Details for: ARFIP1

Gene ID: 27236

Symbol: ARFIP1

Ensembl ID: ENSG00000164144

Description: ARF interacting protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 308.6562
    Cell Significance Index: -48.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 191.6470
    Cell Significance Index: -48.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 106.4342
    Cell Significance Index: -50.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 99.4936
    Cell Significance Index: -40.4200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.1488
    Cell Significance Index: -47.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.4407
    Cell Significance Index: -40.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.0744
    Cell Significance Index: -49.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.1715
    Cell Significance Index: -46.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.9222
    Cell Significance Index: -39.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.6025
    Cell Significance Index: -49.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.8113
    Cell Significance Index: -25.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6154
    Cell Significance Index: 22.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5671
    Cell Significance Index: 314.3600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2965
    Cell Significance Index: 20.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2425
    Cell Significance Index: 24.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1204
    Cell Significance Index: 222.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0636
    Cell Significance Index: 59.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0568
    Cell Significance Index: 190.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8289
    Cell Significance Index: 57.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8206
    Cell Significance Index: 294.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7964
    Cell Significance Index: 97.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7502
    Cell Significance Index: 38.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7327
    Cell Significance Index: 32.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7037
    Cell Significance Index: 384.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6640
    Cell Significance Index: 50.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6568
    Cell Significance Index: 29.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6323
    Cell Significance Index: 23.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6070
    Cell Significance Index: 5.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6019
    Cell Significance Index: 13.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5672
    Cell Significance Index: 14.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5250
    Cell Significance Index: 33.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4803
    Cell Significance Index: 91.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4738
    Cell Significance Index: 327.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4696
    Cell Significance Index: 46.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4686
    Cell Significance Index: 31.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4401
    Cell Significance Index: 11.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3993
    Cell Significance Index: 24.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3918
    Cell Significance Index: 10.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3712
    Cell Significance Index: 50.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3485
    Cell Significance Index: 10.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3146
    Cell Significance Index: 14.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2561
    Cell Significance Index: 113.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2319
    Cell Significance Index: 12.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1963
    Cell Significance Index: 2.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1560
    Cell Significance Index: 25.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1455
    Cell Significance Index: 6.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1103
    Cell Significance Index: 18.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1043
    Cell Significance Index: 196.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1015
    Cell Significance Index: 3.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0832
    Cell Significance Index: 128.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0779
    Cell Significance Index: 35.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0727
    Cell Significance Index: 9.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0726
    Cell Significance Index: 133.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0685
    Cell Significance Index: 43.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0362
    Cell Significance Index: 1.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0072
    Cell Significance Index: -9.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0120
    Cell Significance Index: -7.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0162
    Cell Significance Index: -12.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0263
    Cell Significance Index: -19.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0268
    Cell Significance Index: -3.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0449
    Cell Significance Index: -34.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0489
    Cell Significance Index: -27.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0720
    Cell Significance Index: -5.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0917
    Cell Significance Index: -9.3700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1163
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1218
    Cell Significance Index: -25.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1336
    Cell Significance Index: -15.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1376
    Cell Significance Index: -39.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1841
    Cell Significance Index: -9.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1874
    Cell Significance Index: -24.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2101
    Cell Significance Index: -24.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2152
    Cell Significance Index: -5.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2518
    Cell Significance Index: -18.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2717
    Cell Significance Index: -31.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2745
    Cell Significance Index: -31.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2843
    Cell Significance Index: -29.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3611
    Cell Significance Index: -8.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3923
    Cell Significance Index: -6.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3954
    Cell Significance Index: -9.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4062
    Cell Significance Index: -8.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4389
    Cell Significance Index: -11.7600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4492
    Cell Significance Index: -6.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4996
    Cell Significance Index: -39.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5385
    Cell Significance Index: -34.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5764
    Cell Significance Index: -15.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6287
    Cell Significance Index: -33.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6666
    Cell Significance Index: -40.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6705
    Cell Significance Index: -23.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6888
    Cell Significance Index: -19.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7051
    Cell Significance Index: -18.5400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7235
    Cell Significance Index: -10.3900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8142
    Cell Significance Index: -11.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9308
    Cell Significance Index: -19.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9746
    Cell Significance Index: -31.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9923
    Cell Significance Index: -14.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0033
    Cell Significance Index: -28.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0041
    Cell Significance Index: -31.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0618
    Cell Significance Index: -37.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1155
    Cell Significance Index: -40.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARFIP1 is a cytosolic protein that interacts with ADP-ribosylation factor (ARF) proteins, which are essential for regulating membrane trafficking, vesicle transport, and cytoskeletal dynamics. The protein's ability to bind to phosphatidylinositol-4-phosphate (PI4P) and phospholipids suggests its involvement in lipid metabolism and membrane organization. ARFIP1's domain-specific binding properties enable it to interact with various protein complexes, including the ARF2/3 complex, which is involved in actin nucleation and cytoskeletal dynamics. **Pathways and Functions:** ARFIP1 is implicated in several critical cellular pathways, including: 1. **Negative regulation of retrograde transport**: ARFIP1 interacts with the ARF2/3 complex to regulate the transport of proteins and lipids from the Golgi apparatus to the endoplasmic reticulum (ER). 2. **Regulation of ARP2/3 complex-mediated actin nucleation**: ARFIP1's interaction with the ARF2/3 complex regulates actin nucleation, which is essential for cell migration, cytokinesis, and immune responses. 3. **Regulation of protein secretion**: ARFIP1's involvement in regulating the transport of proteins and lipids from the Golgi apparatus to the plasma membrane is crucial for maintaining cellular homeostasis and immune function. 4. **Intracellular protein transport**: ARFIP1's interaction with PI4P and phospholipids regulates the transport of proteins and lipids within the Golgi apparatus and between the Golgi and ER. **Clinical Significance:** The dysregulation of ARFIP1 has been implicated in various disease states, including: 1. **Immunological disorders**: ARFIP1's role in regulating immune responses and protein secretion makes it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurological disorders**: ARFIP1's involvement in regulating actin nucleation and cytoskeletal dynamics suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Cancer**: ARFIP1's regulation of protein secretion and intracellular transport may impact cancer cell migration, invasion, and metastasis. In conclusion, ARFIP1 is a multifunctional protein that plays a critical role in regulating immune responses, protein secretion, and intracellular transport. Its dysregulation has been implicated in various disease states, highlighting the need for further research into the molecular mechanisms underlying ARFIP1's functions and its potential therapeutic applications.

Genular Protein ID: 2650567913

Symbol: ARFP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9038142

Title: Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes.

PubMed ID: 9038142

DOI: 10.1074/jbc.272.9.5421

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10413101

Title: Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D.

PubMed ID: 10413101

DOI: 10.1016/s0014-5793(99)00771-1

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21239483

Title: Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs.

PubMed ID: 21239483

DOI: 10.1074/jbc.m110.201442

PubMed ID: 22981988

Title: The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network.

PubMed ID: 22981988

DOI: 10.1016/j.devcel.2012.07.019

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30917996

Title: ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIbeta.

PubMed ID: 30917996

DOI: 10.1083/jcb.201901115

Sequence Information:

  • Length: 373
  • Mass: 41738
  • Checksum: 7A315D0E67DECDBF
  • Sequence:
  • MAQESPKNSA AEIPVTSNGE VDDSREHSFN RDLKHSLPSG LGLSETQITS HGFDNTKEGV 
    IEAGAFQGSP APPLPSVMSP SRVAASRLAQ QGSDLIVPAG GQRTQTKSGP VILADEIKNP 
    AMEKLELVRK WSLNTYKCTR QIISEKLGRG SRTVDLELEA QIDILRDNKK KYENILKLAQ 
    TLSTQLFQMV HTQRQLGDAF ADLSLKSLEL HEEFGYNADT QKLLAKNGET LLGAINFFIA 
    SVNTLVNKTI EDTLMTVKQY ESARIEYDAY RTDLEELNLG PRDANTLPKI EQSQHLFQAH 
    KEKYDKMRND VSVKLKFLEE NKVKVLHNQL VLFHNAIAAY FAGNQKQLEQ TLKQFHIKLK 
    TPGVDAPSWL EEQ

Genular Protein ID: 1880723669

Symbol: Q8N8M9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 245
  • Mass: 28416
  • Checksum: 1A85B14566B0506E
  • Sequence:
  • MALTIPKRVL LKQEHFKVAR EHRQKVDLEL EAQIDILRDN KKKYENILKL AQTLSTQLFQ 
    MVHTQRQLGD AFADLSLKSL ELHEEFGYNA DTQKLLAKNG ETLLGAINFF IASVNTLVNK 
    TIEDTLMTVK QYESARIEYD AYRTDLEELN LGPRDANTLP KIEQSQHLFQ AHKEKYDKMR 
    NDVSVKLKFL EENKVKVLHN QLVLFHNAIA AYFAGNQKQL EQTLKQFHIK LKTPGVDAPS 
    WLEEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.