Details for: FOLR3

Gene ID: 2352

Symbol: FOLR3

Ensembl ID: ENSG00000110203

Description: folate receptor gamma

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 4.16
    Marker Score: 4125.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.76
    Marker Score: 3329
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.65
    Marker Score: 4429
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.57
    Marker Score: 3903
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.35
    Marker Score: 1432
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2486
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.18
    Marker Score: 66257
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7398
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.99
    Marker Score: 2516
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.99
    Marker Score: 429
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.95
    Marker Score: 596.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14621
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.86
    Marker Score: 21921
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 627
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 484
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.74
    Marker Score: 1053
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.74
    Marker Score: 751
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.72
    Marker Score: 1196
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.63
    Marker Score: 274
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.63
    Marker Score: 446
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 281
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 461
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.46
    Marker Score: 244
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.42
    Marker Score: 218.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.42
    Marker Score: 1056
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.42
    Marker Score: 185
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.42
    Marker Score: 4829
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.4
    Marker Score: 1655
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.38
    Marker Score: 606
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.38
    Marker Score: 406
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 113
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.34
    Marker Score: 142.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.31
    Marker Score: 304
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.29
    Marker Score: 1780
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.28
    Marker Score: 66
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.28
    Marker Score: 96
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.28
    Marker Score: 359
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.27
    Marker Score: 524
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.27
    Marker Score: 631
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.27
    Marker Score: 162
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.26
    Marker Score: 117
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.26
    Marker Score: 164
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 102
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.23
    Marker Score: 71
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.22
    Marker Score: 567
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.22
    Marker Score: 159
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.22
    Marker Score: 123.5
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.21
    Marker Score: 104
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.21
    Marker Score: 233
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.2
    Marker Score: 484
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.2
    Marker Score: 116
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.19
    Marker Score: 195
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.19
    Marker Score: 124
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.19
    Marker Score: 50
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.18
    Marker Score: 126
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.18
    Marker Score: 91
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.17
    Marker Score: 186.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.17
    Marker Score: 130
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.16
    Marker Score: 111
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.15
    Marker Score: 145
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 131
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.15
    Marker Score: 91
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.14
    Marker Score: 34424
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.14
    Marker Score: 183
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 130
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.14
    Marker Score: 221
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.13
    Marker Score: 27
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.13
    Marker Score: 131
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.12
    Marker Score: 124
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.12
    Marker Score: 272
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.12
    Marker Score: 156
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.11
    Marker Score: 77
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 58
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 27

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Other Information

**Key characteristics:** * FolR3 is a single-pass transmembrane protein with a molecular weight of approximately 120 kDa. * It is a member of the folate receptor family of cell surface receptors. * FolR3 is expressed in high levels in cells that are involved in cell adhesion, such as endothelial cells and epithelial cells. * It is also expressed in cells of the immune system, including neutrophils, macrophages, and dendritic cells. * FolR3 is a key regulator of cell adhesion and migration. It is involved in the formation of cell contacts with other cells and in the regulation of cell migration. * FolR3 is also involved in the regulation of the immune system. It is expressed on immune cells, and it is involved in the recognition of foreign pathogens. * FolR3 is a key regulator of embryonic development. It is expressed in early-stage embryos, and it is required for the development of the cardiovascular and nervous systems. **Pathways and functions:** * FolR3 is a key regulator of cell adhesion and migration. It is involved in the formation of cell contacts with other cells and in the regulation of cell migration. * FolR3 is also involved in the regulation of the immune system. It is expressed on immune cells, and it is involved in the recognition of foreign pathogens. * FolR3 is a key regulator of embryonic development. It is expressed in early-stage embryos, and it is required for the development of the cardiovascular and nervous systems. **Clinical significance:** Mutations in the FOLR3 gene have been linked to a number of human diseases, including birth defects, developmental disorders, and cancer. These mutations can disrupt the normal function of FOLR3, leading to a variety of health problems. **Additional information:** * FolR3 is a highly conserved protein, with similar sequences found in organisms from humans to flies. * FolR3 is a member of the folate receptor family of cell surface receptors. FolR1 and FolR2 are other members of this family. * FolR3 is a type I transmembrane receptor, which means that it has a single transmembrane domain. * FolR3 is a ligand for the chemokine CXCR4. * FolR3 is a key regulator of cell adhesion and migration.

Genular Protein ID: 4190732571

Symbol: FOLR3_HUMAN

Name: Folate receptor gamma

UniProtKB Accession Codes:

P41439 A0A087WXH3 J3KQ90 Q05C14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8110752

Title: Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity.

PubMed ID: 8110752

DOI: 10.1021/bi00171a021

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7727426

Title: Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity.

PubMed ID: 7727426

DOI: 10.1021/bi00016a042

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

Sequence Information:

  • Length: 245
  • Mass: 27885
  • Checksum: 478636F757EC40DB
  • Sequence:
    • MDMAWQMMQL LLLALVTAAG SAQPRSARAR TDLLNVCMNA KHHKTQPSPE DELYGQCSPW 
KKNACCTAST SQELHKDTSR LYNFNWDHCG KMEPTCKRHF IQDSCLYECS PNLGPWIRQV 
NQSWRKERIL NVPLCKEDCE RWWEDCRTSY TCKSNWHKGW NWTSGINECP AGALCSTFES 
YFPTPAALCE GLWSHSFKVS NYSRGSGRCI QMWFDSAQGN PNEEVAKFYA AAMNAGAPSR 
GIIDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.