Details for: STK36

Gene ID: 27148

Symbol: STK36

Ensembl ID: ENSG00000163482

Description: serine/threonine kinase 36

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 73.2263
    Cell Significance Index: -11.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.7479
    Cell Significance Index: -11.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.1493
    Cell Significance Index: -9.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.3028
    Cell Significance Index: -11.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9346
    Cell Significance Index: -11.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8423
    Cell Significance Index: -8.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7031
    Cell Significance Index: 141.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6718
    Cell Significance Index: 66.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5149
    Cell Significance Index: 464.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4260
    Cell Significance Index: 9.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4113
    Cell Significance Index: 81.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3848
    Cell Significance Index: 41.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3731
    Cell Significance Index: 22.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3356
    Cell Significance Index: 54.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3120
    Cell Significance Index: 8.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3066
    Cell Significance Index: 8.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2970
    Cell Significance Index: 13.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2766
    Cell Significance Index: 14.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2461
    Cell Significance Index: 88.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2371
    Cell Significance Index: 6.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2139
    Cell Significance Index: 13.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1947
    Cell Significance Index: 8.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1917
    Cell Significance Index: 5.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1884
    Cell Significance Index: 21.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1790
    Cell Significance Index: 123.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1762
    Cell Significance Index: 96.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1751
    Cell Significance Index: 6.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1661
    Cell Significance Index: 11.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1616
    Cell Significance Index: 11.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1117
    Cell Significance Index: 21.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1081
    Cell Significance Index: 14.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0864
    Cell Significance Index: 2.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0690
    Cell Significance Index: 4.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0645
    Cell Significance Index: 11.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0620
    Cell Significance Index: 2.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0118
    Cell Significance Index: 22.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0112
    Cell Significance Index: 0.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0105
    Cell Significance Index: 6.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0090
    Cell Significance Index: 16.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0071
    Cell Significance Index: 3.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0068
    Cell Significance Index: 10.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0040
    Cell Significance Index: 0.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0014
    Cell Significance Index: 0.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0026
    Cell Significance Index: -3.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0032
    Cell Significance Index: -0.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0054
    Cell Significance Index: -0.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -3.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0089
    Cell Significance Index: -0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0123
    Cell Significance Index: -9.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0126
    Cell Significance Index: -9.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0157
    Cell Significance Index: -0.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0173
    Cell Significance Index: -9.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0212
    Cell Significance Index: -13.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0230
    Cell Significance Index: -3.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0281
    Cell Significance Index: -2.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0288
    Cell Significance Index: -8.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0335
    Cell Significance Index: -0.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0382
    Cell Significance Index: -0.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0511
    Cell Significance Index: -5.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0573
    Cell Significance Index: -12.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0621
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0642
    Cell Significance Index: -7.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0650
    Cell Significance Index: -7.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0668
    Cell Significance Index: -8.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0719
    Cell Significance Index: -3.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0768
    Cell Significance Index: -4.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0783
    Cell Significance Index: -2.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0956
    Cell Significance Index: -1.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0963
    Cell Significance Index: -6.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1009
    Cell Significance Index: -10.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1102
    Cell Significance Index: -8.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1175
    Cell Significance Index: -3.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1196
    Cell Significance Index: -2.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1291
    Cell Significance Index: -8.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1297
    Cell Significance Index: -10.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1328
    Cell Significance Index: -3.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1329
    Cell Significance Index: -8.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1382
    Cell Significance Index: -3.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1459
    Cell Significance Index: -3.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1491
    Cell Significance Index: -5.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1496
    Cell Significance Index: -2.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1561
    Cell Significance Index: -5.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1621
    Cell Significance Index: -3.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1652
    Cell Significance Index: -5.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1711
    Cell Significance Index: -8.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1830
    Cell Significance Index: -5.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1864
    Cell Significance Index: -3.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1907
    Cell Significance Index: -6.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1925
    Cell Significance Index: -4.1600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1977
    Cell Significance Index: -1.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2027
    Cell Significance Index: -10.6500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2032
    Cell Significance Index: -2.8200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2175
    Cell Significance Index: -3.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2297
    Cell Significance Index: -5.7300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2324
    Cell Significance Index: -3.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2357
    Cell Significance Index: -4.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2369
    Cell Significance Index: -3.5700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2373
    Cell Significance Index: -3.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STK36 is a member of the serine/threonine kinase family, characterized by its ability to phosphorylate and regulate the activity of downstream targets. The gene is highly expressed in various tissues, including the brain, where it is involved in the development and maintenance of neural cells. STK36 has been shown to interact with multiple signaling pathways, including the Smoothened signaling pathway, which plays a critical role in developmental processes such as cell fate specification and patterning. **Pathways and Functions:** STK36 has been implicated in various cellular processes, including: 1. **Cytoskeletal dynamics:** STK36 has been shown to regulate the activity of cytoskeletal proteins, such as myosin and actin, which are essential for cell migration, adhesion, and movement. 2. **Signaling pathways:** STK36 has been implicated in the regulation of multiple signaling pathways, including the Smoothened signaling pathway, which is critical for developmental processes such as cell fate specification and patterning. 3. **Transcriptional control:** STK36 has been shown to regulate the activity of transcription factors, including those involved in the regulation of gene expression in response to environmental stimuli. 4. **Cellular movement:** STK36 has been implicated in the regulation of cellular movement, including the movement of cilia and axons. **Clinical Significance:** Dysregulation of STK36 has been implicated in various human diseases, including: 1. **Neurological disorders:** STK36 has been implicated in the regulation of neural development and function, and dysregulation of the gene has been linked to neurological disorders such as autism and schizophrenia. 2. **Cancer:** STK36 has been implicated in the regulation of cell growth and survival, and dysregulation of the gene has been linked to cancer. 3. **Intestinal disorders:** STK36 has been implicated in the regulation of intestinal function, and dysregulation of the gene has been linked to intestinal disorders such as inflammatory bowel disease. In conclusion, STK36 is a multifaceted gene that plays a critical role in various cellular and developmental processes. Further research is needed to fully elucidate the mechanisms by which STK36 regulates these processes and to explore its clinical significance in human diseases. **References:** * [Insert references to relevant research articles] Note: The references provided should be up-to-date and relevant to the topic. The references should also be formatted according to the chosen citation style.

Genular Protein ID: 1124989226

Symbol: STK36_HUMAN

Name: Serine/threonine-protein kinase 36

UniProtKB Accession Codes:

Q9NRP7 B7WPM3 Q8TC32 Q9H9N9 Q9UF35 Q9ULE2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 3 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10806483

Title: Gli regulation by the opposing activities of fused and suppressor of fused.

PubMed ID: 10806483

DOI: 10.1038/35010610

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 28543983

Title: Mutation of serine/threonine protein kinase 36 (STK36) causes primary ciliary dyskinesia with a central pair defect.

PubMed ID: 28543983

DOI: 10.1002/humu.23261

Sequence Information:

  • Length: 1315
  • Mass: 143995
  • Checksum: 793F4638F1871C01
  • Sequence:
    • MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR EIEIMRGLRH 
PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED QVQAIAAQLV SALYYLHSHR 
ILHRDMKPQN ILLAKGGGIK LCDFGFARAM STNTMVLTSI KGTPLYMSPE LVEERPYDHT 
ADLWSVGCIL YELAVGTPPF YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR 
QRLSWPDLLY HPFIAGHVTI ITEPAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR 
ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE SSLLAGILAS 
ELKSSWAKSG TGEVPSAPRE NRTTPDCERA FPEERPEVLG QRSTDVVDLE NEEPDSDNEW 
QHLLETTEPV PIQLKAPLTL LCNPDFCQRI QSQLHEAGGQ ILKGILEGAS HILPAFRVLS 
SLLSSCSDSV ALYSFCREAG LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA 
CTFNLERSQT SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN 
SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPQGA PQVSQPLREQ SEDIPGAISS 
ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS LISGLQHPIL CLHLLKVLYS 
CCLVSEGLCR LLGQEPLALE SLFMLIQGKV KVVDWEESTE VTLYFLSLLV FRLQNLPCGM 
EKLGSDVATL FTHSHVVSLV SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAEVRL 
TPPGSCGFYD GLLILLLQLL TEQGKASLIR DMSSSEMWTV LWHRFSMVLR LPEEASAQEG 
ELSLSSPPSP EPDWTLISPQ GMAALLSLAM ATFTQEPQLC LSCLSQHGSI LMSILKHLLC 
PSFLNQLRQA PHGSEFLPVV VLSVCQLLCF PFALDMDADL LIGVLADLRD SEVAAHLLQV 
CCYHLPLMQV ELPISLLTRL ALMDPTSLNQ FVNTVSASPR TIVSFLSVAL LSDQPLLTSD 
LLSLLAHTAR VLSPSHLSFI QELLAGSDES YRPLRSLLGH PENSVRAHTY RLLGHLLQHS 
MALRGALQSQ SGLLSLLLLG LGDKDPVVRC SASFAVGNAA YQAGPLGPAL AAAVPSMTQL 
LGDPQAGIRR NVASALGNLG PEGLGEELLQ CEVPQRLLEM ACGDPQPNVK EAALIALRSL 
QQEPGIHQVL VSLGASEKLS LLSLGNQSLP HSSPRPASAK HCRKLIHLLR PAHSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.