Details for: GPR82

Gene ID: 27197

Symbol: GPR82

Ensembl ID: ENSG00000171657

Description: G protein-coupled receptor 82

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.7973
    Cell Significance Index: -10.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.6226
    Cell Significance Index: -10.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.4512
    Cell Significance Index: -10.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6761
    Cell Significance Index: -10.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.0284
    Cell Significance Index: -6.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.0158
    Cell Significance Index: -5.4000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.6353
    Cell Significance Index: 5.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6334
    Cell Significance Index: 13.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4272
    Cell Significance Index: 10.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4210
    Cell Significance Index: 380.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3863
    Cell Significance Index: 23.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3597
    Cell Significance Index: 39.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3100
    Cell Significance Index: 50.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2535
    Cell Significance Index: 50.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2407
    Cell Significance Index: 23.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2177
    Cell Significance Index: 3.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1559
    Cell Significance Index: 9.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1538
    Cell Significance Index: 10.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1326
    Cell Significance Index: 6.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1016
    Cell Significance Index: 3.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0904
    Cell Significance Index: 17.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0900
    Cell Significance Index: 5.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0835
    Cell Significance Index: 1.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0598
    Cell Significance Index: 41.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0549
    Cell Significance Index: 11.0100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0517
    Cell Significance Index: 0.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0466
    Cell Significance Index: 5.4300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0399
    Cell Significance Index: 0.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0385
    Cell Significance Index: 21.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0385
    Cell Significance Index: 2.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0331
    Cell Significance Index: 14.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0278
    Cell Significance Index: 3.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0144
    Cell Significance Index: 27.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0138
    Cell Significance Index: 1.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0123
    Cell Significance Index: 16.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0116
    Cell Significance Index: 0.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0109
    Cell Significance Index: 0.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0107
    Cell Significance Index: 19.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0104
    Cell Significance Index: 1.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0104
    Cell Significance Index: 15.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0070
    Cell Significance Index: 2.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0064
    Cell Significance Index: 1.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0007
    Cell Significance Index: 0.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0068
    Cell Significance Index: -4.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0124
    Cell Significance Index: -9.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0177
    Cell Significance Index: -9.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0181
    Cell Significance Index: -11.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0183
    Cell Significance Index: -8.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0229
    Cell Significance Index: -3.3400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0229
    Cell Significance Index: -0.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0241
    Cell Significance Index: -3.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0262
    Cell Significance Index: -2.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0293
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0362
    Cell Significance Index: -4.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0424
    Cell Significance Index: -1.9800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0427
    Cell Significance Index: -1.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0484
    Cell Significance Index: -3.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0531
    Cell Significance Index: -3.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0547
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0549
    Cell Significance Index: -11.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0606
    Cell Significance Index: -10.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0691
    Cell Significance Index: -5.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0824
    Cell Significance Index: -8.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0850
    Cell Significance Index: -1.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0853
    Cell Significance Index: -5.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0856
    Cell Significance Index: -6.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0893
    Cell Significance Index: -1.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0909
    Cell Significance Index: -5.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1038
    Cell Significance Index: -2.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1157
    Cell Significance Index: -5.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1165
    Cell Significance Index: -7.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1427
    Cell Significance Index: -4.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1440
    Cell Significance Index: -3.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1479
    Cell Significance Index: -1.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1577
    Cell Significance Index: -2.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1636
    Cell Significance Index: -5.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1638
    Cell Significance Index: -8.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1684
    Cell Significance Index: -7.4500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1685
    Cell Significance Index: -2.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1746
    Cell Significance Index: -6.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1798
    Cell Significance Index: -2.7100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1836
    Cell Significance Index: -2.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1914
    Cell Significance Index: -5.1200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1995
    Cell Significance Index: -2.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2254
    Cell Significance Index: -7.9000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2336
    Cell Significance Index: -2.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2361
    Cell Significance Index: -7.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2397
    Cell Significance Index: -7.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2416
    Cell Significance Index: -3.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2565
    Cell Significance Index: -8.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2689
    Cell Significance Index: -7.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2800
    Cell Significance Index: -3.8200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2859
    Cell Significance Index: -2.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2871
    Cell Significance Index: -10.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3101
    Cell Significance Index: -6.7900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3128
    Cell Significance Index: -7.8000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3160
    Cell Significance Index: -4.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR82 exhibits a distinct expression pattern, with significant expression in cells involved in immune surveillance and neurotransmission. Its tissue distribution is characterized by the presence in intraepithelial lymphocytes, which play a crucial role in recognizing and responding to pathogens. Additionally, GPR82 is expressed in cerebral cortex GABAergic interneurons, which are essential for regulating neural circuits and maintaining synaptic homeostasis. The receptor's signaling mechanism involves the activation of G-protein coupled receptor activity, leading to the modulation of downstream signaling pathways. **Pathways and Functions:** GPR82's signaling pathways are intricately linked to various cellular processes, including immune responses, neurotransmission, and cellular homeostasis. The receptor's activation leads to the stimulation of G protein-coupled receptor signaling pathway, resulting in the modulation of downstream effectors. This signaling cascade is crucial for regulating the activity of immune cells, such as intraepithelial lymphocytes, and maintaining neural homeostasis. Furthermore, GPR82 has been implicated in the regulation of cellular proliferation, differentiation, and survival in various tissues, including the intestinal epithelium. **Clinical Significance:** The clinical significance of GPR82 is multifaceted, with potential implications in various human diseases. Dysregulation of GPR82 has been linked to autoimmune disorders, such as inflammatory bowel disease (IBD), where the receptor's expression is altered in intestinal epithelial cells. Additionally, GPR82 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease, where the receptor's expression is altered in cerebral cortex GABAergic interneurons. Furthermore, GPR82 has been identified as a potential therapeutic target for the treatment of IBD and other inflammatory diseases, where its modulation can lead to improved immune function and reduced inflammation. In conclusion, GPR82 is an enigmatic GPCR with far-reaching implications in immune function and disease. Its unique expression profile and functional characteristics have shed light on its role in modulating immune responses, neurotransmission, and cellular homeostasis. Further research is necessary to fully elucidate the clinical significance of GPR82 and its potential as a therapeutic target for various human diseases.

Genular Protein ID: 1650504616

Symbol: GPR82_HUMAN

Name: Probable G-protein coupled receptor 82

UniProtKB Accession Codes:

Q96P67 Q5VT13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11574155

Title: Discovery and mapping of ten novel G protein-coupled receptor genes.

PubMed ID: 11574155

DOI: 10.1016/s0378-1119(01)00651-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 12044878

Title: Identification of G protein-coupled receptor genes from the human genome sequence.

PubMed ID: 12044878

DOI: 10.1016/s0014-5793(02)02775-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 336
  • Mass: 38409
  • Checksum: B7691CA18B5824A4
  • Sequence:
    • MNNNTTCIQP SMISSMALPI IYILLCIVGV FGNTLSQWIF LTKIGKKTST HIYLSHLVTA 
NLLVCSAMPF MSIYFLKGFQ WEYQSAQCRV VNFLGTLSMH ASMFVSLLIL SWIAISRYAT 
LMQKDSSQET TSCYEKIFYG HLLKKFRQPN FARKLCIYIW GVVLGIIIPV TVYYSVIEAT 
EGEESLCYNR QMELGAMISQ IAGLIGTTFI GFSFLVVLTS YYSFVSHLRK IRTCTSIMEK 
DLTYSSVKRH LLVIQILLIV CFLPYSIFKP IFYVLHQRDN CQQLNYLIET KNILTCLASA 
RSSTDPIIFL LLDKTFKKTL YNLFTKSNSA HMQSYG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.