Details for: NALF2

Gene ID: 27112

Symbol: NALF2

Ensembl ID: ENSG00000130054

Description: NALCN channel auxiliary factor 2

Associated with

  • Calcium ion import across plasma membrane
    (GO:0098703)
  • Plasma membrane
    (GO:0005886)
  • Stretch-activated, monoatomic cation-selective, calcium channel activity
    (GO:0015275)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2082
    Cell Significance Index: 29.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5058
    Cell Significance Index: 96.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4211
    Cell Significance Index: 9.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3894
    Cell Significance Index: 38.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3428
    Cell Significance Index: 7.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2644
    Cell Significance Index: 238.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2133
    Cell Significance Index: 2.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1997
    Cell Significance Index: 21.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1876
    Cell Significance Index: 30.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1761
    Cell Significance Index: 10.5700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.1632
    Cell Significance Index: 2.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1413
    Cell Significance Index: 10.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0872
    Cell Significance Index: 6.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0454
    Cell Significance Index: 9.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0377
    Cell Significance Index: 1.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0267
    Cell Significance Index: 1.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0249
    Cell Significance Index: 8.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0188
    Cell Significance Index: 0.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0157
    Cell Significance Index: 0.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0127
    Cell Significance Index: 8.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0121
    Cell Significance Index: 0.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0115
    Cell Significance Index: 0.3300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0082
    Cell Significance Index: 0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0074
    Cell Significance Index: 0.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0049
    Cell Significance Index: 0.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0028
    Cell Significance Index: 0.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0010
    Cell Significance Index: 0.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0013
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0028
    Cell Significance Index: -3.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0034
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.8500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0047
    Cell Significance Index: -2.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0051
    Cell Significance Index: -3.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0053
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0053
    Cell Significance Index: -3.3200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0057
    Cell Significance Index: -3.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0058
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0066
    Cell Significance Index: -1.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0084
    Cell Significance Index: -3.8200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0092
    Cell Significance Index: -0.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0105
    Cell Significance Index: -2.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0106
    Cell Significance Index: -0.7100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0113
    Cell Significance Index: -0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0114
    Cell Significance Index: -2.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0126
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0178
    Cell Significance Index: -3.7500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0187
    Cell Significance Index: -0.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0188
    Cell Significance Index: -2.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0189
    Cell Significance Index: -2.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0202
    Cell Significance Index: -1.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0234
    Cell Significance Index: -3.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0259
    Cell Significance Index: -0.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0269
    Cell Significance Index: -3.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0272
    Cell Significance Index: -3.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0274
    Cell Significance Index: -0.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0287
    Cell Significance Index: -0.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0365
    Cell Significance Index: -1.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0371
    Cell Significance Index: -3.8600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0406
    Cell Significance Index: -0.6000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0419
    Cell Significance Index: -0.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0431
    Cell Significance Index: -0.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0474
    Cell Significance Index: -3.5300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0486
    Cell Significance Index: -0.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0487
    Cell Significance Index: -2.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0547
    Cell Significance Index: -4.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0608
    Cell Significance Index: -2.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0617
    Cell Significance Index: -3.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0634
    Cell Significance Index: -1.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0644
    Cell Significance Index: -0.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0649
    Cell Significance Index: -1.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0687
    Cell Significance Index: -3.2300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0704
    Cell Significance Index: -0.6700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0729
    Cell Significance Index: -0.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0764
    Cell Significance Index: -2.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0779
    Cell Significance Index: -1.6300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0781
    Cell Significance Index: -0.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0782
    Cell Significance Index: -2.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0800
    Cell Significance Index: -2.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0802
    Cell Significance Index: -2.8100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0825
    Cell Significance Index: -1.3900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0870
    Cell Significance Index: -1.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0901
    Cell Significance Index: -2.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0994
    Cell Significance Index: -3.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0999
    Cell Significance Index: -2.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1020
    Cell Significance Index: -2.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1048
    Cell Significance Index: -1.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1074
    Cell Significance Index: -1.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1111
    Cell Significance Index: -2.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1140
    Cell Significance Index: -2.4200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1164
    Cell Significance Index: -1.6100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1164
    Cell Significance Index: -3.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1239
    Cell Significance Index: -3.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1259
    Cell Significance Index: -2.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Auxiliary subunit of NALCN channel**: NALF2 is a regulatory subunit of the NALCN channel, a calcium-selective, monoatomic cation-permeable channel. 2. **Calcium ion transport**: NALF2 facilitates calcium ion import across the plasma membrane, influencing various cellular processes, including muscle contraction, neuronal signaling, and cell differentiation. 3. **Stretch-activated**: NALF2 is involved in stretch-activated calcium channel activity, responding to mechanical forces and maintaining cellular homeostasis. 4. **Widespread expression**: NALF2 is expressed in various cell types, including blood vessel endothelial cells, enterocytes, and neural cells, highlighting its role in maintaining tissue function. **Pathways and Functions:** 1. **Calcium signaling**: NALF2 modulates calcium ion transport, influencing signaling pathways involved in muscle contraction, neuronal signaling, and cell differentiation. 2. **Cell differentiation**: NALF2 plays a role in maintaining the balance of calcium ions, which is essential for cell differentiation and development. 3. **Mechanical forces**: NALF2 is involved in stretch-activated calcium channel activity, responding to mechanical forces and maintaining cellular homeostasis. 4. **Neurotransmission**: NALF2 is expressed in GABAergic interneurons and radial glial cells, suggesting its role in neurotransmission and neuronal development. **Clinical Significance:** 1. **Cardiac arrhythmias**: Mutations in the NALF2 gene have been associated with cardiac arrhythmias, highlighting the importance of calcium ion transport in maintaining cardiac function. 2. **Neurological disorders**: NALF2 expression in GABAergic interneurons and radial glial cells suggests its involvement in neurological disorders, such as epilepsy and developmental disorders. 3. **Gastrointestinal disorders**: NALF2 expression in enterocytes and intestinal crypt stem cells may contribute to gastrointestinal disorders, such as irritable bowel syndrome. 4. **Cancer**: NALF2 expression in various cell types may contribute to cancer development and progression, highlighting the need for further research into its role in cancer biology. In conclusion, NALF2 is a critical regulator of calcium ion transport and cell differentiation, influencing various cellular processes and maintaining tissue function. Its widespread expression across different cell types underscores its importance in maintaining overall health and highlights the need for further research into its role in disease pathology.

Genular Protein ID: 1910351315

Symbol: NALF2_HUMAN

Name: Protein TED

UniProtKB Accession Codes:

O75949 B1ALV6 B9EGK1 D3DVU1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 32494638

Title: The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium.

PubMed ID: 32494638

DOI: 10.1126/sciadv.aaz3154

Sequence Information:

  • Length: 472
  • Mass: 52477
  • Checksum: 709FAB4CEF99B54C
  • Sequence:
    • MFRGAWMWPG KDAAALTICC CCCCWAPRPS DKPCADSERA QRWRLSLASL LFFTVLLADH 
LWLCAGARPR ARELSSAMRP PWGAGRERQP VPPRAVLPLP PPPPGEPSAP PGTCGPRYSN 
LTKAAPAAGS RPVCGGVPEP TGLDAACTKL QSLQRLFEPT TPAPPLRPPD SLSRAPAEFP 
SAKKNLLKGH FRNFTLSFCD TYTVWDLLLG MDRPDSLDCS LDTLMGDLLA VVASPGSGAW 
EACSNCIEAY QRLDRHAQEK YDEFDLVLHK YLQAEEYSIR SCTKGCKAVY KAWLCSEYFS 
VTQQECQRWV PCKQYCLEVQ TRCPFILPDN EEMVYGGLPG FICTGLLDTS PKRLETKCCD 
VQWVSCEAKK KKFKESEAPK THQQQFHHSY FHHYHQQYHH YHPHHDPPGR VSNKPALLPV 
SGGSRLSPSR IRLCVLVLML LHTVVSFSSN QGGGGLGLET LPALEEGLTR EE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.