Details for: AMT

Gene ID: 275

Symbol: AMT

Ensembl ID: ENSG00000145020

Description: aminomethyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 43.9743
    Cell Significance Index: -6.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.0422
    Cell Significance Index: -7.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.0027
    Cell Significance Index: -7.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.2431
    Cell Significance Index: -7.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.8129
    Cell Significance Index: -8.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4754
    Cell Significance Index: -9.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6501
    Cell Significance Index: -5.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.2427
    Cell Significance Index: -8.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3154
    Cell Significance Index: 78.9700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0370
    Cell Significance Index: 8.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9634
    Cell Significance Index: 25.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9420
    Cell Significance Index: 20.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6268
    Cell Significance Index: 21.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5975
    Cell Significance Index: 65.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5460
    Cell Significance Index: 24.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5164
    Cell Significance Index: 4.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4154
    Cell Significance Index: 21.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3388
    Cell Significance Index: 7.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3172
    Cell Significance Index: 57.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3014
    Cell Significance Index: 7.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2948
    Cell Significance Index: 8.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2615
    Cell Significance Index: 16.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2614
    Cell Significance Index: 18.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2563
    Cell Significance Index: 13.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2533
    Cell Significance Index: 31.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2400
    Cell Significance Index: 48.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2389
    Cell Significance Index: 32.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2225
    Cell Significance Index: 121.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2169
    Cell Significance Index: 3.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1934
    Cell Significance Index: 36.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1833
    Cell Significance Index: 6.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1752
    Cell Significance Index: 7.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1690
    Cell Significance Index: 21.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1598
    Cell Significance Index: 12.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1499
    Cell Significance Index: 4.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1483
    Cell Significance Index: 24.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1335
    Cell Significance Index: 3.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1326
    Cell Significance Index: 119.7300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.1112
    Cell Significance Index: 0.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1043
    Cell Significance Index: 2.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0815
    Cell Significance Index: 29.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0726
    Cell Significance Index: 4.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0716
    Cell Significance Index: 3.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0668
    Cell Significance Index: 7.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0523
    Cell Significance Index: 5.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0513
    Cell Significance Index: 1.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0256
    Cell Significance Index: 0.9000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0117
    Cell Significance Index: 0.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0030
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0057
    Cell Significance Index: -8.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0057
    Cell Significance Index: -2.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0062
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0108
    Cell Significance Index: -7.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0113
    Cell Significance Index: -6.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0138
    Cell Significance Index: -8.7700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0143
    Cell Significance Index: -0.2400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0144
    Cell Significance Index: -0.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0147
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0151
    Cell Significance Index: -9.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0160
    Cell Significance Index: -1.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0183
    Cell Significance Index: -8.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0206
    Cell Significance Index: -0.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0207
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0226
    Cell Significance Index: -3.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0260
    Cell Significance Index: -7.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0268
    Cell Significance Index: -0.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0311
    Cell Significance Index: -1.4500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0346
    Cell Significance Index: -0.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0381
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0403
    Cell Significance Index: -8.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0427
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0433
    Cell Significance Index: -4.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0435
    Cell Significance Index: -5.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0436
    Cell Significance Index: -0.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0469
    Cell Significance Index: -9.3100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0549
    Cell Significance Index: -0.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0594
    Cell Significance Index: -8.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0601
    Cell Significance Index: -4.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0669
    Cell Significance Index: -7.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0712
    Cell Significance Index: -2.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0735
    Cell Significance Index: -1.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0852
    Cell Significance Index: -8.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0884
    Cell Significance Index: -2.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0884
    Cell Significance Index: -0.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0900
    Cell Significance Index: -6.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0962
    Cell Significance Index: -1.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1013
    Cell Significance Index: -6.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1076
    Cell Significance Index: -2.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1305
    Cell Significance Index: -2.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1353
    Cell Significance Index: -4.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1463
    Cell Significance Index: -4.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1512
    Cell Significance Index: -5.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1565
    Cell Significance Index: -4.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1574
    Cell Significance Index: -3.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1600
    Cell Significance Index: -2.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1627
    Cell Significance Index: -5.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AMT is a type of transferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to a variety of substrates, including glycine. This reaction is an essential step in the degradation of glycine, which is then converted into other metabolites, such as carbon dioxide and formic acid. AMT has been found to be expressed in various tissues, including the brain, liver, and intestinal epithelial cells, and has been implicated in several diseases, including neurological disorders and cancer. **Pathways and Functions:** AMT is involved in several metabolic pathways, including: 1. **Glycine degradation:** AMT catalyzes the transfer of a methyl group from SAM to glycine, resulting in the formation of sarcosine and formic acid. 2. **Glyoxylate metabolism:** AMT has been shown to play a role in the metabolism of glyoxylate, a key intermediate in the degradation of fatty acids and amino acids. 3. **Metabolism of amino acids and derivatives:** AMT has been implicated in the metabolism of various amino acids, including glycine, glutamate, and aspartate. 4. **Neurotransmitter synthesis:** AMT has been shown to play a role in the synthesis of neurotransmitters, such as GABA, which is involved in the regulation of neuronal excitability. **Clinical Significance:** Dysregulation of AMT has been implicated in several diseases, including: 1. **Neurological disorders:** AMT has been shown to play a role in the regulation of GABA levels, which is essential for maintaining normal neuronal function. Dysregulation of AMT has been implicated in several neurological disorders, including epilepsy, Parkinson's disease, and schizophrenia. 2. **Cancer:** AMT has been shown to be overexpressed in several types of cancer, including colon cancer and glioblastoma. Overexpression of AMT has been associated with poor prognosis and reduced survival rates. 3. **Metabolic disorders:** AMT has been implicated in the regulation of energy metabolism, and dysregulation of AMT has been associated with metabolic disorders, such as obesity and type 2 diabetes. In conclusion, AMT is an essential enzyme that plays a crucial role in various metabolic pathways, including glycine degradation, glyoxylate metabolism, and neurotransmitter synthesis. Dysregulation of AMT has been implicated in several diseases, including neurological disorders, cancer, and metabolic disorders. Further research is needed to fully understand the function and clinical significance of AMT. **Significantly expressed cells:** Primitive red blood cell, erythroid progenitor cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, absorptive cell, tuft cell of colon, BEST4+ intestinal epithelial cell, human, intestinal crypt stem cell of colon, transit amplifying cell, abnormal cell. **Proteins:** GCST_HUMAN

Genular Protein ID: 2095740534

Symbol: GCST_HUMAN

Name: N/A

UniProtKB Accession Codes:

P48728 A8K3I5 B4DE61 B4DJQ0 E9PBG1 Q96IG6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7916605

Title: Isolation and sequence determination of cDNA encoding human T-protein of the glycine cleavage system.

PubMed ID: 7916605

DOI: 10.1006/bbrc.1993.1480

PubMed ID: 8188235

Title: Structure and chromosomal localization of the aminomethyltransferase gene (AMT).

PubMed ID: 8188235

DOI: 10.1006/geno.1994.1007

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28244183

Title: Nonketotic Hyperglycinemia: functional assessment of missense variants in GLDC to understand phenotypes of the disease.

PubMed ID: 28244183

DOI: 10.1002/humu.23208

PubMed ID: 16051266

Title: Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia.

PubMed ID: 16051266

DOI: 10.1016/j.jmb.2005.06.056

PubMed ID: 8005589

Title: Identification of the mutations in the T-protein gene causing typical and atypical nonketotic hyperglycinemia.

PubMed ID: 8005589

DOI: 10.1007/bf00201565

PubMed ID: 9600239

Title: A missense mutation (His42Arg) in the T-protein gene from a large Israeli-Arab kindred with nonketotic hyperglycinemia.

PubMed ID: 9600239

DOI: 10.1007/s004390050716

PubMed ID: 9621520

Title: A one-base deletion (183delC) and a missense mutation (D276H) in the T-protein gene from a Japanese family with nonketotic hyperglycinemia.

PubMed ID: 9621520

DOI: 10.1007/s100380050055

PubMed ID: 10873393

Title: Biochemical and molecular investigations of patients with nonketotic hyperglycinemia.

PubMed ID: 10873393

DOI: 10.1006/mgme.2000.3000

PubMed ID: 11286506

Title: Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): a strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH).

PubMed ID: 11286506

DOI: 10.1006/mgme.2001.3158

PubMed ID: 26371980

Title: A novel AMT gene mutation in a newborn with nonketotic hyperglycinemia and early myoclonic encephalopathy.

PubMed ID: 26371980

DOI: 10.1016/j.ejpn.2015.08.008

Sequence Information:

  • Length: 403
  • Mass: 43946
  • Checksum: 218DC9EEADFA9102
  • Sequence:
    • MQRAVSVVAR LGFRLQAFPP ALCRPLSCAQ EVLRRTPLYD FHLAHGGKMV AFAGWSLPVQ 
YRDSHTDSHL HTRQHCSLFD VSHMLQTKIL GSDRVKLMES LVVGDIAELR PNQGTLSLFT 
NEAGGILDDL IVTNTSEGHL YVVSNAGCWE KDLALMQDKV RELQNQGRDV GLEVLDNALL 
ALQGPTAAQV LQAGVADDLR KLPFMTSAVM EVFGVSGCRV TRCGYTGEDG VEISVPVAGA 
VHLATAILKN PEVKLAGLAA RDSLRLEAGL CLYGNDIDEH TTPVEGSLSW TLGKRRRAAM 
DFPGAKVIVP QLKGRVQRRR VGLMCEGAPM RAHSPILNME GTKIGTVTSG CPSPSLKKNV 
AMGYVPCEYS RPGTMLLVEV RRKQQMAVVS KMPFVPTNYY TLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.