Details for: FMO5

Gene ID: 2330

Symbol: FMO5

Ensembl ID: ENSG00000131781

Description: flavin containing dimethylaniline monoxygenase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 76.5051
    Cell Significance Index: -11.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.7228
    Cell Significance Index: -11.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.8610
    Cell Significance Index: -11.7300
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 20.9330
    Cell Significance Index: 14.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.6678
    Cell Significance Index: -11.9200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 6.0603
    Cell Significance Index: 102.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3941
    Cell Significance Index: 475.1200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.6905
    Cell Significance Index: 10.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6807
    Cell Significance Index: 100.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5229
    Cell Significance Index: 69.0300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.2972
    Cell Significance Index: 7.4700
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.8864
    Cell Significance Index: 8.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8486
    Cell Significance Index: 24.4500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.7275
    Cell Significance Index: 2.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7252
    Cell Significance Index: 15.8800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.7167
    Cell Significance Index: 7.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5477
    Cell Significance Index: 63.8300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5257
    Cell Significance Index: 7.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5245
    Cell Significance Index: 51.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4869
    Cell Significance Index: 12.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4413
    Cell Significance Index: 33.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3926
    Cell Significance Index: 24.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3606
    Cell Significance Index: 6.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3414
    Cell Significance Index: 5.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3380
    Cell Significance Index: 12.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3336
    Cell Significance Index: 17.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3266
    Cell Significance Index: 11.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3223
    Cell Significance Index: 6.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3014
    Cell Significance Index: 60.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2930
    Cell Significance Index: 6.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2851
    Cell Significance Index: 12.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2831
    Cell Significance Index: 13.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2635
    Cell Significance Index: 6.3200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2433
    Cell Significance Index: 2.5100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1845
    Cell Significance Index: 2.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1717
    Cell Significance Index: 27.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1548
    Cell Significance Index: 11.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1439
    Cell Significance Index: 1.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1391
    Cell Significance Index: 4.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1144
    Cell Significance Index: 21.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1115
    Cell Significance Index: 77.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0898
    Cell Significance Index: 1.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0847
    Cell Significance Index: 12.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0605
    Cell Significance Index: 21.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0549
    Cell Significance Index: 9.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0280
    Cell Significance Index: 0.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0261
    Cell Significance Index: 19.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0238
    Cell Significance Index: 2.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0206
    Cell Significance Index: 3.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0136
    Cell Significance Index: 25.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0082
    Cell Significance Index: 1.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0075
    Cell Significance Index: 13.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0075
    Cell Significance Index: 11.6200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0018
    Cell Significance Index: 2.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0016
    Cell Significance Index: 1.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0060
    Cell Significance Index: -3.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0061
    Cell Significance Index: -2.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0069
    Cell Significance Index: -3.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0131
    Cell Significance Index: -7.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0136
    Cell Significance Index: -10.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0213
    Cell Significance Index: -13.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0317
    Cell Significance Index: -2.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0355
    Cell Significance Index: -4.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0406
    Cell Significance Index: -0.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0432
    Cell Significance Index: -2.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0435
    Cell Significance Index: -12.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0481
    Cell Significance Index: -6.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0587
    Cell Significance Index: -12.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0598
    Cell Significance Index: -6.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0691
    Cell Significance Index: -1.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0742
    Cell Significance Index: -9.5800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0808
    Cell Significance Index: -1.0200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0943
    Cell Significance Index: -0.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0967
    Cell Significance Index: -10.0700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1001
    Cell Significance Index: -1.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1018
    Cell Significance Index: -2.1800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1026
    Cell Significance Index: -2.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1060
    Cell Significance Index: -12.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1072
    Cell Significance Index: -8.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1131
    Cell Significance Index: -8.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1168
    Cell Significance Index: -3.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1187
    Cell Significance Index: -3.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1232
    Cell Significance Index: -5.7900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1302
    Cell Significance Index: -1.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1328
    Cell Significance Index: -7.4500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1557
    Cell Significance Index: -1.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1648
    Cell Significance Index: -10.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1700
    Cell Significance Index: -2.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1710
    Cell Significance Index: -10.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1916
    Cell Significance Index: -9.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2138
    Cell Significance Index: -6.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2141
    Cell Significance Index: -11.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2212
    Cell Significance Index: -7.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2276
    Cell Significance Index: -7.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2434
    Cell Significance Index: -6.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2465
    Cell Significance Index: -3.5300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2604
    Cell Significance Index: -4.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FMO5 exhibits the following key characteristics: * **Flavin-containing structure:** FMO5 contains a flavin adenine dinucleotide (FAD) cofactor, which is essential for its catalytic activity. * **Monooxygenase activity:** FMO5 possesses monooxygenase activity, which allows it to selectively oxidize one oxygen atom from its substrates, resulting in the formation of a hydroxyl group. * **Substrate specificity:** FMO5 is capable of metabolizing a diverse range of substrates, including aromatic amines, aldehydes, and fatty acids. * **Tissue expression:** FMO5 is highly expressed in the liver, kidney, lung, and other tissues, where it plays a critical role in maintaining normal metabolic homeostasis. **Pathways and Functions:** FMO5 is involved in the following pathways and functions: * **Xenobiotic metabolism:** FMO5 plays a crucial role in the metabolism of xenobiotics, including drugs, environmental pollutants, and other foreign compounds. * **Lipid processing:** FMO5 is involved in the oxidation of fatty acids, which is essential for the regulation of lipid metabolism and the maintenance of normal lipid homeostasis. * **Regulation of cholesterol metabolism:** FMO5 has been shown to regulate cholesterol metabolism by oxidizing cholesterol and its derivatives. * **Regulation of lipid metabolic process:** FMO5 is involved in the regulation of lipid metabolic processes, including the oxidation of fatty acids and the formation of lipid metabolites. **Clinical Significance:** FMO5 has significant clinical implications, particularly in the context of: * **Xenobiotic metabolism:** Abnormalities in FMO5 activity have been linked to the development of various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. * **Lipid disorders:** FMO5 plays a critical role in regulating lipid metabolism, and abnormalities in its activity have been implicated in the development of lipid disorders, such as hyperlipidemia and atherosclerosis. * **Cancer:** FMO5 has been shown to regulate the metabolism of certain carcinogens, and its activity has been linked to the development of various types of cancer. In conclusion, FMO5 is a critical enzyme involved in the metabolism of xenobiotics, lipids, and other endogenous compounds. Its unique flavin-containing structure and monooxygenase activity enable it to catalyze the oxidation of a wide range of substrates, and its tissue-specific expression makes it a key player in maintaining normal metabolic homeostasis. Further research is needed to fully elucidate the clinical significance of FMO5 and its role in various diseases.

Genular Protein ID: 1323066882

Symbol: FMO5_HUMAN

Name: Flavin-containing monooxygenase 5

UniProtKB Accession Codes:

P49326 B2RBG1 C9JJD1 Q8IV22

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 74 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 10 Ensembl 4 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 8 Rhea 20 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7872795

Title: Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog.

PubMed ID: 7872795

DOI: 10.1006/abbi.1995.1163

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20947616

Title: A Baeyer-Villiger oxidation specifically catalyzed by human flavin-containing monooxygenase 5.

PubMed ID: 20947616

DOI: 10.1124/dmd.110.035360

PubMed ID: 26771671

Title: Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans.

PubMed ID: 26771671

DOI: 10.1021/acschembio.5b01016

PubMed ID: 28783300

Title: Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug Metabolism.

PubMed ID: 28783300

DOI: 10.1021/acschembio.7b00470

PubMed ID: 12527699

Title: Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.

PubMed ID: 12527699

DOI: 10.1124/dmd.31.2.187

Sequence Information:

  • Length: 533
  • Mass: 60221
  • Checksum: F9D9F092F1DD71DA
  • Sequence:
    • MTKKRIAVIG GGVSGLSSIK CCVEEGLEPV CFERTDDIGG LWRFQENPEE GRASIYKSVI 
INTSKEMMCF SDYPIPDHYP NFMHNAQVLE YFRMYAKEFD LLKYIRFKTT VCSVKKQPDF 
ATSGQWEVVT ESEGKKEMNV FDGVMVCTGH HTNAHLPLES FPGIEKFKGQ YFHSRDYKNP 
EGFTGKRVII IGIGNSGGDL AVEISQTAKQ VFLSTRRGAW ILNRVGDYGY PADVLFSSRL 
THFIWKICGQ SLANKYLEKK INQRFDHEMF GLKPKHRALS QHPTLNDDLP NRIISGLVKV 
KGNVKEFTET AAIFEDGSRE DDIDAVIFAT GYSFDFPFLE DSVKVVKNKI SLYKKVFPPN 
LERPTLAIIG LIQPLGAIMP ISELQGRWAT QVFKGLKTLP SQSEMMAEIS KAQEEIDKRY 
VESQRHTIQG DYIDTMEELA DLVGVRPNLL SLAFTDPKLA LHLLLGPCTP IHYRVQGPGK 
WDGARKAILT TDDRIRKPLM TRVVERSSSM TSTMTIGKFM LALAFFAIII AYF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.