Details for: PKD2L2

Gene ID: 27039

Symbol: PKD2L2

Ensembl ID: ENSG00000078795

Description: polycystin 2 like 2, transient receptor potential cation channel

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 52.5892
    Cell Significance Index: -8.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.4077
    Cell Significance Index: -8.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.6507
    Cell Significance Index: -8.2000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.1668
    Cell Significance Index: 28.4700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.1447
    Cell Significance Index: 18.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7337
    Cell Significance Index: 10.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.6643
    Cell Significance Index: 11.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6470
    Cell Significance Index: 16.6300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.5789
    Cell Significance Index: 7.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4853
    Cell Significance Index: 37.2500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4650
    Cell Significance Index: 6.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4316
    Cell Significance Index: 85.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3496
    Cell Significance Index: 66.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3279
    Cell Significance Index: 7.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3259
    Cell Significance Index: 6.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2536
    Cell Significance Index: 15.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2509
    Cell Significance Index: 36.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2391
    Cell Significance Index: 1.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2352
    Cell Significance Index: 162.6500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2197
    Cell Significance Index: 1.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2124
    Cell Significance Index: 5.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1917
    Cell Significance Index: 38.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1818
    Cell Significance Index: 5.0800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1712
    Cell Significance Index: 2.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1537
    Cell Significance Index: 1.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1494
    Cell Significance Index: 5.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1304
    Cell Significance Index: 7.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1195
    Cell Significance Index: 107.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1170
    Cell Significance Index: 11.5700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1157
    Cell Significance Index: 1.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1131
    Cell Significance Index: 174.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1070
    Cell Significance Index: 1.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1008
    Cell Significance Index: 4.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0979
    Cell Significance Index: 4.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0895
    Cell Significance Index: 9.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0877
    Cell Significance Index: 4.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0822
    Cell Significance Index: 2.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0800
    Cell Significance Index: 147.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0722
    Cell Significance Index: 25.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0679
    Cell Significance Index: 127.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0600
    Cell Significance Index: 9.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0546
    Cell Significance Index: 9.8500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0543
    Cell Significance Index: 0.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0519
    Cell Significance Index: 70.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0499
    Cell Significance Index: 1.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0444
    Cell Significance Index: 1.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0298
    Cell Significance Index: 1.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0219
    Cell Significance Index: 0.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0163
    Cell Significance Index: 1.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0155
    Cell Significance Index: 1.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0132
    Cell Significance Index: 0.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0100
    Cell Significance Index: 0.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0078
    Cell Significance Index: 3.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0051
    Cell Significance Index: 3.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0003
    Cell Significance Index: -0.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0033
    Cell Significance Index: -0.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0064
    Cell Significance Index: -3.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0073
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0104
    Cell Significance Index: -7.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -7.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0123
    Cell Significance Index: -1.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0127
    Cell Significance Index: -9.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0140
    Cell Significance Index: -7.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0158
    Cell Significance Index: -9.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0175
    Cell Significance Index: -1.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0192
    Cell Significance Index: -5.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0264
    Cell Significance Index: -4.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0301
    Cell Significance Index: -0.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0349
    Cell Significance Index: -4.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0412
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0412
    Cell Significance Index: -8.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0447
    Cell Significance Index: -0.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0498
    Cell Significance Index: -3.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0512
    Cell Significance Index: -6.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0545
    Cell Significance Index: -2.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0574
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0578
    Cell Significance Index: -6.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0610
    Cell Significance Index: -0.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0640
    Cell Significance Index: -2.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0679
    Cell Significance Index: -8.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0725
    Cell Significance Index: -7.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0801
    Cell Significance Index: -1.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0917
    Cell Significance Index: -2.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0980
    Cell Significance Index: -2.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1048
    Cell Significance Index: -5.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1066
    Cell Significance Index: -8.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1109
    Cell Significance Index: -5.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1175
    Cell Significance Index: -8.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1179
    Cell Significance Index: -3.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1239
    Cell Significance Index: -3.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1262
    Cell Significance Index: -8.1400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1291
    Cell Significance Index: -1.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1338
    Cell Significance Index: -2.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1353
    Cell Significance Index: -7.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1356
    Cell Significance Index: -2.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1367
    Cell Significance Index: -4.7900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1395
    Cell Significance Index: -1.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1539
    Cell Significance Index: -3.0900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1552
    Cell Significance Index: -1.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Structure:** The PKD2L2 gene is a single-coding gene that spans approximately 4.5 kilobases. 2. **Protein Function:** The PKD2L2 protein is a transmembrane cation channel that regulates calcium influx into cells. 3. **Expression Pattern:** The PKD2L2 gene is highly expressed in skeletal muscle, colon, and cardiac tissue, with lower expression levels in other tissues. 4. **Cell Type-Specific Expression:** The PKD2L2 gene is specifically expressed in cells with distinct functions, such as GABAergic interneurons in the cerebral cortex and lens epithelial cells. **Pathways and Functions:** 1. **Calcium Signaling:** The PKD2L2 protein regulates calcium influx into cells, which is essential for various cellular processes, including muscle contraction, cell growth, and differentiation. 2. **Mechanoreception:** The PKD2L2 protein is involved in mechanoreception, allowing cells to detect mechanical stimuli, such as touch and pressure. 3. **Cell Growth and Differentiation:** The PKD2L2 protein regulates cell growth and differentiation by modulating calcium signaling and mechanoreception. 4. **Neurotransmission:** The PKD2L2 protein is expressed in GABAergic interneurons, suggesting a role in neurotransmission and synaptic plasticity. **Clinical Significance:** 1. **Polycystic Kidney Disease (PKD):** The PKD2L2 gene has been implicated in PKD, a genetic disorder characterized by the growth of cysts in the kidneys. 2. **Cancer:** The PKD2L2 gene has been identified as a potential oncogene, with overexpression associated with various types of cancer, including breast and lung cancer. 3. **Neurological Disorders:** The PKD2L2 gene has been linked to neurological disorders, such as epilepsy and schizophrenia, due to its expression in GABAergic interneurons. 4. **Cardiovascular Disease:** The PKD2L2 gene has been implicated in cardiovascular disease, with altered expression levels associated with cardiac hypertrophy and fibrosis. In conclusion, the PKD2L2 gene plays a critical role in various cellular processes, including calcium signaling, mechanoreception, and cell growth. Its widespread expression and involvement in diseases such as PKD, cancer, and neurological disorders highlight the importance of further research into the PKD2L2 gene and its potential therapeutic applications.

Genular Protein ID: 903800640

Symbol: PK2L2_HUMAN

Name: Polycystin-2-like protein 2

UniProtKB Accession Codes:

Q9NZM6 A6NK98 B4DXD2 E9PC91 E9PDG4 Q86YB4 Q9UNJ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 5 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 RefSeq 5 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10602361

Title: Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2).

PubMed ID: 10602361

DOI: 10.1038/sj.ejhg.5200383

PubMed ID: 10756092

Title: Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization.

PubMed ID: 10756092

DOI: 10.1006/geno.2000.6131

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11698076

Title: Polycystin channels and kidney disease.

PubMed ID: 11698076

DOI: 10.1016/s0165-6147(00)01832-0

Sequence Information:

  • Length: 624
  • Mass: 73790
  • Checksum: 7D9FFA04542A47A4
  • Sequence:
    • MAEASRWHRG GASKHKLHYR KEVEITTTLQ ELLLYFIFLI NLCILTFGMV NPHMYYLNKV 
MSSLFLDTSV PGEERTNFKS IRSITDFWKF MEGPLLEGLY WDSWYNNQQL YNLKNSSRIY 
YENILLGVPR VRQLKVRNNT CKVYSSFQSL MSECYGKYTS ANEDLSNFGL QINTEWRYST 
SNTNSPWHWG FLGVYRNGGY IFTLSKSKSE TKNKFIDLRL NSWITRGTRV IFIDFSLYNA 
NVNLFCIIRL VAEFPATGGI LTSWQFYSVK LLRYVSYYDY FIASCEITFC IFLFVFTTQE 
VKKIKEFKSA YFKSIWNWLE LLLLLLCFVA VSFNTYYNVQ IFLLLGQLLK STEKYSDFYF 
LACWHIYYNN IIAITIFFAW IKIFKFISFN KTMSQLSSTL SRCVKDIVGF AIMFFIIFFA 
YAQLGFLVFG SQVDDFSTFQ NSIFAQFRIV LGDFNFAGIQ QANPILGPIY FITFIFFVFF 
VLLNMFLAII NDTYSEVKAD YSIGRRLDFE LGKMIKQSYK NVLEKFRLKK AQKDEDKKTK 
GSGDLAEQAR REGFDENEIQ NAEQMKKWKE RLEKKYYSME IQDDYQPVTQ EEFRELFLYA 
VELEKELHYI NLKLNQVVRK VSAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.