Details for: SESN1

Gene ID: 27244

Symbol: SESN1

Ensembl ID: ENSG00000080546

Description: sestrin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 341.3798
    Cell Significance Index: -53.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 204.2632
    Cell Significance Index: -51.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 115.6903
    Cell Significance Index: -54.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.6904
    Cell Significance Index: -43.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 101.4415
    Cell Significance Index: -52.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.3790
    Cell Significance Index: -44.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.2943
    Cell Significance Index: -53.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.0469
    Cell Significance Index: -48.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.0874
    Cell Significance Index: -33.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6668
    Cell Significance Index: -53.9300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 8.2453
    Cell Significance Index: 133.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 7.6887
    Cell Significance Index: 187.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.9551
    Cell Significance Index: 127.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.4083
    Cell Significance Index: 261.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1867
    Cell Significance Index: 438.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6561
    Cell Significance Index: 269.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6298
    Cell Significance Index: 584.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6261
    Cell Significance Index: 1468.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4593
    Cell Significance Index: 81.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2811
    Cell Significance Index: 254.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2808
    Cell Significance Index: 48.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1460
    Cell Significance Index: 50.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1268
    Cell Significance Index: 69.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0807
    Cell Significance Index: 747.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.9354
    Cell Significance Index: 16.0300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9167
    Cell Significance Index: 19.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8789
    Cell Significance Index: 95.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7059
    Cell Significance Index: 16.9300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.5825
    Cell Significance Index: 7.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4849
    Cell Significance Index: 29.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4673
    Cell Significance Index: 9.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4655
    Cell Significance Index: 21.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4607
    Cell Significance Index: 83.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4033
    Cell Significance Index: 27.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3379
    Cell Significance Index: 23.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3116
    Cell Significance Index: 20.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3101
    Cell Significance Index: 38.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2959
    Cell Significance Index: 3.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2415
    Cell Significance Index: 153.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2009
    Cell Significance Index: 88.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1711
    Cell Significance Index: 32.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1689
    Cell Significance Index: 16.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1656
    Cell Significance Index: 4.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1574
    Cell Significance Index: 3.4100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1333
    Cell Significance Index: 1.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1245
    Cell Significance Index: 56.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0995
    Cell Significance Index: 187.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0972
    Cell Significance Index: 179.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0687
    Cell Significance Index: 105.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0551
    Cell Significance Index: 30.0800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0411
    Cell Significance Index: 0.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0239
    Cell Significance Index: 0.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0037
    Cell Significance Index: 0.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0216
    Cell Significance Index: -13.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0303
    Cell Significance Index: -22.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0569
    Cell Significance Index: -41.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0669
    Cell Significance Index: -37.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0693
    Cell Significance Index: -52.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0734
    Cell Significance Index: -12.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0803
    Cell Significance Index: -10.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0948
    Cell Significance Index: -1.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1245
    Cell Significance Index: -12.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1497
    Cell Significance Index: -31.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1629
    Cell Significance Index: -46.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1863
    Cell Significance Index: -27.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2064
    Cell Significance Index: -5.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2238
    Cell Significance Index: -26.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2903
    Cell Significance Index: -3.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2943
    Cell Significance Index: -38.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3058
    Cell Significance Index: -21.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3091
    Cell Significance Index: -36.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3224
    Cell Significance Index: -20.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3623
    Cell Significance Index: -19.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3662
    Cell Significance Index: -41.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4028
    Cell Significance Index: -41.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4127
    Cell Significance Index: -47.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4189
    Cell Significance Index: -19.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4395
    Cell Significance Index: -9.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4861
    Cell Significance Index: -12.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4896
    Cell Significance Index: -36.4900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4915
    Cell Significance Index: -3.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4965
    Cell Significance Index: -25.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4969
    Cell Significance Index: -10.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5764
    Cell Significance Index: -29.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5973
    Cell Significance Index: -47.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6366
    Cell Significance Index: -18.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6931
    Cell Significance Index: -14.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6984
    Cell Significance Index: -18.7200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7053
    Cell Significance Index: -11.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7321
    Cell Significance Index: -20.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7758
    Cell Significance Index: -36.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8252
    Cell Significance Index: -50.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8442
    Cell Significance Index: -27.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8697
    Cell Significance Index: -27.7000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9038
    Cell Significance Index: -11.2700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9080
    Cell Significance Index: -13.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9235
    Cell Significance Index: -18.2600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9314
    Cell Significance Index: -18.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Oxidative Stress Sensor:** SESN1 is a peroxiredoxin-like protein that detects the levels of reactive oxygen species (ROS) in the cell, thereby regulating the activity of the Nrf2 pathway. 2. **Keap1-Nrf2 Interactor:** SESN1 interacts with Keap1, a protein that binds to Nrf2 and prevents its activation, thereby modulating the expression of antioxidant and detoxification genes. 3. **Antioxidant and Detoxification Genes Regulator:** SESN1 regulates the expression of genes involved in antioxidant defenses, such as glutathione peroxidase and superoxide dismutase, as well as detoxification genes, such as glutathione S-transferases. 4. **Metabolic Gene Regulator:** SESN1 also regulates the expression of metabolic genes, including those involved in glucose and leucine metabolism, thereby influencing cellular energy homeostasis. **Pathways and Functions:** 1. **Keap1-Nrf2 Pathway:** SESN1 interacts with Keap1 to regulate the activity of Nrf2, a transcription factor that modulates the expression of antioxidant and detoxification genes. 2. **Cellular Oxidant Detoxification:** SESN1 regulates the expression of genes involved in cellular oxidant detoxification, including glutathione peroxidase and superoxide dismutase. 3. **Cellular Response to Stress:** SESN1 plays a critical role in regulating the cellular response to stress, including oxidative stress, chemical stress, and amino acid starvation. 4. **Metabolic Regulation:** SESN1 regulates the expression of metabolic genes, including those involved in glucose and leucine metabolism, thereby influencing cellular energy homeostasis. **Clinical Significance:** 1. **Cancer:** SESN1 has been implicated in cancer development and progression, as its expression is often downregulated in cancer cells. 2. **Metabolic Disorders:** SESN1 dysfunction has been linked to metabolic disorders, such as type 2 diabetes and obesity, due to its role in regulating glucose and leucine metabolism. 3. **Neurodegenerative Diseases:** SESN1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, due to its role in regulating oxidative stress and antioxidant defenses. 4. **Cardiovascular Disease:** SESN1 has been linked to cardiovascular disease, as its expression is often downregulated in cardiac tissues, leading to impaired antioxidant defenses and increased oxidative stress. In conclusion, SESN1 is a critical regulator of cellular stress response and metabolism, and its dysregulation has been implicated in various diseases. Further studies are needed to fully elucidate the mechanisms by which SESN1 regulates cellular homeostasis and to explore its therapeutic potential in disease prevention and treatment.

Genular Protein ID: 3920834170

Symbol: SESN1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y6P5 Q2M2B7 Q5T316 Q9NV00 Q9UPD5 Q9Y6P6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 7 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9926927

Title: PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes.

PubMed ID: 9926927

DOI: 10.1038/sj.onc.1202274

PubMed ID: 12607115

Title: PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.

PubMed ID: 12607115

DOI: 10.1007/s00439-003-0917-5

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15105503

Title: Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.

PubMed ID: 15105503

DOI: 10.1126/science.1095569

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23274085

Title: Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.

PubMed ID: 23274085

DOI: 10.1016/j.cmet.2012.12.002

PubMed ID: 25259925

Title: Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

PubMed ID: 25259925

DOI: 10.1016/j.cell.2014.08.038

PubMed ID: 25263562

Title: The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.

PubMed ID: 25263562

DOI: 10.1016/j.celrep.2014.09.014

PubMed ID: 26449471

Title: Sestrin2 is a leucine sensor for the mTORC1 pathway.

PubMed ID: 26449471

DOI: 10.1126/science.aab2674

Sequence Information:

  • Length: 492
  • Mass: 56557
  • Checksum: 824CF6513634C35E
  • Sequence:
    • MRLAAAANEA YTAPLAVSGL LGCKQCGGGR DQDEELGIRI PRPLGQGPSR FIPEKEILQV 
GSEDAQMHAL FADSFAALGR LDNITLVMVF HPQYLESFLK TQHYLLQMDG PLPLHYRHYI 
GIMAAARHQC SYLVNLHVND FLHVGGDPKW LNGLENAPQK LQNLGELNKV LAHRPWLITK 
EHIEGLLKAE EHSWSLAELV HAVVLLTHYH SLASFTFGCG ISPEIHCDGG HTFRPPSVSN 
YCICDITNGN HSVDEMPVNS AENVSVSDSF FEVEALMEKM RQLQECRDEE EASQEEMASR 
FEIEKRESMF VFSSDDEEVT PARAVSRHFE DTSYGYKDFS RHGMHVPTFR VQDYCWEDHG 
YSLVNRLYPD VGQLIDEKFH IAYNLTYNTM AMHKDVDTSM LRRAIWNYIH CMFGIRYDDY 
DYGEINQLLD RSFKVYIKTV VCTPEKVTKR MYDSFWRQFK HSEKVHVNLL LIEARMQAEL 
LYALRAITRY MT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.