Details for: P2RY10

Gene ID: 27334

Symbol: P2RY10

Ensembl ID: ENSG00000078589

Description: P2Y receptor family member 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 43.9101
    Cell Significance Index: -6.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.4795
    Cell Significance Index: -6.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 9.5375
    Cell Significance Index: 335.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.5720
    Cell Significance Index: -6.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.5131
    Cell Significance Index: 112.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 4.3075
    Cell Significance Index: 89.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.0485
    Cell Significance Index: 116.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1116
    Cell Significance Index: -6.8100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.2490
    Cell Significance Index: 22.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.9339
    Cell Significance Index: -5.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5712
    Cell Significance Index: 34.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.2655
    Cell Significance Index: -3.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1000
    Cell Significance Index: 209.3400
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.0107
    Cell Significance Index: 4.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8683
    Cell Significance Index: 85.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7540
    Cell Significance Index: 680.8400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.7431
    Cell Significance Index: 7.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5424
    Cell Significance Index: 15.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4300
    Cell Significance Index: 6.4800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.3848
    Cell Significance Index: 6.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3817
    Cell Significance Index: 8.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3520
    Cell Significance Index: 57.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3388
    Cell Significance Index: 36.8500
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.2879
    Cell Significance Index: 1.4400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.2352
    Cell Significance Index: 0.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1990
    Cell Significance Index: 13.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1127
    Cell Significance Index: 3.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0542
    Cell Significance Index: 6.3900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0181
    Cell Significance Index: 0.1300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0157
    Cell Significance Index: 0.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0112
    Cell Significance Index: 0.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0052
    Cell Significance Index: -7.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0060
    Cell Significance Index: -8.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0089
    Cell Significance Index: -6.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0108
    Cell Significance Index: -0.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0128
    Cell Significance Index: -7.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0143
    Cell Significance Index: -9.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0143
    Cell Significance Index: -0.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0154
    Cell Significance Index: -7.0100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0185
    Cell Significance Index: -0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0199
    Cell Significance Index: -7.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0246
    Cell Significance Index: -1.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0247
    Cell Significance Index: -1.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0286
    Cell Significance Index: -8.2200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0347
    Cell Significance Index: -0.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0348
    Cell Significance Index: -6.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0350
    Cell Significance Index: -7.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0386
    Cell Significance Index: -1.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0414
    Cell Significance Index: -7.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0417
    Cell Significance Index: -5.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0425
    Cell Significance Index: -7.2600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0434
    Cell Significance Index: -0.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0434
    Cell Significance Index: -1.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0541
    Cell Significance Index: -7.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0621
    Cell Significance Index: -9.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0635
    Cell Significance Index: -7.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0635
    Cell Significance Index: -7.2800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0656
    Cell Significance Index: -0.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0677
    Cell Significance Index: -8.7500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0679
    Cell Significance Index: -0.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0760
    Cell Significance Index: -7.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0927
    Cell Significance Index: -5.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0964
    Cell Significance Index: -4.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1078
    Cell Significance Index: -8.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1118
    Cell Significance Index: -7.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1149
    Cell Significance Index: -7.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1185
    Cell Significance Index: -8.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1271
    Cell Significance Index: -3.4000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1304
    Cell Significance Index: -1.2200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1330
    Cell Significance Index: -1.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1379
    Cell Significance Index: -6.4300
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.1573
    Cell Significance Index: -0.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1584
    Cell Significance Index: -8.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1696
    Cell Significance Index: -1.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1709
    Cell Significance Index: -4.3700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1820
    Cell Significance Index: -1.5500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1951
    Cell Significance Index: -1.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1951
    Cell Significance Index: -8.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1959
    Cell Significance Index: -7.1900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2021
    Cell Significance Index: -2.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2032
    Cell Significance Index: -7.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2165
    Cell Significance Index: -3.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2205
    Cell Significance Index: -7.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2236
    Cell Significance Index: -7.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2271
    Cell Significance Index: -8.6000
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.2295
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2326
    Cell Significance Index: -6.3300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2349
    Cell Significance Index: -2.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2505
    Cell Significance Index: -6.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2505
    Cell Significance Index: -7.0000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2564
    Cell Significance Index: -2.5900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2583
    Cell Significance Index: -8.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2639
    Cell Significance Index: -7.5300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2674
    Cell Significance Index: -3.8000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2695
    Cell Significance Index: -6.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2696
    Cell Significance Index: -6.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2846
    Cell Significance Index: -7.1000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2936
    Cell Significance Index: -3.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** P2RY10 is a member of the P2Y receptor family, which is characterized by its ability to bind to nucleotide-like ligands, such as ATP and UTP. This gene is specifically expressed in various cell types, including goblet cells, thymocytes, B cells, and intestinal epithelial cells. The expression patterns of P2RY10 are highly tissue-specific, suggesting a specialized role in immune regulation and cellular proliferation. **Pathways and Functions:** P2RY10 is involved in several signaling pathways, including Gαq signaling events, GPCR downstream signaling, and GPCR ligand binding. These pathways are critical for regulating various cellular processes, including: 1. **Immune regulation:** P2RY10 is involved in the regulation of immune responses, including the activation of B cells and the proliferation of T cells. 2. **Cellular proliferation:** P2RY10 is expressed in intestinal epithelial cells and plays a role in regulating cellular proliferation and differentiation. 3. **Rho protein signaling:** P2RY10 is involved in the regulation of Rho protein signaling, which is critical for various cellular processes, including cell migration and proliferation. **Clinical Significance:** P2RY10 has significant implications in various clinical contexts, including: 1. **Immunotherapy:** P2RY10 is involved in the regulation of immune responses, making it a potential target for immunotherapeutic interventions. 2. **Cancer:** P2RY10 is expressed in various types of cancer, including colon cancer, suggesting a potential role in cancer progression and metastasis. 3. **Inflammatory diseases:** P2RY10 is involved in the regulation of inflammatory responses, making it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis. In conclusion, P2RY10 is a complex gene that plays a critical role in regulating immune responses, cellular proliferation, and signal transduction pathways. Further research is necessary to fully elucidate the functional implications of P2RY10 in various cellular contexts and to explore its potential as a therapeutic target. **Recommendations:** 1. **Further research:** Conducting further research on the expression patterns and signaling pathways of P2RY10 in various cellular contexts. 2. **Functional analysis:** Conducting functional analysis of P2RY10 to understand its role in regulating immune responses, cellular proliferation, and signal transduction pathways. 3. **Therapeutic targeting:** Exploring the potential of P2RY10 as a therapeutic target for immunotherapeutic interventions and the treatment of inflammatory diseases. By continuing to investigate the complexities of P2RY10, we can gain a deeper understanding of its role in regulating immune responses, cellular proliferation, and signal transduction pathways, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1361545152

Symbol: P2Y10_HUMAN

Name: Putative P2Y purinoceptor 10

UniProtKB Accession Codes:

O00398 D3DTE5 Q4VBN7 Q86V16

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 2 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11004484

Title: Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.

PubMed ID: 11004484

DOI: 10.1016/s0167-4781(00)00094-4

Sequence Information:

  • Length: 339
  • Mass: 38774
  • Checksum: 2C043E4DC342FA0D
  • Sequence:
    • MANLDKYTET FKMGSNSTST AEIYCNVTNV KFQYSLYATT YILIFIPGLL ANSAALWVLC 
RFISKKNKAI IFMINLSVAD LAHVLSLPLR IYYYISHHWP FQRALCLLCF YLKYLNMYAS 
ICFLTCISLQ RCFFLLKPFR ARDWKRRYDV GISAAIWIVV GTACLPFPIL RSTDLNNNKS 
CFADLGYKQM NAVALVGMIT VAELAGFVIP VIIIAWCTWK TTISLRQPPM AFQGISERQK 
ALRMVFMCAA VFFICFTPYH INFIFYTMVK ETIISSCPVV RIALYFHPFC LCLASLCCLL 
DPILYYFMAS EFRDQLSRHG SSVTRSRLMS KESGSSMIG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.