Details for: FMO2

Gene ID: 2327

Symbol: FMO2

Ensembl ID: ENSG00000094963

Description: flavin containing dimethylaniline monoxygenase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.1810
    Cell Significance Index: -13.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.9200
    Cell Significance Index: -13.2900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.8078
    Cell Significance Index: 25.8000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 3.6305
    Cell Significance Index: 52.1400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.0657
    Cell Significance Index: 12.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.0038
    Cell Significance Index: 291.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.9660
    Cell Significance Index: 38.3700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7537
    Cell Significance Index: 10.8400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.3820
    Cell Significance Index: 3.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3219
    Cell Significance Index: 16.2700
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.3099
    Cell Significance Index: 2.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2037
    Cell Significance Index: 5.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1409
    Cell Significance Index: 89.5100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1215
    Cell Significance Index: 1.5300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0480
    Cell Significance Index: 0.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0459
    Cell Significance Index: 86.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0238
    Cell Significance Index: 1.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0194
    Cell Significance Index: 1.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0036
    Cell Significance Index: 0.1700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0036
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0063
    Cell Significance Index: -4.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0153
    Cell Significance Index: -28.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0170
    Cell Significance Index: -12.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0183
    Cell Significance Index: -28.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0206
    Cell Significance Index: -2.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0212
    Cell Significance Index: -28.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0237
    Cell Significance Index: -17.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0239
    Cell Significance Index: -10.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0265
    Cell Significance Index: -11.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0310
    Cell Significance Index: -17.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0319
    Cell Significance Index: -4.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0364
    Cell Significance Index: -7.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0455
    Cell Significance Index: -13.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0489
    Cell Significance Index: -17.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0550
    Cell Significance Index: -9.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0858
    Cell Significance Index: -18.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0917
    Cell Significance Index: -10.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0944
    Cell Significance Index: -9.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0949
    Cell Significance Index: -11.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0953
    Cell Significance Index: -19.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0967
    Cell Significance Index: -16.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1323
    Cell Significance Index: -15.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1393
    Cell Significance Index: -1.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1533
    Cell Significance Index: -12.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1613
    Cell Significance Index: -16.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1735
    Cell Significance Index: -13.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1763
    Cell Significance Index: -13.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1776
    Cell Significance Index: -24.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1845
    Cell Significance Index: -5.4400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1899
    Cell Significance Index: -3.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2107
    Cell Significance Index: -3.2600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2446
    Cell Significance Index: -3.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2623
    Cell Significance Index: -16.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2762
    Cell Significance Index: -17.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2768
    Cell Significance Index: -18.6100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2877
    Cell Significance Index: -1.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3217
    Cell Significance Index: -8.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3272
    Cell Significance Index: -12.0100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3299
    Cell Significance Index: -8.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3580
    Cell Significance Index: -16.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3737
    Cell Significance Index: -12.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3958
    Cell Significance Index: -22.2100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4002
    Cell Significance Index: -17.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4230
    Cell Significance Index: -22.2100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4608
    Cell Significance Index: -9.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4648
    Cell Significance Index: -20.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5136
    Cell Significance Index: -13.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5201
    Cell Significance Index: -27.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5427
    Cell Significance Index: -13.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5432
    Cell Significance Index: -20.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5776
    Cell Significance Index: -20.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5986
    Cell Significance Index: -16.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6019
    Cell Significance Index: -15.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6143
    Cell Significance Index: -20.1100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.6167
    Cell Significance Index: -7.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6178
    Cell Significance Index: -14.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6291
    Cell Significance Index: -20.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6434
    Cell Significance Index: -17.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6563
    Cell Significance Index: -18.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6722
    Cell Significance Index: -14.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7034
    Cell Significance Index: -16.8700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.7373
    Cell Significance Index: -8.2000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7414
    Cell Significance Index: -11.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7465
    Cell Significance Index: -19.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7596
    Cell Significance Index: -14.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7682
    Cell Significance Index: -16.8200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.8009
    Cell Significance Index: -9.5300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8062
    Cell Significance Index: -20.1100
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.8241
    Cell Significance Index: -9.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8291
    Cell Significance Index: -21.8000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8476
    Cell Significance Index: -11.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8523
    Cell Significance Index: -23.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8577
    Cell Significance Index: -30.1400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.8636
    Cell Significance Index: -8.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.8700
    Cell Significance Index: -17.0100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.8919
    Cell Significance Index: -13.0000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.8963
    Cell Significance Index: -8.4200
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.9019
    Cell Significance Index: -8.3700
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.9139
    Cell Significance Index: -13.0000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.9153
    Cell Significance Index: -28.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Flavin-containing enzyme**: FMO2 is a flavin-containing enzyme, which means it requires FAD as a cofactor to catalyze its reactions. 2. **Monoxygenase activity**: FMO2 exhibits monoxygenase activity, which involves the incorporation of one atom of oxygen into a substrate, resulting in the formation of a hydroxylated product. 3. **Nucleophile hydroxylation**: FMO2 specifically hydroxylates nucleophiles, including compounds such as dimethylaniline and hypotaurine. 4. **Tissue-specific expression**: FMO2 is widely expressed in various tissues, including the lung, liver, and skeletal muscle. **Pathways and Functions:** 1. **Biological oxidations**: FMO2 is involved in the oxidative metabolism of various compounds, including xenobiotics and endogenous substances. 2. **Endoplasmic reticulum membrane**: FMO2 is localized to the endoplasmic reticulum membrane, where it can interact with other enzymes and proteins. 3. **Energy homeostasis**: FMO2 has been implicated in the regulation of fatty acid oxidation, which is an important process for energy homeostasis. 4. **Detoxification**: FMO2 plays a role in the detoxification of various compounds, including xenobiotics and endogenous substances. 5. **Phase I functionalization**: FMO2 is involved in the phase I functionalization of compounds, which involves the introduction of a hydroxyl group into a substrate. **Clinical Significance:** 1. **Lung function**: FMO2 is highly expressed in the lung, where it plays a role in the regulation of fatty acid oxidation and the metabolism of organic acids. 2. **Respiratory diseases**: Alterations in FMO2 expression or activity have been implicated in various respiratory diseases, including chronic obstructive pulmonary disease (COPD) and asthma. 3. **Cancer**: FMO2 has been shown to play a role in the detoxification of carcinogens, and alterations in its expression or activity may contribute to the development of cancer. 4. **Neurological disorders**: FMO2 has been implicated in the regulation of fatty acid oxidation and the metabolism of organic acids, which may contribute to the development of neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, FMO2 is an important enzyme involved in the oxidative metabolism and detoxification of various compounds, and its dysregulation has been implicated in various diseases, including respiratory diseases, cancer, and neurological disorders. Further studies are needed to fully understand the role of FMO2 in human health and disease.

Genular Protein ID: 3253330861

Symbol: FMO2_HUMAN

Name: Dimethylaniline oxidase 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9804831

Title: The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein.

PubMed ID: 9804831

DOI: 10.1074/jbc.273.46.30599

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11042094

Title: Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans.

PubMed ID: 11042094

DOI: 10.1006/taap.2000.9050

PubMed ID: 15294458

Title: S-oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2.

PubMed ID: 15294458

DOI: 10.1016/j.bcp.2004.05.051

PubMed ID: 15144220

Title: Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione.

PubMed ID: 15144220

DOI: 10.1021/tx034253s

PubMed ID: 18930751

Title: Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes.

PubMed ID: 18930751

DOI: 10.1016/j.taap.2008.09.017

PubMed ID: 18948378

Title: Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.

PubMed ID: 18948378

DOI: 10.1124/dmd.108.024158

PubMed ID: 20388717

Title: In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.

PubMed ID: 20388717

DOI: 10.1074/jbc.m110.106955

PubMed ID: 12527699

Title: Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.

PubMed ID: 12527699

DOI: 10.1124/dmd.31.2.187

PubMed ID: 18794725

Title: The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa.

PubMed ID: 18794725

DOI: 10.1097/fpc.0b013e3283097311

Sequence Information:

  • Length: 535
  • Mass: 60907
  • Checksum: 39A5587AC7BF50B8
  • Sequence:
  • MAKKVAVIGA GVSGLISLKC CVDEGLEPTC FERTEDIGGV WRFKENVEDG RASIYQSVVT 
    NTSKEMSCFS DFPMPEDFPN FLHNSKLLEY FRIFAKKFDL LKYIQFQTTV LSVRKCPDFS 
    SSGQWKVVTQ SNGKEQSAVF DAVMVCSGHH ILPHIPLKSF PGMERFKGQY FHSRQYKHPD 
    GFEGKRILVI GMGNSGSDIA VELSKNAAQV FISTRHGTWV MSRISEDGYP WDSVFHTRFR 
    SMLRNVLPRT AVKWMIEQQM NRWFNHENYG LEPQNKYIMK EPVLNDDVPS RLLCGAIKVK 
    STVKELTETS AIFEDGTVEE NIDVIIFATG YSFSFPFLED SLVKVENNMV SLYKYIFPAH 
    LDKSTLACIG LIQPLGSIFP TAELQARWVT RVFKGLCSLP SERTMMMDII KRNEKRIDLF 
    GESQSQTLQT NYVDYLDELA LEIGAKPDFC SLLFKDPKLA VRLYFGPCNS YQYRLVGPGQ 
    WEGARNAIFT QKQRILKPLK TRALKDSSNF SVSFLLKILG LLAVVVAFFC QLQWS

Genular Protein ID: 1802205996

Symbol: Q5JPC7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 471
  • Mass: 53610
  • Checksum: 76084CCD709FE948
  • Sequence:
  • MAKKVAVIGA GVSGLISLKC CVDEGLEPTC FERTEDIGGV WRFKENVEDG RASIYQSVVT 
    NTSKEMSCFS DLPMPEDFPN FLHNSKLLEY FRIFAKKFDL LKYIQFQTTV LSVRKCPDFS 
    SSGQWKVVTQ SNGKEQSAVF DAVMVCSGHH ILPHIPLKSF PGMERFKGQY FHSRQYKHPD 
    GFEGKRILVI GMGNSGSDIA VELSKNAAQV FISTRHGTWV MSRISEDGYP WDSVFHTRFR 
    SMLRNVLPRT AVKWMIEQQM NRWFNHENYG LEPQNKYIMK EPVLNDDVPS RLLCGAIKVK 
    STVKELTETS AIFEDGTVEE NIDVIIFATG YSFSFPFLED SLVKVENNMV SLYKYIFPAH 
    LDKSTLACIG LIQPLGSIFP TAELQARWVT RVFKGLCSLP SERTMMMDII KRNEKRIDLF 
    GESQSQTLQT NYVDYLDELA LEIGAKPDFC SLLFKDPKLA VRLYFGPCNS Y

Genular Protein ID: 705624521

Symbol: B4E2Q9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 251
  • Mass: 28972
  • Checksum: A52523B822C3292B
  • Sequence:
  • MSRISEDGYP WDSVFHTRFR SMLRNVLPRT AVKWMIEQQM NRWFNHENYG LEPQNKYIMK 
    EPVLNDDVPS RLLCGAIKVK STVKELTETS AIFEDGTVEE NIDVIIFATG YSFSFPFLED 
    SLVKVENNMV SLYKYIFPAH LDKSTLACIG LIQPLGSIFP TAELQARWVT RVFKGLCSLP 
    SERTMMMDII KRNEKRIDLF GESQSQTLQT NYVDYLDELA LEIGAKPDFC SLLFKDPKLA 
    VRLYFGPCNS Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.