Details for: MLH3

Gene ID: 27030

Symbol: MLH3

Ensembl ID: ENSG00000119684

Description: mutL homolog 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 247.5807
    Cell Significance Index: -38.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 139.7632
    Cell Significance Index: -35.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 81.6851
    Cell Significance Index: -33.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 79.9792
    Cell Significance Index: -37.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.0602
    Cell Significance Index: -30.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.5478
    Cell Significance Index: -35.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.4810
    Cell Significance Index: -37.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.5009
    Cell Significance Index: -31.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.4934
    Cell Significance Index: -38.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.1754
    Cell Significance Index: -35.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.8656
    Cell Significance Index: -38.9300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1422
    Cell Significance Index: -28.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.6116
    Cell Significance Index: -14.4700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.6317
    Cell Significance Index: 59.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.3375
    Cell Significance Index: 231.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3573
    Cell Significance Index: 272.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2974
    Cell Significance Index: 141.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2188
    Cell Significance Index: 73.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9749
    Cell Significance Index: 349.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8496
    Cell Significance Index: 168.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8118
    Cell Significance Index: 23.3900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.7601
    Cell Significance Index: 5.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7486
    Cell Significance Index: 14.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7016
    Cell Significance Index: 96.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6577
    Cell Significance Index: 29.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5751
    Cell Significance Index: 12.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5713
    Cell Significance Index: 32.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5379
    Cell Significance Index: 41.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5312
    Cell Significance Index: 95.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5311
    Cell Significance Index: 27.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4850
    Cell Significance Index: 56.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4322
    Cell Significance Index: 27.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4197
    Cell Significance Index: 11.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4160
    Cell Significance Index: 53.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3943
    Cell Significance Index: 11.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3789
    Cell Significance Index: 26.2100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3693
    Cell Significance Index: 4.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2810
    Cell Significance Index: 3.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2792
    Cell Significance Index: 12.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2738
    Cell Significance Index: 10.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2647
    Cell Significance Index: 239.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2569
    Cell Significance Index: 140.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2259
    Cell Significance Index: 141.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2018
    Cell Significance Index: 38.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1952
    Cell Significance Index: 24.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1748
    Cell Significance Index: 120.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1727
    Cell Significance Index: 76.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1487
    Cell Significance Index: 279.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1293
    Cell Significance Index: 6.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0785
    Cell Significance Index: 120.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0723
    Cell Significance Index: 2.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0629
    Cell Significance Index: 39.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0569
    Cell Significance Index: 3.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0528
    Cell Significance Index: 97.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0510
    Cell Significance Index: 1.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0492
    Cell Significance Index: 22.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0213
    Cell Significance Index: 28.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0081
    Cell Significance Index: 1.3300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0021
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0022
    Cell Significance Index: -0.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0035
    Cell Significance Index: -0.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0068
    Cell Significance Index: -0.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0164
    Cell Significance Index: -2.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0177
    Cell Significance Index: -9.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0216
    Cell Significance Index: -16.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0333
    Cell Significance Index: -0.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0357
    Cell Significance Index: -0.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0380
    Cell Significance Index: -28.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0458
    Cell Significance Index: -3.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0942
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0962
    Cell Significance Index: -20.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0979
    Cell Significance Index: -4.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1057
    Cell Significance Index: -5.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1058
    Cell Significance Index: -1.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1116
    Cell Significance Index: -32.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1185
    Cell Significance Index: -12.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1236
    Cell Significance Index: -3.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1310
    Cell Significance Index: -16.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1581
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1648
    Cell Significance Index: -18.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2242
    Cell Significance Index: -7.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2255
    Cell Significance Index: -26.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2497
    Cell Significance Index: -26.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2555
    Cell Significance Index: -19.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2560
    Cell Significance Index: -8.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3130
    Cell Significance Index: -4.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3332
    Cell Significance Index: -38.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3459
    Cell Significance Index: -18.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3508
    Cell Significance Index: -8.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3631
    Cell Significance Index: -5.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3637
    Cell Significance Index: -5.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3982
    Cell Significance Index: -31.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4039
    Cell Significance Index: -11.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4578
    Cell Significance Index: -28.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6221
    Cell Significance Index: -38.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6393
    Cell Significance Index: -14.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6509
    Cell Significance Index: -20.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6711
    Cell Significance Index: -14.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6827
    Cell Significance Index: -22.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MLH3 is a DNA mismatch repair protein that belongs to the mutL homolog family. It is highly expressed in various cell types, including pulmonary interstitial fibroblasts, GABAergic cortical interneurons, and pigmented epithelial cells. The gene is encoded by the MLH3_HUMAN protein, which is a dimeric complex consisting of two subunits, MLH3A and MLH3B. MLH3 has been shown to interact with other MMR proteins, such as MSH2 and PMS2, to form a functional complex. **Pathways and Functions:** MLH3 is involved in several key pathways, including: 1. **Mismatch Repair (MMR) pathway:** MLH3 plays a central role in the MMR pathway, which corrects errors in DNA replication and recombination. The MLH3-MSH2-PMS2 complex recognizes and repairs mismatched bases, maintaining genome stability. 2. **Cell Cycle regulation:** MLH3 is involved in the regulation of the cell cycle, particularly during the G2/M phase. It helps to ensure accurate DNA replication and prevent aberrant cell proliferation. 3. **Centromeric DNA binding:** MLH3 binds to centromeric DNA, a region essential for meiotic recombination and chromosome segregation. 4. **Meiotic recombination:** MLH3 is involved in the regulation of meiotic recombination, a process that ensures genetic diversity and proper chromosome segregation. **Clinical Significance:** MLH3 mutations have been associated with several genetic disorders, including: 1. **Hereditary nonpolyposis colorectal cancer (HNPCC):** MLH3 mutations can increase the risk of colorectal cancer and other cancers. 2. **Meiotic disorders:** MLH3 mutations can lead to meiotic abnormalities, resulting in infertility and genetic disorders. 3. **Neurological disorders:** MLH3 mutations have been linked to neurological disorders, such as epilepsy and schizophrenia. In conclusion, MLH3 is a critical gene involved in DNA repair, meiotic recombination, and cell cycle regulation. Its dysregulation can lead to genetic disorders and cancer. Further research is needed to fully understand the complex functions of MLH3 and its role in maintaining genome stability. **References:** * [Insert relevant references] Note: This article is a hypothetical example of an expert immunologist discussing the gene MLH3. Please consult the provided information and references to ensure accuracy and comprehensiveness.

Genular Protein ID: 1826364484

Symbol: MLH3_HUMAN

Name: DNA mismatch repair protein Mlh3

UniProtKB Accession Codes:

Q9UHC1 P49751 Q56DK9 Q9P292 Q9UHC0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10615123

Title: MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability.

PubMed ID: 10615123

DOI: 10.1038/71643

PubMed ID: 11292842

Title: The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2.

PubMed ID: 11292842

DOI: 10.1093/nar/29.8.1695

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 7596406

Title: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

PubMed ID: 7596406

DOI: 10.1038/375754a0

PubMed ID: 11317354

Title: Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: evidence for somatic mutation in colorectal cancers.

PubMed ID: 11317354

DOI: 10.1002/humu.1114

PubMed ID: 20603073

Title: A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

PubMed ID: 20603073

DOI: 10.1016/j.molcel.2010.06.023

PubMed ID: 11586295

Title: A role for MLH3 in hereditary nonpolyposis colorectal cancer.

PubMed ID: 11586295

DOI: 10.1038/ng1001-137

Sequence Information:

  • Length: 1453
  • Mass: 163711
  • Checksum: 3D063427457DB033
  • Sequence:
    • MIKCLSVEVQ AKLRSGLAIS SLGQCVEELA LNSIDAEAKC VAVRVNMETF QVQVIDNGFG 
MGSDDVEKVG NRYFTSKCHS VQDLENPRFY GFRGEALANI ADMASAVEIS SKKNRTMKTF 
VKLFQSGKAL KACEADVTRA SAGTTVTVYN LFYQLPVRRK CMDPRLEFEK VRQRIEALSL 
MHPSISFSLR NDVSGSMVLQ LPKTKDVCSR FCQIYGLGKS QKLREISFKY KEFELSGYIS 
SEAHYNKNMQ FLFVNKRLVL RTKLHKLIDF LLRKESIICK PKNGPTSRQM NSSLRHRSTP 
ELYGIYVINV QCQFCEYDVC MEPAKTLIEF QNWDTLLFCI QEGVKMFLKQ EKLFVELSGE 
DIKEFSEDNG FSLFDATLQK RVTSDERSNF QEACNNILDS YEMFNLQSKA VKRKTTAENV 
NTQSSRDSEA TRKNTNDAFL YIYESGGPGH SKMTEPSLQN KDSSCSESKM LEQETIVASE 
AGENEKHKKS FLEHSSLENP CGTSLEMFLS PFQTPCHFEE SGQDLEIWKE STTVNGMAAN 
ILKNNRIQNQ PKRFKDATEV GCQPLPFATT LWGVHSAQTE KEKKKESSNC GRRNVFSYGR 
VKLCSTGFIT HVVQNEKTKS TETEHSFKNY VRPGPTRAQE TFGNRTRHSV ETPDIKDLAS 
TLSKESGQLP NKKNCRTNIS YGLENEPTAT YTMFSAFQEG SKKSQTDCIL SDTSPSFPWY 
RHVSNDSRKT DKLIGFSKPI VRKKLSLSSQ LGSLEKFKRQ YGKVENPLDT EVEESNGVTT 
NLSLQVEPDI LLKDKNRLEN SDVCKITTME HSDSDSSCQP ASHILNSEKF PFSKDEDCLE 
QQMPSLRESP MTLKELSLFN RKPLDLEKSS ESLASKLSRL KGSERETQTM GMMSRFNELP 
NSDSSRKDSK LCSVLTQDFC MLFNNKHEKT ENGVIPTSDS ATQDNSFNKN SKTHSNSNTT 
ENCVISETPL VLPYNNSKVT GKDSDVLIRA SEQQIGSLDS PSGMLMNPVE DATGDQNGIC 
FQSEESKARA CSETEESNTC CSDWQRHFDV ALGRMVYVNK MTGLSTFIAP TEDIQAACTK 
DLTTVAVDVV LENGSQYRCQ PFRSDLVLPF LPRARAERTV MRQDNRDTVD DTVSSESLQS 
LFSEWDNPVF ARYPEVAVDV SSGQAESLAV KIHNILYPYR FTKGMIHSMQ VLQQVDNKFI 
ACLMSTKTEE NGEAGGNLLV LVDQHAAHER IRLEQLIIDS YEKQQAQGSG RKKLLSSTLI 
PPLEITVTEE QRRLLWCYHK NLEDLGLEFV FPDTSDSLVL VGKVPLCFVE REANELRRGR 
STVTKSIVEE FIREQLELLQ TTGGIQGTLP LTVQKVLASQ ACHGAIKFND GLSLQESCRL 
IEALSSCQLP FQCAHGRPSM LPLADIDHLE QEKQIKPNLT KLRKMAQAWR LFGKAECDTR 
QSLQQSMPPC EPP

Genular Protein ID: 2014546256

Symbol: Q2M1Z1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2M1Z1

Database IDs:

ARBA 3 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 7 Gene3D 4 IntAct 1 InterPro 11 MINT 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 4 SUPFAM 3

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1429
  • Mass: 161038
  • Checksum: 2B354D5A52BEC556
  • Sequence:
    • MIKCLSVEVQ AKLRSGLAIS SLGQCVEELA LNSIDAEAKC VAVRVNMETF QVQVIDNGFG 
MGSDDVEKVG NRYFTSKCHS VQDLENPRFY GFRGEALANI ADMASAVEIS SKKNRTMKTF 
VKLFQSGKAL KACEADVTRA SAGTTVTVYN LFYQLPVRRK CMDPRLEFEK VRQRIEALSL 
MHPSISFSLR NDVSGSMVLQ LPKTKDVCSR FCQIYGLGKS QKLREISFKY KEFELSGYIS 
SEAHYNKNMQ FLFVNKRLVL RTKLHKLIDF LLRKESIICK PKNGPTSRQM NSSLRHRSTP 
ELYGIYVINV QCQFCEYDVC MEPAKTLIEF QNWDTLLFCI QEGVKMFLKQ EKLFVELSGE 
DIKEFSEDNG FSLFDATLQK RVTSDERSNF QEACNNILDS YEMFNLQSKA VKRKTTAENV 
NTQSSRDSEA TRKNTNDAFL YIYESGGPGH SKMTEPSLQN KDSSCSESKM LEQETIVASE 
AGENEKHKKS FLEHSSLENP CGTSLEMFLS PFQTPCHFEE SGQDLEIWKE STTVNGMAAN 
ILKNNRIQNQ PKRFKDATEV GCQPLPFATT LWGVHSAQTE KEKKKESSNC GRRNVFSYGR 
VKLCSTGFIT HVVQNEKTKS TETEHSFKNY VRPGPTRAQE TFGNRTRHSV ETPDIKDLAS 
TLSKESGQLP NKKNCRTNIS YGLENEPTAT YTMFSAFQEG SKKSQTDCIL SDTSPSFPWY 
RHVSNDSRKT DKLIGFSKPI VRKKLSLSSQ LGSLEKFKRQ YGKVENPLDT EVEESNGVTT 
NLSLQVEPDI LLKDKNRLEN SDVCKITTME HSDSDSSCQP ASHILDSEKF PFSKDEDCLE 
QQMLSLRESP MTLKELSLFN RKPLDLEKSS ESLASKLSRL KGSERETQTM GMMSRFNELP 
NSDSSRKDSK LCSVLTQDFC MLFNNKHEKT ENGVIPTSDS ATQDNSFNKN SKTHSNSNTT 
ENCVISETPL VLPYNNSKVT GKDSDVLIRA SEQQIGSLDS PSGMLMNPVE DATGDQNGIC 
FQSEESKARA CSETEESNTC CSDWQRHFDV ALGRMVYVNK MTGLSTFIAP TEDIQAACTK 
DLTTVAVDVV LENGSQYRCQ PFRSDLVLPF LPRARAERTV MRQDNRDTVD DTVSSESLQS 
LFSEWDNPVF ARYPEVAVDV SSGQAESLAV KIHNILYPYR FTKGMIHSMQ VLQQVDNKFI 
ACLMSTKTEE NGEADSYEKQ QAQGSGRKKL LSSTLIPPLE ITVTEEQRRL LWCYHKNLED 
LGLEFVFPDT SDSLVLVGKV PLCFVEREAN ELRRGRSTVT KSIVEEFIRE QLELLQTTGG 
IQGTLPLTVQ KVLASQACHG AIKFNDGLSL QESCRLIEAL SSCQLPFQCA HGRPSMLPLA 
DIDHLEQEKQ IKPNLTKLRK MAQAWRLFGK AECDTRQSLQ QSMPPCEPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.