Details for: GALNT1

Gene ID: 2589

Symbol: GALNT1

Ensembl ID: ENSG00000141429

Description: polypeptide N-acetylgalactosaminyltransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.07
    Marker Score: 3047
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2
    Marker Score: 18766
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.95
    Marker Score: 4439
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.94
    Marker Score: 1320
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.89
    Marker Score: 69746
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.85
    Marker Score: 7671
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.82
    Marker Score: 61426
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.74
    Marker Score: 7069
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.69
    Marker Score: 8862
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.68
    Marker Score: 58115.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.64
    Marker Score: 15598
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.64
    Marker Score: 100802
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.64
    Marker Score: 16893
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.63
    Marker Score: 12326
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.57
    Marker Score: 27835
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.55
    Marker Score: 772
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.55
    Marker Score: 23175
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.54
    Marker Score: 1598
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.53
    Marker Score: 5931
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.53
    Marker Score: 58100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.52
    Marker Score: 6378
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.5
    Marker Score: 12870
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.49
    Marker Score: 822
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.44
    Marker Score: 28737
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.43
    Marker Score: 2212
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.43
    Marker Score: 1724
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.42
    Marker Score: 344
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.42
    Marker Score: 6551
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.41
    Marker Score: 412
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.41
    Marker Score: 823
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.39
    Marker Score: 3316
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.37
    Marker Score: 29239
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.36
    Marker Score: 6517
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.35
    Marker Score: 7270
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.3
    Marker Score: 605
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.27
    Marker Score: 401
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.26
    Marker Score: 10878
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.26
    Marker Score: 2224
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.24
    Marker Score: 465
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.23
    Marker Score: 717
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.23
    Marker Score: 2691
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.22
    Marker Score: 9343
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.22
    Marker Score: 1051
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.22
    Marker Score: 767.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.2
    Marker Score: 5003
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2
    Marker Score: 592
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.18
    Marker Score: 1244
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.18
    Marker Score: 986
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18417
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.17
    Marker Score: 2665
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.17
    Marker Score: 339
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.17
    Marker Score: 584
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.17
    Marker Score: 2248
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.14
    Marker Score: 989
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.14
    Marker Score: 3812
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.12
    Marker Score: 586
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.11
    Marker Score: 740
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.11
    Marker Score: 1230
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.1
    Marker Score: 1270
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1
    Marker Score: 11170
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.09
    Marker Score: 678
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.08
    Marker Score: 1075
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.08
    Marker Score: 1233
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.08
    Marker Score: 2472
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.07
    Marker Score: 6842
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.07
    Marker Score: 520
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.07
    Marker Score: 3356
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.07
    Marker Score: 979
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.06
    Marker Score: 1128
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.06
    Marker Score: 213
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.05
    Marker Score: 716
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.04
    Marker Score: 1432
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.04
    Marker Score: 526
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.03
    Marker Score: 787
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.03
    Marker Score: 2445.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.03
    Marker Score: 576
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.02
    Marker Score: 290
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.02
    Marker Score: 1264
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.02
    Marker Score: 695
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.01
    Marker Score: 250
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1
    Marker Score: 376
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71609
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47834
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.99
    Marker Score: 561
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.99
    Marker Score: 1981
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.99
    Marker Score: 401
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.99
    Marker Score: 568
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.99
    Marker Score: 370
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.98
    Marker Score: 2003
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.98
    Marker Score: 694
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.98
    Marker Score: 219
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30372
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.98
    Marker Score: 391
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.98
    Marker Score: 2064
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.97
    Marker Score: 408
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.97
    Marker Score: 617
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.97
    Marker Score: 477
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.97
    Marker Score: 5730
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.96
    Marker Score: 1402
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.96
    Marker Score: 963

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Other Information

**Key characteristics:** * GALNT1 is a type of glycosyltransferase, which is an enzyme that adds sugar molecules to proteins. * It is responsible for the addition of galactose sugar molecules to proteins. * GALNT1 is a tetraspanin, which is a family of proteins that are involved in the formation of the Golgi apparatus. * It is a highly conserved protein, with similar sequences found in organisms from yeast to humans. **Pathways and functions:** * GALNT1 is involved in the following pathways: * Copi-independent golgi-to-er retrograde traffic * Golgi-to-er retrograde transport * Infectious disease * Intra-golgi and retrograde golgi-to-er traffic * Late sars-cov-2 infection events * Maturation of protein 3a * Membrane trafficking * Metabolism of proteins * O-linked glycosylation * O-linked glycosylation of mucins * It is involved in the post-translational modification of proteins, as it is a key enzyme in the O-linked glycosylation of mucins. * GALNT1 is also involved in the translation of structural proteins, as it is a component of the ribosome. * It is a key regulator of protein trafficking, as it controls the flow of proteins between the Golgi apparatus and the cell membrane. **Clinical significance:** GALNT1 gene mutations have been linked to several human diseases, including cancer, neurodegenerative disorders, and infectious diseases. Mutations in GALNT1 can lead to the accumulation of galactose-containing glycoproteins in cells, which can result in a variety of symptoms, including cancer, neurodegenerative disorders, and infectious diseases. **Additional notes:** * GALNT1 is a highly conserved protein, with a sequence that is similar to GALNT1 proteins found in other organisms. * It is a well-characterized protein that has been extensively studied in vitro and in vivo. * It is a promising target for cancer therapy, as it is a key enzyme in the post-translational modification of proteins.

Genular Protein ID: 3668781706

Symbol: GALT1_HUMAN

Name: Polypeptide GalNAc transferase 1

UniProtKB Accession Codes:

Q10472 Q86TJ7 Q9UM86

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 2 CCDS 1 CDD 2 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 4 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 Rhea 8 SABIO-RK 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8690719

Title: cDNA cloning, expression, and chromosomal localization of a human UDP-GalNAc:polypeptide, N-acetylgalactosaminyltransferase.

PubMed ID: 8690719

DOI: 10.1093/oxfordjournals.jbchem.a124947

PubMed ID: 7592619

Title: Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase.

PubMed ID: 7592619

DOI: 10.1074/jbc.270.41.24156

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8727794

Title: Organization of a human UDP-GalNAc:polypeptide, N-acetylgalactosaminyltransferase gene and a related processed pseudogene.

PubMed ID: 8727794

DOI: 10.1093/glycob/6.2.231

PubMed ID: 9295285

Title: Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.

PubMed ID: 9295285

DOI: 10.1074/jbc.272.38.23503

PubMed ID: 9394011

Title: Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus.

PubMed ID: 9394011

DOI: 10.1242/jcs.111.1.45

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 559
  • Mass: 64219
  • Checksum: CD68118CB201EE5B
  • Sequence:
    • MRKFAYCKVV LATSLIWVLL DMFLLLYFSE CNKCDEKKER GLPAGDVLEP VQKPHEGPGE 
MGKPVVIPKE DQEKMKEMFK INQFNLMASE MIALNRSLPD VRLEGCKTKV YPDNLPTTSV 
VIVFHNEAWS TLLRTVHSVI NRSPRHMIEE IVLVDDASER DFLKRPLESY VKKLKVPVHV 
IRMEQRSGLI RARLKGAAVS KGQVITFLDA HCECTVGWLE PLLARIKHDR RTVVCPIIDV 
ISDDTFEYMA GSDMTYGGFN WKLNFRWYPV PQREMDRRKG DRTLPVRTPT MAGGLFSIDR 
DYFQEIGTYD AGMDIWGGEN LEISFRIWQC GGTLEIVTCS HVGHVFRKAT PYTFPGGTGQ 
IINKNNRRLA EVWMDEFKNF FYIISPGVTK VDYGDISSRV GLRHKLQCKP FSWYLENIYP 
DSQIPRHYFS LGEIRNVETN QCLDNMARKE NEKVGIFNCH GMGGNQVFSY TANKEIRTDD 
LCLDVSKLNG PVTMLKCHHL KGNQLWEYDP VKLTLQHVNS NQCLDKATEE DSQVPSIRDC 
NGSRSQQWLL RNVTLPEIF

Genular Protein ID: 3121034876

Symbol: Q05BM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05BM8

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 2 UniPathway 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 499
  • Mass: 57337
  • Checksum: 071862AC56C5CF96
  • Sequence:
    • MGKPVVIPKE DQEKMKEMFK INQFNLMASE MIALNRSLPD VRLEGCKTKV YPDNLPTTSV 
VIVFHNEAWS TLLRTVHSVI NRSPRHMIEE IVLVDDASER DFLKRPLESY VKKLKVPVHV 
IRMEQRSGLI RARLKGAAVS KGQVITFLDA HCECTVGWLE PLLARIKHDR RTVVCPIIDV 
ISDDTFEYMA GSDMTYGGFN WKLNFRWYPV PQREMDRRKG DRTLPVRTPT MAGGLFSIDI 
DYFQEIGTYD AGMDIWGGEN LEISFRIWQC GGTLEIVTCS HVGHVFRKAT PYTFPGGTGQ 
IINKNNRRLA EVWMDEFKNF FYIISPGVTK VDYGDISSRV GLRHKLQCKP FSWYLENIYP 
DSQIPRHYFS LGEIRNVETN QCLDNMARKE NEKVGIFNCH GMGGNQVFSY TANKEIRTDD 
LCLDVSKLNG PVTMLKCHHL KGNQLWEYDP VKLTLQHVNS NQCLDKATEE DSQVPSIRDC 
NGSRSQQWLL RNVTLPEIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.