Details for: GLI4

Gene ID: 2738

Symbol: GLI4

Ensembl ID: ENSG00000250571

Description: GLI family zinc finger 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.2424
    Cell Significance Index: -12.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.7470
    Cell Significance Index: -13.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 25.3701
    Cell Significance Index: -13.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 19.4777
    Cell Significance Index: -13.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.9493
    Cell Significance Index: -13.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4820
    Cell Significance Index: -13.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2551
    Cell Significance Index: -8.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.1174
    Cell Significance Index: -9.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4014
    Cell Significance Index: 138.6300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2669
    Cell Significance Index: 20.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1331
    Cell Significance Index: 1023.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8497
    Cell Significance Index: 51.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8442
    Cell Significance Index: 91.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7271
    Cell Significance Index: 118.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6638
    Cell Significance Index: 34.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4598
    Cell Significance Index: 53.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4483
    Cell Significance Index: 31.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4478
    Cell Significance Index: 80.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4077
    Cell Significance Index: 18.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3840
    Cell Significance Index: 77.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3645
    Cell Significance Index: 23.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3636
    Cell Significance Index: 10.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3635
    Cell Significance Index: 16.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3522
    Cell Significance Index: 4.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3496
    Cell Significance Index: 7.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3287
    Cell Significance Index: 40.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2823
    Cell Significance Index: 2.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2666
    Cell Significance Index: 7.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2661
    Cell Significance Index: 36.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2161
    Cell Significance Index: 41.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1959
    Cell Significance Index: 107.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1945
    Cell Significance Index: 12.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1524
    Cell Significance Index: 67.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1490
    Cell Significance Index: 53.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1441
    Cell Significance Index: 3.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1141
    Cell Significance Index: 8.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1139
    Cell Significance Index: 22.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1104
    Cell Significance Index: 7.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0809
    Cell Significance Index: 4.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0788
    Cell Significance Index: 1.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0746
    Cell Significance Index: 2.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0624
    Cell Significance Index: 8.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0550
    Cell Significance Index: 2.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0544
    Cell Significance Index: 0.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0424
    Cell Significance Index: 1.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0288
    Cell Significance Index: 3.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0230
    Cell Significance Index: 0.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0075
    Cell Significance Index: 14.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0053
    Cell Significance Index: 0.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0014
    Cell Significance Index: -1.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -9.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0068
    Cell Significance Index: -4.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0072
    Cell Significance Index: -0.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0091
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0093
    Cell Significance Index: -12.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0127
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0173
    Cell Significance Index: -12.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0186
    Cell Significance Index: -8.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0200
    Cell Significance Index: -3.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0221
    Cell Significance Index: -12.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0238
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0264
    Cell Significance Index: -16.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0304
    Cell Significance Index: -4.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0306
    Cell Significance Index: -0.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0311
    Cell Significance Index: -8.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0470
    Cell Significance Index: -3.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0486
    Cell Significance Index: -2.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0522
    Cell Significance Index: -0.5400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0576
    Cell Significance Index: -0.8300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0619
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0715
    Cell Significance Index: -15.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0737
    Cell Significance Index: -8.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0809
    Cell Significance Index: -4.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1056
    Cell Significance Index: -3.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1108
    Cell Significance Index: -1.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1108
    Cell Significance Index: -2.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1244
    Cell Significance Index: -12.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1251
    Cell Significance Index: -9.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1282
    Cell Significance Index: -2.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1299
    Cell Significance Index: -5.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1420
    Cell Significance Index: -3.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1464
    Cell Significance Index: -3.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1637
    Cell Significance Index: -6.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1784
    Cell Significance Index: -10.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1814
    Cell Significance Index: -4.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1822
    Cell Significance Index: -4.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1877
    Cell Significance Index: -4.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1962
    Cell Significance Index: -2.8100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2263
    Cell Significance Index: -3.4100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2263
    Cell Significance Index: -2.4600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2343
    Cell Significance Index: -1.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2500
    Cell Significance Index: -2.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2540
    Cell Significance Index: -7.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2544
    Cell Significance Index: -8.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2627
    Cell Significance Index: -8.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2651
    Cell Significance Index: -7.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2806
    Cell Significance Index: -9.8300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2924
    Cell Significance Index: -6.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GLI4 is a transcription factor that belongs to the GLI family of proteins, which are zinc finger proteins that interact with the Shh signaling pathway. GLI4 is a transcriptional activator that regulates the expression of target genes in response to Shh signaling. It is highly conserved across species and has a unique DNA-binding domain that allows it to interact with Shh ligands and respond to their presence. GLI4 is also involved in regulating cellular processes such as proliferation, differentiation, and survival. **Pathways and Functions:** GLI4 is a key component of the Shh signaling pathway, which is a critical regulator of embryonic development, tissue patterning, and cell fate determination. The Shh signaling pathway involves the binding of Shh ligands to Patched receptors, which activates the Smoothened receptor and triggers a cascade of signaling events that ultimately lead to the activation of GLI4. Once activated, GLI4 translocates to the nucleus and regulates the expression of target genes involved in cellular processes such as proliferation, differentiation, and survival. GLI4 also interacts with other transcription factors and co-regulators to modulate the expression of genes involved in cellular differentiation and survival. **Clinical Significance:** Dysregulation of the Shh signaling pathway, including abnormal expression of GLI4, has been implicated in various diseases, including cancer, neurological disorders, and birth defects. For example, mutations in the GLI4 gene have been linked to medulloblastoma, a type of brain cancer, and other forms of cancer such as pancreatic and colorectal cancer. Additionally, GLI4 has been implicated in neurological disorders such as spina bifida and other congenital defects. Understanding the role of GLI4 in these diseases can provide valuable insights into the development of novel therapeutic strategies. In conclusion, the GLI4 gene is a critical regulator of developmental and cellular processes, and its dysregulation has been implicated in various diseases. Further research into the function and regulation of GLI4 is necessary to fully understand its role in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 3480047243

Symbol: GLI4_HUMAN

Name: Zinc finger protein GLI4

UniProtKB Accession Codes:

P10075 Q96CK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2850480

Title: The GLI-Kruppel family of human genes.

PubMed ID: 2850480

DOI: 10.1128/mcb.8.8.3104-3113.1988

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 376
  • Mass: 41145
  • Checksum: 68B1A638CC0758BC
  • Sequence:
    • MAALGDIQES PSVPSPVSLS SPGTPGTQHH EPQLHLHGHQ HGSPGSSPKV LSQPSDLDLQ 
DVEEVEIGRD TFWPDSEPKP EQAPRSPGSQ APDEGAGGAL RSLLRSLPRR ARCSAGFGPE 
SSAERPAGQP PGAVPCAQPR GAWRVTLVQQ AAAGPEGAPE RAAELGVNFG RSRQGSARGA 
KPHRCEACGK SFKYNSLLLK HQRIHTGEKP YACHECGKRF RGWSGFIQHH RIHTGEKPYE 
CGQCGRAFSH SSHFTQHLRI HNGEKPYKCG ECGQAFSQSS NLVRHQRLHT GEKPYACSQC 
GKAFIWSSVL IEHQRIHTGE KPYECSDCGK AFRGRSHFFR HLRTHTGEKP FACGACGKAF 
GQSSQLIQHQ RVHYRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.