Details for: MORC1

Gene ID: 27136

Symbol: MORC1

Ensembl ID: ENSG00000114487

Description: MORC family CW-type zinc finger 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.9019
    Cell Significance Index: -4.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.7558
    Cell Significance Index: -4.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3403
    Cell Significance Index: 60.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9084
    Cell Significance Index: 172.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6885
    Cell Significance Index: 68.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.6762
    Cell Significance Index: -1.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5947
    Cell Significance Index: 536.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4331
    Cell Significance Index: 12.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3854
    Cell Significance Index: 3.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3570
    Cell Significance Index: 5.3800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3092
    Cell Significance Index: 2.3400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.3030
    Cell Significance Index: 3.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2767
    Cell Significance Index: 45.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2725
    Cell Significance Index: 29.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2538
    Cell Significance Index: 5.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2531
    Cell Significance Index: 8.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1592
    Cell Significance Index: 11.0100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1396
    Cell Significance Index: 3.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1179
    Cell Significance Index: 2.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0370
    Cell Significance Index: 2.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0198
    Cell Significance Index: 5.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0156
    Cell Significance Index: 3.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0064
    Cell Significance Index: 4.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0014
    Cell Significance Index: 0.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0011
    Cell Significance Index: 0.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0010
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0045
    Cell Significance Index: -2.8300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0061
    Cell Significance Index: -0.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0062
    Cell Significance Index: -2.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.8600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0067
    Cell Significance Index: -0.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0070
    Cell Significance Index: -3.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0087
    Cell Significance Index: -4.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0090
    Cell Significance Index: -1.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0094
    Cell Significance Index: -1.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0144
    Cell Significance Index: -2.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0171
    Cell Significance Index: -0.3700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0186
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0237
    Cell Significance Index: -5.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0259
    Cell Significance Index: -1.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0269
    Cell Significance Index: -3.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0282
    Cell Significance Index: -3.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0284
    Cell Significance Index: -3.9000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0313
    Cell Significance Index: -0.4000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0314
    Cell Significance Index: -0.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0316
    Cell Significance Index: -0.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0348
    Cell Significance Index: -3.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0357
    Cell Significance Index: -1.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0366
    Cell Significance Index: -0.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0403
    Cell Significance Index: -4.2000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0510
    Cell Significance Index: -0.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0555
    Cell Significance Index: -3.7300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0566
    Cell Significance Index: -0.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0566
    Cell Significance Index: -4.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0584
    Cell Significance Index: -1.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0592
    Cell Significance Index: -3.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0660
    Cell Significance Index: -4.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0726
    Cell Significance Index: -3.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0731
    Cell Significance Index: -2.5600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0743
    Cell Significance Index: -0.8100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0775
    Cell Significance Index: -1.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0806
    Cell Significance Index: -2.6400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0810
    Cell Significance Index: -1.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0839
    Cell Significance Index: -4.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0878
    Cell Significance Index: -2.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0878
    Cell Significance Index: -3.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0886
    Cell Significance Index: -1.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0895
    Cell Significance Index: -3.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0914
    Cell Significance Index: -3.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0936
    Cell Significance Index: -1.9600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0992
    Cell Significance Index: -1.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1010
    Cell Significance Index: -3.5100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1015
    Cell Significance Index: -1.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1030
    Cell Significance Index: -2.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1082
    Cell Significance Index: -2.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1093
    Cell Significance Index: -3.2200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1110
    Cell Significance Index: -3.5100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1139
    Cell Significance Index: -1.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1194
    Cell Significance Index: -2.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1228
    Cell Significance Index: -6.2100
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1241
    Cell Significance Index: -1.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1266
    Cell Significance Index: -3.3800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1293
    Cell Significance Index: -1.5200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1302
    Cell Significance Index: -1.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1305
    Cell Significance Index: -3.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1315
    Cell Significance Index: -2.7900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1348
    Cell Significance Index: -3.2900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1349
    Cell Significance Index: -3.3700
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1367
    Cell Significance Index: -1.4500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1374
    Cell Significance Index: -1.5000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1389
    Cell Significance Index: -2.9000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1389
    Cell Significance Index: -2.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MORC1 is a member of the MORC family of proteins, characterized by the presence of a CW-type zinc finger domain. This domain is essential for its function in recognizing and binding to specific DNA sequences. MORC1 is a large protein, with an estimated molecular weight of 320 kDa, and is primarily localized to the nucleus. Its expression is widespread, with significant levels detected in various cell types, including those involved in immune responses, development, and tissue repair. **Pathways and Functions:** MORC1 is involved in multiple cellular pathways, including: 1. **Epigenetic Programming:** MORC1 plays a crucial role in regulating epigenetic marks, such as DNA methylation and histone modification, to maintain genome stability and silence gene expression. 2. **Cell Differentiation:** MORC1 is involved in the regulation of cell differentiation, particularly in the development of neural progenitor cells and male germ cells. 3. **Spermatogenesis:** MORC1 is essential for the regulation of spermatogenesis, a complex process involving the coordinated expression of genes involved in sperm development and maturation. 4. **Retrotransposition:** MORC1 acts as a negative regulator of retrotransposition, preventing the insertion of retrotransposons into the genome and maintaining genome stability. 5. **Regulatory NCRNA-mediated Gene Silencing:** MORC1 is involved in the regulation of gene expression through the interaction with non-coding RNAs (ncRNAs), particularly microRNAs and long non-coding RNAs. **Clinical Significance:** Dysregulation of MORC1 has been implicated in various diseases, including: 1. **Cancer:** Alterations in MORC1 expression have been observed in several types of cancer, including leukemia, lymphoma, and ovarian cancer. 2. **Neurological Disorders:** MORC1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Reproductive Disorders:** Dysregulation of MORC1 has been linked to reproductive disorders, including infertility and testicular cancer. In conclusion, the MORC1 gene plays a critical role in regulating epigenetic programming, cell differentiation, and spermatogenesis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying MORC1 function.

Genular Protein ID: 1424061557

Symbol: MORC1_HUMAN

Name: MORC family CW-type zinc finger protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10369865

Title: New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis.

PubMed ID: 10369865

DOI: 10.1093/hmg/8.7.1201

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

Sequence Information:

  • Length: 984
  • Mass: 112881
  • Checksum: 613163D31E2317A6
  • Sequence:
  • MDDRYPALQR AQLRLDFIHA NSTTHSFLFG ALAELLDNAR DAGAERLDVF SVDNEKLQGG 
    FMLCFLDDGC GMSPEEASDI IYFGRSKKRL STLKFIGQYG NGLKSGSMRI GKDFILFTKK 
    EETMTCVFFS QTFCEEESLS EVVVPMPSWL IRTRESVTDD PQKFAMELSI IYKYSPFKTE 
    AELMQQFDVI YGKCGTLLVI YNLKLLLNGE PELDVKTDKE DILMAGALED FPARWSFRAY 
    TSVLYFNPWM RIFIQAKRVK TKHLCYCLYR PRKYLYVTSS FKGAFKDEVK KAEEAVKIAE 
    SILKEAQIKV NQCDRTSLSS AKDVLQRALE DVEAKQKNLK EKQRELKTAR TLSLFYGVNV 
    ENRSQAGMFI YSNNRLIKMH EKVGSQLKLK SLLGAGVVGI VNIPLEVMEP SHNKQEFLNV 
    QEYNHLLKVM GQYLVQYCKD TGINNRNLTL FCNEFGYQND IDVEKPLNSF QYQRRQAMGI 
    PFIIQCDLCL KWRVLPSSTN YQEKEFFDIW ICANNPNRLE NSCHQVECLP SIPLGTMSTI 
    SPSKNEKEKQ LRESVIKYQN RLAEQQPQPQ FIPVDEITVT STCLTSAHKE NTKTQKIRLL 
    GDDLKHESLS SFELSASRRG QKRNIEETDS DVEYISETKI MKKSMEEKMN SQQQRIPVAL 
    PENVKLAERS QRSQIANITT VWRAQPTEGC LKNAQAASWE MKRKQSLNFV EECKVLTEDE 
    NTSDSDIILV SDKSNTDVSL KQEKKEIPLL NQEKQELCND VLAMKRSSSL PSWKSLLNVP 
    MEDVNLSSGH IARVSVSGSC KVASSPASSQ STPVKETVRK LKSKLREILL YFFPEHQLPS 
    ELEEPALSCE LEQCPEQMNK KLKMCFNQIQ NTYMVQYEKK IKRKLQSIIY DSNTRGIHNE 
    ISLGQCENKR KISEDKLKNL RIKLALLLQK LQLGGPEGDL EQTDTYLEAL LKEDNLLFQN 
    NLNKVTIDAR HRLPLEKNEK TSEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.