Details for: NSG1

Gene ID: 27065

Symbol: NSG1

Ensembl ID: ENSG00000168824

Description: neuronal vesicle trafficking associated 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.0084
    Cell Significance Index: -19.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.8643
    Cell Significance Index: -19.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8956
    Cell Significance Index: -23.8300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 6.3597
    Cell Significance Index: 49.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.1730
    Cell Significance Index: 113.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.7086
    Cell Significance Index: 247.2200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.8706
    Cell Significance Index: 22.7400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 3.6650
    Cell Significance Index: 17.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.3732
    Cell Significance Index: 432.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.3535
    Cell Significance Index: -10.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.1690
    Cell Significance Index: 40.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.1060
    Cell Significance Index: 99.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.6161
    Cell Significance Index: 68.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5842
    Cell Significance Index: 70.3400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.5150
    Cell Significance Index: 5.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3988
    Cell Significance Index: 124.6100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.3726
    Cell Significance Index: 20.9000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.3708
    Cell Significance Index: 17.0000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.1923
    Cell Significance Index: 12.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1063
    Cell Significance Index: 68.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0465
    Cell Significance Index: 54.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8432
    Cell Significance Index: 11.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8373
    Cell Significance Index: 20.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5494
    Cell Significance Index: 110.2000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5149
    Cell Significance Index: 7.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4658
    Cell Significance Index: 9.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4638
    Cell Significance Index: 28.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4125
    Cell Significance Index: 147.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3494
    Cell Significance Index: 154.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3401
    Cell Significance Index: 41.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3059
    Cell Significance Index: 55.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2690
    Cell Significance Index: 16.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2463
    Cell Significance Index: 134.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1687
    Cell Significance Index: 7.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1414
    Cell Significance Index: 88.2800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1262
    Cell Significance Index: 1.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1093
    Cell Significance Index: 11.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0974
    Cell Significance Index: 4.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0658
    Cell Significance Index: 1.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0617
    Cell Significance Index: 11.7400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0527
    Cell Significance Index: 0.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0415
    Cell Significance Index: 1.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0291
    Cell Significance Index: 26.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0245
    Cell Significance Index: 0.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0066
    Cell Significance Index: -12.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0119
    Cell Significance Index: -0.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0124
    Cell Significance Index: -22.9500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0127
    Cell Significance Index: -0.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0139
    Cell Significance Index: -21.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0142
    Cell Significance Index: -7.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0145
    Cell Significance Index: -0.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0155
    Cell Significance Index: -2.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0170
    Cell Significance Index: -2.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0173
    Cell Significance Index: -1.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0181
    Cell Significance Index: -11.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0183
    Cell Significance Index: -24.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0267
    Cell Significance Index: -20.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0285
    Cell Significance Index: -0.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0290
    Cell Significance Index: -1.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0307
    Cell Significance Index: -22.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0344
    Cell Significance Index: -7.2500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0355
    Cell Significance Index: -0.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0365
    Cell Significance Index: -7.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0400
    Cell Significance Index: -1.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0433
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0498
    Cell Significance Index: -22.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0508
    Cell Significance Index: -1.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0592
    Cell Significance Index: -17.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0743
    Cell Significance Index: -12.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0762
    Cell Significance Index: -5.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0764
    Cell Significance Index: -8.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1261
    Cell Significance Index: -12.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1268
    Cell Significance Index: -18.4300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1414
    Cell Significance Index: -0.9200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1714
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1733
    Cell Significance Index: -19.7800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.1736
    Cell Significance Index: -1.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1760
    Cell Significance Index: -22.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1782
    Cell Significance Index: -11.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1921
    Cell Significance Index: -22.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1936
    Cell Significance Index: -19.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1957
    Cell Significance Index: -4.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2031
    Cell Significance Index: -4.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2099
    Cell Significance Index: -24.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2266
    Cell Significance Index: -23.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2271
    Cell Significance Index: -2.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2286
    Cell Significance Index: -4.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2363
    Cell Significance Index: -8.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2555
    Cell Significance Index: -5.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2643
    Cell Significance Index: -17.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2645
    Cell Significance Index: -16.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2647
    Cell Significance Index: -3.7900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2960
    Cell Significance Index: -2.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2971
    Cell Significance Index: -22.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3165
    Cell Significance Index: -23.5900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3208
    Cell Significance Index: -4.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3241
    Cell Significance Index: -8.3300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3306
    Cell Significance Index: -2.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The NSG1 gene is a single-copy gene that encodes a protein of unknown function. Despite its name, NSG1 does not appear to be a member of any known gene family. Instead, it is a unique gene that has been identified through its expression in various cell types, including neurons, germ cells, and ovarian surface epithelial cells. The NSG1 protein is highly expressed in the nervous system, particularly in Purkinje cells, primary sensory neurons, and glycinergic neurons. **Pathways and Functions:** The NSG1 gene is involved in a wide range of cellular processes, including: 1. **Neuronal Vesicle Trafficking:** NSG1 plays a crucial role in regulating the trafficking of vesicles within neurons, particularly in the context of synaptic transmission. This involves the interaction with clathrin-coated vesicles and the regulation of endosomal transport. 2. **Apoptotic Process:** NSG1 has been implicated in the regulation of apoptotic processes, particularly in the context of neuronal survival and death. 3. **Neurotransmitter Receptor Signaling Pathway:** NSG1 is involved in the regulation of neurotransmitter receptor signaling pathways, including the glutamatergic and GABAergic systems. 4. **Endoplasmic Reticulum and Golgi Apparatus:** NSG1 interacts with the endoplasmic reticulum and Golgi apparatus, regulating the folding and transport of proteins. **Clinical Significance:** The NSG1 gene has been associated with several neurological disorders, including: 1. **Neurodegenerative Diseases:** NSG1 has been implicated in the regulation of amyloid precursor protein metabolism, which is a key component of Alzheimer's disease. 2. **Synaptic Dysfunction:** NSG1 plays a crucial role in regulating synaptic function, particularly in the context of glutamatergic and GABAergic systems. Dysregulation of NSG1 has been implicated in various neurological disorders, including Parkinson's disease and schizophrenia. 3. **Neurodevelopmental Disorders:** NSG1 has been associated with neurodevelopmental disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD). In conclusion, the NSG1 gene is a fascinating component of the human genome that plays a crucial role in regulating neuronal vesicle trafficking and synaptic function. Further research is needed to fully understand the mechanisms by which NSG1 regulates these processes and to explore its potential as a therapeutic target for neurological disorders.

Genular Protein ID: 2855830987

Symbol: NSG1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P42857 B4DXC5 Q49AQ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 9 ExpressionAtlas 1 GO 34 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9013775

Title: Variable subcellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons.

PubMed ID: 9013775

DOI: 10.1016/s0169-328x(96)00115-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20599942

Title: D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage.

PubMed ID: 20599942

DOI: 10.1016/j.yexcr.2010.06.025

PubMed ID: 20878061

Title: Identification of NEEP21, encoding neuron-enriched endosomal protein of 21 kDa, as a transcriptional target of tumor suppressor p53.

PubMed ID: 20878061

DOI: 10.3892/ijo_00000765

PubMed ID: 30312582

Title: Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape and Invasive Growth.

PubMed ID: 30312582

DOI: 10.1016/j.ajpath.2018.09.006

Sequence Information:

  • Length: 185
  • Mass: 20913
  • Checksum: 4B7086C18BC11605
  • Sequence:
    • MVKLGNNFAE KGTKQPLLED GFDTIPLMTP LDVNQLQFPP PDKVVVKTKT EYEPDRKKGK 
ARPPQIAEFT VSITEGVTER FKVSVLVLFA LAFLTCVVFL VVYKVYKYDR ACPDGFVLKN 
TQCIPEGLES YYAEQDSSAR EKFYTVINHY NLAKQSITRS VSPWMSVLSE EKLSEQETEA 
AEKSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.