Details for: OR7C1

Gene ID: 26664

Symbol: OR7C1

Ensembl ID: ENSG00000127530

Description: olfactory receptor family 7 subfamily C member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.0687
    Cell Significance Index: 34.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7755
    Cell Significance Index: 20.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2009
    Cell Significance Index: 12.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1705
    Cell Significance Index: 27.7300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1418
    Cell Significance Index: 2.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1342
    Cell Significance Index: 2.3000
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.1231
    Cell Significance Index: 0.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1179
    Cell Significance Index: 22.4500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1045
    Cell Significance Index: 0.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0777
    Cell Significance Index: 1.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0772
    Cell Significance Index: 1.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0678
    Cell Significance Index: 1.8500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0624
    Cell Significance Index: 0.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0287
    Cell Significance Index: 1.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0192
    Cell Significance Index: 3.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0144
    Cell Significance Index: 1.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0079
    Cell Significance Index: 2.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0029
    Cell Significance Index: 0.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0015
    Cell Significance Index: 2.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0012
    Cell Significance Index: -0.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0017
    Cell Significance Index: -0.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0019
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0030
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0031
    Cell Significance Index: -2.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0035
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0040
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0041
    Cell Significance Index: -0.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0045
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0054
    Cell Significance Index: -1.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0055
    Cell Significance Index: -0.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0056
    Cell Significance Index: -0.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0062
    Cell Significance Index: -1.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0084
    Cell Significance Index: -0.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0090
    Cell Significance Index: -1.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0111
    Cell Significance Index: -1.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0130
    Cell Significance Index: -0.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0132
    Cell Significance Index: -1.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0136
    Cell Significance Index: -0.9400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0136
    Cell Significance Index: -0.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0175
    Cell Significance Index: -0.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0204
    Cell Significance Index: -0.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0205
    Cell Significance Index: -2.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0208
    Cell Significance Index: -0.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0235
    Cell Significance Index: -0.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0246
    Cell Significance Index: -2.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0255
    Cell Significance Index: -2.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0258
    Cell Significance Index: -1.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0260
    Cell Significance Index: -1.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0265
    Cell Significance Index: -0.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0270
    Cell Significance Index: -2.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0283
    Cell Significance Index: -0.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0305
    Cell Significance Index: -0.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0315
    Cell Significance Index: -1.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0335
    Cell Significance Index: -2.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0340
    Cell Significance Index: -1.6000
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0342
    Cell Significance Index: -0.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0384
    Cell Significance Index: -1.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0391
    Cell Significance Index: -1.3700
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0392
    Cell Significance Index: -0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0395
    Cell Significance Index: -2.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0421
    Cell Significance Index: -2.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0433
    Cell Significance Index: -2.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0436
    Cell Significance Index: -1.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0438
    Cell Significance Index: -0.6600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0443
    Cell Significance Index: -1.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0448
    Cell Significance Index: -0.9500
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0478
    Cell Significance Index: -0.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0488
    Cell Significance Index: -0.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0502
    Cell Significance Index: -1.2900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0514
    Cell Significance Index: -0.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0515
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0524
    Cell Significance Index: -0.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0525
    Cell Significance Index: -1.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0528
    Cell Significance Index: -1.0600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0546
    Cell Significance Index: -0.5700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0552
    Cell Significance Index: -0.7800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0557
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0564
    Cell Significance Index: -1.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0565
    Cell Significance Index: -1.4100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0569
    Cell Significance Index: -1.4500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0579
    Cell Significance Index: -0.8000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0582
    Cell Significance Index: -1.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0605
    Cell Significance Index: -1.1800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0608
    Cell Significance Index: -0.8100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0613
    Cell Significance Index: -1.0100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0617
    Cell Significance Index: -0.7500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0620
    Cell Significance Index: -0.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0630
    Cell Significance Index: -0.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0634
    Cell Significance Index: -0.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0641
    Cell Significance Index: -1.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0642
    Cell Significance Index: -1.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0657
    Cell Significance Index: -2.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0673
    Cell Significance Index: -2.4700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0709
    Cell Significance Index: -0.7600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0712
    Cell Significance Index: -1.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR7C1 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family. Its primary function is to detect chemical stimuli, which is essential for the sensory perception of smell. The gene's expression in various tissues, including the gastrointestinal tract and the brain, suggests its involvement in multiple physiological processes. OR7C1's ability to modulate spermatogenesis and its role in signal transduction pathways further underscore its significance in the body. **Pathways and Functions:** OR7C1's functions can be attributed to its involvement in several key pathways: 1. **Detection of Chemical Stimuli:** OR7C1's primary function is to detect chemical stimuli, which is essential for the sensory perception of smell. This is achieved through its interaction with odorant molecules, leading to the activation of G proteins and subsequent signal transduction. 2. **G Protein-Coupled Receptor Activity:** OR7C1's ability to activate G proteins is crucial for its function in detecting chemical stimuli. This activation leads to the modulation of various downstream signaling pathways. 3. **Expression and Translocation of Olfactory Receptors:** OR7C1's expression in olfactory receptors is essential for the detection of chemical stimuli. Its translocation to the plasma membrane is necessary for its function in detecting odorant molecules. 4. **Spermatogenesis:** OR7C1's involvement in spermatogenesis highlights its role in reproductive processes. The gene's expression in testicular tissue suggests its potential role in regulating sperm development and maturation. 5. **Signal Transduction:** OR7C1's involvement in signal transduction pathways underscores its ability to modulate various physiological processes. Its interaction with G proteins and other signaling molecules leads to the activation of downstream pathways. **Clinical Significance:** OR7C1's functions and significance are far-reaching and have significant implications for various diseases and disorders. Some potential clinical applications of OR7C1 include: 1. **Olfactory Disorders:** OR7C1's role in detecting chemical stimuli makes it an important target for the development of treatments for olfactory disorders, such as anosmia and hyposmia. 2. **Reproductive Disorders:** OR7C1's involvement in spermatogenesis suggests its potential role in regulating reproductive processes. Its dysregulation may contribute to reproductive disorders, such as infertility and erectile dysfunction. 3. **Neurological Disorders:** OR7C1's expression in the brain, particularly in GABAergic interneurons and radial glial cells, suggests its potential role in neurological processes. Its dysregulation may contribute to neurological disorders, such as epilepsy and schizophrenia. In conclusion, OR7C1 is a multifaceted gene with significant implications for various physiological and pathological processes. Further research is necessary to fully elucidate its functions and clinical significance, but its involvement in detection of chemical stimuli, spermatogenesis, and signal transduction pathways highlights its importance in the body.

Genular Protein ID: 2509126580

Symbol: OR7C1_HUMAN

Name: Olfactory receptor 7C1

UniProtKB Accession Codes:

O76099 Q15621 Q6IFP2 Q96R94

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 9119360

Title: Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

PubMed ID: 9119360

DOI: 10.1006/geno.1996.4490

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 320
  • Mass: 35519
  • Checksum: BBDCC409721D70C4
  • Sequence:
    • METGNQTHAQ EFLLLGFSAT SEIQFILFGL FLSMYLVTFT GNLLIILAIC SDSHLHTPMY 
FFLSNLSFAD LCFTSTTVPK MLLNILTQNK FITYAGCLSQ IFFFTSFGCL DNLLLTVMAY 
DRFVAVCHPL HYTVIMNPQL CGLLVLGSWC ISVMGSLLET LTVLRLSFCT EMEIPHFFCD 
LLEVLKLACS DTFINNVVIY FATGVLGVIS FTGIFFSYYK IVFSILRISS AGRKHKAFST 
CGSHLSVVTL FYGTGFGVYL SSAATPSSRT SLVASVMYTM VTPMLNPFIY SLRNTDMKRA 
LGRLLSRATF FNGDITAGLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.