Details for: GOT2
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hepatoblast (CL0005026)
Fold Change: 1.99
Marker Score: 6526 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.79
Marker Score: 1429.5 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.64
Marker Score: 2418 - Cell Name: osteoclast (CL0000092)
Fold Change: 1.54
Marker Score: 768 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.49
Marker Score: 1013 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167533 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.39
Marker Score: 3791 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.37
Marker Score: 3455 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.33
Marker Score: 537 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.32
Marker Score: 3535.5 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.25
Marker Score: 12941 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1.24
Marker Score: 1333 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.22
Marker Score: 1295 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.19
Marker Score: 18580 - Cell Name: Unknown (CL0002371)
Fold Change: 1.18
Marker Score: 1250 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.18
Marker Score: 2456 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.17
Marker Score: 1243 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.17
Marker Score: 11734.5 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.15
Marker Score: 42552 - Cell Name: neuron (CL0000540)
Fold Change: 1.15
Marker Score: 4695.5 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.14
Marker Score: 1898 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.14
Marker Score: 1755 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.14
Marker Score: 69808 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.12
Marker Score: 883 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.11
Marker Score: 1119 - Cell Name: stem cell (CL0000034)
Fold Change: 1.11
Marker Score: 2633.5 - Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.1
Marker Score: 369 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.09
Marker Score: 9395 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.08
Marker Score: 813 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.07
Marker Score: 2181 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.06
Marker Score: 3319 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.06
Marker Score: 2873 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.06
Marker Score: 8242 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.05
Marker Score: 579 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.05
Marker Score: 1314 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.04
Marker Score: 4105.5 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.03
Marker Score: 1079 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.02
Marker Score: 240 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.02
Marker Score: 683 - Cell Name: plasmablast (CL0000980)
Fold Change: 1.02
Marker Score: 1360 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.02
Marker Score: 9649 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.01
Marker Score: 38397 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71691 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47914 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.99
Marker Score: 1407 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.99
Marker Score: 9322 - Cell Name: neural crest cell (CL0011012)
Fold Change: 0.98
Marker Score: 1049 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30388 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.98
Marker Score: 921 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.98
Marker Score: 7279.5 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.98
Marker Score: 8421 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.98
Marker Score: 613 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.97
Marker Score: 21783 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.97
Marker Score: 1653.5 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.97
Marker Score: 649 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.96
Marker Score: 4152 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.96
Marker Score: 3967.5 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.96
Marker Score: 3693 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.95
Marker Score: 3885.5 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2394 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.94
Marker Score: 495 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.94
Marker Score: 279 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.93
Marker Score: 6064 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 480 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.93
Marker Score: 18510 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.92
Marker Score: 2736 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 435 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.92
Marker Score: 2097 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5219 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.9
Marker Score: 1014 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.9
Marker Score: 5774 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.9
Marker Score: 936 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2698 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.89
Marker Score: 2096 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.89
Marker Score: 935 - Cell Name: keratinocyte (CL0000312)
Fold Change: 0.87
Marker Score: 730 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5293 - Cell Name: Unknown (CL0000548)
Fold Change: 0.87
Marker Score: 633 - Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.87
Marker Score: 410 - Cell Name: oogonial cell (CL0000024)
Fold Change: 0.86
Marker Score: 1243 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.86
Marker Score: 585 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.86
Marker Score: 3957 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.85
Marker Score: 15163.5 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.84
Marker Score: 2991 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.83
Marker Score: 831 - Cell Name: oocyte (CL0000023)
Fold Change: 0.83
Marker Score: 206 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.83
Marker Score: 6344 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.83
Marker Score: 5320 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.83
Marker Score: 4444 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.83
Marker Score: 997 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.82
Marker Score: 776.5 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.82
Marker Score: 12264 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.81
Marker Score: 473 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.81
Marker Score: 259 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.8
Marker Score: 751 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.8
Marker Score: 372 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8
Marker Score: 319 - Cell Name: malignant cell (CL0001064)
Fold Change: 0.79
Marker Score: 10638 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.79
Marker Score: 155
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Other Information
Genular Protein ID: 3969622653
Symbol: AATM_HUMAN
Name: Aspartate aminotransferase, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3207426
Title: Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA.
PubMed ID: 3207426
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 4052435
Title: The primary structure of mitochondrial aspartate aminotransferase from human heart.
PubMed ID: 4052435
PubMed ID: 9537447
Title: Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells.
PubMed ID: 9537447
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 31422819
Title: Bi-allelic GOT2 mutations cause a treatable malate-aspartate shuttle-related encephalopathy.
PubMed ID: 31422819
PubMed ID: 26902786
Title: Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase.
PubMed ID: 26902786
Sequence Information:
- Length: 430
- Mass: 47518
- Checksum: F559567ABF2DB346
- Sequence:
MALLHSGRVL PGIAAAFHPG LAAAASARAS SWWTHVEMGP PDPILGVTEA FKRDTNSKKM NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK NLDKEYLPIG GLAEFCKASA ELALGENSEV LKSGRFVTVQ TISGTGALRI GASFLQRFFK FSRDVFLPKP TWGNHTPIFR DAGMQLQGYR YYDPKTCGFD FTGAVEDISK IPEQSVLLLH ACAHNPTGVD PRPEQWKEIA TVVKKRNLFA FFDMAYQGFA SGDGDKDAWA VRHFIEQGIN VCLCQSYAKN MGLYGERVGA FTMVCKDADE AKRVESQLKI LIRPMYSNPP LNGARIAAAI LNTPDLRKQW LQEVKVMADR IIGMRTQLVS NLKKEGSTHN WQHITDQIGM FCFTGLKPEQ VERLIKEFSI YMTKDGRISV AGVTSSNVGY LAHAIHQVTK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.