Details for: FRZB

Gene ID: 2487

Symbol: FRZB

Ensembl ID: ENSG00000162998

Description: frizzled related protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 38.2528
    Cell Significance Index: -18.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 27.3463
    Cell Significance Index: -18.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 6.1788
    Cell Significance Index: 898.1600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 4.1964
    Cell Significance Index: 48.3300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.5438
    Cell Significance Index: 20.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.9454
    Cell Significance Index: 560.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.4712
    Cell Significance Index: 26.8700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.9201
    Cell Significance Index: 24.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2299
    Cell Significance Index: 143.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2003
    Cell Significance Index: 63.0200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.1825
    Cell Significance Index: 5.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1100
    Cell Significance Index: 1002.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0668
    Cell Significance Index: 116.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0442
    Cell Significance Index: 169.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.9798
    Cell Significance Index: 11.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8038
    Cell Significance Index: 16.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7997
    Cell Significance Index: 48.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6698
    Cell Significance Index: 296.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6001
    Cell Significance Index: 41.5000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5336
    Cell Significance Index: 9.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5049
    Cell Significance Index: 49.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4593
    Cell Significance Index: 58.8800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.3816
    Cell Significance Index: 2.4000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.2899
    Cell Significance Index: 2.2300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.2777
    Cell Significance Index: 1.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2313
    Cell Significance Index: 6.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1963
    Cell Significance Index: 107.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1915
    Cell Significance Index: 121.6300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1869
    Cell Significance Index: 1.5700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1644
    Cell Significance Index: 3.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1519
    Cell Significance Index: 9.5800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.1212
    Cell Significance Index: 0.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0846
    Cell Significance Index: 16.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0600
    Cell Significance Index: 1.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0504
    Cell Significance Index: 34.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0437
    Cell Significance Index: 15.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0229
    Cell Significance Index: 1.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0156
    Cell Significance Index: 29.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0077
    Cell Significance Index: 3.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0053
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0065
    Cell Significance Index: -4.0900
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.0067
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0107
    Cell Significance Index: -16.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0114
    Cell Significance Index: -21.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0152
    Cell Significance Index: -20.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0188
    Cell Significance Index: -10.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0241
    Cell Significance Index: -18.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0242
    Cell Significance Index: -3.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0248
    Cell Significance Index: -18.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0253
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0325
    Cell Significance Index: -6.8500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0415
    Cell Significance Index: -0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0484
    Cell Significance Index: -13.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0498
    Cell Significance Index: -1.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0547
    Cell Significance Index: -2.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0598
    Cell Significance Index: -7.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0679
    Cell Significance Index: -11.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0710
    Cell Significance Index: -14.0900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0744
    Cell Significance Index: -0.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0762
    Cell Significance Index: -13.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0780
    Cell Significance Index: -10.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0858
    Cell Significance Index: -5.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0879
    Cell Significance Index: -1.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1015
    Cell Significance Index: -10.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1191
    Cell Significance Index: -2.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1244
    Cell Significance Index: -15.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1274
    Cell Significance Index: -4.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1309
    Cell Significance Index: -14.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1387
    Cell Significance Index: -14.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1509
    Cell Significance Index: -17.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1518
    Cell Significance Index: -9.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1770
    Cell Significance Index: -12.5200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2049
    Cell Significance Index: -3.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2156
    Cell Significance Index: -14.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2178
    Cell Significance Index: -16.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2223
    Cell Significance Index: -10.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2304
    Cell Significance Index: -6.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2360
    Cell Significance Index: -17.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2970
    Cell Significance Index: -6.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3099
    Cell Significance Index: -12.7000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.3516
    Cell Significance Index: -1.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3676
    Cell Significance Index: -16.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3677
    Cell Significance Index: -19.1000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3737
    Cell Significance Index: -3.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3799
    Cell Significance Index: -19.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4229
    Cell Significance Index: -10.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4257
    Cell Significance Index: -19.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4463
    Cell Significance Index: -15.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4481
    Cell Significance Index: -16.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4503
    Cell Significance Index: -11.8400
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.4633
    Cell Significance Index: -2.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4850
    Cell Significance Index: -16.9900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4904
    Cell Significance Index: -5.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4919
    Cell Significance Index: -13.1400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.5067
    Cell Significance Index: -5.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5079
    Cell Significance Index: -5.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FRZB is a secreted protein that belongs to the frizzled-related protein family. It is primarily expressed in various cell types, including kidney interstitial cells, Mueller cells, and hematopoietic stem cells. FRZB's primary function is to bind to Wnt proteins, thereby inhibiting their interaction with Frizzled receptors and preventing the activation of downstream signaling pathways. **Pathways and Functions:** FRZB is involved in several Wnt signaling pathways, including the canonical and non-canonical pathways. In the canonical pathway, FRZB binds to Wnt proteins, preventing their interaction with Frizzled receptors and inhibiting the activation of the beta-catenin-dependent transcriptional complex. In the non-canonical pathway, FRZB interacts with Wnt proteins and the Frizzled receptors, modulating the activity of the planar cell polarity (PCP) pathway. FRZB's regulatory functions extend beyond Wnt signaling, as it also modulates the activity of other signaling pathways, including the apoptotic process and cell growth. **Clinical Significance:** Dysregulation of Wnt signaling pathways has been implicated in various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. FRZB's role in modulating Wnt signaling pathways makes it a potential therapeutic target for the treatment of these diseases. Additionally, FRZB's involvement in cellular development and differentiation processes highlights its importance in maintaining tissue homeostasis. Alterations in FRZB expression have been observed in various diseases, including cancer, where it is often associated with poor prognosis. **Significantly Expressed Cells:** FRZB is expressed in various cell types, including: * Kidney interstitial cells * Mueller cells * Renal interstitial pericytes * Hematopoietic stem cells * Pigmented ciliary epithelial cells * Mesodermal cells * Supporting cells * Tracheobronchial smooth muscle cells * Non-pigmented ciliary epithelial cells * Granulocyte monocyte progenitor cells In conclusion, FRZB plays a crucial role in regulating Wnt signaling pathways and cellular development, highlighting its importance in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which FRZB modulates Wnt signaling pathways and its clinical significance in various diseases.

Genular Protein ID: 1853531258

Symbol: SFRP3_HUMAN

Name: Secreted frizzled-related protein 3

UniProtKB Accession Codes:

Q92765 O00181 Q99686

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8824257

Title: Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis.

PubMed ID: 8824257

DOI: 10.1074/jbc.271.42.26131

PubMed ID: 9178261

Title: Fritz: a secreted frizzled-related protein that inhibits Wnt activity.

PubMed ID: 9178261

DOI: 10.1016/s0925-4773(97)00035-x

PubMed ID: 9118218

Title: Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.

PubMed ID: 9118218

DOI: 10.1016/s0092-8674(00)81921-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 19188438

Title: Myocilin is a modulator of Wnt signaling.

PubMed ID: 19188438

DOI: 10.1128/mcb.01274-08

PubMed ID: 15210948

Title: Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

PubMed ID: 15210948

DOI: 10.1073/pnas.0403456101

Sequence Information:

  • Length: 325
  • Mass: 36254
  • Checksum: 8337C51BBA9A4B07
  • Sequence:
    • MVCGSPGGML LLRAGLLALA ALCLLRVPGA RAAACEPVRI PLCKSLPWNM TKMPNHLHHS 
TQANAILAIE QFEGLLGTHC SPDLLFFLCA MYAPICTIDF QHEPIKPCKS VCERARQGCE 
PILIKYRHSW PENLACEELP VYDRGVCISP EAIVTADGAD FPMDSSNGNC RGASSERCKC 
KPIRATQKTY FRNNYNYVIR AKVKEIKTKC HDVTAVVEVK EILKSSLVNI PRDTVNLYTS 
SGCLCPPLNV NEEYIIMGYE DEERSRLLLV EGSIAEKWKD RLGKKVKRWD MKLRHLGLSK 
SDSSNSDSTQ SQKSGRNSNP RQARN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.