Details for: GNG7

Gene ID: 2788

Symbol: GNG7

Ensembl ID: ENSG00000176533

Description: G protein subunit gamma 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 237.9372
    Cell Significance Index: -37.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 133.0608
    Cell Significance Index: -33.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.6570
    Cell Significance Index: -38.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.0822
    Cell Significance Index: -37.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.3643
    Cell Significance Index: -38.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.0464
    Cell Significance Index: -37.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5741
    Cell Significance Index: -37.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2010
    Cell Significance Index: -15.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.7781
    Cell Significance Index: 255.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.1811
    Cell Significance Index: 196.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.9385
    Cell Significance Index: 879.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8220
    Cell Significance Index: 139.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4097
    Cell Significance Index: 505.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2626
    Cell Significance Index: 253.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2219
    Cell Significance Index: 15.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9868
    Cell Significance Index: 46.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8128
    Cell Significance Index: 54.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6518
    Cell Significance Index: 129.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4620
    Cell Significance Index: 29.8100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.4228
    Cell Significance Index: 5.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3880
    Cell Significance Index: 350.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3846
    Cell Significance Index: 38.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3472
    Cell Significance Index: 40.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3297
    Cell Significance Index: 17.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2506
    Cell Significance Index: 173.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.2274
    Cell Significance Index: 23.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2066
    Cell Significance Index: 33.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1971
    Cell Significance Index: 37.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1112
    Cell Significance Index: 12.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0941
    Cell Significance Index: 177.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0808
    Cell Significance Index: 2.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0700
    Cell Significance Index: 1.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0694
    Cell Significance Index: 106.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0688
    Cell Significance Index: 126.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0474
    Cell Significance Index: 0.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0398
    Cell Significance Index: 5.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0311
    Cell Significance Index: 19.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0228
    Cell Significance Index: 0.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0205
    Cell Significance Index: 15.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0153
    Cell Significance Index: 0.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0106
    Cell Significance Index: -5.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0126
    Cell Significance Index: -9.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0178
    Cell Significance Index: -11.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0178
    Cell Significance Index: -7.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0198
    Cell Significance Index: -1.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0305
    Cell Significance Index: -0.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0315
    Cell Significance Index: -1.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0339
    Cell Significance Index: -18.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0359
    Cell Significance Index: -6.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0422
    Cell Significance Index: -1.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0460
    Cell Significance Index: -34.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0572
    Cell Significance Index: -10.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0692
    Cell Significance Index: -4.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0800
    Cell Significance Index: -9.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0983
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1064
    Cell Significance Index: -22.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1067
    Cell Significance Index: -14.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1074
    Cell Significance Index: -30.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1075
    Cell Significance Index: -15.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1080
    Cell Significance Index: -13.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1233
    Cell Significance Index: -5.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1308
    Cell Significance Index: -16.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1355
    Cell Significance Index: -13.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1770
    Cell Significance Index: -5.0500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1931
    Cell Significance Index: -2.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2008
    Cell Significance Index: -23.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2320
    Cell Significance Index: -10.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2772
    Cell Significance Index: -20.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2951
    Cell Significance Index: -23.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3152
    Cell Significance Index: -7.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3191
    Cell Significance Index: -4.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3356
    Cell Significance Index: -20.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3386
    Cell Significance Index: -38.6500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3388
    Cell Significance Index: -7.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3895
    Cell Significance Index: -8.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4064
    Cell Significance Index: -8.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4220
    Cell Significance Index: -21.9200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4262
    Cell Significance Index: -5.9600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4448
    Cell Significance Index: -7.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4487
    Cell Significance Index: -14.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4579
    Cell Significance Index: -28.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4682
    Cell Significance Index: -9.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5046
    Cell Significance Index: -16.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5425
    Cell Significance Index: -38.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5764
    Cell Significance Index: -18.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6146
    Cell Significance Index: -16.7300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6299
    Cell Significance Index: -13.6100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6504
    Cell Significance Index: -8.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6505
    Cell Significance Index: -17.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6929
    Cell Significance Index: -13.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6974
    Cell Significance Index: -24.4300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6987
    Cell Significance Index: -8.9600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.7130
    Cell Significance Index: -8.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7462
    Cell Significance Index: -15.9500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7535
    Cell Significance Index: -9.5100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.7556
    Cell Significance Index: -10.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7705
    Cell Significance Index: -16.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7983
    Cell Significance Index: -27.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8920
    Cell Significance Index: -32.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** GNG7 is highly expressed in the central nervous system, including the retina, cerebral cortex, and brainstem, as well as in immune cells, smooth muscle cells, and certain types of cancer cells. 2. **Subunit Interactions:** The gamma-7 subunit interacts with various GPCR subunits, including Gα12/13, Gαi, Gαq, Gαs, and Gαz, to modulate signaling pathways. 3. **Signaling Pathways:** GNG7 regulates a diverse array of signaling pathways, including those involved in neurotransmission, insulin secretion, inflammation, and immune responses. 4. **Cellular Functions:** GNG7 plays a crucial role in regulating cellular processes, including neurotransmission, insulin secretion, inflammation, and immune responses. **Pathways and Functions:** 1. **Neurotransmission:** GNG7 regulates neurotransmission by modulating the activity of GPCRs involved in synaptic transmission, including GABA receptors and glutamate receptors. 2. **Insulin Secretion:** GNG7 influences insulin secretion by regulating the activity of GPCRs involved in glucose metabolism, including glucagon-like peptide-1 (GLP-1) receptors. 3. **Inflammation:** GNG7 modulates inflammatory responses by regulating the activity of GPCRs involved in immune signaling, including adhesion molecule receptors and chemokine receptors. 4. **Immune Responses:** GNG7 plays a crucial role in regulating immune responses, including the activation of immune cells, such as macrophages and T cells. 5. **Cellular Signaling:** GNG7 regulates cellular signaling by interacting with various GPCR subunits to modulate signaling pathways involved in cell growth, differentiation, and survival. **Clinical Significance:** 1. **Neurological Disorders:** GNG7 dysregulation has been implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and epilepsy. 2. **Metabolic Disorders:** GNG7 influences glucose metabolism and insulin secretion, making it a potential target for the treatment of metabolic disorders, such as type 2 diabetes. 3. **Inflammatory Diseases:** GNG7 modulates inflammatory responses, making it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and asthma. 4. **Cancer:** GNG7 is overexpressed in certain types of cancer, including breast cancer and lung cancer, making it a potential target for cancer therapy. In conclusion, the GNG7 gene plays a multifaceted role in regulating cellular signaling and function, influencing a wide range of physiological processes, including neurotransmission, insulin secretion, inflammation, and immune responses. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention.

Genular Protein ID: 3214649118

Symbol: GBG7_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9600093

Title: Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer.

PubMed ID: 9600093

DOI: 10.1006/bbrc.1998.8581

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18219292

Title: Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer.

PubMed ID: 18219292

DOI: 10.1038/sj.bjc.6604124

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 68
  • Mass: 7522
  • Checksum: 704133C7BEC7FD72
  • Sequence:
  • MSATNNIAQA RKLVEQLRIE AGIERIKVSK AASDLMSYCE QHARNDPLLV GVPASENPFK 
    DKKPCIIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.