Details for: FOXS1

Gene ID: 2307

Symbol: FOXS1

Ensembl ID: ENSG00000179772

Description: forkhead box S1

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Blood vessel development
    (GO:0001568)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuromuscular process controlling balance
    (GO:0050885)
  • Nucleus
    (GO:0005634)
  • Positive regulation of multicellular organism growth
    (GO:0040018)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.2275
    Cell Significance Index: -4.1600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.5155
    Cell Significance Index: 21.1300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.3766
    Cell Significance Index: 36.7700
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.4595
    Cell Significance Index: 3.4400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.4137
    Cell Significance Index: 1.9100
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.3368
    Cell Significance Index: 1.6800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1046
    Cell Significance Index: 1.6600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0617
    Cell Significance Index: 0.5100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0434
    Cell Significance Index: 0.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0108
    Cell Significance Index: 1.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0055
    Cell Significance Index: 0.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0056
    Cell Significance Index: -4.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0064
    Cell Significance Index: -4.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0096
    Cell Significance Index: -7.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0105
    Cell Significance Index: -5.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0110
    Cell Significance Index: -6.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0125
    Cell Significance Index: -0.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0134
    Cell Significance Index: -4.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0147
    Cell Significance Index: -9.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0171
    Cell Significance Index: -4.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0191
    Cell Significance Index: -8.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0193
    Cell Significance Index: -0.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0247
    Cell Significance Index: -4.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0260
    Cell Significance Index: -2.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0264
    Cell Significance Index: -5.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0294
    Cell Significance Index: -1.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0296
    Cell Significance Index: -3.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0354
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0401
    Cell Significance Index: -6.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0448
    Cell Significance Index: -9.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0526
    Cell Significance Index: -6.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0657
    Cell Significance Index: -3.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0666
    Cell Significance Index: -8.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0719
    Cell Significance Index: -5.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0791
    Cell Significance Index: -4.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0816
    Cell Significance Index: -5.4900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0873
    Cell Significance Index: -1.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0932
    Cell Significance Index: -2.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0955
    Cell Significance Index: -5.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0996
    Cell Significance Index: -2.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1059
    Cell Significance Index: -3.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1072
    Cell Significance Index: -5.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1158
    Cell Significance Index: -8.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1181
    Cell Significance Index: -6.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1192
    Cell Significance Index: -3.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1214
    Cell Significance Index: -5.6600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1247
    Cell Significance Index: -3.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1341
    Cell Significance Index: -3.6500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1380
    Cell Significance Index: -1.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1383
    Cell Significance Index: -2.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1462
    Cell Significance Index: -2.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1524
    Cell Significance Index: -6.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1527
    Cell Significance Index: -5.3500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1566
    Cell Significance Index: -2.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1570
    Cell Significance Index: -5.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1620
    Cell Significance Index: -1.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1636
    Cell Significance Index: -4.3800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1652
    Cell Significance Index: -1.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1677
    Cell Significance Index: -5.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1683
    Cell Significance Index: -4.5100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1745
    Cell Significance Index: -7.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1781
    Cell Significance Index: -6.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1822
    Cell Significance Index: -4.8700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1836
    Cell Significance Index: -1.7700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1859
    Cell Significance Index: -2.5700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1870
    Cell Significance Index: -2.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1920
    Cell Significance Index: -5.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1992
    Cell Significance Index: -4.9700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2010
    Cell Significance Index: -4.0900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2019
    Cell Significance Index: -2.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2023
    Cell Significance Index: -4.4300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2024
    Cell Significance Index: -1.7200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2033
    Cell Significance Index: -5.1800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2051
    Cell Significance Index: -2.5000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2102
    Cell Significance Index: -2.5200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.2105
    Cell Significance Index: -2.1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2112
    Cell Significance Index: -3.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2125
    Cell Significance Index: -2.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2177
    Cell Significance Index: -7.9900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2186
    Cell Significance Index: -2.8000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.2205
    Cell Significance Index: -2.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2213
    Cell Significance Index: -5.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2219
    Cell Significance Index: -4.3300
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2230
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.2235
    Cell Significance Index: -2.8200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2279
    Cell Significance Index: -2.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2306
    Cell Significance Index: -5.5300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2316
    Cell Significance Index: -5.7900
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.2360
    Cell Significance Index: -1.0900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2407
    Cell Significance Index: -5.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2408
    Cell Significance Index: -5.1100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2431
    Cell Significance Index: -3.5300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2436
    Cell Significance Index: -2.6700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2481
    Cell Significance Index: -2.6400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2492
    Cell Significance Index: -5.2000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2493
    Cell Significance Index: -3.7300
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.2502
    Cell Significance Index: -2.6800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2505
    Cell Significance Index: -5.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FOXS1 is a transcription factor that belongs to the forkhead box family, which is characterized by the presence of a forkhead domain. This domain is responsible for the protein's ability to bind to specific DNA sequences, thereby regulating gene expression. FOXS1 is a multifunctional protein that can act as both a transcriptional activator and repressor, depending on the context. It is also known to interact with other transcription factors and signaling molecules to modulate its activity. **Pathways and Functions:** FOXS1 is involved in various signaling pathways, including the PI3K/AKT, MAPK, and NF-κB pathways. These pathways regulate cell growth, differentiation, and survival, and FOXS1 plays a key role in modulating their activity. FOXS1 is also involved in the regulation of chromatin structure and epigenetic modifications, which is essential for gene expression and cellular differentiation. In terms of its functional roles, FOXS1 is involved in: * Cell differentiation: FOXS1 regulates the expression of genes involved in cell fate determination, including those involved in neuronal development and immune cell differentiation. * Development: FOXS1 is involved in the regulation of embryonic development, including the development of the nervous system and immune system. * Growth and proliferation: FOXS1 regulates cell growth and proliferation by modulating the activity of signaling pathways involved in these processes. * Apoptosis: FOXS1 can also regulate apoptosis (programmed cell death) by modulating the activity of pro-apoptotic and anti-apoptotic genes. **Clinical Significance:** Dysregulation of FOXS1 has been implicated in several diseases, including: * Cancer: FOXS1 is often overexpressed in various types of cancer, including leukemia, lymphoma, and breast cancer, and its dysregulation is associated with poor prognosis. * Autoimmune disorders: FOXS1 is involved in the regulation of immune cell function, and its dysregulation has been implicated in autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. * Neurological disorders: FOXS1 is involved in the regulation of neuronal development and function, and its dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FOXS1 is a critical transcription factor that plays a key role in regulating cellular differentiation, development, and growth. Its dysregulation has been implicated in several diseases, and further research is needed to fully understand its role in human disease.

Genular Protein ID: 1835144014

Symbol: FOXS1_HUMAN

Name: Forkhead box protein S1

UniProtKB Accession Codes:

O43638 Q96D28

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9325056

Title: Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene.

PubMed ID: 9325056

DOI: 10.1006/geno.1997.4864

Sequence Information:

  • Length: 330
  • Mass: 35434
  • Checksum: BBF10321A8DC1744
  • Sequence:
    • MQQQPLPGPG APTTEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG RFAFYRHNRP 
GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD MFEHGSFLRR RRRFTRQTGA 
EGTRGPAKAR RGPLRATSQD PGVPNATTGR QCSFPPELPD PKGLSFGGLV GAMPASMCPA 
TTDGRPRPPM EPKEISTPKP ACPGELPVAT SSSSCPAFGF PAGFSEAESF NKAPTPVLSP 
ESGIGSSYQC RLQALNFCMG ADPGLEHLLA SAAPSPAPPT PPGSLRAPLP LPTDHKEPWV 
AGGFPVQGGS GYPLGLTPCL YRTPGMFFFE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.