Details for: RGS17

Gene ID: 26575

Symbol: RGS17

Ensembl ID: ENSG00000091844

Description: regulator of G protein signaling 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 145.3597
    Cell Significance Index: -22.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.0818
    Cell Significance Index: -22.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.0392
    Cell Significance Index: -17.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.3191
    Cell Significance Index: -17.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.9911
    Cell Significance Index: 87.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.6647
    Cell Significance Index: 163.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.5745
    Cell Significance Index: 44.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.5007
    Cell Significance Index: 110.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.2233
    Cell Significance Index: 53.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.1892
    Cell Significance Index: 82.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6393
    Cell Significance Index: 100.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6240
    Cell Significance Index: 325.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1179
    Cell Significance Index: 58.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1068
    Cell Significance Index: 765.4900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7891
    Cell Significance Index: 12.6600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.7699
    Cell Significance Index: 8.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7321
    Cell Significance Index: 49.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7303
    Cell Significance Index: 20.8400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5486
    Cell Significance Index: 9.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5340
    Cell Significance Index: 191.5400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5188
    Cell Significance Index: 6.4400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4773
    Cell Significance Index: 6.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4266
    Cell Significance Index: 42.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4128
    Cell Significance Index: 372.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3815
    Cell Significance Index: 21.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3063
    Cell Significance Index: 58.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2056
    Cell Significance Index: 33.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1129
    Cell Significance Index: 12.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0834
    Cell Significance Index: 4.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0630
    Cell Significance Index: 2.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0582
    Cell Significance Index: 10.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0549
    Cell Significance Index: 1.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0252
    Cell Significance Index: 38.8200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0207
    Cell Significance Index: 0.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0122
    Cell Significance Index: 1.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0042
    Cell Significance Index: 5.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0040
    Cell Significance Index: 7.4900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0035
    Cell Significance Index: 0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0021
    Cell Significance Index: 3.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0017
    Cell Significance Index: 1.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0014
    Cell Significance Index: 0.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0090
    Cell Significance Index: -5.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0171
    Cell Significance Index: -9.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0233
    Cell Significance Index: -14.7900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0242
    Cell Significance Index: -0.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0246
    Cell Significance Index: -3.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0258
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0263
    Cell Significance Index: -5.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0269
    Cell Significance Index: -19.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0312
    Cell Significance Index: -23.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0318
    Cell Significance Index: -17.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0325
    Cell Significance Index: -5.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0328
    Cell Significance Index: -14.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0397
    Cell Significance Index: -18.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0415
    Cell Significance Index: -1.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0490
    Cell Significance Index: -7.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0492
    Cell Significance Index: -6.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0561
    Cell Significance Index: -3.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0607
    Cell Significance Index: -17.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0667
    Cell Significance Index: -13.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0674
    Cell Significance Index: -1.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0760
    Cell Significance Index: -4.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0847
    Cell Significance Index: -11.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0937
    Cell Significance Index: -10.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1220
    Cell Significance Index: -3.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1274
    Cell Significance Index: -3.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1638
    Cell Significance Index: -21.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1711
    Cell Significance Index: -5.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1772
    Cell Significance Index: -20.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1858
    Cell Significance Index: -21.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1864
    Cell Significance Index: -2.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2037
    Cell Significance Index: -20.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2078
    Cell Significance Index: -4.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2156
    Cell Significance Index: -22.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2163
    Cell Significance Index: -4.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2391
    Cell Significance Index: -18.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2526
    Cell Significance Index: -17.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2613
    Cell Significance Index: -16.8600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2974
    Cell Significance Index: -2.8300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3083
    Cell Significance Index: -7.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3132
    Cell Significance Index: -19.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3242
    Cell Significance Index: -5.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3321
    Cell Significance Index: -17.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3531
    Cell Significance Index: -12.3700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3587
    Cell Significance Index: -3.4000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3689
    Cell Significance Index: -2.4000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3707
    Cell Significance Index: -4.3300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3732
    Cell Significance Index: -4.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3813
    Cell Significance Index: -8.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3817
    Cell Significance Index: -7.9900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3865
    Cell Significance Index: -4.8200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.4040
    Cell Significance Index: -4.6000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4121
    Cell Significance Index: -4.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4133
    Cell Significance Index: -8.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4135
    Cell Significance Index: -19.4400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4561
    Cell Significance Index: -3.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4654
    Cell Significance Index: -21.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4744
    Cell Significance Index: -13.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4887
    Cell Significance Index: -4.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RGS17 is a member of the regulator of G protein signaling (RGS) family, which consists of proteins that negatively regulate G protein signaling by accelerating the GTPase activity of Gα subunits. This function is essential for terminating signal transduction and maintaining cellular homeostasis. RGS17 is specifically expressed in various cell types, including neurons, glial cells, and epithelial cells, suggesting its widespread involvement in neural and non-neural functions. **Pathways and Functions:** RGS17 is associated with multiple signaling pathways, including: 1. **GPCR signaling pathway:** RGS17 modulates the activity of GPCRs, which are key receptors that respond to a wide range of ligands, including hormones, neurotransmitters, and drugs. By regulating GPCR signaling, RGS17 influences various physiological processes, such as neurotransmission, hormone secretion, and cardiovascular function. 2. **Gα(i), Gα(Q), and Gα(Z) signaling events:** RGS17 interacts with Gα(i), Gα(Q), and Gα(Z) subunits, which are involved in different signaling cascades. This interaction helps to terminate signal transduction and maintain cellular homeostasis. 3. **GTPase activator activity:** RGS17 possesses GTPase activator activity, which is essential for regulating the activity of Gα subunits and terminating signal transduction. 4. **Negative regulation of signal transduction:** RGS17 acts as a negative regulator of signal transduction by accelerating the GTPase activity of Gα subunits, thereby terminating signal transduction and maintaining cellular homeostasis. **Clinical Significance:** RGS17's involvement in various signaling pathways makes it a potential target for the treatment of diseases associated with dysregulated signaling. Some potential clinical implications of RGS17 include: 1. **Neurological disorders:** RGS17's role in regulating GPCR signaling and neuronal function suggests its potential involvement in neurological disorders, such as Parkinson's disease, Alzheimer's disease, and schizophrenia. 2. **Cardiovascular disease:** RGS17's involvement in GPCR signaling and cardiovascular function makes it a potential target for the treatment of cardiovascular disease. 3. **Cancer:** RGS17's role in regulating cell signaling and proliferation makes it a potential target for the treatment of cancer. In conclusion, RGS17 is a critical gene involved in regulating various signaling pathways, including GPCR signaling, Gα subunit signaling, and GTPase activity. Its widespread expression in different cell types and its potential involvement in various diseases make it an attractive target for therapeutic intervention. Further research is needed to fully elucidate the functional significance of RGS17 and its potential applications in disease treatment.

Genular Protein ID: 3355249607

Symbol: RGS17_HUMAN

Name: Regulator of G-protein signaling 17

UniProtKB Accession Codes:

Q9UGC6 Q5TF49 Q8TD61 Q9UJS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15096504

Title: RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling.

PubMed ID: 15096504

DOI: 10.1074/jbc.m401800200

PubMed ID: 18434541

Title: Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

PubMed ID: 18434541

DOI: 10.1073/pnas.0801508105

Sequence Information:

  • Length: 210
  • Mass: 24359
  • Checksum: 0AFA22A43BF5E481
  • Sequence:
    • MRKRQQSQNE GTPAVSQAPG NQRPNNTCCF CWCCCCSCSC LTVRNEERGE NAGRPTHTTK 
MESIQVLEEC QNPTAEEVLS WSQNFDKMMK APAGRNLFRE FLRTEYSEEN LLFWLACEDL 
KKEQNKKVIE EKARMIYEDY ISILSPKEVS LDSRVREVIN RNLLDPNPHM YEDAQLQIYT 
LMHRDSFPRF LNSQIYKSFV ESTAGSSSES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.