Details for: KCNMB4

Gene ID: 27345

Symbol: KCNMB4

Ensembl ID: ENSG00000135643

Description: potassium calcium-activated channel subfamily M regulatory beta subunit 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 160.4678
    Cell Significance Index: -24.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.9866
    Cell Significance Index: -24.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.2145
    Cell Significance Index: -20.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.2359
    Cell Significance Index: -24.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3431
    Cell Significance Index: -25.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5822
    Cell Significance Index: -7.8400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.2260
    Cell Significance Index: 53.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4160
    Cell Significance Index: 484.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.1223
    Cell Significance Index: 36.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7979
    Cell Significance Index: 120.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7584
    Cell Significance Index: 56.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.6116
    Cell Significance Index: 45.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5881
    Cell Significance Index: 71.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2454
    Cell Significance Index: 237.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9653
    Cell Significance Index: 59.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9328
    Cell Significance Index: 22.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9163
    Cell Significance Index: 40.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9062
    Cell Significance Index: 50.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8847
    Cell Significance Index: 33.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8498
    Cell Significance Index: 84.0600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.7627
    Cell Significance Index: 7.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6887
    Cell Significance Index: 621.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5112
    Cell Significance Index: 26.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4339
    Cell Significance Index: 70.5700
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.3369
    Cell Significance Index: 2.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3356
    Cell Significance Index: 36.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3201
    Cell Significance Index: 6.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3201
    Cell Significance Index: 114.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2902
    Cell Significance Index: 3.6000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2283
    Cell Significance Index: 1.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2202
    Cell Significance Index: 4.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2056
    Cell Significance Index: 142.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1304
    Cell Significance Index: 71.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1033
    Cell Significance Index: 7.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0986
    Cell Significance Index: 2.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0706
    Cell Significance Index: 2.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0656
    Cell Significance Index: 1.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0519
    Cell Significance Index: 6.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0508
    Cell Significance Index: 6.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0429
    Cell Significance Index: 80.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0037
    Cell Significance Index: 1.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0087
    Cell Significance Index: -13.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0119
    Cell Significance Index: -22.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0125
    Cell Significance Index: -2.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0149
    Cell Significance Index: -20.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0150
    Cell Significance Index: -9.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0170
    Cell Significance Index: -7.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0182
    Cell Significance Index: -2.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0295
    Cell Significance Index: -21.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0335
    Cell Significance Index: -24.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0350
    Cell Significance Index: -1.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0353
    Cell Significance Index: -26.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0444
    Cell Significance Index: -27.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0452
    Cell Significance Index: -0.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0462
    Cell Significance Index: -26.0400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0526
    Cell Significance Index: -0.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0527
    Cell Significance Index: -10.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0570
    Cell Significance Index: -1.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0740
    Cell Significance Index: -21.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0830
    Cell Significance Index: -9.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0953
    Cell Significance Index: -13.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0958
    Cell Significance Index: -3.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1238
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1274
    Cell Significance Index: -26.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1328
    Cell Significance Index: -16.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1398
    Cell Significance Index: -14.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1421
    Cell Significance Index: -3.9700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1539
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1547
    Cell Significance Index: -26.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1736
    Cell Significance Index: -22.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1771
    Cell Significance Index: -1.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1914
    Cell Significance Index: -8.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2244
    Cell Significance Index: -23.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2264
    Cell Significance Index: -13.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2372
    Cell Significance Index: -27.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2482
    Cell Significance Index: -19.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2618
    Cell Significance Index: -16.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2620
    Cell Significance Index: -4.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2691
    Cell Significance Index: -5.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2738
    Cell Significance Index: -6.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2836
    Cell Significance Index: -22.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2887
    Cell Significance Index: -21.5200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3047
    Cell Significance Index: -6.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3179
    Cell Significance Index: -16.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3429
    Cell Significance Index: -8.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3568
    Cell Significance Index: -5.1100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3830
    Cell Significance Index: -5.5000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3862
    Cell Significance Index: -4.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4014
    Cell Significance Index: -18.8700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4104
    Cell Significance Index: -8.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4176
    Cell Significance Index: -26.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4285
    Cell Significance Index: -15.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4397
    Cell Significance Index: -22.8400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4580
    Cell Significance Index: -4.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5075
    Cell Significance Index: -17.6400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5153
    Cell Significance Index: -4.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5372
    Cell Significance Index: -14.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5409
    Cell Significance Index: -14.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5743
    Cell Significance Index: -12.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5955
    Cell Significance Index: -17.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **KCNMB4 is a regulatory subunit**: It interacts with KCNQ4 and KCNQ3 to form functional KCa channels. This interaction is essential for the proper functioning of these channels. 2. **Calcium-activated**: KCNMB4 is activated by an increase in intracellular calcium levels, which triggers the opening of KCa channels. 3. **Regulation of neuronal activity**: KCNMB4 is expressed in various types of neurons, where it helps regulate their excitability and neurotransmitter release. 4. **Expression in immune cells**: KCNMB4 is also expressed in immune cells, including enterocytes and oligodendrocytes, suggesting its role in immune function and regulation. **Pathways and Functions:** 1. **Calcium-activated potassium channels**: KCNMB4 is essential for the formation and function of KCa channels, which play a crucial role in neuronal signaling, neurotransmitter secretion, and blood clotting. 2. **Neuronal signaling**: KCNMB4 regulates the excitability of neurons and modulates neurotransmitter release, which is essential for synaptic transmission and learning. 3. **Immune regulation**: KCNMB4 is expressed in immune cells, where it helps regulate immune responses and inflammation. 4. **Cardiovascular function**: KCNMB4 is also expressed in cardiac neurons, where it helps regulate heart rate and blood pressure. **Clinical Significance:** 1. **Neurological disorders**: Dysregulation of KCNMB4 has been implicated in various neurological disorders, including epilepsy, migraines, and Parkinson's disease. 2. **Cardiovascular disease**: Abnormalities in KCNMB4 expression have been linked to cardiovascular disease, including hypertension and arrhythmias. 3. **Inflammatory disorders**: KCNMB4's role in immune regulation makes it a potential target for the treatment of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. 4. **Therapeutic potential**: Understanding the function and regulation of KCNMB4 has therapeutic implications for the development of novel treatments for these disorders. In conclusion, KCNMB4 is a crucial regulator of calcium-activated potassium channels, with significant implications for our understanding of neurological and cardiovascular disorders. Further research is needed to fully elucidate the function and therapeutic potential of KCNMB4.

Genular Protein ID: 52822171

Symbol: KCMB4_HUMAN

Name: Calcium-activated potassium channel subunit beta-4

UniProtKB Accession Codes:

Q86W47 Q8IVR3 Q9NPA4 Q9P0G5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 6 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10792058

Title: A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.

PubMed ID: 10792058

DOI: 10.1073/pnas.100118597

PubMed ID: 10828459

Title: hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family.

PubMed ID: 10828459

DOI: 10.1016/s0014-5793(00)01584-2

PubMed ID: 10692449

Title: Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4.

PubMed ID: 10692449

DOI: 10.1074/jbc.275.9.6453

PubMed ID: 10804197

Title: A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels.

PubMed ID: 10804197

DOI: 10.1523/jneurosci.20-10-03563.2000

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11790768

Title: Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit.

PubMed ID: 11790768

DOI: 10.1074/jbc.m107682200

PubMed ID: 12223479

Title: Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels.

PubMed ID: 12223479

DOI: 10.1074/jbc.m205795200

PubMed ID: 12136044

Title: New disguises for an old channel: MaxiK channel beta-subunits.

PubMed ID: 12136044

DOI: 10.1152/nips.01387.2002

PubMed ID: 25561520

Title: Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures.

PubMed ID: 25561520

DOI: 10.1073/pnas.1423094112

Sequence Information:

  • Length: 210
  • Mass: 23949
  • Checksum: A59D56DD034F027A
  • Sequence:
    • MAKLRVAYEY TEAEDKSIRL GLFLIISGVV SLFIFGFCWL SPALQDLQAT EANCTVLSVQ 
QIGEVFECTF TCGADCRGTS QYPCVQVYVN NSESNSRALL HSDEHQLLTN PKCSYIPPCK 
RENQKNLESV MNWQQYWKDE IGSQPFTCYF NQHQRPDDVL LHRTHDEIVL LHCFLWPLVT 
FVVGVLIVVL TICAKSLAVK AEAMKKRKFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.