Details for: GALNT1

Gene ID: 2589

Symbol: GALNT1

Ensembl ID: ENSG00000141429

Description: polypeptide N-acetylgalactosaminyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 379.1180
    Cell Significance Index: -58.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 224.0350
    Cell Significance Index: -56.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 121.2286
    Cell Significance Index: -49.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 113.0087
    Cell Significance Index: -58.1300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.9254
    Cell Significance Index: -62.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.9302
    Cell Significance Index: -49.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.0285
    Cell Significance Index: -60.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.2035
    Cell Significance Index: -59.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.4417
    Cell Significance Index: -50.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.7499
    Cell Significance Index: -34.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.4838
    Cell Significance Index: -61.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.1970
    Cell Significance Index: 29.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5240
    Cell Significance Index: 117.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.4605
    Cell Significance Index: 267.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2710
    Cell Significance Index: 117.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0451
    Cell Significance Index: 368.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8873
    Cell Significance Index: 232.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.4565
    Cell Significance Index: 37.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4480
    Cell Significance Index: 290.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1747
    Cell Significance Index: 641.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1623
    Cell Significance Index: 65.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1574
    Cell Significance Index: 229.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1557
    Cell Significance Index: 51.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1456
    Cell Significance Index: 15.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1014
    Cell Significance Index: 179.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0873
    Cell Significance Index: 390.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0233
    Cell Significance Index: 38.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9203
    Cell Significance Index: 26.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.7239
    Cell Significance Index: 82.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7219
    Cell Significance Index: 32.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6465
    Cell Significance Index: 49.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6337
    Cell Significance Index: 16.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6266
    Cell Significance Index: 433.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5833
    Cell Significance Index: 35.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5056
    Cell Significance Index: 69.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4909
    Cell Significance Index: 217.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4863
    Cell Significance Index: 29.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4676
    Cell Significance Index: 10.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4066
    Cell Significance Index: 52.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3925
    Cell Significance Index: 25.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3691
    Cell Significance Index: 17.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3426
    Cell Significance Index: 44.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1832
    Cell Significance Index: 5.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1817
    Cell Significance Index: 17.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1784
    Cell Significance Index: 9.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1745
    Cell Significance Index: 110.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1681
    Cell Significance Index: 316.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1533
    Cell Significance Index: 26.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1254
    Cell Significance Index: 8.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1053
    Cell Significance Index: 3.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0614
    Cell Significance Index: 55.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0366
    Cell Significance Index: 0.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0359
    Cell Significance Index: 48.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0243
    Cell Significance Index: 11.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0228
    Cell Significance Index: 35.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0043
    Cell Significance Index: 7.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0209
    Cell Significance Index: -13.0300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0233
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0379
    Cell Significance Index: -28.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0490
    Cell Significance Index: -35.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0551
    Cell Significance Index: -41.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0555
    Cell Significance Index: -10.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0596
    Cell Significance Index: -8.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0761
    Cell Significance Index: -0.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0806
    Cell Significance Index: -45.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1405
    Cell Significance Index: -3.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1800
    Cell Significance Index: -37.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1824
    Cell Significance Index: -52.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2437
    Cell Significance Index: -18.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2440
    Cell Significance Index: -24.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2463
    Cell Significance Index: -5.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2861
    Cell Significance Index: -33.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3108
    Cell Significance Index: -7.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3284
    Cell Significance Index: -22.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3329
    Cell Significance Index: -20.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3488
    Cell Significance Index: -41.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3879
    Cell Significance Index: -7.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4257
    Cell Significance Index: -48.5900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4341
    Cell Significance Index: -9.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4487
    Cell Significance Index: -10.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5351
    Cell Significance Index: -55.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6070
    Cell Significance Index: -19.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6682
    Cell Significance Index: -52.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7427
    Cell Significance Index: -12.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8073
    Cell Significance Index: -13.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8079
    Cell Significance Index: -21.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9864
    Cell Significance Index: -28.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0020
    Cell Significance Index: -52.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0091
    Cell Significance Index: -61.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1449
    Cell Significance Index: -39.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1592
    Cell Significance Index: -36.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1784
    Cell Significance Index: -25.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1896
    Cell Significance Index: -38.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.1908
    Cell Significance Index: -27.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2124
    Cell Significance Index: -31.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.2528
    Cell Significance Index: -45.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2707
    Cell Significance Index: -36.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3197
    Cell Significance Index: -46.2300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.3241
    Cell Significance Index: -19.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.3402
    Cell Significance Index: -22.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **O-Linked Glycosylation**: GALNT1 is responsible for the transfer of GalNAc to serine or threonine residues on proteins, resulting in the formation of O-glycans. These modifications play a crucial role in protein stability, localization, and function. 2. **Tissue Expression**: GALNT1 is highly expressed in epithelial cells, neurons, and immune cells, indicating its importance in maintaining tissue homeostasis and immune function. 3. **Mucin Glycosylation**: GALNT1 is involved in the glycosylation of mucins, which are key components of the mucosal barrier. The proper glycosylation of mucins is essential for maintaining the integrity of the epithelial barrier. 4. **Immune Function**: GALNT1 has been implicated in the regulation of immune responses, including the activation of T cells and the production of cytokines. **Pathways and Functions** 1. **Glycosylation Pathway**: GALNT1 is involved in the transfer of GalNAc to serine or threonine residues on proteins, resulting in the formation of O-glycans. This process is essential for protein stability, localization, and function. 2. **Immune Response**: GALNT1 has been implicated in the regulation of immune responses, including the activation of T cells and the production of cytokines. 3. **Mucosal Barrier Function**: GALNT1 is involved in the glycosylation of mucins, which are key components of the mucosal barrier. The proper glycosylation of mucins is essential for maintaining the integrity of the epithelial barrier. 4. **Neurotransmission**: GALNT1 has been implicated in the regulation of neurotransmission, including the glycosylation of neurotransmitter receptors and the modulation of synaptic plasticity. **Clinical Significance** 1. **Cancer**: Alterations in GALNT1 expression have been observed in various cancers, including colorectal, breast, and lung cancer. GALNT1 may play a role in cancer progression and metastasis. 2. **Neurological Disorders**: Alterations in GALNT1 expression have been observed in various neurological disorders, including Alzheimer's disease and Parkinson's disease. GALNT1 may play a role in the regulation of protein aggregation and neurodegeneration. 3. **Immunodeficiency**: Alterations in GALNT1 expression have been observed in individuals with immunodeficiency disorders, including primary immunodeficiency diseases. GALNT1 may play a role in the regulation of immune responses and the maintenance of epithelial barrier function. In conclusion, GALNT1 is a crucial enzyme involved in O-linked glycosylation and immune function. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and immunodeficiency disorders. Further research is needed to fully understand the role of GALNT1 in human disease and to develop therapeutic strategies targeting this enzyme.

Genular Protein ID: 3668781706

Symbol: GALT1_HUMAN

Name: Polypeptide GalNAc transferase 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8690719

Title: cDNA cloning, expression, and chromosomal localization of a human UDP-GalNAc:polypeptide, N-acetylgalactosaminyltransferase.

PubMed ID: 8690719

DOI: 10.1093/oxfordjournals.jbchem.a124947

PubMed ID: 7592619

Title: Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase.

PubMed ID: 7592619

DOI: 10.1074/jbc.270.41.24156

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8727794

Title: Organization of a human UDP-GalNAc:polypeptide, N-acetylgalactosaminyltransferase gene and a related processed pseudogene.

PubMed ID: 8727794

DOI: 10.1093/glycob/6.2.231

PubMed ID: 9295285

Title: Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.

PubMed ID: 9295285

DOI: 10.1074/jbc.272.38.23503

PubMed ID: 9394011

Title: Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus.

PubMed ID: 9394011

DOI: 10.1242/jcs.111.1.45

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 559
  • Mass: 64219
  • Checksum: CD68118CB201EE5B
  • Sequence:
  • MRKFAYCKVV LATSLIWVLL DMFLLLYFSE CNKCDEKKER GLPAGDVLEP VQKPHEGPGE 
    MGKPVVIPKE DQEKMKEMFK INQFNLMASE MIALNRSLPD VRLEGCKTKV YPDNLPTTSV 
    VIVFHNEAWS TLLRTVHSVI NRSPRHMIEE IVLVDDASER DFLKRPLESY VKKLKVPVHV 
    IRMEQRSGLI RARLKGAAVS KGQVITFLDA HCECTVGWLE PLLARIKHDR RTVVCPIIDV 
    ISDDTFEYMA GSDMTYGGFN WKLNFRWYPV PQREMDRRKG DRTLPVRTPT MAGGLFSIDR 
    DYFQEIGTYD AGMDIWGGEN LEISFRIWQC GGTLEIVTCS HVGHVFRKAT PYTFPGGTGQ 
    IINKNNRRLA EVWMDEFKNF FYIISPGVTK VDYGDISSRV GLRHKLQCKP FSWYLENIYP 
    DSQIPRHYFS LGEIRNVETN QCLDNMARKE NEKVGIFNCH GMGGNQVFSY TANKEIRTDD 
    LCLDVSKLNG PVTMLKCHHL KGNQLWEYDP VKLTLQHVNS NQCLDKATEE DSQVPSIRDC 
    NGSRSQQWLL RNVTLPEIF

Genular Protein ID: 3121034876

Symbol: Q05BM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 499
  • Mass: 57337
  • Checksum: 071862AC56C5CF96
  • Sequence:
  • MGKPVVIPKE DQEKMKEMFK INQFNLMASE MIALNRSLPD VRLEGCKTKV YPDNLPTTSV 
    VIVFHNEAWS TLLRTVHSVI NRSPRHMIEE IVLVDDASER DFLKRPLESY VKKLKVPVHV 
    IRMEQRSGLI RARLKGAAVS KGQVITFLDA HCECTVGWLE PLLARIKHDR RTVVCPIIDV 
    ISDDTFEYMA GSDMTYGGFN WKLNFRWYPV PQREMDRRKG DRTLPVRTPT MAGGLFSIDI 
    DYFQEIGTYD AGMDIWGGEN LEISFRIWQC GGTLEIVTCS HVGHVFRKAT PYTFPGGTGQ 
    IINKNNRRLA EVWMDEFKNF FYIISPGVTK VDYGDISSRV GLRHKLQCKP FSWYLENIYP 
    DSQIPRHYFS LGEIRNVETN QCLDNMARKE NEKVGIFNCH GMGGNQVFSY TANKEIRTDD 
    LCLDVSKLNG PVTMLKCHHL KGNQLWEYDP VKLTLQHVNS NQCLDKATEE DSQVPSIRDC 
    NGSRSQQWLL RNVTLPEIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.