Details for: OR2L2

Gene ID: 26246

Symbol: OR2L2

Ensembl ID: ENSG00000203663

Description: olfactory receptor family 2 subfamily L member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.1323
    Cell Significance Index: -2.5700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5427
    Cell Significance Index: 8.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3504
    Cell Significance Index: 70.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1723
    Cell Significance Index: 10.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0998
    Cell Significance Index: 3.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0940
    Cell Significance Index: 4.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0854
    Cell Significance Index: 30.6300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0579
    Cell Significance Index: 0.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0509
    Cell Significance Index: 3.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0257
    Cell Significance Index: 1.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0249
    Cell Significance Index: 1.4000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0200
    Cell Significance Index: 0.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0153
    Cell Significance Index: 0.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0139
    Cell Significance Index: 1.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0137
    Cell Significance Index: 0.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0121
    Cell Significance Index: 3.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0102
    Cell Significance Index: 0.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0034
    Cell Significance Index: 0.1700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0011
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0005
    Cell Significance Index: 0.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0029
    Cell Significance Index: -0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0038
    Cell Significance Index: -2.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0046
    Cell Significance Index: -2.6100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0048
    Cell Significance Index: -2.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0052
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0074
    Cell Significance Index: -1.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0076
    Cell Significance Index: -1.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0104
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0105
    Cell Significance Index: -1.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0133
    Cell Significance Index: -1.8300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0145
    Cell Significance Index: -0.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0146
    Cell Significance Index: -0.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0149
    Cell Significance Index: -2.1600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0153
    Cell Significance Index: -2.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0164
    Cell Significance Index: -0.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0206
    Cell Significance Index: -2.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0211
    Cell Significance Index: -2.7200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0211
    Cell Significance Index: -0.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0222
    Cell Significance Index: -2.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0252
    Cell Significance Index: -1.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0255
    Cell Significance Index: -2.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0264
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0276
    Cell Significance Index: -5.8100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0286
    Cell Significance Index: -0.3700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0308
    Cell Significance Index: -0.3300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0316
    Cell Significance Index: -0.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0338
    Cell Significance Index: -2.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0349
    Cell Significance Index: -1.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0357
    Cell Significance Index: -1.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0362
    Cell Significance Index: -2.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0375
    Cell Significance Index: -0.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0402
    Cell Significance Index: -1.2800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0445
    Cell Significance Index: -0.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0460
    Cell Significance Index: -0.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0476
    Cell Significance Index: -5.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0485
    Cell Significance Index: -1.3200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0486
    Cell Significance Index: -0.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0491
    Cell Significance Index: -2.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0491
    Cell Significance Index: -1.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0492
    Cell Significance Index: -1.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0501
    Cell Significance Index: -1.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0514
    Cell Significance Index: -1.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0537
    Cell Significance Index: -2.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0554
    Cell Significance Index: -0.6600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0572
    Cell Significance Index: -1.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0576
    Cell Significance Index: -0.8300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0577
    Cell Significance Index: -1.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0624
    Cell Significance Index: -0.6800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0641
    Cell Significance Index: -0.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0659
    Cell Significance Index: -1.9400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0677
    Cell Significance Index: -0.6700
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0680
    Cell Significance Index: -0.6900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0694
    Cell Significance Index: -0.8100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0716
    Cell Significance Index: -1.4100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0717
    Cell Significance Index: -1.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0757
    Cell Significance Index: -1.6400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0761
    Cell Significance Index: -0.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0762
    Cell Significance Index: -1.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0787
    Cell Significance Index: -1.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0796
    Cell Significance Index: -1.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0821
    Cell Significance Index: -1.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0822
    Cell Significance Index: -2.2000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0829
    Cell Significance Index: -1.0500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0833
    Cell Significance Index: -1.0900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0851
    Cell Significance Index: -1.1800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0866
    Cell Significance Index: -1.1100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0894
    Cell Significance Index: -0.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0906
    Cell Significance Index: -2.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function**: OR2L2 is a G protein-coupled receptor that responds to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Broad Tissue Expression**: OR2L2 is expressed in multiple cell types, including goblet cells, mural cells, granulocyte monocyte progenitor cells, intestinal crypt stem cells, and transit amplifying cells, indicating a diverse range of biological activities. 3. **Cellular Localizations**: OR2L2 is found on the plasma membrane, where it can interact with odorant molecules and initiate signaling pathways. **Pathways and Functions:** 1. **G Protein-Coupled Receptor Signaling Pathway**: OR2L2 activates G proteins, which in turn trigger a cascade of downstream signaling events that ultimately lead to the perception of smell. 2. **Olfactory Signaling Pathway**: OR2L2 is integral to the olfactory signaling pathway, which involves the detection of odorant molecules, transmission of signals to the brain, and ultimately, the perception of smell. 3. **G Protein-Coupled Receptor Activity**: OR2L2 exhibits G protein-coupled receptor activity, which allows it to regulate various cellular processes, including cell growth, differentiation, and survival. 4. **Expression and Translocation of Olfactory Receptors**: OR2L2 is involved in the expression and translocation of olfactory receptors, ensuring that the correct receptors are expressed on the surface of olfactory sensory neurons. **Clinical Significance:** OR2L2 has been implicated in various diseases and disorders, including: 1. **Olfactory Dysfunction**: Mutations in the OR2L2 gene have been linked to olfactory dysfunction, highlighting the importance of this receptor in maintaining normal olfactory function. 2. **Gastrointestinal Disorders**: OR2L2 expression in gastrointestinal cells suggests that this receptor may play a role in the regulation of gut function and the development of gastrointestinal disorders, such as irritable bowel syndrome. 3. **Cancer**: OR2L2 has been found to be overexpressed in certain types of cancer, including colorectal cancer, suggesting that this receptor may contribute to tumorigenesis and cancer progression. In conclusion, OR2L2 is a multifunctional receptor that plays a critical role in olfactory perception and has implications for various diseases and disorders. Further research is needed to fully elucidate the biological activities of OR2L2 and its role in human health and disease.

Genular Protein ID: 3627377451

Symbol: OR2L2_HUMAN

Name: Olfactory receptor 2L2

UniProtKB Accession Codes:

Q8NH16 Q2M3T5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1370859

Title: Expression of members of the putative olfactory receptor gene family in mammalian germ cells.

PubMed ID: 1370859

DOI: 10.1038/355453a0

Sequence Information:

  • Length: 312
  • Mass: 35495
  • Checksum: C85F0368D685C1DE
  • Sequence:
    • MENYNQTSTD FILLGLFPQS RIGLFVFTLI FLIFLMALIG NLSMILLIFL DIHLHTPMYF 
LLSQLSLIDL NYISTIVPKM VYDFLYGNKS ISFTGCGIQS FFFLTLAVAE GLLLTSMAYD 
RYVAICFPLH YPIRISKRVC VMMITGSWMI SSINSCAHTV YALCIPYCKS RAINHFFCDV 
PAMLTLACTD TWVYESTVFL SSTIFLVLPF TGIACSYGRV LLAVYRMHSA EGRKKAYSTC 
STHLTVVSFY YAPFAYTYVR PRSLRSPTED KILAVFYTIL TPMLNPIIYS LRNKEVMGAL 
TQVIQKIFSV KM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.