Details for: FNTB

Gene ID: 2342

Symbol: FNTB

Ensembl ID: ENSG00000257365

Description: farnesyltransferase, CAAX box, subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 94.0562
    Cell Significance Index: -14.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.9016
    Cell Significance Index: -14.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 30.7547
    Cell Significance Index: -14.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.6857
    Cell Significance Index: -10.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.3119
    Cell Significance Index: -15.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.8933
    Cell Significance Index: -11.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.0245
    Cell Significance Index: -13.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2412
    Cell Significance Index: 64.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1900
    Cell Significance Index: 238.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9045
    Cell Significance Index: 89.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7678
    Cell Significance Index: 275.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7228
    Cell Significance Index: 31.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7183
    Cell Significance Index: 648.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6898
    Cell Significance Index: 26.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6754
    Cell Significance Index: 37.9000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6184
    Cell Significance Index: 7.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5926
    Cell Significance Index: 45.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5627
    Cell Significance Index: 61.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5409
    Cell Significance Index: 32.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5133
    Cell Significance Index: 83.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4641
    Cell Significance Index: 54.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4508
    Cell Significance Index: 27.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4473
    Cell Significance Index: 11.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4361
    Cell Significance Index: 10.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4109
    Cell Significance Index: 14.2800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.3301
    Cell Significance Index: 4.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3299
    Cell Significance Index: 9.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2854
    Cell Significance Index: 6.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2802
    Cell Significance Index: 19.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2592
    Cell Significance Index: 6.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2319
    Cell Significance Index: 11.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2307
    Cell Significance Index: 43.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2123
    Cell Significance Index: 11.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1780
    Cell Significance Index: 8.0700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1574
    Cell Significance Index: 3.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1334
    Cell Significance Index: 2.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1164
    Cell Significance Index: 33.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1011
    Cell Significance Index: 12.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0863
    Cell Significance Index: 4.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0834
    Cell Significance Index: 15.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0809
    Cell Significance Index: 2.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0607
    Cell Significance Index: 33.1800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0514
    Cell Significance Index: 0.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0341
    Cell Significance Index: 15.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0292
    Cell Significance Index: 5.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0216
    Cell Significance Index: 0.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0119
    Cell Significance Index: 1.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0028
    Cell Significance Index: -0.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0077
    Cell Significance Index: -14.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0099
    Cell Significance Index: -15.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0105
    Cell Significance Index: -14.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0130
    Cell Significance Index: -8.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0167
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0167
    Cell Significance Index: -12.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0179
    Cell Significance Index: -0.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0224
    Cell Significance Index: -10.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0239
    Cell Significance Index: -13.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0243
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0287
    Cell Significance Index: -17.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0290
    Cell Significance Index: -1.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0373
    Cell Significance Index: -2.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0381
    Cell Significance Index: -3.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0447
    Cell Significance Index: -0.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0484
    Cell Significance Index: -1.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0582
    Cell Significance Index: -7.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0605
    Cell Significance Index: -10.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0675
    Cell Significance Index: -7.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0749
    Cell Significance Index: -8.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0750
    Cell Significance Index: -15.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0801
    Cell Significance Index: -11.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0961
    Cell Significance Index: -6.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1086
    Cell Significance Index: -7.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1220
    Cell Significance Index: -7.4800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1227
    Cell Significance Index: -1.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1275
    Cell Significance Index: -9.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1369
    Cell Significance Index: -3.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1441
    Cell Significance Index: -15.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1496
    Cell Significance Index: -11.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1504
    Cell Significance Index: -3.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1539
    Cell Significance Index: -10.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1620
    Cell Significance Index: -5.1900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2131
    Cell Significance Index: -2.6900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2519
    Cell Significance Index: -3.6100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2526
    Cell Significance Index: -2.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2528
    Cell Significance Index: -6.8800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2574
    Cell Significance Index: -4.4500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2669
    Cell Significance Index: -2.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2743
    Cell Significance Index: -8.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2971
    Cell Significance Index: -8.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3198
    Cell Significance Index: -2.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3283
    Cell Significance Index: -12.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3377
    Cell Significance Index: -9.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3394
    Cell Significance Index: -10.8100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3395
    Cell Significance Index: -7.0900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3488
    Cell Significance Index: -4.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3495
    Cell Significance Index: -5.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3524
    Cell Significance Index: -7.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Farnesyltransferase activity:** The FNTB gene encodes a subunit of the farnesyltransferase complex, which catalyzes the post-translational modification of proteins by adding a farnesyl group to their C-terminus. 2. **CAAX box:** The FNTB gene contains a CAAX box, a specific sequence motif that is essential for the recognition and processing of Ras proteins by the farnesyltransferase complex. 3. **Signaling pathways:** The FNTB gene is involved in various signaling pathways, including the MAPK1/3 cascade, Ras processing, and the phototransduction cascade, which regulate cellular responses to stimuli. 4. **Cellular localization:** The FNTB gene is expressed in multiple cell types, including neurons, astrocytes, and immune cells, highlighting its broader role in cellular function. **Pathways and Functions:** 1. **MAPK1/3 signaling cascade:** The FNTB gene is involved in the regulation of the MAPK1/3 signaling cascade, which plays a crucial role in cellular responses to stress, inflammation, and immune responses. 2. **Ras processing:** The FNTB gene is essential for the proper processing and activation of Ras proteins, which are key regulators of cellular signaling pathways. 3. **Phototransduction cascade:** The FNTB gene is involved in the regulation of the phototransduction cascade, which is responsible for the transduction of light signals in the retina. 4. **Protein farnesylation:** The FNTB gene encodes a subunit of the farnesyltransferase complex, which catalyzes the post-translational modification of proteins by adding a farnesyl group to their C-terminus. **Clinical Significance:** 1. **Infectious diseases:** The FNTB gene has been implicated in the regulation of viral infections, including SARS-CoV, highlighting its potential as a therapeutic target. 2. **Neurological disorders:** The FNTB gene has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its role in neurodegenerative processes. 3. **Immune system regulation:** The FNTB gene is involved in the regulation of the immune system, including the activation of immune cells and the regulation of inflammatory responses. 4. **Potential therapeutics:** The FNTB gene has been identified as a potential therapeutic target for the treatment of various diseases, including SARS-CoV infections and neurological disorders. In conclusion, the FNTB gene plays a complex and multifaceted role in cellular function, including protein farnesylation, signal transduction, and immune regulation. Its involvement in various signaling pathways and its potential as a therapeutic target make it an area of significant interest for further research.

Genular Protein ID: 1338802992

Symbol: A0A384MEJ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A384MEJ5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 4 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 Pfam 1 RefSeq 1 Rhea 3 RuleBase 1 SFLD 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 437
  • Mass: 48774
  • Checksum: 8E8E571846146709
  • Sequence:
    • MASPSSFTYY CPPSSSPVWS EPLYSLRPEH ARERLQDDSV ETVTSIEQAK VEEKIQEVFS 
SYKFNHLVPR LVLQREKHFH YLKRGLRQLT DAYECLDASR PWLCYWILHS LELLDEPIPQ 
IVATDVCQFL ELCQSPEGGF GGGPGQYPHL APTYAAVNAL CIIGTEEAYD IINREKLLQY 
LYSLKQPDGS FLMHVGGEVD VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG 
GVPGMEAHGG YTFCGLAALV ILKRERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY 
SFWQAGLLPL LHRALHAQGD PALSMSHWMF HQQALQEYIL MCCQCPAGGL LDKPGKSRDF 
YHTCYCLSGL SIAQHFGSGA MLHDVVLGVP ENALQPTHPV YNIGPDKVIQ ATTYFLQKPV 
PGFEELKDET SAEPATD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.