Details for: ZBTB11

Gene ID: 27107

Symbol: ZBTB11

Ensembl ID: ENSG00000066422

Description: zinc finger and BTB domain containing 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 174.6116
    Cell Significance Index: -27.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.9021
    Cell Significance Index: -27.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.8482
    Cell Significance Index: -24.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.8725
    Cell Significance Index: -28.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.9546
    Cell Significance Index: -24.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.0179
    Cell Significance Index: -28.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.5530
    Cell Significance Index: -28.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3027
    Cell Significance Index: -22.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2680
    Cell Significance Index: -28.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4367
    Cell Significance Index: -9.7100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.7762
    Cell Significance Index: 29.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5249
    Cell Significance Index: 177.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1950
    Cell Significance Index: 194.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0882
    Cell Significance Index: 218.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7480
    Cell Significance Index: 21.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7273
    Cell Significance Index: 144.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6946
    Cell Significance Index: 75.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6675
    Cell Significance Index: 40.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6559
    Cell Significance Index: 29.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5524
    Cell Significance Index: 35.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5293
    Cell Significance Index: 13.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5100
    Cell Significance Index: 182.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4931
    Cell Significance Index: 48.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4080
    Cell Significance Index: 18.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3957
    Cell Significance Index: 357.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3912
    Cell Significance Index: 21.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3873
    Cell Significance Index: 20.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3719
    Cell Significance Index: 9.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3697
    Cell Significance Index: 45.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3283
    Cell Significance Index: 12.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3244
    Cell Significance Index: 143.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3216
    Cell Significance Index: 22.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3205
    Cell Significance Index: 57.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3200
    Cell Significance Index: 43.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2672
    Cell Significance Index: 20.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2601
    Cell Significance Index: 142.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2396
    Cell Significance Index: 5.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2333
    Cell Significance Index: 161.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2109
    Cell Significance Index: 5.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1783
    Cell Significance Index: 12.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1679
    Cell Significance Index: 10.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1606
    Cell Significance Index: 9.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1594
    Cell Significance Index: 30.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1437
    Cell Significance Index: 6.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1327
    Cell Significance Index: 8.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1099
    Cell Significance Index: 3.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0655
    Cell Significance Index: 1.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0416
    Cell Significance Index: 7.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0343
    Cell Significance Index: 1.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0340
    Cell Significance Index: 4.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0307
    Cell Significance Index: 0.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0270
    Cell Significance Index: 50.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0269
    Cell Significance Index: 0.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0152
    Cell Significance Index: 9.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0066
    Cell Significance Index: 10.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0013
    Cell Significance Index: 2.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0011
    Cell Significance Index: 1.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0091
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0126
    Cell Significance Index: -9.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0150
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0180
    Cell Significance Index: -13.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0203
    Cell Significance Index: -12.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0298
    Cell Significance Index: -22.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0322
    Cell Significance Index: -18.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0334
    Cell Significance Index: -4.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0392
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0750
    Cell Significance Index: -15.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0768
    Cell Significance Index: -7.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0830
    Cell Significance Index: -9.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0837
    Cell Significance Index: -24.0800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0901
    Cell Significance Index: -1.8700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0935
    Cell Significance Index: -1.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1055
    Cell Significance Index: -1.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1099
    Cell Significance Index: -14.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1204
    Cell Significance Index: -6.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1578
    Cell Significance Index: -3.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1768
    Cell Significance Index: -3.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1968
    Cell Significance Index: -4.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2030
    Cell Significance Index: -2.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2086
    Cell Significance Index: -15.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2141
    Cell Significance Index: -11.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2242
    Cell Significance Index: -4.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2354
    Cell Significance Index: -6.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2492
    Cell Significance Index: -25.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2841
    Cell Significance Index: -7.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2872
    Cell Significance Index: -7.7000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3062
    Cell Significance Index: -1.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3128
    Cell Significance Index: -24.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3369
    Cell Significance Index: -8.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3566
    Cell Significance Index: -12.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4505
    Cell Significance Index: -7.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4570
    Cell Significance Index: -9.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4598
    Cell Significance Index: -7.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4900
    Cell Significance Index: -30.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4959
    Cell Significance Index: -25.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5006
    Cell Significance Index: -16.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5019
    Cell Significance Index: -11.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5149
    Cell Significance Index: -16.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5322
    Cell Significance Index: -11.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZBTB11 belongs to the BTB/POZ family of transcription factors, which are characterized by the presence of a BTB domain and a POZ domain. These domains are essential for the protein's ability to bind to DNA and regulate gene expression. ZBTB11 is a metal ion-binding protein, which suggests its ability to interact with various metal ions and modulate its transcriptional activity. The protein's expression pattern, with high levels in germ cells, mural cells, and neural cells, indicates its involvement in cell differentiation and development. **Pathways and Functions:** ZBTB11 is involved in various biological pathways, including: 1. **DNA-binding transcription factor activity**: ZBTB11 regulates gene expression by binding to specific DNA sequences, thereby modulating the transcription of target genes. 2. **RNA polymerase II-specific**: ZBTB11 interacts with the RNA polymerase II complex, which is responsible for transcribing protein-coding genes. 3. **Metal ion binding**: ZBTB11's metal ion-binding capacity allows it to interact with various metal ions, which may modulate its transcriptional activity. 4. **Regulation of DNA-templated transcription**: ZBTB11 regulates the transcription of genes involved in DNA replication and repair. 5. **Regulation of transcription by RNA polymerase II**: ZBTB11 modulates the transcription of genes involved in cell differentiation, development, and function. **Functions:** ZBTB11's functions are diverse and far-reaching, including: 1. **Cell differentiation**: ZBTB11 regulates the differentiation of germ cells, mural cells, and neural cells, ensuring proper development and function. 2. **Gene expression**: ZBTB11 regulates the expression of target genes involved in various biological processes, including development, cell differentiation, and function. 3. **Transcriptional regulation**: ZBTB11 modulates the transcription of genes involved in DNA replication, repair, and transcription. **Clinical Significance:** ZBTB11's involvement in various biological processes makes it a potential therapeutic target for diseases related to cell differentiation, development, and function. For example: 1. **Neurological disorders**: ZBTB11's role in regulating neural cell differentiation and function makes it a potential target for treating neurological disorders, such as Parkinson's disease and Alzheimer's disease. 2. **Cancer**: ZBTB11's involvement in regulating gene expression and cell differentiation makes it a potential target for cancer therapy. 3. **Developmental disorders**: ZBTB11's role in regulating cell differentiation and development makes it a potential target for treating developmental disorders, such as Down syndrome. In conclusion, ZBTB11 is a transcription factor protein with diverse implications in development, cell differentiation, and function. Its involvement in various biological pathways and functions makes it a potential therapeutic target for diseases related to cell differentiation, development, and function. Further research is needed to fully understand the mechanisms of ZBTB11 and its potential applications in human disease.

Genular Protein ID: 3873566934

Symbol: ZBT11_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28397838

Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PubMed ID: 28397838

DOI: 10.1038/mp.2017.60

PubMed ID: 29893856

Title: Biallelic missense variants in ZBTB11 can cause intellectual disability in humans.

PubMed ID: 29893856

DOI: 10.1093/hmg/ddy220

Sequence Information:

  • Length: 1053
  • Mass: 119384
  • Checksum: 156765B7334BF101
  • Sequence:
  • MSSEESYRAI LRYLTNEREP YAPGTEGNVK RKIRKAAACY VVRGGTLYYQ RRQRHRKTFA 
    ELEVVLQPER RRDLIEAAHL GPGGTHHTRH QTWHYLSKTY WWRGILKQVK DYIKQCSKCQ 
    EKLDRSRPIS DVSEMLEELG LDLESGEESN ESEDDLSNFT SSPTTASKPA KKKPVSKHEL 
    VFVDTKGVVK RSSPKHCQAV LKQLNEQRLS NQFCDVTLLI EGEEYKAHKS VLSANSEYFR 
    DLFIEKGAVS SHEAVVDLSG FCKASFLPLL EFAYTSVLSF DFCSMADVAI LARHLFMSEV 
    LEICESVHKL MEEKQLTVYK KGEVQTVAST QDLRVQNGGT APPVASSEGT TTSLPTELGD 
    CEIVLLVNGE LPEAEQNGEV GRQPEPQVSS EAESALSSVG CIADSHPEME SVDLITKNNQ 
    TELETSNNRE NNTVSNIHPK LSKENVISSS PEDSGMGNDI SAEDICAEDI PKHRQKVDQP 
    LKDQENLVAS TAKTDFGPDD DTYRSRLRQR SVNEGAYIRL HKGMEKKLQK RKAVPKSAVQ 
    QVAQKLVQRG KKMKQPKRDA KENTEEASHK CGECGMVFQR RYALIMHKLK HERARDYKCP 
    LCKKQFQYSA SLRAHLIRHT RKDAPSSSSS NSTSNEASGT SSEKGRTKRE FICSICGRTL 
    PKLYSLRIHM LKHTGVKPHA CQVCGKTFIY KHGLKLHQSL HQSQKQFQCE LCVKSFVTKR 
    SLQEHMSIHT GESKYLCSVC GKSFHRGSGL SKHFKKHQPK PEVRGYHCTQ CEKSFFEARD 
    LRQHMNKHLG VKPFQCQFCD KCYSWKKDWY SHVKSHSVTE PYRCNICGKE FYEKALFRRH 
    VKKATHGKKG RAKQNLERVC EKCGRKFTQL REYRRHMNNH EGVKPFECLT CGVAWADARS 
    LKRHVRTHTG ERPYVCPVCS EAYIDARTLR KHMTKFHRDY VPCKIMLEKD TLQFHNQGTQ 
    VAHAVSILTA GMQEQESSGP QELETVVVTG ETMEALEAVA ATEEYPSVST LSDQSIMQVV 
    NYVLAQQQGQ KLSEVAEAIQ TVKVEVAHIS GGE

Genular Protein ID: 931977201

Symbol: Q59H97_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 700
  • Mass: 79424
  • Checksum: EA0944D04DDD7374
  • Sequence:
  • LPTELGDCEI VLLVNGELPE AEQNGEVGRQ PEPQVSSEAE SALSSVGCIA DSHPEMESVD 
    LITKNNQTEL ETSNNRENNT VSNIHPKLSK ENVISSSPED SGMGNDISAE DICAEDIPKH 
    RQKVDQPLKD QENLVASTAK TDFGPDDDTY RSRLRQRSVN EGAYIRLHKG MEKKLQKRKA 
    VPKSAVQQVA QKLVQRGKKM KQPKRDAKEN TEEASHKCGE CGMVFQRRYA LIMHKLKHER 
    ARDYKCPLCK KQFQYSASLR AHLIRHTRKD APSSSSSNST SNEASGTSSE KGRTKREFIC 
    SICGRTLPKL YSLRIHMLKH TGVKPHACQV CGKTFIYKHG LKLHQSLHQS QKQFQCELCV 
    KSFVTKRSLQ EHMSIHTGES KYLCSVCGKS FHRGSGLSKH FKKHQPKPEV RGYHCTQCEK 
    SFFEARDLRQ HMNKHLGVKP FQCQFCDKCY SWKKDWYSHV KSHSVTEPYR CNICGKEFYE 
    KALFRRHVKK ATHGKKGRAK QNLERVCEKC GRKFTQLREY RRHMNNHEGV KPFECLTCGV 
    AWADARSLKR HVRTHTGERP YVCPVCSEAY IDARTLRKHM TKFHRDYVPC KIMLEKDTLQ 
    FHNQGTQVAH AVSILTAGMQ EQESSGPQEL ETVVVTGETM EALEAVAATE EYPSVSTLSD 
    QSIMQVVNYV LAQQQGQKLS EVAEAIQTVK VEVAHISGGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.