Details for: FOXS1

Gene ID: 2307

Symbol: FOXS1

Ensembl ID: ENSG00000179772

Description: forkhead box S1

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Blood vessel development
    (GO:0001568)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuromuscular process controlling balance
    (GO:0050885)
  • Nucleus
    (GO:0005634)
  • Positive regulation of multicellular organism growth
    (GO:0040018)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1513
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.24
    Marker Score: 882
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.06
    Marker Score: 1011
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.99
    Marker Score: 947
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.94
    Marker Score: 275
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.83
    Marker Score: 219
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 502
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.73
    Marker Score: 1378.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.67
    Marker Score: 668
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 387
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.62
    Marker Score: 389
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.6
    Marker Score: 646
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.59
    Marker Score: 661
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 274
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.53
    Marker Score: 118
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.52
    Marker Score: 147
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 206
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.49
    Marker Score: 286
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.46
    Marker Score: 868
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.42
    Marker Score: 1546
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.4
    Marker Score: 262
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.38
    Marker Score: 108
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.34
    Marker Score: 551
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.32
    Marker Score: 5031
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.32
    Marker Score: 513
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3
    Marker Score: 614
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.29
    Marker Score: 485
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 150
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.25
    Marker Score: 1474
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.22
    Marker Score: 265
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 124
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.18
    Marker Score: 208
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.18
    Marker Score: 171
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.17
    Marker Score: 93
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.17
    Marker Score: 515
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.17
    Marker Score: 100
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.16
    Marker Score: 224
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.15
    Marker Score: 236
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 120
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 75.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.11
    Marker Score: 22
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.11
    Marker Score: 1260
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.11
    Marker Score: 99
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.1
    Marker Score: 75
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.1
    Marker Score: 262
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.1
    Marker Score: 183
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.09
    Marker Score: 612
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.09
    Marker Score: 44
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 162
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 40.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.07
    Marker Score: 59
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.07
    Marker Score: 116
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.06
    Marker Score: 34.5

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Other Information

**Key characteristics:** - Forkhead domain: A conserved DNA-binding domain that recognizes DNA sequences known as forkhead box (FOXO) motifs. - Transcription factor activity: FOXS1 is a transcription factor with the ability to regulate gene expression by binding to FOXO DNA sequences and modulating the expression of target genes. - Expression: FOXS1 is highly expressed in certain cell types, including conventional dendritic cells, granulocyte monocyte progenitor cells, kidney interstitial cells, goblet cells, B cells, and neural cells. **Pathways and functions:** - **Forkhead domain function:** FOXS1 acts as a transcriptional activator by binding to FOXO DNA sequences and promoting the expression of downstream target genes. - **Tissue homeostasis and development:** It plays a crucial role in maintaining tissue integrity, regulating cell proliferation, and suppressing tumor growth. - **Immune responses:** FOXS1 is expressed in various immune cells, including dendritic cells, macrophages, and T cells. It regulates the development and function of immune cells by modulating the expression of immune checkpoint molecules and stimulating inflammatory responses. **Clinical significance:** - Dysfunction of FOXS1 has been linked to various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. - Targeted therapies that modulate FOXS1 activity are being investigated as potential therapeutic strategies for these diseases. **Additional notes:** - The FOXS1 gene is located on chromosome 17q21.1. - It is a highly conserved protein with homologs found in other species. - FOXS1 is a well-studied transcription factor with a significant impact on human health.

Genular Protein ID: 1835144014

Symbol: FOXS1_HUMAN

Name: Forkhead box protein S1

UniProtKB Accession Codes:

O43638 Q96D28

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9325056

Title: Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene.

PubMed ID: 9325056

DOI: 10.1006/geno.1997.4864

Sequence Information:

  • Length: 330
  • Mass: 35434
  • Checksum: BBF10321A8DC1744
  • Sequence:
    • MQQQPLPGPG APTTEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG RFAFYRHNRP 
GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD MFEHGSFLRR RRRFTRQTGA 
EGTRGPAKAR RGPLRATSQD PGVPNATTGR QCSFPPELPD PKGLSFGGLV GAMPASMCPA 
TTDGRPRPPM EPKEISTPKP ACPGELPVAT SSSSCPAFGF PAGFSEAESF NKAPTPVLSP 
ESGIGSSYQC RLQALNFCMG ADPGLEHLLA SAAPSPAPPT PPGSLRAPLP LPTDHKEPWV 
AGGFPVQGGS GYPLGLTPCL YRTPGMFFFE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.