Details for: FMO2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 33.1810
Cell Significance Index: -13.4800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 13.9200
Cell Significance Index: -13.2900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 3.8078
Cell Significance Index: 25.8000 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 3.6305
Cell Significance Index: 52.1400 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 2.0657
Cell Significance Index: 12.7800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 2.0038
Cell Significance Index: 291.2800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.9660
Cell Significance Index: 38.3700 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.7537
Cell Significance Index: 10.8400 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.3820
Cell Significance Index: 3.9400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.3219
Cell Significance Index: 16.2700 - Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
Fold Change: 0.3099
Cell Significance Index: 2.1800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2037
Cell Significance Index: 5.8400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1409
Cell Significance Index: 89.5100 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.1215
Cell Significance Index: 1.5300 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.0480
Cell Significance Index: 0.8200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0459
Cell Significance Index: 86.4500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0238
Cell Significance Index: 1.1200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0194
Cell Significance Index: 1.0100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0036
Cell Significance Index: 0.1700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0036
Cell Significance Index: -0.0300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0063
Cell Significance Index: -4.8000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0153
Cell Significance Index: -28.2300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0170
Cell Significance Index: -12.4300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0183
Cell Significance Index: -28.1500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0206
Cell Significance Index: -2.6600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0212
Cell Significance Index: -28.8700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0237
Cell Significance Index: -17.5800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0239
Cell Significance Index: -10.8400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0265
Cell Significance Index: -11.7000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0310
Cell Significance Index: -17.5000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0319
Cell Significance Index: -4.0900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0364
Cell Significance Index: -7.2200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0455
Cell Significance Index: -13.0900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0489
Cell Significance Index: -17.5500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0550
Cell Significance Index: -9.9200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0858
Cell Significance Index: -18.0800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0917
Cell Significance Index: -10.6900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0944
Cell Significance Index: -9.6500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0949
Cell Significance Index: -11.6700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0953
Cell Significance Index: -19.1200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0967
Cell Significance Index: -16.5200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1323
Cell Significance Index: -15.1600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1393
Cell Significance Index: -1.9000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1533
Cell Significance Index: -12.1400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1613
Cell Significance Index: -16.8000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1735
Cell Significance Index: -13.3200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1763
Cell Significance Index: -13.1400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1776
Cell Significance Index: -24.3900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1845
Cell Significance Index: -5.4400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.1899
Cell Significance Index: -3.3600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.2107
Cell Significance Index: -3.2600 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.2446
Cell Significance Index: -3.8800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2623
Cell Significance Index: -16.1200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2762
Cell Significance Index: -17.4100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2768
Cell Significance Index: -18.6100 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.2877
Cell Significance Index: -1.9100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3217
Cell Significance Index: -8.9900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3272
Cell Significance Index: -12.0100 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3299
Cell Significance Index: -8.2400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3580
Cell Significance Index: -16.2300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3737
Cell Significance Index: -12.9900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3958
Cell Significance Index: -22.2100 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.4002
Cell Significance Index: -17.4000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4230
Cell Significance Index: -22.2100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.4608
Cell Significance Index: -9.8500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4648
Cell Significance Index: -20.5600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5136
Cell Significance Index: -13.1200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5201
Cell Significance Index: -27.0200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5427
Cell Significance Index: -13.9500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5432
Cell Significance Index: -20.5700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5776
Cell Significance Index: -20.2400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5986
Cell Significance Index: -16.0400 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.6019
Cell Significance Index: -15.0100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6143
Cell Significance Index: -20.1100 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.6167
Cell Significance Index: -7.3300 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.6178
Cell Significance Index: -14.9700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6291
Cell Significance Index: -20.0400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.6434
Cell Significance Index: -17.1800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.6563
Cell Significance Index: -18.7300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.6722
Cell Significance Index: -14.0700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.7034
Cell Significance Index: -16.8700 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.7373
Cell Significance Index: -8.2000 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.7414
Cell Significance Index: -11.2600 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.7465
Cell Significance Index: -19.0200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.7596
Cell Significance Index: -14.0400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.7682
Cell Significance Index: -16.8200 - Cell Name: basal cell (CL0000646)
Fold Change: -0.8009
Cell Significance Index: -9.5300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.8062
Cell Significance Index: -20.1100 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.8241
Cell Significance Index: -9.5700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.8291
Cell Significance Index: -21.8000 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.8476
Cell Significance Index: -11.8800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.8523
Cell Significance Index: -23.2000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.8577
Cell Significance Index: -30.1400 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.8636
Cell Significance Index: -8.3600 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.8700
Cell Significance Index: -17.0100 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.8919
Cell Significance Index: -13.0000 - Cell Name: fibroblast (CL0000057)
Fold Change: -0.8963
Cell Significance Index: -8.4200 - Cell Name: adventitial cell (CL0002503)
Fold Change: -0.9019
Cell Significance Index: -8.3700 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.9139
Cell Significance Index: -13.0000 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.9153
Cell Significance Index: -28.9500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3253330861
Symbol: FMO2_HUMAN
Name: Dimethylaniline oxidase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9804831
Title: The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein.
PubMed ID: 9804831
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11042094
Title: Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans.
PubMed ID: 11042094
PubMed ID: 15294458
Title: S-oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2.
PubMed ID: 15294458
PubMed ID: 15144220
Title: Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione.
PubMed ID: 15144220
DOI: 10.1021/tx034253s
PubMed ID: 18930751
Title: Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes.
PubMed ID: 18930751
PubMed ID: 18948378
Title: Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.
PubMed ID: 18948378
PubMed ID: 20388717
Title: In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.
PubMed ID: 20388717
PubMed ID: 12527699
Title: Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.
PubMed ID: 12527699
DOI: 10.1124/dmd.31.2.187
PubMed ID: 18794725
Title: The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa.
PubMed ID: 18794725
Sequence Information:
- Length: 535
- Mass: 60907
- Checksum: 39A5587AC7BF50B8
- Sequence:
MAKKVAVIGA GVSGLISLKC CVDEGLEPTC FERTEDIGGV WRFKENVEDG RASIYQSVVT NTSKEMSCFS DFPMPEDFPN FLHNSKLLEY FRIFAKKFDL LKYIQFQTTV LSVRKCPDFS SSGQWKVVTQ SNGKEQSAVF DAVMVCSGHH ILPHIPLKSF PGMERFKGQY FHSRQYKHPD GFEGKRILVI GMGNSGSDIA VELSKNAAQV FISTRHGTWV MSRISEDGYP WDSVFHTRFR SMLRNVLPRT AVKWMIEQQM NRWFNHENYG LEPQNKYIMK EPVLNDDVPS RLLCGAIKVK STVKELTETS AIFEDGTVEE NIDVIIFATG YSFSFPFLED SLVKVENNMV SLYKYIFPAH LDKSTLACIG LIQPLGSIFP TAELQARWVT RVFKGLCSLP SERTMMMDII KRNEKRIDLF GESQSQTLQT NYVDYLDELA LEIGAKPDFC SLLFKDPKLA VRLYFGPCNS YQYRLVGPGQ WEGARNAIFT QKQRILKPLK TRALKDSSNF SVSFLLKILG LLAVVVAFFC QLQWS
Genular Protein ID: 1802205996
Symbol: Q5JPC7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 471
- Mass: 53610
- Checksum: 76084CCD709FE948
- Sequence:
MAKKVAVIGA GVSGLISLKC CVDEGLEPTC FERTEDIGGV WRFKENVEDG RASIYQSVVT NTSKEMSCFS DLPMPEDFPN FLHNSKLLEY FRIFAKKFDL LKYIQFQTTV LSVRKCPDFS SSGQWKVVTQ SNGKEQSAVF DAVMVCSGHH ILPHIPLKSF PGMERFKGQY FHSRQYKHPD GFEGKRILVI GMGNSGSDIA VELSKNAAQV FISTRHGTWV MSRISEDGYP WDSVFHTRFR SMLRNVLPRT AVKWMIEQQM NRWFNHENYG LEPQNKYIMK EPVLNDDVPS RLLCGAIKVK STVKELTETS AIFEDGTVEE NIDVIIFATG YSFSFPFLED SLVKVENNMV SLYKYIFPAH LDKSTLACIG LIQPLGSIFP TAELQARWVT RVFKGLCSLP SERTMMMDII KRNEKRIDLF GESQSQTLQT NYVDYLDELA LEIGAKPDFC SLLFKDPKLA VRLYFGPCNS Y
Genular Protein ID: 705624521
Symbol: B4E2Q9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 251
- Mass: 28972
- Checksum: A52523B822C3292B
- Sequence:
MSRISEDGYP WDSVFHTRFR SMLRNVLPRT AVKWMIEQQM NRWFNHENYG LEPQNKYIMK EPVLNDDVPS RLLCGAIKVK STVKELTETS AIFEDGTVEE NIDVIIFATG YSFSFPFLED SLVKVENNMV SLYKYIFPAH LDKSTLACIG LIQPLGSIFP TAELQARWVT RVFKGLCSLP SERTMMMDII KRNEKRIDLF GESQSQTLQT NYVDYLDELA LEIGAKPDFC SLLFKDPKLA VRLYFGPCNS Y
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.