Details for: GNG7

Gene ID: 2788

Symbol: GNG7

Ensembl ID: ENSG00000176533

Description: G protein subunit gamma 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.61
    Marker Score: 7928
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.45
    Marker Score: 777
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.45
    Marker Score: 2886.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.37
    Marker Score: 5666
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.36
    Marker Score: 2012
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.23
    Marker Score: 1107
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.15
    Marker Score: 680
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.12
    Marker Score: 2084
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.11
    Marker Score: 12539.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.09
    Marker Score: 79299
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.07
    Marker Score: 8593
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.04
    Marker Score: 45655
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.03
    Marker Score: 1222
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.03
    Marker Score: 74731
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.02
    Marker Score: 43088
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.92
    Marker Score: 5229.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.87
    Marker Score: 677
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.86
    Marker Score: 27821
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.82
    Marker Score: 6469
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8
    Marker Score: 6953
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.8
    Marker Score: 3655
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.78
    Marker Score: 556
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.68
    Marker Score: 684
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.66
    Marker Score: 1561
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.65
    Marker Score: 15657
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.64
    Marker Score: 32531.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.57
    Marker Score: 506
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.56
    Marker Score: 1033
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.55
    Marker Score: 3662
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.54
    Marker Score: 11834
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.51
    Marker Score: 533
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168053
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.44
    Marker Score: 945
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.43
    Marker Score: 12289
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.42
    Marker Score: 2579
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2162.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.4
    Marker Score: 586
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.4
    Marker Score: 769
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.39
    Marker Score: 1720
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.35
    Marker Score: 1208
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.35
    Marker Score: 1360
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.35
    Marker Score: 2350
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.34
    Marker Score: 21007
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.28
    Marker Score: 772
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.28
    Marker Score: 632
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.25
    Marker Score: 2843
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.25
    Marker Score: 76705
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.25
    Marker Score: 287
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.23
    Marker Score: 12702
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.22
    Marker Score: 426
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.21
    Marker Score: 309
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.2
    Marker Score: 11302
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.2
    Marker Score: 1610.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.17
    Marker Score: 1411
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.15
    Marker Score: 872
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.15
    Marker Score: 1925
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.13
    Marker Score: 309
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.12
    Marker Score: 4693
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.08
    Marker Score: 342
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.07
    Marker Score: 469
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.06
    Marker Score: 2222
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.03
    Marker Score: 602
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.02
    Marker Score: 6114
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1
    Marker Score: 477
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71743
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47968
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1
    Marker Score: 1079
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 662
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.96
    Marker Score: 742
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.95
    Marker Score: 2551.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.95
    Marker Score: 246
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.95
    Marker Score: 575
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.94
    Marker Score: 2688
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.93
    Marker Score: 925
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.91
    Marker Score: 1205
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.91
    Marker Score: 785
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.89
    Marker Score: 959
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.89
    Marker Score: 1806
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.88
    Marker Score: 461
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.87
    Marker Score: 972
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4964
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.85
    Marker Score: 624
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.85
    Marker Score: 1633
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.82
    Marker Score: 8351
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.81
    Marker Score: 840
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 607
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.79
    Marker Score: 988.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.79
    Marker Score: 200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.78
    Marker Score: 1098
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.77
    Marker Score: 734
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.77
    Marker Score: 280

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Other Information

**Key characteristics:** - GNG7 is a type of G protein subunit. - It is expressed in high levels in the central nervous system. - It is involved in a variety of cellular processes, including water transport, ion signaling, and cell migration. **Pathways and functions:** - GNG7 is involved in the aquaporin-mediated transport pathway, which is responsible for the movement of water across cell membranes. - It is also involved in the regulation of potassium channels, which are essential for maintaining the resting membrane potential of cells. - GNG7 is also involved in the signaling pathways that control cell migration and differentiation. **Clinical significance:** - Mutations in GNG7 have been linked to a number of neurological disorders, including cerebral palsy, epilepsy, and schizophrenia. - These disorders are characterized by a variety of symptoms that are consistent with GNG7 dysfunction, including muscle weakness, seizures, and cognitive impairment. - Therefore, GNG7 is an important target for the treatment of these disorders. **Additional information:** - GNG7 is a highly conserved protein, with a similar sequence in mice and humans. - It is expressed in a variety of cell types, including neurons, astrocytes, and oligodendrocytes. - It is a key regulator of water and ion homeostasis in the central nervous system.

Genular Protein ID: 3214649118

Symbol: GBG7_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

UniProtKB Accession Codes:

O60262 B2R496

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 28 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9600093

Title: Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer.

PubMed ID: 9600093

DOI: 10.1006/bbrc.1998.8581

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18219292

Title: Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer.

PubMed ID: 18219292

DOI: 10.1038/sj.bjc.6604124

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 68
  • Mass: 7522
  • Checksum: 704133C7BEC7FD72
  • Sequence:
    • MSATNNIAQA RKLVEQLRIE AGIERIKVSK AASDLMSYCE QHARNDPLLV GVPASENPFK 
DKKPCIIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.