Details for: FRZB

Gene ID: 2487

Symbol: FRZB

Ensembl ID: ENSG00000162998

Description: frizzled related protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.74
    Marker Score: 1950
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.52
    Marker Score: 3492
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.36
    Marker Score: 2254
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.29
    Marker Score: 1208
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.08
    Marker Score: 706
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.86
    Marker Score: 24587
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.63
    Marker Score: 3072
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.5
    Marker Score: 439
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.5
    Marker Score: 437
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 859
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.27
    Marker Score: 8265
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.19
    Marker Score: 303
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.16
    Marker Score: 993
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.16
    Marker Score: 260
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4795
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.14
    Marker Score: 814
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.05
    Marker Score: 1268
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.03
    Marker Score: 602
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.99
    Marker Score: 948
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.98
    Marker Score: 2302
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.98
    Marker Score: 922
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.97
    Marker Score: 276
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.96
    Marker Score: 1102
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.95
    Marker Score: 251
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.9
    Marker Score: 374
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.89
    Marker Score: 745.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5087
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5277
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.86
    Marker Score: 1756
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.86
    Marker Score: 2244
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.8
    Marker Score: 4762.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.76
    Marker Score: 808
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 680
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.74
    Marker Score: 388
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 701
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.71
    Marker Score: 325
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.67
    Marker Score: 616
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.66
    Marker Score: 299
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.66
    Marker Score: 908
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10226
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.64
    Marker Score: 406
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.64
    Marker Score: 786.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.63
    Marker Score: 421
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1181
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.62
    Marker Score: 21119
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.61
    Marker Score: 1248
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.61
    Marker Score: 179
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.6
    Marker Score: 394
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.59
    Marker Score: 350
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.56
    Marker Score: 210
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.55
    Marker Score: 365
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 230
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.55
    Marker Score: 3278
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.52
    Marker Score: 147
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.51
    Marker Score: 713
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.5
    Marker Score: 565
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.49
    Marker Score: 959
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 293
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 232
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.47
    Marker Score: 800.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.47
    Marker Score: 148
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.46
    Marker Score: 536
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 440
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.43
    Marker Score: 2864.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.43
    Marker Score: 310
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.41
    Marker Score: 15044
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.39
    Marker Score: 98
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.39
    Marker Score: 98
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.37
    Marker Score: 253
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.36
    Marker Score: 343
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.36
    Marker Score: 1014
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.35
    Marker Score: 153
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.35
    Marker Score: 141
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.34
    Marker Score: 366
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.34
    Marker Score: 368
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.33
    Marker Score: 403
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.33
    Marker Score: 211
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.33
    Marker Score: 175
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.32
    Marker Score: 11197
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.32
    Marker Score: 103
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.32
    Marker Score: 241
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.32
    Marker Score: 1322
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.31
    Marker Score: 474
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.31
    Marker Score: 91

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Other Information

**Key characteristics:** - FRZB is a secreted protein that is expressed in various cell types, including kidney interstitial cells, hematopoietic stem cells, and mesenchymal cells. - It is known to be a key regulator of organogenesis, tissue development, and cancer. - It is a secreted protein that acts as a signaling molecule and is involved in cell-cell interactions. **Pathways and functions:** - The canonical wnt signaling pathway is a key regulator of cell proliferation, differentiation, and apoptosis. - The non-canonical wnt signaling pathway is involved in cell survival, proliferation, and differentiation. - FRZB negatively regulates the canonical wnt pathway by interacting with the Wnt co-receptor LRP6. - It also positively regulates the non-canonical wnt pathway by binding to Wnt proteins and facilitating their degradation. - FRZB has been shown to play a role in embryonic development, tissue homeostasis, and cancer. **Clinical significance:** - Mutations in the FRZB gene have been linked to several human diseases, including kidney diseases, cancer, and developmental disorders. - Targeting FRZB has emerged as a potential therapeutic strategy for these diseases. - FRZB inhibitors are being investigated as novel drugs to treat cancer and other diseases that are characterized by abnormal cell growth and proliferation. **Additional information:** - The FRZB gene is located on chromosome 17q21.1. - It is a large gene with a complex structure. - It contains multiple alternatively spliced transcripts that encode different isoforms of the FRZB protein.

Genular Protein ID: 1853531258

Symbol: SFRP3_HUMAN

Name: Secreted frizzled-related protein 3

UniProtKB Accession Codes:

Q92765 O00181 Q99686

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8824257

Title: Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis.

PubMed ID: 8824257

DOI: 10.1074/jbc.271.42.26131

PubMed ID: 9178261

Title: Fritz: a secreted frizzled-related protein that inhibits Wnt activity.

PubMed ID: 9178261

DOI: 10.1016/s0925-4773(97)00035-x

PubMed ID: 9118218

Title: Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.

PubMed ID: 9118218

DOI: 10.1016/s0092-8674(00)81921-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 19188438

Title: Myocilin is a modulator of Wnt signaling.

PubMed ID: 19188438

DOI: 10.1128/mcb.01274-08

PubMed ID: 15210948

Title: Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

PubMed ID: 15210948

DOI: 10.1073/pnas.0403456101

Sequence Information:

  • Length: 325
  • Mass: 36254
  • Checksum: 8337C51BBA9A4B07
  • Sequence:
    • MVCGSPGGML LLRAGLLALA ALCLLRVPGA RAAACEPVRI PLCKSLPWNM TKMPNHLHHS 
TQANAILAIE QFEGLLGTHC SPDLLFFLCA MYAPICTIDF QHEPIKPCKS VCERARQGCE 
PILIKYRHSW PENLACEELP VYDRGVCISP EAIVTADGAD FPMDSSNGNC RGASSERCKC 
KPIRATQKTY FRNNYNYVIR AKVKEIKTKC HDVTAVVEVK EILKSSLVNI PRDTVNLYTS 
SGCLCPPLNV NEEYIIMGYE DEERSRLLLV EGSIAEKWKD RLGKKVKRWD MKLRHLGLSK 
SDSSNSDSTQ SQKSGRNSNP RQARN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.