Gene GATA3 - ENSG00000107485 | NCBI Gene ID: 2625

Details for: GATA3

Gene ID: 2625

Symbol: GATA3

Ensembl ID: ENSG00000107485

Description: GATA binding protein 3

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the nephric duct
(R-HSA-9830364)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Signaling by interleukins
(R-HSA-449147)
Signaling by nuclear receptors
(R-HSA-9006931)
Transcriptional regulation by runx1
(R-HSA-8878171)
Ub-specific processing proteases
(R-HSA-5689880)
Anatomical structure morphogenesis
(GO:0009653)
Aortic valve morphogenesis
(GO:0003180)
Axon guidance
(GO:0007411)
Cardiac right ventricle morphogenesis
(GO:0003215)
Cell fate commitment
(GO:0045165)
Cell fate determination
(GO:0001709)
Cell population proliferation
(GO:0008283)
Cellular response to interferon-alpha
(GO:0035457)
Chromatin remodeling
(GO:0006338)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Defense response
(GO:0006952)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Ear development
(GO:0043583)
Embryonic hemopoiesis
(GO:0035162)
Erythrocyte differentiation
(GO:0030218)
Hmg box domain binding
(GO:0071837)
Humoral immune response
(GO:0006959)
Identical protein binding
(GO:0042802)
Immune system development
(GO:0002520)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Inner ear morphogenesis
(GO:0042472)
Interleukin-2 receptor binding
(GO:0005134)
In utero embryonic development
(GO:0001701)
Kidney development
(GO:0001822)
Lens development in camera-type eye
(GO:0002088)
Macrophage differentiation
(GO:0030225)
Male gonad development
(GO:0008584)
Mesonephros development
(GO:0001823)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of interleukin-2 production
(GO:0032703)
Negative regulation of mammary gland epithelial cell proliferation
(GO:0033600)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of type ii interferon production
(GO:0032689)
Neuron migration
(GO:0001764)
Norepinephrine biosynthetic process
(GO:0042421)
Parathyroid hormone secretion
(GO:0035898)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of interleukin-5 production
(GO:0032754)
Positive regulation of interleukin-13 production
(GO:0032736)
Positive regulation of signal transduction
(GO:0009967)
Positive regulation of t cell differentiation
(GO:0045582)
Post-embryonic development
(GO:0009791)
Pro-t cell differentiation
(GO:0002572)
Protein binding
(GO:0005515)
Regulation of cytokine production
(GO:0001817)
Regulation of epithelial cell differentiation
(GO:0030856)
Regulation of neuron apoptotic process
(GO:0043523)
Regulation of neuron projection development
(GO:0010975)
Regulation of t-helper cell differentiation
(GO:0045622)
Response to estrogen
(GO:0043627)
Response to virus
(GO:0009615)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction
(GO:0007165)
T-helper 2 cell differentiation
(GO:0045064)
T cell differentiation
(GO:0030217)
Thymic t cell selection
(GO:0045061)
Tor signaling
(GO:0031929)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Ureter maturation
(GO:0035799)
Ventricular septum development
(GO:0003281)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: taste receptor cell (CL0000209)
Fold Change: 4.64
Marker Score: 4011
Cell Name: chromaffin cell (CL0000166)
Fold Change: 3.82
Marker Score: 5373
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.78
Marker Score: 6999
Cell Name: renal principal cell (CL0005009)
Fold Change: 2.59
Marker Score: 1999
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.18
Marker Score: 8583
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.15
Marker Score: 3167
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.04
Marker Score: 8757
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.98
Marker Score: 1971
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.86
Marker Score: 5151
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.86
Marker Score: 365
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.84
Marker Score: 609
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.83
Marker Score: 798
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.78
Marker Score: 2515
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.63
Marker Score: 1728
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.62
Marker Score: 1517
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.59
Marker Score: 1307
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.58
Marker Score: 1151
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.54
Marker Score: 1662
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.51
Marker Score: 1049
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.51
Marker Score: 9633
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.47
Marker Score: 297
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.45
Marker Score: 4069
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 1.44
Marker Score: 1091
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.34
Marker Score: 983
Cell Name: mature T cell (CL0002419)
Fold Change: 1.32
Marker Score: 13109
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.31
Marker Score: 430
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.31
Marker Score: 2314
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.3
Marker Score: 68754
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 1.3
Marker Score: 939
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.29
Marker Score: 1832
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.26
Marker Score: 739
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.25
Marker Score: 1111
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.24
Marker Score: 838
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.19
Marker Score: 999
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.19
Marker Score: 4569
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.18
Marker Score: 3725.5
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 1.17
Marker Score: 3302
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4780
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 1.14
Marker Score: 2779
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.1
Marker Score: 870
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.09
Marker Score: 2672
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.07
Marker Score: 1471
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251759
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.03
Marker Score: 1848
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.01
Marker Score: 312
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71777
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48003
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30403
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.97
Marker Score: 1666
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 497
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 451
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.95
Marker Score: 394
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.94
Marker Score: 1038
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5234
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2729
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 364
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.91
Marker Score: 558
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.9
Marker Score: 741
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.9
Marker Score: 950.5
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.89
Marker Score: 533
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.88
Marker Score: 509
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.88
Marker Score: 843
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 318
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.88
Marker Score: 2010
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.88
Marker Score: 404
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5270
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.86
Marker Score: 1692
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.86
Marker Score: 765
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 0.85
Marker Score: 296
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.85
Marker Score: 287
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.84
Marker Score: 609
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.84
Marker Score: 431
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.83
Marker Score: 730
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.82
Marker Score: 411
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.82
Marker Score: 1352
Cell Name: Unknown (CL0000548)
Fold Change: 0.79
Marker Score: 577
Cell Name: memory T cell (CL0000813)
Fold Change: 0.79
Marker Score: 339
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 597
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.77
Marker Score: 334
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1248
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 697
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.76
Marker Score: 193
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.75
Marker Score: 176.5
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 387
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.75
Marker Score: 722
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.73
Marker Score: 223
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.71
Marker Score: 1046
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.71
Marker Score: 586
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7
Marker Score: 451
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 0.7
Marker Score: 778
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.7
Marker Score: 622
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.69
Marker Score: 1544
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.68
Marker Score: 245
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.68
Marker Score: 1988
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.67
Marker Score: 2739
Cell Name: naive T cell (CL0000898)
Fold Change: 0.66
Marker Score: 425
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.65
Marker Score: 547
Cell Name: neural cell (CL0002319)
Fold Change: 0.64
Marker Score: 309

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**Key characteristics**: - GATA3 is a transcription factor that belongs to the GATA family of transcription factors. - It is a key regulator of immune cell development and function. - It is expressed in high levels in immune cells, including T cells, B cells, and macrophages. - It is involved in the regulation of cell cycle, differentiation, and proliferation in immune cells. - It is also involved in the regulation of inflammation and tissue development. **Pathways and functions**: - GATA3 is involved in the regulation of cytokine signaling. - It is a key regulator of the development and function of dendritic cells, which are cells that present antigens to T cells. - It is also involved in the regulation of macrophage differentiation and activation. - It is involved in the regulation of platelet production and function. - It is involved in the regulation of kidney development and function. - It is involved in the regulation of metabolism of proteins. - It is involved in the regulation of inflammation. **Clinical significance**: GATA3 is a potential therapeutic target for a variety of diseases, including cancer and autoimmune disorders. By targeting GATA3, it may be possible to inhibit the growth and proliferation of cancer cells and to treat autoimmune disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Trans-acting T-cell-specific transcription factor GATA-3

Genular Protein ID: 1485958748

Symbol: GATA3_HUMAN

Name: Trans-acting T-cell-specific transcription factor GATA-3

UniProtKB Accession Codes:

P23771 Q5VWG7 Q5VWG8 Q96J16

Database IDs:

Citations:

PubMed ID: 2050118

Title: A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.

PubMed ID: 2050118

DOI: 10.1002/j.1460-2075.1991.tb07706.x

PubMed ID: 1827068

Title: Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

PubMed ID: 1827068

DOI: 10.1002/j.1460-2075.1991.tb08059.x

PubMed ID: 2017177

Title: Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.

PubMed ID: 2017177

DOI: 10.1128/mcb.11.5.2778-2784.1991

PubMed ID: 1871134

Title: The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.

PubMed ID: 1871134

DOI: 10.1073/pnas.88.16.7284

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10935639

Title: GATA3 haplo-insufficiency causes human HDR syndrome.

PubMed ID: 10935639

DOI: 10.1038/35019088

PubMed ID: 15662016

Title: T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

PubMed ID: 15662016

DOI: 10.1126/science.1103336

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23824597

Title: Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity.

PubMed ID: 23824597

DOI: 10.1371/journal.pone.0066468

PubMed ID: 23142663

Title: DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation.

PubMed ID: 23142663

DOI: 10.1016/j.celrep.2012.10.012

PubMed ID: 11389161

Title: GATA3 abnormalities and the phenotypic spectrum of HDR syndrome.

PubMed ID: 11389161

DOI: 10.1136/jmg.38.6.374

PubMed ID: 17224074

Title: Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.

PubMed ID: 17224074

DOI: 10.1186/bcr1637

PubMed ID: 26514990

Title: A novel loss-of-function mutation of GATA3 (p.R299Q) in a Japanese family with Hypoparathyroidism, Deafness, and Renal Dysplasia (HDR) syndrome.

PubMed ID: 26514990

DOI: 10.1186/s12902-015-0065-7

Sequence Information:

Length: 443
Mass: 47916
Checksum: F24C58681E1D02A5
Sequence:

MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LSHSYMDAAQ YPLPEEVDVL FNIDGQGNHV 
PPYYGNSVRA TVQRYPPTHH GSQVCRPPLL HGSLPWLDGG KALGSHHTAS PWNLSPFSKT 
SIHHGSPGPL SVYPPASSSS LSGGHASPHL FTFPPTPPKD VSPDPSLSTP GSAGSARQDE 
KECLKYQVPL PDSMKLESSH SRGSMTALGG ASSSTHHPIT TYPPYVPEYS SGLFPPSSLL 
GGSPTGFGCK SRPKARSSTG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL 
IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI NRPLTMKKEG 
IQTRNRKMSS KSKKCKKVHD SLEDFPKNSS FNPAALSRHM SSLSHISPFS HSSHMLTTPT 
PMHPPSSLSF GPHHPSSMVT AMG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GATA3

Associated with

Cells (max top 100)

Other Information

A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. PubMed ID: 2050118

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. PubMed ID: 1827068

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. PubMed ID: 2017177

The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. PubMed ID: 1871134

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

GATA3 haplo-insufficiency causes human HDR syndrome. PubMed ID: 10935639

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. PubMed ID: 15662016

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity. PubMed ID: 23824597

DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation. PubMed ID: 23142663

GATA3 abnormalities and the phenotypic spectrum of HDR syndrome. PubMed ID: 11389161

Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas. PubMed ID: 17224074

A novel loss-of-function mutation of GATA3 (p.R299Q) in a Japanese family with Hypoparathyroidism, Deafness, and Renal Dysplasia (HDR) syndrome. PubMed ID: 26514990