Details for: FGF12

Gene ID: 2257

Symbol: FGF12

Ensembl ID: ENSG00000114279

Description: fibroblast growth factor 12

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.38
    Marker Score: 120,133
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.16
    Marker Score: 91,677
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.66
    Marker Score: 21,564
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.38
    Marker Score: 148,028
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 4.27
    Marker Score: 15,169
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.13
    Marker Score: 22,208
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.64
    Marker Score: 1,900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 3.3
    Marker Score: 1,667
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.17
    Marker Score: 42,166
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.06
    Marker Score: 1,371
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.92
    Marker Score: 58,017
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.89
    Marker Score: 4,849
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.87
    Marker Score: 22,009
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.84
    Marker Score: 42,500
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.82
    Marker Score: 6,473
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.73
    Marker Score: 103,791
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10,869
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.58
    Marker Score: 1,081
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.57
    Marker Score: 19,386
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.55
    Marker Score: 7,286
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90,729
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.42
    Marker Score: 12,716
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.37
    Marker Score: 2,933
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.35
    Marker Score: 9,094
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.23
    Marker Score: 7,474
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.21
    Marker Score: 851
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,676
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.1
    Marker Score: 21,645
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,983
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.02
    Marker Score: 8,208
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,341
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.93
    Marker Score: 527
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.92
    Marker Score: 631
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,166
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.85
    Marker Score: 4,053
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.72
    Marker Score: 7,161
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.7
    Marker Score: 1,960
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2,551
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.62
    Marker Score: 2,021
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,159
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.58
    Marker Score: 3,210
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.56
    Marker Score: 904
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.54
    Marker Score: 3,125
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.53
    Marker Score: 463
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168,047
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.46
    Marker Score: 875
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.38
    Marker Score: 823
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21,297
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.34
    Marker Score: 28,506
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.29
    Marker Score: 618
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 848
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.19
    Marker Score: 1,482
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.18
    Marker Score: 471
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.17
    Marker Score: 901
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.1
    Marker Score: 345
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.07
    Marker Score: 598
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,768
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.03
    Marker Score: 679
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,015
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.94
    Marker Score: 5,642
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.93
    Marker Score: 1,129
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.93
    Marker Score: 492
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,290
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.92
    Marker Score: 2,176
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.91
    Marker Score: 858
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.89
    Marker Score: 5,395
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.87
    Marker Score: 3,630
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.86
    Marker Score: 347
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.83
    Marker Score: 427
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.81
    Marker Score: 8,210
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.79
    Marker Score: 285
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.78
    Marker Score: 258
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.77
    Marker Score: 201
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,256
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.76
    Marker Score: 364
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 495
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.75
    Marker Score: 369
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.73
    Marker Score: 1,744
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.68
    Marker Score: 959
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.68
    Marker Score: 818
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.67
    Marker Score: 241
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.67
    Marker Score: 325
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.67
    Marker Score: 373
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.63
    Marker Score: 1,813
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 389
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.61
    Marker Score: 252

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FGF12 is a secreted protein that belongs to the fibroblast growth factor family, characterized by its ability to bind to heparan sulfate proteoglycans and interact with cell surface receptors. It is primarily expressed in various tissues, including the heart, adrenal gland, and immune cells, such as lymphocytes and neurons. FGF12 exhibits a high degree of homology with other FGFs, particularly FGF1 and FGF2, suggesting a conserved mechanism of action. **Pathways and Functions:** FGF12 is involved in multiple signaling pathways that regulate immune responses, cardiac development, and cellular behavior. Some of the key pathways include: 1. **Cell-cell signaling:** FGF12 interacts with cell surface receptors, such as FGF receptors, to initiate signaling cascades that regulate cellular behavior, including proliferation, differentiation, and survival. 2. **Cardiac conduction:** FGF12 is expressed in cardiac myocytes and plays a crucial role in regulating cardiac conduction and contraction. 3. **Immune regulation:** FGF12 modulates immune responses by influencing the function of immune cells, such as lymphocytes and neurons. 4. **Neurotransmission:** FGF12 interacts with neuronal receptors to regulate neurotransmission and synaptic plasticity. **Clinical Significance:** The dysregulation of FGF12 has been implicated in various diseases, including cardiovascular disorders, immune-related conditions, and neurological disorders. Some of the potential clinical applications of FGF12 include: 1. **Cardiovascular disease:** FGF12 may play a role in the development of cardiovascular disease, particularly in the context of cardiac conduction disorders. 2. **Immune-related disorders:** FGF12 dysregulation may contribute to immune-related conditions, such as autoimmune diseases and cancer. 3. **Neurological disorders:** FGF12 may be involved in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FGF12 is a multifaceted protein that plays a crucial role in regulating immune responses, cardiac function, and cellular behavior. Further research is needed to fully understand the mechanisms of FGF12 and its potential clinical applications.

Genular Protein ID: 3751533319

Symbol: FGF12_HUMAN

Name: Fibroblast growth factor 12

UniProtKB Accession Codes:

P61328 B2R6B7 B2R976 O35339 P70376 Q8TBG5 Q92912 Q93001

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8790420

Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

PubMed ID: 8790420

DOI: 10.1073/pnas.93.18.9850

PubMed ID: 10049777

Title: Cloning and characterization of a cDNA encoding a novel fibroblast growth factor preferentially expressed in human heart.

PubMed ID: 10049777

DOI: 10.1006/bbrc.1999.0178

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27164707

Title: Gain-of-function FHF1 mutation causes early-onset epileptic encephalopathy with cerebellar atrophy.

PubMed ID: 27164707

DOI: 10.1212/wnl.0000000000002752

Sequence Information:

  • Length: 243
  • Mass: 27399
  • Checksum: 773ED10B5BDD033C
  • Sequence:
    • MAAAIASSLI RQKRQARESN SDRVSASKRR SSPSKDGRSL CERHVLGVFS KVRFCSGRKR 
PVRRRPEPQL KGIVTRLFSQ QGYFLQMHPD GTIDGTKDEN SDYTLFNLIP VGLRVVAIQG 
VKASLYVAMN GEGYLYSSDV FTPECKFKES VFENYYVIYS STLYRQQESG RAWFLGLNKE 
GQIMKGNRVK KTKPSSHFVP KPIEVCMYRE PSLHEIGEKQ GRSRKSSGTP TMNGGKVVNQ 
DST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.