Details for: RPUSD2

Gene ID: 27079

Symbol: RPUSD2

Ensembl ID: ENSG00000166133

Description: RNA pseudouridine synthase domain containing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.6766
    Cell Significance Index: -8.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.8087
    Cell Significance Index: -8.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8930
    Cell Significance Index: -7.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.8113
    Cell Significance Index: 38.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3756
    Cell Significance Index: 136.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0131
    Cell Significance Index: 60.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9416
    Cell Significance Index: 850.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7455
    Cell Significance Index: 121.2500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.6029
    Cell Significance Index: 8.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5838
    Cell Significance Index: 15.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5585
    Cell Significance Index: 35.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4659
    Cell Significance Index: 32.2200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4482
    Cell Significance Index: 7.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2360
    Cell Significance Index: 24.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2264
    Cell Significance Index: 11.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2207
    Cell Significance Index: 15.6100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1881
    Cell Significance Index: 1.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1808
    Cell Significance Index: 79.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1689
    Cell Significance Index: 3.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1647
    Cell Significance Index: 1.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1609
    Cell Significance Index: 19.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1514
    Cell Significance Index: 20.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1472
    Cell Significance Index: 80.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1465
    Cell Significance Index: 6.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1457
    Cell Significance Index: 3.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1433
    Cell Significance Index: 6.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1416
    Cell Significance Index: 25.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1392
    Cell Significance Index: 4.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1367
    Cell Significance Index: 7.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1296
    Cell Significance Index: 16.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1091
    Cell Significance Index: 1.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0965
    Cell Significance Index: 7.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0920
    Cell Significance Index: 10.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0893
    Cell Significance Index: 17.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0811
    Cell Significance Index: 16.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0696
    Cell Significance Index: 1.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0694
    Cell Significance Index: 1.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0674
    Cell Significance Index: 12.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0583
    Cell Significance Index: 0.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0544
    Cell Significance Index: 0.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0533
    Cell Significance Index: 3.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0338
    Cell Significance Index: 0.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0336
    Cell Significance Index: 4.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0319
    Cell Significance Index: 1.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0301
    Cell Significance Index: 10.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0243
    Cell Significance Index: 0.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0134
    Cell Significance Index: 0.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0107
    Cell Significance Index: 0.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0007
    Cell Significance Index: 0.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0015
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0016
    Cell Significance Index: -0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -11.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0069
    Cell Significance Index: -10.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0104
    Cell Significance Index: -7.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0110
    Cell Significance Index: -6.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0127
    Cell Significance Index: -0.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0165
    Cell Significance Index: -7.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0165
    Cell Significance Index: -10.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0184
    Cell Significance Index: -0.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0191
    Cell Significance Index: -5.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0208
    Cell Significance Index: -0.6100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0339
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0353
    Cell Significance Index: -4.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0413
    Cell Significance Index: -4.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0442
    Cell Significance Index: -3.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0455
    Cell Significance Index: -6.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0495
    Cell Significance Index: -10.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0556
    Cell Significance Index: -1.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0592
    Cell Significance Index: -1.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0614
    Cell Significance Index: -3.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0678
    Cell Significance Index: -0.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0706
    Cell Significance Index: -2.2600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0751
    Cell Significance Index: -0.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0773
    Cell Significance Index: -0.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0779
    Cell Significance Index: -1.8000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0792
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0800
    Cell Significance Index: -0.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0812
    Cell Significance Index: -4.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0819
    Cell Significance Index: -5.5100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0843
    Cell Significance Index: -1.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0854
    Cell Significance Index: -4.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0936
    Cell Significance Index: -7.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0972
    Cell Significance Index: -10.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1169
    Cell Significance Index: -7.1700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1202
    Cell Significance Index: -1.0100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1557
    Cell Significance Index: -1.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1668
    Cell Significance Index: -7.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1782
    Cell Significance Index: -4.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1941
    Cell Significance Index: -7.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1955
    Cell Significance Index: -3.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2040
    Cell Significance Index: -6.0100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2121
    Cell Significance Index: -2.6800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2146
    Cell Significance Index: -1.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2155
    Cell Significance Index: -7.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2208
    Cell Significance Index: -4.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2252
    Cell Significance Index: -4.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPUSD2 is a pseudogen, meaning it has undergone significant degradation and is no longer a fully functional gene. Despite this, it retains the RNA pseudouridine synthase domain, which is a functional motif that has been conserved across species. The gene's expression pattern is highly tissue-specific, with significant expression in cells that require rapid proliferation and differentiation, such as germ cells and intestinal stem cells. This suggests that RPUSD2 may play a role in regulating cellular processes that are essential for the maintenance of tissue homeostasis. **Pathways and Functions** RPUSD2 is involved in several cellular pathways, including: 1. **RNA pseudouridine synthesis**: RPUSD2's pseudouridine synthase domain is responsible for the synthesis of pseudouridine, a modified nucleotide that is essential for RNA stability and function. 2. **mRNA processing**: RPUSD2's expression in cells that undergo rapid proliferation and differentiation suggests that it may play a role in regulating mRNA processing, including splicing and translation. 3. **RNA binding**: RPUSD2's expression in cells that require rapid RNA turnover suggests that it may also play a role in regulating RNA binding, including the recruitment of RNA-binding proteins. **Clinical Significance** While RPUSD2 is not directly linked to any human diseases, its expression in specific cell types suggests that it may play a role in regulating cellular processes that are essential for tissue homeostasis. Further studies are needed to determine the functional significance of RPUSD2 and its potential role in human disease. In particular, RPUSD2's expression in germ cells and neurons suggests that it may play a role in regulating cellular processes that are essential for fertility and neurological function. Additionally, its expression in intestinal epithelial cells suggests that it may play a role in regulating cellular processes that are essential for intestinal homeostasis. In summary, RPUSD2 is a pseudogene that encodes a pseudouridine synthase domain, which is involved in RNA pseudouridine synthesis, mRNA processing, and RNA binding. Its highly tissue-specific expression pattern suggests that it may play a role in regulating cellular processes that are essential for tissue homeostasis, and further studies are needed to determine its functional significance and potential clinical relevance.

Genular Protein ID: 984322226

Symbol: RUSD2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IZ73 B4DDD1 Q7L989 Q92939 Q96IA7 Q96N50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31477916

Title: mRNA structure determines modification by pseudouridine synthase 1.

PubMed ID: 31477916

DOI: 10.1038/s41589-019-0353-z

PubMed ID: 35051350

Title: Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing.

PubMed ID: 35051350

DOI: 10.1016/j.molcel.2021.12.023

Sequence Information:

  • Length: 545
  • Mass: 61311
  • Checksum: 16E8B71918A6E0B7
  • Sequence:
    • MWLDRRGWLR VLGHWRYDLR RPSFTRTWSG DKGPMAETVS TQVGTEGGLR ASHQQNGDAG 
GDAKVELSPG PPKPAGREVE PAPVGGEHPS AAAPGPGKHK KRRGATRERV VPPPKKRRTG 
VSFGDEHFAE TSYYFEGGLR KVRPYYFDFR TYCKGRWVGH SLLHVFSTEF RAQPLAYYEA 
AVRAGRLQLN EKPVQDLNIV LKDNDFLRNT VHRHEPPVTA EPIRLLAENE DVVVVDKPSS 
IPVHPCGRFR HNTVIFILGK EHQLKELHPL HRLDRLTSGV LMFAKTAAVS ERIHEQVRDR 
QLEKEYVCRV EGEFPTEEVT CKEPILVVSY KVGVCRVDPR GKPCETVFQR LSYNGQSSVV 
RCRPLTGRTH QIRVHLQFLG HPILNDPIYN SVAWGPSRGR GGYIPKTNEE LLRDLVAEHQ 
AKQSLDVLDL CEGDLSPGLT DSTAPSSELG KDDLEELAAA AQKMEEVAEA APQELDTIAL 
ASEKAVETDV MNQETDPLCA ECRLVRQDPL PQDLVMFLHA LRYKGPGFEY FSPMPAWAQD 
DWQKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.