GNG7 | ENSG00000176533 | NCBI 2788

Details for: GNG7

Associated with

Activation of gabab receptors
(R-HSA-991365)
Activation of g protein gated potassium channels
(R-HSA-1296041)
Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adp signalling through p2y purinoceptor 1
(R-HSA-418592)
Adp signalling through p2y purinoceptor 12
(R-HSA-392170)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Chaperonin-mediated protein folding
(R-HSA-390466)
Class b/2 (secretin family receptors)
(R-HSA-373080)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G-protein activation
(R-HSA-202040)
G-protein beta:gamma signalling
(R-HSA-397795)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
G beta:gamma signalling through btk
(R-HSA-8964315)
G beta:gamma signalling through cdc42
(R-HSA-8964616)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
G beta:gamma signalling through plc beta
(R-HSA-418217)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon-type ligand receptors
(R-HSA-420092)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Gper1 signaling
(R-HSA-9634597)
G protein gated potassium channels
(R-HSA-1296059)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Infectious disease
(R-HSA-5663205)
Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
(R-HSA-997272)
Integration of energy metabolism
(R-HSA-163685)
Inwardly rectifying k+ channels
(R-HSA-1296065)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet homeostasis
(R-HSA-418346)
Potassium channels
(R-HSA-1296071)
Presynaptic function of kainate receptors
(R-HSA-500657)
Prostacyclin signalling through prostacyclin receptor
(R-HSA-392851)
Protein folding
(R-HSA-391251)
Regulation of insulin secretion
(R-HSA-422356)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Thromboxane signalling through tp receptor
(R-HSA-428930)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Behavioral fear response
(GO:0001662)
Extracellular exosome
(GO:0070062)
G-protein beta-subunit binding
(GO:0031681)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heterotrimeric g-protein complex
(GO:0005834)
Locomotory behavior
(GO:0007626)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Receptor guanylyl cyclase signaling pathway
(GO:0007168)
Regulation of adenylate cyclase activity
(GO:0045761)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Synapse
(GO:0045202)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

large pre-B-II cell CL0000957

CSI 13.22

rCSI 37.75%

PRS 79.42
late pro-B cell CL0002048

CSI 11.92

rCSI 29.86%

PRS 88.9
plasma cell CL0000786

CSI 11.18

rCSI 14.66%

PRS 89.48
lung ciliated cell CL1000271

CSI 10.07

rCSI 11.64%

PRS 61.25
immature B cell CL0000816

CSI 8.81

rCSI 6.55%

PRS 82.83
medium spiny neuron CL1001474

CSI 7.84

rCSI 67.56%

PRS 57.38
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 7.72

rCSI 24.16%

PRS 55.76
differentiation-committed oligodendrocyte precursor CL4023059

CSI 7.57

rCSI 13.75%

PRS 61.71
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 7.08

rCSI 41.67%

PRS 52.57
H2 horizontal cell CL0004218

CSI 6.8

rCSI 33.79%

PRS 66.17
pro-B cell CL0000826

CSI 6.45

rCSI 5.34%

PRS 72.79
plasmablast CL0000980

CSI 5.96

rCSI 4.69%

PRS 76.82
cerebellar granule cell CL0001031

CSI 5.78

rCSI 8.5%

PRS 63.37
naive B cell CL0000788

CSI 5.7

rCSI 4.89%

PRS 77.86
memory B cell CL0000787

CSI 5.37

rCSI 5.3%

PRS 88.16
mature B cell CL0000785

CSI 5.35

rCSI 4.65%

PRS 80.84
amacrine cell CL0000561

CSI 5.32

rCSI 15.43%

PRS 59.5
retinal bipolar neuron CL0000748

CSI 5.14

rCSI 9.63%

PRS 58
glioblast CL0000030

CSI 5.08

rCSI 8.1%

PRS 62.03
pvalb GABAergic cortical interneuron CL4023018

CSI 5.07

rCSI 6.31%

PRS 49.56
dendritic cell, human CL0001056

CSI 4.95

rCSI 7.6%

PRS 79.61
early lymphoid progenitor CL0000936

CSI 4.93

rCSI 4.33%

PRS 75.72
unswitched memory B cell CL0000970

CSI 4.91

rCSI 4.13%

PRS 85.49
oligodendrocyte CL0000128

CSI 4.85

rCSI 14.34%

PRS 60.24
inhibitory interneuron CL0000498

CSI 4.34

rCSI 10.02%

PRS 58.43
lamp5 GABAergic cortical interneuron CL4023011

CSI 4.34

rCSI 7.29%

PRS 51.49
oligodendrocyte precursor cell CL0002453

CSI 4.3

rCSI 9.45%

PRS 53.99
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 4.22

rCSI 10.92%

PRS 65.15
melanocyte CL0000148

CSI 4.13

rCSI 3.06%

PRS 63.1
vascular leptomeningeal cell CL4023051

CSI 4.05

rCSI 7.1%

PRS 62.74
near-projecting glutamatergic cortical neuron CL4023012

CSI 4.03

rCSI 15.22%

PRS 52.06
precursor B cell CL0000817

CSI 3.91

rCSI 3.43%

PRS 78.9
interneuron CL0000099

CSI 3.9

rCSI 7.84%

PRS 59.5
fraction A pre-pro B cell CL0002045

CSI 3.8

rCSI 4.35%

PRS 85.26
plasmacytoid dendritic cell, human CL0001058

CSI 3.73

rCSI 2.61%

PRS 73.17
adipocyte CL0000136

CSI 3.68

rCSI 4.73%

PRS 61.6
B cell CL0000236

CSI 3.65

rCSI 4.88%

PRS 83.18
myoepithelial cell CL0000185

CSI 3.63

rCSI 9.19%

PRS 77.2
CD1c-positive myeloid dendritic cell CL0002399

CSI 3.61

rCSI 4.36%

PRS 79.3
H1 horizontal cell CL0004217

CSI 3.59

rCSI 14.21%

PRS 67.92
parietal epithelial cell CL1000452

CSI 3.46

rCSI 9.25%

PRS 61.26
mononuclear phagocyte CL0000113

CSI 3.46

rCSI 7.61%

PRS 74.45
IgA plasma cell CL0000987

CSI 3.45

rCSI 3.53%

PRS 81.76
basophil CL0000767

CSI 3.38

rCSI 7.15%

PRS 85.28
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 3.36

rCSI 4.77%

PRS 66.47
Mueller cell CL0000636

CSI 3.31

rCSI 7.56%

PRS 61.67
VIP GABAergic cortical interneuron CL4023016

CSI 3.3

rCSI 3.94%

PRS 51.31
class switched memory B cell CL0000972

CSI 3.17

rCSI 2.36%

PRS 85.17
GABAergic neuron CL0000617

CSI 3.06

rCSI 10.26%

PRS 54.76
small pre-B-II cell CL0000954

CSI 3.05

rCSI 2.93%

PRS 88.26
retinal rod cell CL0000604

CSI 2.99

rCSI 5.26%

PRS 66.4
L6b glutamatergic cortical neuron CL4023038

CSI 2.92

rCSI 9.11%

PRS 53.27
subcutaneous adipocyte CL0002521

CSI 2.87

rCSI 14.72%

PRS 74.65
contractile cell CL0000183

CSI 2.87

rCSI 8.46%

PRS 69.52
blood vessel endothelial cell CL0000071

CSI 2.72

rCSI 5.65%

PRS 67.33
Hofbauer cell CL3000001

CSI 2.72

rCSI 5.13%

PRS 80.29
direct pathway medium spiny neuron CL4023026

CSI 2.7

rCSI 64.55%

PRS 50.51
indirect pathway medium spiny neuron CL4023029

CSI 2.67

rCSI 64.34%

PRS 51.13
mature astrocyte CL0002627

CSI 2.63

rCSI 11.17%

PRS 63.06
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 2.61

rCSI 6.34%

PRS 49.87
common dendritic progenitor CL0001029

CSI 2.58

rCSI 3.24%

PRS 80.3
cardiac muscle cell CL0000746

CSI 2.57

rCSI 3.69%

PRS 59.74
hematopoietic stem cell CL0000037

CSI 2.54

rCSI 1.69%

PRS 73.15
macroglial cell CL0000126

CSI 2.53

rCSI 6.5%

PRS 68.52
central nervous system macrophage CL0000878

CSI 2.51

rCSI 8.32%

PRS 75.39
retina horizontal cell CL0000745

CSI 2.38

rCSI 3.64%

PRS 66.55
mature microglial cell CL0002629

CSI 2.32

rCSI 9.65%

PRS 69.96
hepatocyte CL0000182

CSI 2.3

rCSI 4.11%

PRS 69.7
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.28

rCSI 5.95%

PRS 70.65
hepatic stellate cell CL0000632

CSI 2.23

rCSI 8.34%

PRS 62.22
cerebral cortex endothelial cell CL1001602

CSI 2.19

rCSI 3.79%

PRS 60.68
ependymal cell CL0000065

CSI 2.15

rCSI 4.36%

PRS 48.55
renal alpha-intercalated cell CL0005011

CSI 2.14

rCSI 2.86%

PRS 78.43
transitional stage B cell CL0000818

CSI 2.14

rCSI 6.99%

PRS 90.4
sst GABAergic cortical interneuron CL4023017

CSI 2.11

rCSI 2.72%

PRS 52.84
chondrocyte CL0000138

CSI 2.07

rCSI 3.29%

PRS 62.93
type B pancreatic cell CL0000169

CSI 2.07

rCSI 4.58%

PRS 68.91
choroid plexus epithelial cell CL0000706

CSI 2.06

rCSI 3.37%

PRS 59.31
Kupffer cell CL0000091

CSI 2.04

rCSI 4.67%

PRS 70.89
IgG plasma cell CL0000985

CSI 2.02

rCSI 2.42%

PRS 84.51
common myeloid progenitor CL0000049

CSI 2.01

rCSI 1.62%

PRS 72.15
Bergmann glial cell CL0000644

CSI 1.95

rCSI 2.67%

PRS 62.59
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 1.93

rCSI 4.39%

PRS 65.47
pancreatic D cell CL0000173

CSI 1.87

rCSI 1.84%

PRS 72.88
kidney connecting tubule epithelial cell CL1000768

CSI 1.86

rCSI 4.72%

PRS 59.89
cerebral cortex neuron CL0010012

CSI 1.83

rCSI 7.48%

PRS 63.28
conjunctival epithelial cell CL1000432

CSI 1.81

rCSI 2.76%

PRS 70.96
cardiac neuron CL0010022

CSI 1.78

rCSI 5.69%

PRS 67.37
antibody secreting cell CL0000946

CSI 1.74

rCSI 7.76%

PRS 93.72
epithelial cell of proximal tubule CL0002306

CSI 1.73

rCSI 4.23%

PRS 63.36
basal cell CL0000646

CSI 1.71

rCSI 2.28%

PRS 70.07
lung secretory cell CL1000272

CSI 1.69

rCSI 4.18%

PRS 69.09
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.68

rCSI 2.97%

PRS 50.59
astrocyte of the cerebral cortex CL0002605

CSI 1.67

rCSI 3.74%

PRS 52.11
renal interstitial pericyte CL1001318

CSI 1.62

rCSI 4.47%

PRS 65.25
pancreatic A cell CL0000171

CSI 1.62

rCSI 1.7%

PRS 73.86
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 1.61

rCSI 5.29%

PRS 56.8
Schwann cell CL0002573

CSI 1.58

rCSI 4.48%

PRS 67.38
glycinergic amacrine cell CL4030028

CSI 1.57

rCSI 4.09%

PRS 66.53
sncg GABAergic cortical interneuron CL4023015

CSI 1.52

rCSI 2.45%

PRS 53.37

acinar cell of salivary gland CL0002623

CSI 0.2

rCSI 5.0%

PRS 85.9%
ON midget ganglion cell CL4033046

CSI 0.2

rCSI 4.6%

PRS 60.6%
OFF midget ganglion cell CL4033047

CSI 0.2

rCSI 4.6%

PRS 62.1%
B-2 B cell CL0000822

CSI 0.3

rCSI 6.1%

PRS 90.5%
central nervous system neuron CL2000029

CSI 0.4

rCSI 2.7%

PRS 57.0%
ON parasol ganglion cell CL4033052

CSI 0.4

rCSI 5.4%

PRS 61.3%
regular ventricular cardiac myocyte CL0002131

CSI 0.5

rCSI 2.8%

PRS 61.7%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.5

rCSI 2.0%

PRS 88.3%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.6

rCSI 5.8%

PRS 67.6%
podocyte CL0000653

CSI 0.6

rCSI 2.5%

PRS 70.5%
GABAergic amacrine cell CL4030027

CSI 0.6

rCSI 2.2%

PRS 58.1%
cerebellar neuron CL1001611

CSI 0.7

rCSI 6.0%

PRS 58.3%
dopaminergic neuron CL0000700

CSI 0.7

rCSI 4.1%

PRS 55.7%
myeloid dendritic cell CL0000782

CSI 0.8

rCSI 1.1%

PRS 85.0%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 0.8

rCSI 6.7%

PRS 66.2%
IgM plasma cell CL0000986

CSI 0.8

rCSI 3.5%

PRS 92.3%
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 0.9

rCSI 2.0%

PRS 58.0%
pancreatic ductal cell CL0002079

CSI 1.0

rCSI 1.9%

PRS 73.7%
germinal center B cell CL0000844

CSI 1.0

rCSI 3.0%

PRS 83.8%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 1.1

rCSI 3.8%

PRS 49.7%
serotonergic neuron CL0000850

CSI 1.1

rCSI 4.8%

PRS 54.1%
regular atrial cardiac myocyte CL0002129

CSI 1.1

rCSI 3.5%

PRS 67.9%
alveolar macrophage CL0000583

CSI 1.1

rCSI 1.8%

PRS 75.5%
glial cell CL0000125

CSI 1.1

rCSI 4.4%

PRS 60.8%
retinal ganglion cell CL0000740

CSI 1.2

rCSI 2.6%

PRS 56.2%
retinal blood vessel endothelial cell CL0002585

CSI 1.2

rCSI 1.9%

PRS 74.5%
follicular B cell CL0000843

CSI 1.3

rCSI 4.6%

PRS 89.4%
renal principal cell CL0005009

CSI 1.3

rCSI 3.4%

PRS 72.8%
renal beta-intercalated cell CL0002201

CSI 1.3

rCSI 3.1%

PRS 70.7%
tracheobronchial serous cell CL0019001

CSI 1.3

rCSI 5.8%

PRS 80.5%
retinal pigment epithelial cell CL0002586

CSI 1.3

rCSI 2.7%

PRS 66.9%
microglial cell CL0000129

CSI 1.5

rCSI 5.8%

PRS 73.3%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.5

rCSI 1.3%

PRS 67.7%
innate lymphoid cell CL0001065

CSI 1.5

rCSI 3.1%

PRS 69.8%
sncg GABAergic cortical interneuron CL4023015

CSI 1.5

rCSI 2.5%

PRS 53.4%
glycinergic amacrine cell CL4030028

CSI 1.6

rCSI 4.1%

PRS 66.5%
Schwann cell CL0002573

CSI 1.6

rCSI 4.5%

PRS 67.4%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 1.6

rCSI 5.3%

PRS 56.8%
pancreatic A cell CL0000171

CSI 1.6

rCSI 1.7%

PRS 73.9%
renal interstitial pericyte CL1001318

CSI 1.6

rCSI 4.5%

PRS 65.3%
astrocyte of the cerebral cortex CL0002605

CSI 1.7

rCSI 3.7%

PRS 52.1%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.7

rCSI 3.0%

PRS 50.6%
lung secretory cell CL1000272

CSI 1.7

rCSI 4.2%

PRS 69.1%
basal cell CL0000646

CSI 1.7

rCSI 2.3%

PRS 70.1%
epithelial cell of proximal tubule CL0002306

CSI 1.7

rCSI 4.2%

PRS 63.4%
antibody secreting cell CL0000946

CSI 1.7

rCSI 7.8%

PRS 93.7%
cardiac neuron CL0010022

CSI 1.8

rCSI 5.7%

PRS 67.4%
conjunctival epithelial cell CL1000432

CSI 1.8

rCSI 2.8%

PRS 71.0%
cerebral cortex neuron CL0010012

CSI 1.8

rCSI 7.5%

PRS 63.3%
kidney connecting tubule epithelial cell CL1000768

CSI 1.9

rCSI 4.7%

PRS 59.9%
pancreatic D cell CL0000173

CSI 1.9

rCSI 1.8%

PRS 72.9%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 1.9

rCSI 4.4%

PRS 65.5%
Bergmann glial cell CL0000644

CSI 2.0

rCSI 2.7%

PRS 62.6%
common myeloid progenitor CL0000049

CSI 2.0

rCSI 1.6%

PRS 72.2%
IgG plasma cell CL0000985

CSI 2.0

rCSI 2.4%

PRS 84.5%
Kupffer cell CL0000091

CSI 2.0

rCSI 4.7%

PRS 70.9%
choroid plexus epithelial cell CL0000706

CSI 2.1

rCSI 3.4%

PRS 59.3%
type B pancreatic cell CL0000169

CSI 2.1

rCSI 4.6%

PRS 68.9%
chondrocyte CL0000138

CSI 2.1

rCSI 3.3%

PRS 62.9%
sst GABAergic cortical interneuron CL4023017

CSI 2.1

rCSI 2.7%

PRS 52.8%
transitional stage B cell CL0000818

CSI 2.1

rCSI 7.0%

PRS 90.4%
renal alpha-intercalated cell CL0005011

CSI 2.1

rCSI 2.9%

PRS 78.4%
ependymal cell CL0000065

CSI 2.2

rCSI 4.4%

PRS 48.6%
cerebral cortex endothelial cell CL1001602

CSI 2.2

rCSI 3.8%

PRS 60.7%
hepatic stellate cell CL0000632

CSI 2.2

rCSI 8.3%

PRS 62.2%
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.3

rCSI 6.0%

PRS 70.7%
hepatocyte CL0000182

CSI 2.3

rCSI 4.1%

PRS 69.7%
mature microglial cell CL0002629

CSI 2.3

rCSI 9.7%

PRS 70.0%
retina horizontal cell CL0000745

CSI 2.4

rCSI 3.6%

PRS 66.6%
central nervous system macrophage CL0000878

CSI 2.5

rCSI 8.3%

PRS 75.4%
macroglial cell CL0000126

CSI 2.5

rCSI 6.5%

PRS 68.5%
hematopoietic stem cell CL0000037

CSI 2.5

rCSI 1.7%

PRS 73.2%
cardiac muscle cell CL0000746

CSI 2.6

rCSI 3.7%

PRS 59.7%
common dendritic progenitor CL0001029

CSI 2.6

rCSI 3.2%

PRS 80.3%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 2.6

rCSI 6.3%

PRS 49.9%
mature astrocyte CL0002627

CSI 2.6

rCSI 11.2%

PRS 63.1%
indirect pathway medium spiny neuron CL4023029

CSI 2.7

rCSI 64.3%

PRS 51.1%
direct pathway medium spiny neuron CL4023026

CSI 2.7

rCSI 64.6%

PRS 50.5%
Hofbauer cell CL3000001

CSI 2.7

rCSI 5.1%

PRS 80.3%
blood vessel endothelial cell CL0000071

CSI 2.7

rCSI 5.7%

PRS 67.3%
contractile cell CL0000183

CSI 2.9

rCSI 8.5%

PRS 69.5%
subcutaneous adipocyte CL0002521

CSI 2.9

rCSI 14.7%

PRS 74.7%
L6b glutamatergic cortical neuron CL4023038

CSI 2.9

rCSI 9.1%

PRS 53.3%
retinal rod cell CL0000604

CSI 3.0

rCSI 5.3%

PRS 66.4%
small pre-B-II cell CL0000954

CSI 3.1

rCSI 2.9%

PRS 88.3%
GABAergic neuron CL0000617

CSI 3.1

rCSI 10.3%

PRS 54.8%
class switched memory B cell CL0000972

CSI 3.2

rCSI 2.4%

PRS 85.2%
VIP GABAergic cortical interneuron CL4023016

CSI 3.3

rCSI 3.9%

PRS 51.3%
Mueller cell CL0000636

CSI 3.3

rCSI 7.6%

PRS 61.7%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 3.4

rCSI 4.8%

PRS 66.5%
basophil CL0000767

CSI 3.4

rCSI 7.2%

PRS 85.3%
IgA plasma cell CL0000987

CSI 3.5

rCSI 3.5%

PRS 81.8%
mononuclear phagocyte CL0000113

CSI 3.5

rCSI 7.6%

PRS 74.5%
parietal epithelial cell CL1000452

CSI 3.5

rCSI 9.3%

PRS 61.3%
H1 horizontal cell CL0004217

CSI 3.6

rCSI 14.2%

PRS 67.9%
CD1c-positive myeloid dendritic cell CL0002399

CSI 3.6

rCSI 4.4%

PRS 79.3%
myoepithelial cell CL0000185

CSI 3.6

rCSI 9.2%

PRS 77.2%
B cell CL0000236

CSI 3.7

rCSI 4.9%

PRS 83.2%
adipocyte CL0000136

CSI 3.7

rCSI 4.7%

PRS 61.6%
plasmacytoid dendritic cell, human CL0001058

CSI 3.7

rCSI 2.6%

PRS 73.2%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [GNG7](/details-gene/2788), or G protein subunit gamma 7, is a protein-coding gene located on chromosome 19p13.3. It encodes a member of the G protein gamma subunit family, which, along with beta subunits, forms the G beta-gamma complex. This complex is a crucial component of heterotrimeric G protein signaling, a ubiquitous system that transduces extracellular signals from G protein-coupled receptors (GPCRs) to intracellular effector proteins. Expression data highlights its significant role across the B-cell lineage, from [pro-B cells](/details-cell/CL0000826) to terminally differentiated [plasma cells](/details-cell/CL0000786), suggesting a fundamental function in B-cell development and function. Additionally, [GNG7](/details-gene/2788) shows prominent expression in specific neuronal subtypes and ciliated cells, indicating diverse physiological roles. Research has also implicated its downregulation in certain malignancies, such as pancreatic and oesophageal cancer, suggesting a potential tumor suppressor function [Link](https://doi.org/10.1006/bbrc.1998.8581), [Link](https://doi.org/10.1038/sj.bjc.6604124). ## Cellular Roles and Expression Landscape The expression profile of [GNG7](/details-gene/2788) reveals a dual specialization in the hematopoietic and nervous systems. **Overall**, the gene is most significantly expressed in cells of the B-lymphocyte lineage. It demonstrates high significance across multiple developmental stages, including [large pre-B-II cells](/details-cell/CL0000957) (CSI: 13.22), [late pro-B cells](/details-cell/CL0002048) (CSI: 11.92), and [immature B cells](/details-cell/CL0000816) (CSI: 8.81). Its high significance is maintained in mature and effector cells, such as [naive B cells](/details-cell/CL0000788) (CSI: 5.70), [memory B cells](/details-cell/CL0000787) (CSI: 5.37), [plasmablasts](/details-cell/CL0000980) (CSI: 5.96), and notably, [plasma cells](/details-cell/CL0000786) (CSI: 11.18). This consistent, high-level expression across the B-cell continuum suggests a core role for [GNG7](/details-gene/2788)-mediated signaling in B-cell differentiation, activation, and antibody production. Beyond the immune system, [GNG7](/details-gene/2788) is a significant marker in several specialized cell types. It has a high CSI in [lung ciliated cells](/details-cell/CL1000271) (CSI: 10.07), suggesting a role in mucosal function. Furthermore, it is prominently expressed in specific neuronal populations, including [medium spiny neurons](/details-cell/CL1001474) (CSI: 7.84), [chandelier pvalb GABAergic cortical interneurons](/details-cell/CL4023036) (CSI: 7.72), and [corticothalamic-projecting glutamatergic cortical neurons](/details-cell/CL4023013) (CSI: 7.08). This points towards a specific function in synaptic transmission and neural circuit modulation within the brain. Its expression in [differentiation-committed oligodendrocyte precursors](/details-cell/CL4023059) (CSI: 7.57) also suggests a potential involvement in myelination. ## Pathways and Molecular Function Functionally, [GNG7](/details-gene/2788) is integral to signal transduction at the plasma membrane. As a gamma subunit, its primary molecular function is [G-protein beta-subunit binding](/details-go/GO:0031681) to form the G beta-gamma dimer, a key component of the [heterotrimeric g-protein complex](/details-go/GO:0005834). This role places it centrally within the [G protein-coupled receptor signaling pathway](/details-go/GO:0007186). The vast array of Reactome pathways associated with [GNG7](/details-gene/2788) underscores its pleiotropic nature. Its involvement in [G alpha (i) signalling events](/details-reactome/R-HSA-418594), [G alpha (q) signalling events](/details-reactome/R-HSA-416476), and [G beta:gamma signalling](/details-reactome/R-HSA-397795) confirms its role as a versatile signaling hub. This is consistent with its high expression in neurons, where it participates in pathways like [Neurotransmitter receptors and postsynaptic signal transmission](/details-reactome/R-HSA-112314) and [Gaba b receptor activation](/details-reactome/R-HSA-977444). Its connection to the [synapse](/details-go/GO:0045202) cellular component further strengthens this link. In the context of B-cells and other immune cells, pathways such as [G beta:gamma signalling through pi3kgamma](/details-reactome/R-HSA-392451) and [Platelet activation, signaling and aggregation](/details-reactome/R-HSA-76002) are particularly relevant, highlighting its potential role in immune cell activation and hemostasis. ## Research Directions The expression pattern and functional annotations of [GNG7](/details-gene/2788) suggest several avenues for future research, particularly concerning its roles in immunology, neuroscience, and oncology. ### Proposed Hypotheses: 1. **Hypothesis on B-Cell Function:** Given its sustained high expression from early precursors to terminal [plasma cells](/details-cell/CL0000786), we hypothesize that [GNG7](/details-gene/2788) is essential for the maturation and effector function of B-lymphocytes, potentially by transducing signals from chemokine or other B-cell relevant GPCRs that are critical for cell survival, proliferation, or class-switch recombination. 2. **Hypothesis on Neuronal Modulation:** The specific expression of [GNG7](/details-gene/2788) in neuronal subtypes like [medium spiny neurons](/details-cell/CL1001474) and its annotated role in GABA receptor pathways ([R-HSA-977444](https://reactome.org/content/detail/R-HSA-977444)) suggest that [GNG7](/details-gene/2788) is a key determinant of inhibitory signaling efficacy in the striatum and cortex, thereby modulating motor control and cognitive processes. 3. **Hypothesis on Tumor Suppression:** Based on reports that [GNG7](/details-gene/2788) is downregulated in pancreatic and oesophageal cancers [Link](https://doi.org/10.1006/bbrc.1998.8581), [Link](https://doi.org/10.1038/sj.bjc.6604124), we hypothesize that its loss disrupts GPCR-mediated pathways that normally restrain cell proliferation or induce apoptosis, thus contributing to malignant transformation in these tissues. ### Key Experimental Approach: To test the hypothesis regarding its role in B-cell function, a conditional knockout mouse model would be highly informative. By crossing a mouse with floxed *Gng7* alleles to a CD19-Cre driver mouse, one could achieve B-cell lineage-specific deletion of the gene. Subsequent analysis should include: * **Immunophenotyping:** Using flow cytometry to quantify B-cell populations at different developmental stages in the bone marrow, spleen, and lymph nodes to identify any block in maturation. * **Functional Assays:** Immunizing the knockout mice with a T-cell dependent antigen (e.g., NP-CGG) and measuring the resulting antigen-specific IgM and IgG titers via ELISA to assess the primary and memory antibody responses. * **In vitro stimulation:** Culturing purified B cells from knockout and control mice with stimuli like anti-CD40 and IL-4 to assess their proliferation, survival, and differentiation into antibody-secreting cells. ### Therapeutic Potential: The current evidence suggests [GNG7](/details-gene/2788) may act as a tumor suppressor. Therefore, therapeutic strategies would likely focus on restoring its function rather than inhibition. This presents a significant challenge for conventional small molecule drug development. However, its expression level could serve as a prognostic biomarker in cancers where it is downregulated. In the long term, gene therapy approaches aimed at re-introducing [GNG7](/details-gene/2788) expression in tumor cells could be explored. Conversely, if specific pathogenic cell types, such as autoreactive B-cells in autoimmune disease, were found to be uniquely dependent on [GNG7](/details-gene/2788), targeted inhibition could become a viable strategy, though this remains highly speculative.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Genular Protein ID: 3214649118

Symbol: GBG7_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

UniProtKB Accession Codes:

O60262 B2R496

Database IDs:

Citations:

PubMed ID: 9600093

Title: Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer.

PubMed ID: 9600093

DOI: 10.1006/bbrc.1998.8581

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18219292

Title: Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer.

PubMed ID: 18219292

DOI: 10.1038/sj.bjc.6604124

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

Length: 68
Mass: 7522
Checksum: 704133C7BEC7FD72
Sequence:

MSATNNIAQA RKLVEQLRIE AGIERIKVSK AASDLMSYCE QHARNDPLLV GVPASENPFK 
DKKPCIIL

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast cancer MONDO0007254
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	Interventricular septum UBERON0002094
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	\|— Prefrontal cortex Healthy UBERON0000451_PATO0000461
	Primary motor cortex UBERON0001384
	\|— Primary motor cortex Healthy UBERON0001384_PATO0000461
	Primary visual cortex UBERON0002436
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Right cardiac atrium UBERON0002078
	\|— Right cardiac atrium Healthy UBERON0002078_PATO0000461
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: GNG7

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer. PubMed ID: 9600093

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer. PubMed ID: 18219292

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330