Details for: FOLR3

Gene ID: 2352

Symbol: FOLR3

Ensembl ID: ENSG00000110203

Description: folate receptor gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 2.2076
    Cell Significance Index: 7.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.1020
    Cell Significance Index: 38.8500
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.8647
    Cell Significance Index: 7.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4246
    Cell Significance Index: 6.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.2330
    Cell Significance Index: -0.5100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.2218
    Cell Significance Index: 0.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1636
    Cell Significance Index: 12.9600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1605
    Cell Significance Index: 2.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1044
    Cell Significance Index: 76.5400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.0980
    Cell Significance Index: 0.6500
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.0317
    Cell Significance Index: 0.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0099
    Cell Significance Index: 0.2500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -4.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -3.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0038
    Cell Significance Index: -2.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0038
    Cell Significance Index: -2.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0045
    Cell Significance Index: -1.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0049
    Cell Significance Index: -2.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0051
    Cell Significance Index: -3.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0067
    Cell Significance Index: -1.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0078
    Cell Significance Index: -2.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0079
    Cell Significance Index: -0.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0080
    Cell Significance Index: -3.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0105
    Cell Significance Index: -2.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0115
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0185
    Cell Significance Index: -3.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0193
    Cell Significance Index: -3.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0216
    Cell Significance Index: -2.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0218
    Cell Significance Index: -3.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0246
    Cell Significance Index: -3.0200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0250
    Cell Significance Index: -0.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0252
    Cell Significance Index: -0.3900
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0260
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0272
    Cell Significance Index: -3.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0277
    Cell Significance Index: -2.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0309
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0325
    Cell Significance Index: -3.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0368
    Cell Significance Index: -0.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0448
    Cell Significance Index: -0.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0491
    Cell Significance Index: -3.7700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0518
    Cell Significance Index: -0.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0524
    Cell Significance Index: -3.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0537
    Cell Significance Index: -3.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0558
    Cell Significance Index: -3.6000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0580
    Cell Significance Index: -0.6900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0590
    Cell Significance Index: -0.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0652
    Cell Significance Index: -3.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0675
    Cell Significance Index: -1.8100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0712
    Cell Significance Index: -1.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0733
    Cell Significance Index: -4.6200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0791
    Cell Significance Index: -1.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0796
    Cell Significance Index: -3.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0798
    Cell Significance Index: -2.8000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0801
    Cell Significance Index: -1.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0818
    Cell Significance Index: -4.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0825
    Cell Significance Index: -3.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0849
    Cell Significance Index: -2.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0871
    Cell Significance Index: -2.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0904
    Cell Significance Index: -2.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0918
    Cell Significance Index: -2.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0942
    Cell Significance Index: -2.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0948
    Cell Significance Index: -2.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0961
    Cell Significance Index: -3.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0978
    Cell Significance Index: -3.5900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0985
    Cell Significance Index: -1.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0986
    Cell Significance Index: -3.1400
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1047
    Cell Significance Index: -1.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1050
    Cell Significance Index: -3.6900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1055
    Cell Significance Index: -1.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1061
    Cell Significance Index: -2.6500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1074
    Cell Significance Index: -1.1600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1075
    Cell Significance Index: -1.5400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1086
    Cell Significance Index: -1.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1096
    Cell Significance Index: -2.4000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1106
    Cell Significance Index: -1.4700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1143
    Cell Significance Index: -1.0300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1149
    Cell Significance Index: -1.1000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1179
    Cell Significance Index: -2.9400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1181
    Cell Significance Index: -1.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1235
    Cell Significance Index: -2.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1241
    Cell Significance Index: -3.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1251
    Cell Significance Index: -3.5700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1254
    Cell Significance Index: -1.7600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1257
    Cell Significance Index: -3.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1291
    Cell Significance Index: -3.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1293
    Cell Significance Index: -3.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1323
    Cell Significance Index: -0.9000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1330
    Cell Significance Index: -2.0200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1365
    Cell Significance Index: -2.2100
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.1369
    Cell Significance Index: -0.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1384
    Cell Significance Index: -2.9900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1404
    Cell Significance Index: -2.4000
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1413
    Cell Significance Index: -1.5100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1419
    Cell Significance Index: -2.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FOLR3 is a member of the Folate Receptor Family, which consists of three subtypes: FOLR1, FOLR2, and FOLR3. FOLR3 is characterized by its high affinity for folate, a B-vitamin essential for DNA synthesis, repair, and methylation. This receptor is expressed on various cell types, including immune cells, epithelial cells, and neural cells. FOLR3 is a type II transmembrane glycoprotein with two extracellular domains, which facilitate binding to folate and other ligands. **Pathways and Functions:** FOLR3 is involved in multiple signaling pathways, including: 1. **Folic acid binding and transport**: FOLR3 mediates the uptake of folate across cell membranes, regulating its availability for DNA synthesis, repair, and methylation. 2. **Cell adhesion**: FOLR3 interacts with other cell surface molecules, influencing cell-to-cell adhesion and migration. 3. **Immune system regulation**: FOLR3 is expressed on immune cells, such as monocytes and T cells, where it modulates immune responses and cell activation. 4. **Sperm-egg recognition**: FOLR3 is involved in fertilization, where it facilitates the fusion of sperm and egg plasma membranes. 5. **Neuronal signaling**: FOLR3 is expressed on GABAergic interneurons in the cerebral cortex, where it regulates neuronal signaling and synaptic plasticity. **Clinical Significance:** Dysregulation of FOLR3 has been implicated in various diseases, including: 1. **Cancer**: FOLR3 overexpression is observed in certain types of cancer, such as ovarian and breast cancer, where it may contribute to tumor growth and metastasis. 2. **Neurological disorders**: FOLR3 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it may play a role in neuronal signaling and synaptic dysfunction. 3. **Infectious diseases**: FOLR3 is involved in the immune response to infections, such as malaria, where it regulates the uptake of folate by infected red blood cells. 4. **Birth defects**: FOLR3 mutations have been associated with congenital anomalies, such as spina bifida and neural tube defects, where folate deficiency may contribute to embryonic development. In conclusion, FOLR3 is a multifunctional receptor that plays a crucial role in folate transport, immune regulation, and cell adhesion. Its dysregulation has been implicated in various diseases, highlighting the importance of FOLR3 in maintaining cellular homeostasis and overall health. Further research is needed to elucidate the mechanisms underlying FOLR3's functions and to explore its therapeutic potential in disease treatment.

Genular Protein ID: 4190732571

Symbol: FOLR3_HUMAN

Name: Folate receptor gamma

UniProtKB Accession Codes:

P41439 A0A087WXH3 J3KQ90 Q05C14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8110752

Title: Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity.

PubMed ID: 8110752

DOI: 10.1021/bi00171a021

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7727426

Title: Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity.

PubMed ID: 7727426

DOI: 10.1021/bi00016a042

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

Sequence Information:

  • Length: 245
  • Mass: 27885
  • Checksum: 478636F757EC40DB
  • Sequence:
    • MDMAWQMMQL LLLALVTAAG SAQPRSARAR TDLLNVCMNA KHHKTQPSPE DELYGQCSPW 
KKNACCTAST SQELHKDTSR LYNFNWDHCG KMEPTCKRHF IQDSCLYECS PNLGPWIRQV 
NQSWRKERIL NVPLCKEDCE RWWEDCRTSY TCKSNWHKGW NWTSGINECP AGALCSTFES 
YFPTPAALCE GLWSHSFKVS NYSRGSGRCI QMWFDSAQGN PNEEVAKFYA AAMNAGAPSR 
GIIDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.