Details for: FGF12

Gene ID: 2257

Symbol: FGF12

Ensembl ID: ENSG00000114279

Description: fibroblast growth factor 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 166.2347
    Cell Significance Index: -68.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.3513
    Cell Significance Index: -57.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 9.7323
    Cell Significance Index: 746.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 8.6155
    Cell Significance Index: 147.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.0737
    Cell Significance Index: -17.6700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 5.8095
    Cell Significance Index: 75.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 5.7971
    Cell Significance Index: 356.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 5.6389
    Cell Significance Index: 2022.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 5.3941
    Cell Significance Index: 153.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.8379
    Cell Significance Index: 213.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.7505
    Cell Significance Index: 179.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 4.2648
    Cell Significance Index: 102.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 4.1989
    Cell Significance Index: 52.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.1502
    Cell Significance Index: 279.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.6929
    Cell Significance Index: 740.8000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.4037
    Cell Significance Index: 50.2500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.6695
    Cell Significance Index: 35.6100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.3153
    Cell Significance Index: 33.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0455
    Cell Significance Index: 54.8100
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 1.5450
    Cell Significance Index: 12.4800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.4038
    Cell Significance Index: 10.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0545
    Cell Significance Index: 23.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6017
    Cell Significance Index: 119.4000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.5854
    Cell Significance Index: 7.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3145
    Cell Significance Index: 142.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.1974
    Cell Significance Index: 4.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1717
    Cell Significance Index: 32.6700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1503
    Cell Significance Index: 1.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1455
    Cell Significance Index: 7.6400
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.1069
    Cell Significance Index: 0.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0734
    Cell Significance Index: 66.2400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0629
    Cell Significance Index: 1.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0592
    Cell Significance Index: 1.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0384
    Cell Significance Index: 0.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0302
    Cell Significance Index: 46.5600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0174
    Cell Significance Index: 0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0082
    Cell Significance Index: -15.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0104
    Cell Significance Index: -19.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0228
    Cell Significance Index: -14.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0235
    Cell Significance Index: -31.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0320
    Cell Significance Index: -5.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0531
    Cell Significance Index: -0.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0770
    Cell Significance Index: -43.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0909
    Cell Significance Index: -57.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0916
    Cell Significance Index: -67.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0967
    Cell Significance Index: -73.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1182
    Cell Significance Index: -64.5300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1349
    Cell Significance Index: -1.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1380
    Cell Significance Index: -24.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1443
    Cell Significance Index: -30.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1591
    Cell Significance Index: -5.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1829
    Cell Significance Index: -80.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1983
    Cell Significance Index: -57.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2131
    Cell Significance Index: -34.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2291
    Cell Significance Index: -8.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2766
    Cell Significance Index: -8.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3329
    Cell Significance Index: -32.9400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3473
    Cell Significance Index: -4.2100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3557
    Cell Significance Index: -4.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3648
    Cell Significance Index: -53.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3667
    Cell Significance Index: -45.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4115
    Cell Significance Index: -56.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4218
    Cell Significance Index: -45.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4381
    Cell Significance Index: -26.8600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5063
    Cell Significance Index: -6.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5117
    Cell Significance Index: -66.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5173
    Cell Significance Index: -10.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5180
    Cell Significance Index: -52.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5579
    Cell Significance Index: -15.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5814
    Cell Significance Index: -68.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5934
    Cell Significance Index: -61.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5968
    Cell Significance Index: -69.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6145
    Cell Significance Index: -70.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6211
    Cell Significance Index: -70.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6250
    Cell Significance Index: -28.3300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6262
    Cell Significance Index: -8.0300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.6263
    Cell Significance Index: -6.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6385
    Cell Significance Index: -35.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6584
    Cell Significance Index: -18.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.7561
    Cell Significance Index: -96.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.7711
    Cell Significance Index: -53.3300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7776
    Cell Significance Index: -16.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7934
    Cell Significance Index: -25.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8458
    Cell Significance Index: -50.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8516
    Cell Significance Index: -67.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8695
    Cell Significance Index: -64.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9255
    Cell Significance Index: -43.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9469
    Cell Significance Index: -23.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9481
    Cell Significance Index: -49.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0159
    Cell Significance Index: -35.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.1043
    Cell Significance Index: -57.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.1498
    Cell Significance Index: -81.3200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.1705
    Cell Significance Index: -24.4300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.2045
    Cell Significance Index: -15.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2241
    Cell Significance Index: -77.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2527
    Cell Significance Index: -31.3200
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -1.2770
    Cell Significance Index: -14.6400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.3183
    Cell Significance Index: -15.3800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -1.3260
    Cell Significance Index: -14.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FGF12 is a secreted protein that belongs to the fibroblast growth factor family, characterized by its ability to bind to heparan sulfate proteoglycans and interact with cell surface receptors. It is primarily expressed in various tissues, including the heart, adrenal gland, and immune cells, such as lymphocytes and neurons. FGF12 exhibits a high degree of homology with other FGFs, particularly FGF1 and FGF2, suggesting a conserved mechanism of action. **Pathways and Functions:** FGF12 is involved in multiple signaling pathways that regulate immune responses, cardiac development, and cellular behavior. Some of the key pathways include: 1. **Cell-cell signaling:** FGF12 interacts with cell surface receptors, such as FGF receptors, to initiate signaling cascades that regulate cellular behavior, including proliferation, differentiation, and survival. 2. **Cardiac conduction:** FGF12 is expressed in cardiac myocytes and plays a crucial role in regulating cardiac conduction and contraction. 3. **Immune regulation:** FGF12 modulates immune responses by influencing the function of immune cells, such as lymphocytes and neurons. 4. **Neurotransmission:** FGF12 interacts with neuronal receptors to regulate neurotransmission and synaptic plasticity. **Clinical Significance:** The dysregulation of FGF12 has been implicated in various diseases, including cardiovascular disorders, immune-related conditions, and neurological disorders. Some of the potential clinical applications of FGF12 include: 1. **Cardiovascular disease:** FGF12 may play a role in the development of cardiovascular disease, particularly in the context of cardiac conduction disorders. 2. **Immune-related disorders:** FGF12 dysregulation may contribute to immune-related conditions, such as autoimmune diseases and cancer. 3. **Neurological disorders:** FGF12 may be involved in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FGF12 is a multifaceted protein that plays a crucial role in regulating immune responses, cardiac function, and cellular behavior. Further research is needed to fully understand the mechanisms of FGF12 and its potential clinical applications.

Genular Protein ID: 3751533319

Symbol: FGF12_HUMAN

Name: Fibroblast growth factor 12

UniProtKB Accession Codes:

P61328 B2R6B7 B2R976 O35339 P70376 Q8TBG5 Q92912 Q93001

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8790420

Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

PubMed ID: 8790420

DOI: 10.1073/pnas.93.18.9850

PubMed ID: 10049777

Title: Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart.

PubMed ID: 10049777

DOI: 10.1006/bbrc.1999.0178

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27164707

Title: Gain-of-function FHF1 mutation causes early-onset epileptic encephalopathy with cerebellar atrophy.

PubMed ID: 27164707

DOI: 10.1212/wnl.0000000000002752

Sequence Information:

  • Length: 243
  • Mass: 27399
  • Checksum: 773ED10B5BDD033C
  • Sequence:
    • MAAAIASSLI RQKRQARESN SDRVSASKRR SSPSKDGRSL CERHVLGVFS KVRFCSGRKR 
PVRRRPEPQL KGIVTRLFSQ QGYFLQMHPD GTIDGTKDEN SDYTLFNLIP VGLRVVAIQG 
VKASLYVAMN GEGYLYSSDV FTPECKFKES VFENYYVIYS STLYRQQESG RAWFLGLNKE 
GQIMKGNRVK KTKPSSHFVP KPIEVCMYRE PSLHEIGEKQ GRSRKSSGTP TMNGGKVVNQ 
DST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.