Details for: GLI4

Gene ID: 2738

Symbol: GLI4

Ensembl ID: ENSG00000250571

Description: GLI family zinc finger 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71763
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47987
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2718
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13754
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5011
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5261
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.79
    Marker Score: 632
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.78
    Marker Score: 1204
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.75
    Marker Score: 1518
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.73
    Marker Score: 6289
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.72
    Marker Score: 6827
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.71
    Marker Score: 655
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 644
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 282
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.69
    Marker Score: 2540
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.68
    Marker Score: 1556
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.68
    Marker Score: 41804
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2825
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.64
    Marker Score: 1512
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.62
    Marker Score: 898
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.61
    Marker Score: 905
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.58
    Marker Score: 578
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.55
    Marker Score: 160
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.55
    Marker Score: 331
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.53
    Marker Score: 166
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.53
    Marker Score: 5330
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.5
    Marker Score: 245
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 320
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.49
    Marker Score: 4627
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.49
    Marker Score: 996
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.49
    Marker Score: 1311.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.49
    Marker Score: 1732
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.49
    Marker Score: 806
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.48
    Marker Score: 2871
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.47
    Marker Score: 264
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.46
    Marker Score: 290
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.46
    Marker Score: 484
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.46
    Marker Score: 644
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.44
    Marker Score: 269
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.44
    Marker Score: 16289
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.44
    Marker Score: 1111
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.44
    Marker Score: 374
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.44
    Marker Score: 4541
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.43
    Marker Score: 469
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 283
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.43
    Marker Score: 479
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.43
    Marker Score: 125
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.43
    Marker Score: 289
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.42
    Marker Score: 234
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.42
    Marker Score: 152
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.41
    Marker Score: 429
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.41
    Marker Score: 133
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.41
    Marker Score: 1654
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.41
    Marker Score: 3501
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.41
    Marker Score: 140
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.39
    Marker Score: 246
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.39
    Marker Score: 397
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 186
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.39
    Marker Score: 163
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.39
    Marker Score: 13444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 160
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.38
    Marker Score: 331
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.38
    Marker Score: 142
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.38
    Marker Score: 379
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.38
    Marker Score: 4282
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.38
    Marker Score: 154
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.38
    Marker Score: 211
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.38
    Marker Score: 113
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.37
    Marker Score: 1534
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.37
    Marker Score: 1615
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.37
    Marker Score: 881
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.37
    Marker Score: 636
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.37
    Marker Score: 73
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.37
    Marker Score: 466
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.37
    Marker Score: 309
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.37
    Marker Score: 202
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.36
    Marker Score: 1411
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.36
    Marker Score: 168
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.36
    Marker Score: 756
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 94
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.35
    Marker Score: 4622
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.35
    Marker Score: 6939
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.35
    Marker Score: 140
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.35
    Marker Score: 13236
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.35
    Marker Score: 86
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.35
    Marker Score: 150
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.35
    Marker Score: 110
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.35
    Marker Score: 827
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.34
    Marker Score: 142

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Other Information

**Key characteristics:** * GLI4 is a transcription factor that is expressed in a variety of cell types. * It is involved in the regulation of gene expression, cell differentiation, and apoptosis. * GLI4 is a key regulator of neural differentiation and survival. * It is also involved in the development of the central nervous system. **Pathways and functions:** * GLI4 is a key regulator of neural differentiation and survival. * It is expressed in proliferating neural stem cells and is necessary for their survival. * It also plays a role in the development of the central nervous system, including the formation of neurons and the growth of new neurons. * GLI4 is also involved in the regulation of apoptosis, or programmed cell death. **Clinical significance:** * Mutations in the GLI4 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. * These mutations can disrupt the normal function of GLI4, leading to cell death and a variety of neurological symptoms. * As such, GLI4 is a promising target for the treatment of neurological disorders. **Additional information:** * GLI4 is a member of the zinc finger family of transcription factors. * It is a highly conserved protein that is found in vertebrates. * The GLI4 gene is located on chromosome 17q21.1. * It is a large gene that encodes a protein of approximately 600 amino acids.

Genular Protein ID: 3480047243

Symbol: GLI4_HUMAN

Name: Zinc finger protein GLI4

UniProtKB Accession Codes:

P10075 Q96CK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2850480

Title: The GLI-Kruppel family of human genes.

PubMed ID: 2850480

DOI: 10.1128/mcb.8.8.3104-3113.1988

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 376
  • Mass: 41145
  • Checksum: 68B1A638CC0758BC
  • Sequence:
    • MAALGDIQES PSVPSPVSLS SPGTPGTQHH EPQLHLHGHQ HGSPGSSPKV LSQPSDLDLQ 
DVEEVEIGRD TFWPDSEPKP EQAPRSPGSQ APDEGAGGAL RSLLRSLPRR ARCSAGFGPE 
SSAERPAGQP PGAVPCAQPR GAWRVTLVQQ AAAGPEGAPE RAAELGVNFG RSRQGSARGA 
KPHRCEACGK SFKYNSLLLK HQRIHTGEKP YACHECGKRF RGWSGFIQHH RIHTGEKPYE 
CGQCGRAFSH SSHFTQHLRI HNGEKPYKCG ECGQAFSQSS NLVRHQRLHT GEKPYACSQC 
GKAFIWSSVL IEHQRIHTGE KPYECSDCGK AFRGRSHFFR HLRTHTGEKP FACGACGKAF 
GQSSQLIQHQ RVHYRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.