Details for: CPNE7

Gene ID: 27132

Symbol: CPNE7

Ensembl ID: ENSG00000178773

Description: copine 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 38.5097
    Cell Significance Index: -5.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.2610
    Cell Significance Index: -5.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.8664
    Cell Significance Index: -6.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2289
    Cell Significance Index: 136.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9001
    Cell Significance Index: -5.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6427
    Cell Significance Index: 35.9700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.8312
    Cell Significance Index: 6.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7607
    Cell Significance Index: 75.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5977
    Cell Significance Index: 17.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5498
    Cell Significance Index: 28.5600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5482
    Cell Significance Index: 6.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4203
    Cell Significance Index: 45.7200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.4126
    Cell Significance Index: 3.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4061
    Cell Significance Index: 24.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3943
    Cell Significance Index: 355.9800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3887
    Cell Significance Index: 5.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3869
    Cell Significance Index: 62.9200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3435
    Cell Significance Index: 2.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3387
    Cell Significance Index: 121.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3108
    Cell Significance Index: 9.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2722
    Cell Significance Index: 54.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2716
    Cell Significance Index: 14.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2354
    Cell Significance Index: 5.1000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2205
    Cell Significance Index: 2.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2204
    Cell Significance Index: 41.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2203
    Cell Significance Index: 4.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1906
    Cell Significance Index: 5.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1749
    Cell Significance Index: 12.1000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1689
    Cell Significance Index: 2.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1682
    Cell Significance Index: 30.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1618
    Cell Significance Index: 32.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1306
    Cell Significance Index: 6.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1244
    Cell Significance Index: 2.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1101
    Cell Significance Index: 3.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0827
    Cell Significance Index: 3.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0803
    Cell Significance Index: 55.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0536
    Cell Significance Index: 6.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0470
    Cell Significance Index: 1.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0409
    Cell Significance Index: 3.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0259
    Cell Significance Index: 0.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0232
    Cell Significance Index: 0.5800
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: 0.0223
    Cell Significance Index: 0.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0133
    Cell Significance Index: 0.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0054
    Cell Significance Index: 0.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0054
    Cell Significance Index: 0.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0039
    Cell Significance Index: 1.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -3.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0028
    Cell Significance Index: -0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0029
    Cell Significance Index: -4.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0035
    Cell Significance Index: -0.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0062
    Cell Significance Index: -0.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0063
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0076
    Cell Significance Index: -0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0080
    Cell Significance Index: -6.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0083
    Cell Significance Index: -6.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0091
    Cell Significance Index: -5.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0094
    Cell Significance Index: -5.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0104
    Cell Significance Index: -6.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0112
    Cell Significance Index: -5.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0161
    Cell Significance Index: -4.6400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0194
    Cell Significance Index: -0.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0195
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0227
    Cell Significance Index: -3.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0269
    Cell Significance Index: -5.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0278
    Cell Significance Index: -0.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0315
    Cell Significance Index: -1.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0322
    Cell Significance Index: -0.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0341
    Cell Significance Index: -4.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0347
    Cell Significance Index: -4.7600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0348
    Cell Significance Index: -0.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0361
    Cell Significance Index: -5.2500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0363
    Cell Significance Index: -0.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0367
    Cell Significance Index: -0.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0378
    Cell Significance Index: -4.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0412
    Cell Significance Index: -4.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0453
    Cell Significance Index: -5.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0468
    Cell Significance Index: -1.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0478
    Cell Significance Index: -4.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0512
    Cell Significance Index: -3.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0524
    Cell Significance Index: -0.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0584
    Cell Significance Index: -6.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0603
    Cell Significance Index: -2.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0645
    Cell Significance Index: -4.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0700
    Cell Significance Index: -1.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0741
    Cell Significance Index: -5.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0772
    Cell Significance Index: -4.9800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0824
    Cell Significance Index: -0.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0836
    Cell Significance Index: -2.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0842
    Cell Significance Index: -2.1500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0843
    Cell Significance Index: -1.1700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0863
    Cell Significance Index: -0.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0923
    Cell Significance Index: -2.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0950
    Cell Significance Index: -5.3300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0993
    Cell Significance Index: -4.3200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1057
    Cell Significance Index: -2.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1060
    Cell Significance Index: -5.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1065
    Cell Significance Index: -2.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CPNE7 is a small, cytoplasmic protein that belongs to the copine family, which is known for its involvement in cellular signaling, membrane trafficking, and lipid metabolism. The copine family proteins are characterized by their ability to bind to phospholipids, influencing membrane fluidity and cellular processes. CPNE7, in particular, exhibits high expression levels in various cell types, including colon goblet cells, mural cells, and neurons, suggesting its widespread importance in cellular homeostasis. **Pathways and Functions:** CPNE7 is implicated in multiple pathways, including: 1. **Calcium-dependent phospholipid binding**: CPNE7 interacts with calcium ions, modulating membrane phospholipid composition and influencing cellular signaling. 2. **Lipid metabolic process**: CPNE7 is involved in the regulation of lipid metabolism, including glycerophospholipid biosynthesis and phospholipid metabolism. 3. **Metal ion binding**: CPNE7 can bind to metal ions, such as calcium and magnesium, affecting membrane properties and cellular processes. 4. **Protein binding**: CPNE7 interacts with various proteins, including those involved in membrane trafficking, signaling, and lipid metabolism. **Clinical Significance:** CPNE7's expression in distinct cell types and its involvement in lipid metabolism and calcium-dependent processes make it a potential candidate for involvement in various diseases. Some potential clinical implications of CPNE7 dysregulation include: 1. **Lipid disorders**: Imbalances in lipid metabolism, influenced by CPNE7, may contribute to the development of lipid-related disorders, such as atherosclerosis and obesity. 2. **Neurological disorders**: CPNE7's role in neuronal function and lipid metabolism may be linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Cancer**: Alterations in CPNE7 expression and function may contribute to cancer development and progression, particularly in colon cancer. In conclusion, CPNE7 is a multifunctional protein that plays a crucial role in various cellular processes, including lipid metabolism, calcium-dependent phospholipid binding, and protein binding. Its expression in distinct cell types and potential involvement in disease suggest that further research is necessary to fully elucidate CPNE7's significance in human health and disease.

Genular Protein ID: 988187264

Symbol: CPNE7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UBL6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10534407

Title: Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3.

PubMed ID: 10534407

DOI: 10.1006/geno.1999.5958

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12949241

Title: Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils.

PubMed ID: 12949241

DOI: 10.1189/jlb.0203083

PubMed ID: 21087455

Title: Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting.

PubMed ID: 21087455

DOI: 10.1111/j.1742-4658.2010.07935.x

Sequence Information:

  • Length: 633
  • Mass: 70294
  • Checksum: 8AF4B68D3EFC51BB
  • Sequence:
    • MSAGSERGAA ATPGGLPAPC ASKVELRLSC RHLLDRDPLT KSDPSVALLQ QAQGQWVQVG 
RTEVVRSSLH PVFSKVFTVD YYFEEVQRLR FEVYDTHGPS GFSCQEDDFL GGMECTLGQP 
AQKWLLQVVM RVSVDVLGPA GHCAKHFLCC TESSHLARTG PSFLLRYDDL CLPWATAGAV 
RWWTCRGGHT QGWQIVAQKK VTRPLLLKFG RNAGKSTITV IAEDISGNNG YVELSFRARK 
LDDKDLFSKS DPFLELYRVN DDQGLQLVYR TEVVKNNLNP VWEAFKVSLS SLCSCEETRP 
LKCLVWDYDS RGKHDFIGEF STTFEEMQKA FEEGQAQWDC VNPKYKQKRR SYKNSGVVVL 
ADLKFHRVYS FLDYIMGGCQ IHFTVAIDFT ASNGDPRNSC SLHYINPYQP NEYLKALVSV 
GEICQDYDSD KRFSALGFGA RIPPKYEVSH DFAINFNPED DECEGIQGVV EAYQNCLPRV 
QLYGPTNVAP IISKVARVAA AEESTGKASQ YYILLILTDG VVTDMADTRE AIVRASRLPM 
SIIIVGVGNA DFTDMQVLDG DDGVLRSPRG EPALRDIVQF VPFRELKNAS PAALAKCVLA 
EVPKQVVEYY SHRGLPPRSL GVPAGEASPG CTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.