubMed ID: 15496913