Details for: FGF12

Gene ID: 2257

Symbol: FGF12

Ensembl ID: ENSG00000114279

Description: fibroblast growth factor 12

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.38
    Marker Score: 120133
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.16
    Marker Score: 91677
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.66
    Marker Score: 21564
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.38
    Marker Score: 148028
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 4.27
    Marker Score: 15168.5
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.13
    Marker Score: 22208
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.64
    Marker Score: 1900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 3.3
    Marker Score: 1667
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.17
    Marker Score: 42166
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.06
    Marker Score: 1370.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.92
    Marker Score: 58017
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.89
    Marker Score: 4849
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.87
    Marker Score: 22009
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.84
    Marker Score: 42500
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.82
    Marker Score: 6473
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.73
    Marker Score: 103791
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10869
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.58
    Marker Score: 1081
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.57
    Marker Score: 19386
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.55
    Marker Score: 7286
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90729
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.42
    Marker Score: 12716
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.37
    Marker Score: 2933
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.35
    Marker Score: 9094
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.23
    Marker Score: 7474
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.21
    Marker Score: 851
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20676
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.1
    Marker Score: 21645
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127983
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.02
    Marker Score: 8208
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18341
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.93
    Marker Score: 527
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.92
    Marker Score: 631
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16165.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.85
    Marker Score: 4053
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.72
    Marker Score: 7161
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.7
    Marker Score: 1960
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2551
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.62
    Marker Score: 2021
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1159
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.58
    Marker Score: 3210
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.56
    Marker Score: 903.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.54
    Marker Score: 3125
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.53
    Marker Score: 463
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168047
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.46
    Marker Score: 875
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.38
    Marker Score: 823
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21296.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.34
    Marker Score: 28505.5
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.29
    Marker Score: 618
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 848
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.19
    Marker Score: 1482
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.18
    Marker Score: 471
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.17
    Marker Score: 901
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.1
    Marker Score: 345
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.07
    Marker Score: 598
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251768
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.03
    Marker Score: 679
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48014.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 406.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.94
    Marker Score: 5642
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.93
    Marker Score: 1129
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.93
    Marker Score: 492
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5290
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.92
    Marker Score: 2176
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.91
    Marker Score: 857.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.89
    Marker Score: 5395
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.87
    Marker Score: 3630
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.86
    Marker Score: 347
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.83
    Marker Score: 427
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.81
    Marker Score: 8210
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.79
    Marker Score: 285
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.78
    Marker Score: 258
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.77
    Marker Score: 201
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.76
    Marker Score: 364
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 495
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.75
    Marker Score: 369
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.73
    Marker Score: 1744
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.68
    Marker Score: 959
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.68
    Marker Score: 817.5
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.67
    Marker Score: 241
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.67
    Marker Score: 324.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.67
    Marker Score: 373
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.63
    Marker Score: 1813
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 389
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.61
    Marker Score: 252

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Other Information

**Key characteristics:** * FGF12 is a secreted protein that belongs to the fibroblast growth factor family. * It is a key factor in cardiac development and function. * It is involved in the regulation of cardiac conduction, muscle contraction, and cell-cell signaling. * It also plays a role in neural development and heart development. **Pathways and functions:** * FGF12 binds to its receptor, FGFR1, which is expressed on cardiac cells. * This binding activates FGFR1, which leads to the activation of downstream signaling pathways that promote cardiac cell proliferation, survival, and differentiation. * It also inhibits apoptosis, a process that would otherwise lead to the death of cardiac cells. * FGF12 is involved in the regulation of cardiac conduction by promoting the opening of sodium channels in cardiac cells. * It also plays a role in muscle contraction by promoting the depolarization of cardiac cells and facilitating the opening of voltage-gated sodium channels. * In addition, FGF12 is involved in cell-cell signaling, which is crucial for the coordination of cardiac function. **Clinical significance:** * Mutations in FGF12 have been linked to a number of heart conditions, including cardiomyopathy, heart failure, and arrhythmias. * FGF12 is a potential therapeutic target for these disorders. * Drugs that block FGF12 signaling have been shown to be effective in improving cardiac function in animal models of heart disease. **Additional notes:** * FGF12 is a highly conserved protein with a similar sequence in mammals and humans. * It is a secreted protein that is produced by cardiac cells and is released into the extracellular space. * It is a very effective growth factor, which is why it is used in clinical practice to treat a variety of conditions, including burns, wounds, and tissue damage.

Genular Protein ID: 3751533319

Symbol: FGF12_HUMAN

Name: Fibroblast growth factor 12

UniProtKB Accession Codes:

P61328 B2R6B7 B2R976 O35339 P70376 Q8TBG5 Q92912 Q93001

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8790420

Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

PubMed ID: 8790420

DOI: 10.1073/pnas.93.18.9850

PubMed ID: 10049777

Title: Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart.

PubMed ID: 10049777

DOI: 10.1006/bbrc.1999.0178

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27164707

Title: Gain-of-function FHF1 mutation causes early-onset epileptic encephalopathy with cerebellar atrophy.

PubMed ID: 27164707

DOI: 10.1212/wnl.0000000000002752

Sequence Information:

  • Length: 243
  • Mass: 27399
  • Checksum: 773ED10B5BDD033C
  • Sequence:
    • MAAAIASSLI RQKRQARESN SDRVSASKRR SSPSKDGRSL CERHVLGVFS KVRFCSGRKR 
PVRRRPEPQL KGIVTRLFSQ QGYFLQMHPD GTIDGTKDEN SDYTLFNLIP VGLRVVAIQG 
VKASLYVAMN GEGYLYSSDV FTPECKFKES VFENYYVIYS STLYRQQESG RAWFLGLNKE 
GQIMKGNRVK KTKPSSHFVP KPIEVCMYRE PSLHEIGEKQ GRSRKSSGTP TMNGGKVVNQ 
DST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.