GNG3 | ENSG00000162188 | NCBI 2785

Details for: GNG3

Gene ID: 2785

Symbol: GNG3

Ensembl ID: ENSG00000162188

Description: G protein subunit gamma 3

Associated with

Activation of gabab receptors
(R-HSA-991365)
Activation of g protein gated potassium channels
(R-HSA-1296041)
Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adp signalling through p2y purinoceptor 1
(R-HSA-418592)
Adp signalling through p2y purinoceptor 12
(R-HSA-392170)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Chaperonin-mediated protein folding
(R-HSA-390466)
Class b/2 (secretin family receptors)
(R-HSA-373080)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G-protein activation
(R-HSA-202040)
G-protein beta:gamma signalling
(R-HSA-397795)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
G beta:gamma signalling through btk
(R-HSA-8964315)
G beta:gamma signalling through cdc42
(R-HSA-8964616)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
G beta:gamma signalling through plc beta
(R-HSA-418217)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon-type ligand receptors
(R-HSA-420092)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Gper1 signaling
(R-HSA-9634597)
G protein gated potassium channels
(R-HSA-1296059)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Infectious disease
(R-HSA-5663205)
Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
(R-HSA-997272)
Integration of energy metabolism
(R-HSA-163685)
Inwardly rectifying k+ channels
(R-HSA-1296065)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet homeostasis
(R-HSA-418346)
Potassium channels
(R-HSA-1296071)
Presynaptic function of kainate receptors
(R-HSA-500657)
Prostacyclin signalling through prostacyclin receptor
(R-HSA-392851)
Protein folding
(R-HSA-391251)
Regulation of insulin secretion
(R-HSA-422356)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Thromboxane signalling through tp receptor
(R-HSA-428930)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Cell body
(GO:0044297)
Dendrite
(GO:0030425)
G-protein beta-subunit binding
(GO:0031681)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activity
(GO:0003924)
Heterotrimeric g-protein complex
(GO:0005834)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 140.0236
Cell Significance Index: -21.7800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 45.2970
Cell Significance Index: -18.6600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 42.2639
Cell Significance Index: -17.1700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 17.7379
Cell Significance Index: -21.8700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.2822
Cell Significance Index: 172.3300
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 2.6674
Cell Significance Index: 20.5600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 1.8734
Cell Significance Index: 114.8600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 1.1717
Cell Significance Index: 20.0800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.0619
Cell Significance Index: 34.0100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5888
Cell Significance Index: 118.1200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5726
Cell Significance Index: 108.9700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.5151
Cell Significance Index: 14.7000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3361
Cell Significance Index: 33.2500
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.3156
Cell Significance Index: 2.7800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2919
Cell Significance Index: 263.6100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2865
Cell Significance Index: 102.7500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2767
Cell Significance Index: 17.0100
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1507
Cell Significance Index: 3.3000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1447
Cell Significance Index: 23.5400
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.1048
Cell Significance Index: 1.3000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0935
Cell Significance Index: 10.1800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0104
Cell Significance Index: -19.2700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0118
Cell Significance Index: -0.3400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0121
Cell Significance Index: -22.7700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0124
Cell Significance Index: -19.0500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0133
Cell Significance Index: -0.5800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0135
Cell Significance Index: -18.4000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0176
Cell Significance Index: -12.1800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0191
Cell Significance Index: -0.6700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0250
Cell Significance Index: -18.5100
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0259
Cell Significance Index: -0.6200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0275
Cell Significance Index: -20.1600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0280
Cell Significance Index: -21.1900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0288
Cell Significance Index: -18.3100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0304
Cell Significance Index: -17.1200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0310
Cell Significance Index: -19.3600
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0369
Cell Significance Index: -20.1300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0409
Cell Significance Index: -18.5700
Cell Name: neural cell (CL0002319)
Fold Change: -0.0420
Cell Significance Index: -0.4900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0457
Cell Significance Index: -2.7500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0521
Cell Significance Index: -3.5000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0545
Cell Significance Index: -2.4700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0546
Cell Significance Index: -15.7100
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: -0.0585
Cell Significance Index: -0.4600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0589
Cell Significance Index: -4.0800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0612
Cell Significance Index: -1.5300
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0845
Cell Significance Index: -16.7600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0948
Cell Significance Index: -17.0900
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.0953
Cell Significance Index: -0.6200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0969
Cell Significance Index: -20.4100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0992
Cell Significance Index: -2.1500
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1123
Cell Significance Index: -14.4000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1127
Cell Significance Index: -19.2500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1259
Cell Significance Index: -18.3100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1300
Cell Significance Index: -15.1600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1344
Cell Significance Index: -16.5200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1351
Cell Significance Index: -17.4600
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1390
Cell Significance Index: -2.9500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1463
Cell Significance Index: -20.0900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1471
Cell Significance Index: -9.2700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1524
Cell Significance Index: -15.5700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1570
Cell Significance Index: -18.5200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1863
Cell Significance Index: -21.3400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1909
Cell Significance Index: -3.9600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2112
Cell Significance Index: -11.8500
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.2133
Cell Significance Index: -2.4100
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2165
Cell Significance Index: -4.2800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2372
Cell Significance Index: -17.6800
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.2471
Cell Significance Index: -2.0400
Cell Name: neuron (CL0000540)
Fold Change: -0.2490
Cell Significance Index: -2.3600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2564
Cell Significance Index: -20.3100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2831
Cell Significance Index: -9.2700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2921
Cell Significance Index: -6.2200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3003
Cell Significance Index: -15.6400
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3108
Cell Significance Index: -6.2400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3188
Cell Significance Index: -20.5700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3196
Cell Significance Index: -10.1800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3243
Cell Significance Index: -24.8900
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.3269
Cell Significance Index: -1.9400
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3434
Cell Significance Index: -7.4200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3526
Cell Significance Index: -18.3200
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.3571
Cell Significance Index: -3.7200
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3712
Cell Significance Index: -13.0100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3819
Cell Significance Index: -17.9500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3932
Cell Significance Index: -17.3900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3994
Cell Significance Index: -18.6200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4055
Cell Significance Index: -14.0900
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.4424
Cell Significance Index: -4.8200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4653
Cell Significance Index: -13.0000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4695
Cell Significance Index: -17.7800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4984
Cell Significance Index: -14.6800
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5079
Cell Significance Index: -12.6700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.5178
Cell Significance Index: -7.4200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5310
Cell Significance Index: -11.3500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5347
Cell Significance Index: -19.6300
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.5383
Cell Significance Index: -7.1800
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.5922
Cell Significance Index: -7.9000
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.6067
Cell Significance Index: -19.1900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.6123
Cell Significance Index: -16.1000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.6203
Cell Significance Index: -17.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The gamma-3 subunit is a constitutively active G protein subunit, meaning it is always active and can interact with GPCRs to modulate their signaling activity. It is a part of the G(I)/G(S)/G(O) family of G protein subunits, which are involved in the regulation of various cellular processes. The gamma-3 subunit is characterized by its ability to bind to GPCRs and modulate their signaling activity, as well as its involvement in the regulation of calcium signaling and potassium channel activity. It is also involved in the regulation of protein folding and is required for the proper functioning of certain GPCRs. **Pathways and Functions** The gamma-3 subunit is involved in a wide range of signaling pathways, including: 1. **GABA receptor signaling**: The gamma-3 subunit interacts with GABA receptors to modulate their signaling activity and regulate neurotransmission. 2. **Potassium channel signaling**: The gamma-3 subunit is involved in the regulation of potassium channel activity, influencing neuronal excitability and neurotransmission. 3. **Calcium signaling**: The gamma-3 subunit modulates calcium signaling by interacting with calcium channels and influencing the influx of calcium ions into cells. 4. **Protein folding**: The gamma-3 subunit is involved in the regulation of protein folding, influencing the proper functioning of certain GPCRs. 5. **Immune response**: The gamma-3 subunit is involved in the regulation of immune responses, influencing the production of anti-inflammatory cytokines and the activation of immune cells. **Clinical Significance** The gamma-3 subunit plays a crucial role in various physiological processes, and its dysregulation has been implicated in several diseases, including: 1. **Neurological disorders**: The gamma-3 subunit is involved in the regulation of neurotransmission and neuronal excitability, and its dysregulation has been implicated in neurological disorders such as epilepsy and Parkinson's disease. 2. **Metabolic disorders**: The gamma-3 subunit is involved in the regulation of glucose and lipid metabolism, and its dysregulation has been implicated in metabolic disorders such as diabetes and obesity. 3. **Immune disorders**: The gamma-3 subunit is involved in the regulation of immune responses, and its dysregulation has been implicated in immune disorders such as rheumatoid arthritis and multiple sclerosis. In conclusion, the gamma-3 subunit is a crucial component of the heterotrimeric G protein complex, and its dysregulation has significant implications for various physiological processes and diseases. Further research is needed to fully understand the function and clinical significance of the gamma-3 subunit.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Genular Protein ID: 3600989498

Symbol: GBG3_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

UniProtKB Accession Codes:

P63215 B2R4S7 P29798 Q61014

Database IDs:

Citations:

PubMed ID: 10819326

Title: Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes.

PubMed ID: 10819326

DOI: 10.1093/dnares/7.2.111

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26900580

Title: Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.

PubMed ID: 26900580

DOI: 10.1002/acn3.276

PubMed ID: 34685729

Title: Pediatric Encephalopathy: Clinical, Biochemical and Cellular Insights into the Role of Gln52 of GNAO1 and GNAI1 for the Dominant Disease.

PubMed ID: 34685729

DOI: 10.3390/cells10102749

Sequence Information:

Length: 75
Mass: 8305
Checksum: 35CC03965FE69A9D
Sequence:

MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC EDPLITPVPT 
SENPFREKKF FCALL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GNG3

Associated with

Cells (max top 100)

Other Information

Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. PubMed ID: 10819326

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334