Details for: GNG7

Gene ID: 2788

Symbol: GNG7

Ensembl ID: ENSG00000176533

Description: G protein subunit gamma 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.61
    Marker Score: 7,928
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.45
    Marker Score: 777
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.45
    Marker Score: 2,887
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.37
    Marker Score: 5,666
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.36
    Marker Score: 2,012
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.23
    Marker Score: 1,107
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.15
    Marker Score: 680
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.12
    Marker Score: 2,084
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.11
    Marker Score: 12,540
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.09
    Marker Score: 79,299
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.07
    Marker Score: 8,593
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.04
    Marker Score: 45,655
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.03
    Marker Score: 1,222
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.03
    Marker Score: 74,731
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.02
    Marker Score: 43,088
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.92
    Marker Score: 5,230
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.87
    Marker Score: 677
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.86
    Marker Score: 27,821
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.82
    Marker Score: 6,469
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8
    Marker Score: 6,953
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.8
    Marker Score: 3,655
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.78
    Marker Score: 556
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.68
    Marker Score: 684
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.66
    Marker Score: 1,561
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.65
    Marker Score: 15,657
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.64
    Marker Score: 32,532
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.57
    Marker Score: 506
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.56
    Marker Score: 1,033
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.55
    Marker Score: 3,662
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.54
    Marker Score: 11,834
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.51
    Marker Score: 533
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168,053
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.44
    Marker Score: 945
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.43
    Marker Score: 12,289
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.42
    Marker Score: 2,579
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2,163
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.4
    Marker Score: 586
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.4
    Marker Score: 769
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.39
    Marker Score: 1,720
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.35
    Marker Score: 1,208
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.35
    Marker Score: 1,360
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.35
    Marker Score: 2,350
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.34
    Marker Score: 21,007
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.28
    Marker Score: 772
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.28
    Marker Score: 632
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.25
    Marker Score: 2,843
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.25
    Marker Score: 76,705
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.25
    Marker Score: 287
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.23
    Marker Score: 12,702
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.22
    Marker Score: 426
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.21
    Marker Score: 309
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.2
    Marker Score: 11,302
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.2
    Marker Score: 1,611
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.17
    Marker Score: 1,411
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.15
    Marker Score: 872
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.15
    Marker Score: 1,925
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.13
    Marker Score: 309
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.12
    Marker Score: 4,693
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.08
    Marker Score: 342
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.07
    Marker Score: 469
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.06
    Marker Score: 2,222
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.03
    Marker Score: 602
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.02
    Marker Score: 6,114
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1
    Marker Score: 477
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,743
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,968
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1
    Marker Score: 1,079
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 662
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.96
    Marker Score: 742
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.95
    Marker Score: 2,552
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.95
    Marker Score: 246
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.95
    Marker Score: 575
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.94
    Marker Score: 2,688
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.93
    Marker Score: 925
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,723
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.91
    Marker Score: 1,205
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.91
    Marker Score: 785
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.89
    Marker Score: 959
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.89
    Marker Score: 1,806
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.88
    Marker Score: 461
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.87
    Marker Score: 972
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,964
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.85
    Marker Score: 624
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.85
    Marker Score: 1,633
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.82
    Marker Score: 8,351
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.81
    Marker Score: 840
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 607
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.79
    Marker Score: 989
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.79
    Marker Score: 200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.78
    Marker Score: 1,098
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.77
    Marker Score: 734
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.77
    Marker Score: 280

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** GNG7 is highly expressed in the central nervous system, including the retina, cerebral cortex, and brainstem, as well as in immune cells, smooth muscle cells, and certain types of cancer cells. 2. **Subunit Interactions:** The gamma-7 subunit interacts with various GPCR subunits, including Gα12/13, Gαi, Gαq, Gαs, and Gαz, to modulate signaling pathways. 3. **Signaling Pathways:** GNG7 regulates a diverse array of signaling pathways, including those involved in neurotransmission, insulin secretion, inflammation, and immune responses. 4. **Cellular Functions:** GNG7 plays a crucial role in regulating cellular processes, including neurotransmission, insulin secretion, inflammation, and immune responses. **Pathways and Functions:** 1. **Neurotransmission:** GNG7 regulates neurotransmission by modulating the activity of GPCRs involved in synaptic transmission, including GABA receptors and glutamate receptors. 2. **Insulin Secretion:** GNG7 influences insulin secretion by regulating the activity of GPCRs involved in glucose metabolism, including glucagon-like peptide-1 (GLP-1) receptors. 3. **Inflammation:** GNG7 modulates inflammatory responses by regulating the activity of GPCRs involved in immune signaling, including adhesion molecule receptors and chemokine receptors. 4. **Immune Responses:** GNG7 plays a crucial role in regulating immune responses, including the activation of immune cells, such as macrophages and T cells. 5. **Cellular Signaling:** GNG7 regulates cellular signaling by interacting with various GPCR subunits to modulate signaling pathways involved in cell growth, differentiation, and survival. **Clinical Significance:** 1. **Neurological Disorders:** GNG7 dysregulation has been implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and epilepsy. 2. **Metabolic Disorders:** GNG7 influences glucose metabolism and insulin secretion, making it a potential target for the treatment of metabolic disorders, such as type 2 diabetes. 3. **Inflammatory Diseases:** GNG7 modulates inflammatory responses, making it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and asthma. 4. **Cancer:** GNG7 is overexpressed in certain types of cancer, including breast cancer and lung cancer, making it a potential target for cancer therapy. In conclusion, the GNG7 gene plays a multifaceted role in regulating cellular signaling and function, influencing a wide range of physiological processes, including neurotransmission, insulin secretion, inflammation, and immune responses. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention.

Genular Protein ID: 3214649118

Symbol: GBG7_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

UniProtKB Accession Codes:

O60262 B2R496

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 28 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9600093

Title: Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer.

PubMed ID: 9600093

DOI: 10.1006/bbrc.1998.8581

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18219292

Title: Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer.

PubMed ID: 18219292

DOI: 10.1038/sj.bjc.6604124

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 68
  • Mass: 7522
  • Checksum: 704133C7BEC7FD72
  • Sequence:
    • MSATNNIAQA RKLVEQLRIE AGIERIKVSK AASDLMSYCE QHARNDPLLV GVPASENPFK 
DKKPCIIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.