GNG7 | ENSG00000176533 | NCBI 2788

Details for: GNG7

Gene ID: 2788

Symbol: GNG7

Ensembl ID: ENSG00000176533

Description: G protein subunit gamma 7

Associated with

Activation of gabab receptors
(R-HSA-991365)
Activation of g protein gated potassium channels
(R-HSA-1296041)
Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adp signalling through p2y purinoceptor 1
(R-HSA-418592)
Adp signalling through p2y purinoceptor 12
(R-HSA-392170)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Chaperonin-mediated protein folding
(R-HSA-390466)
Class b/2 (secretin family receptors)
(R-HSA-373080)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G-protein activation
(R-HSA-202040)
G-protein beta:gamma signalling
(R-HSA-397795)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
G beta:gamma signalling through btk
(R-HSA-8964315)
G beta:gamma signalling through cdc42
(R-HSA-8964616)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
G beta:gamma signalling through plc beta
(R-HSA-418217)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon-type ligand receptors
(R-HSA-420092)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Gper1 signaling
(R-HSA-9634597)
G protein gated potassium channels
(R-HSA-1296059)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Infectious disease
(R-HSA-5663205)
Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
(R-HSA-997272)
Integration of energy metabolism
(R-HSA-163685)
Inwardly rectifying k+ channels
(R-HSA-1296065)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet homeostasis
(R-HSA-418346)
Potassium channels
(R-HSA-1296071)
Presynaptic function of kainate receptors
(R-HSA-500657)
Prostacyclin signalling through prostacyclin receptor
(R-HSA-392851)
Protein folding
(R-HSA-391251)
Regulation of insulin secretion
(R-HSA-422356)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Thromboxane signalling through tp receptor
(R-HSA-428930)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Behavioral fear response
(GO:0001662)
Extracellular exosome
(GO:0070062)
G-protein beta-subunit binding
(GO:0031681)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heterotrimeric g-protein complex
(GO:0005834)
Locomotory behavior
(GO:0007626)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Receptor guanylyl cyclase signaling pathway
(GO:0007168)
Regulation of adenylate cyclase activity
(GO:0045761)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Synapse
(GO:0045202)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 237.9372
Cell Significance Index: -37.0100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 133.0608
Cell Significance Index: -33.7500
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 80.6570
Cell Significance Index: -38.0800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 30.0822
Cell Significance Index: -37.0900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.3643
Cell Significance Index: -38.4800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.0464
Cell Significance Index: -37.0000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.5741
Cell Significance Index: -37.7800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.2010
Cell Significance Index: -15.7600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 5.7781
Cell Significance Index: 255.5800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 5.1811
Cell Significance Index: 196.2000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.9385
Cell Significance Index: 879.8100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.8220
Cell Significance Index: 139.8200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.4097
Cell Significance Index: 505.6200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2626
Cell Significance Index: 253.2800
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.2219
Cell Significance Index: 15.1600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9868
Cell Significance Index: 46.0100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.8128
Cell Significance Index: 54.6500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6518
Cell Significance Index: 129.3600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4620
Cell Significance Index: 29.8100
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.4228
Cell Significance Index: 5.9300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3880
Cell Significance Index: 350.3100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3846
Cell Significance Index: 38.0500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3472
Cell Significance Index: 40.9500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3297
Cell Significance Index: 17.3100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2506
Cell Significance Index: 173.3200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.2274
Cell Significance Index: 23.6800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2066
Cell Significance Index: 33.6000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1971
Cell Significance Index: 37.5100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1112
Cell Significance Index: 12.0900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0941
Cell Significance Index: 177.2300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0808
Cell Significance Index: 2.8400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0700
Cell Significance Index: 1.2000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0694
Cell Significance Index: 106.8400
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0688
Cell Significance Index: 126.9700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.0474
Cell Significance Index: 0.7000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0398
Cell Significance Index: 5.1500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0311
Cell Significance Index: 19.7800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0228
Cell Significance Index: 0.5700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0205
Cell Significance Index: 15.0400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0153
Cell Significance Index: 0.9400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0001
Cell Significance Index: 0.0900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0106
Cell Significance Index: -5.9500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0126
Cell Significance Index: -9.3400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0178
Cell Significance Index: -11.1400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0178
Cell Significance Index: -7.8600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0198
Cell Significance Index: -1.1900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0305
Cell Significance Index: -0.8800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0315
Cell Significance Index: -1.7700
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0339
Cell Significance Index: -18.5000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0359
Cell Significance Index: -6.1300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0422
Cell Significance Index: -1.1800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0460
Cell Significance Index: -34.8500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0572
Cell Significance Index: -10.3100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0692
Cell Significance Index: -4.7900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0800
Cell Significance Index: -9.1700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0983
Cell Significance Index: -2.1300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1064
Cell Significance Index: -22.4200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1067
Cell Significance Index: -14.6500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1074
Cell Significance Index: -30.9000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1075
Cell Significance Index: -15.6300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1080
Cell Significance Index: -13.2800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1233
Cell Significance Index: -5.5900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1308
Cell Significance Index: -16.7700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1355
Cell Significance Index: -13.8400
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1770
Cell Significance Index: -5.0500
Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.1931
Cell Significance Index: -2.0700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2008
Cell Significance Index: -23.4000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2320
Cell Significance Index: -10.9100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2772
Cell Significance Index: -20.6600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2951
Cell Significance Index: -23.3700
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3152
Cell Significance Index: -7.5600
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3191
Cell Significance Index: -4.5700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3356
Cell Significance Index: -20.5800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3386
Cell Significance Index: -38.6500
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3388
Cell Significance Index: -7.1900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3895
Cell Significance Index: -8.3000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4064
Cell Significance Index: -8.4300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4220
Cell Significance Index: -21.9200
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.4262
Cell Significance Index: -5.9600
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.4448
Cell Significance Index: -7.6900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4487
Cell Significance Index: -14.3700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4579
Cell Significance Index: -28.8600
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4682
Cell Significance Index: -9.4000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5046
Cell Significance Index: -16.0700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5425
Cell Significance Index: -38.3700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5764
Cell Significance Index: -18.8700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.6146
Cell Significance Index: -16.7300
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.6299
Cell Significance Index: -13.6100
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.6504
Cell Significance Index: -8.1100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6505
Cell Significance Index: -17.4000
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.6929
Cell Significance Index: -13.7000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6974
Cell Significance Index: -24.4300
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.6987
Cell Significance Index: -8.9600
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.7130
Cell Significance Index: -8.8200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.7462
Cell Significance Index: -15.9500
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.7535
Cell Significance Index: -9.5100
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.7556
Cell Significance Index: -10.0800
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.7705
Cell Significance Index: -16.0800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.7983
Cell Significance Index: -27.7400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.8920
Cell Significance Index: -32.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Expression Pattern:** GNG7 is highly expressed in the central nervous system, including the retina, cerebral cortex, and brainstem, as well as in immune cells, smooth muscle cells, and certain types of cancer cells. 2. **Subunit Interactions:** The gamma-7 subunit interacts with various GPCR subunits, including Gα12/13, Gαi, Gαq, Gαs, and Gαz, to modulate signaling pathways. 3. **Signaling Pathways:** GNG7 regulates a diverse array of signaling pathways, including those involved in neurotransmission, insulin secretion, inflammation, and immune responses. 4. **Cellular Functions:** GNG7 plays a crucial role in regulating cellular processes, including neurotransmission, insulin secretion, inflammation, and immune responses. **Pathways and Functions:** 1. **Neurotransmission:** GNG7 regulates neurotransmission by modulating the activity of GPCRs involved in synaptic transmission, including GABA receptors and glutamate receptors. 2. **Insulin Secretion:** GNG7 influences insulin secretion by regulating the activity of GPCRs involved in glucose metabolism, including glucagon-like peptide-1 (GLP-1) receptors. 3. **Inflammation:** GNG7 modulates inflammatory responses by regulating the activity of GPCRs involved in immune signaling, including adhesion molecule receptors and chemokine receptors. 4. **Immune Responses:** GNG7 plays a crucial role in regulating immune responses, including the activation of immune cells, such as macrophages and T cells. 5. **Cellular Signaling:** GNG7 regulates cellular signaling by interacting with various GPCR subunits to modulate signaling pathways involved in cell growth, differentiation, and survival. **Clinical Significance:** 1. **Neurological Disorders:** GNG7 dysregulation has been implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and epilepsy. 2. **Metabolic Disorders:** GNG7 influences glucose metabolism and insulin secretion, making it a potential target for the treatment of metabolic disorders, such as type 2 diabetes. 3. **Inflammatory Diseases:** GNG7 modulates inflammatory responses, making it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and asthma. 4. **Cancer:** GNG7 is overexpressed in certain types of cancer, including breast cancer and lung cancer, making it a potential target for cancer therapy. In conclusion, the GNG7 gene plays a multifaceted role in regulating cellular signaling and function, influencing a wide range of physiological processes, including neurotransmission, insulin secretion, inflammation, and immune responses. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Genular Protein ID: 3214649118

Symbol: GBG7_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

UniProtKB Accession Codes:

O60262 B2R496

Database IDs:

Citations:

PubMed ID: 9600093

Title: Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer.

PubMed ID: 9600093

DOI: 10.1006/bbrc.1998.8581

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18219292

Title: Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer.

PubMed ID: 18219292

DOI: 10.1038/sj.bjc.6604124

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

Length: 68
Mass: 7522
Checksum: 704133C7BEC7FD72
Sequence:

MSATNNIAQA RKLVEQLRIE AGIERIKVSK AASDLMSYCE QHARNDPLLV GVPASENPFK 
DKKPCIIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GNG7

Associated with

Cells (max top 100)

Other Information

Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer. PubMed ID: 9600093

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer. PubMed ID: 18219292

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712