Details for: GP2

Gene ID: 2813

Symbol: GP2

Ensembl ID: ENSG00000169347

Description: glycoprotein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 391.5880
    Cell Significance Index: 196.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.6179
    Cell Significance Index: 447.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.6873
    Cell Significance Index: 321.1100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.3374
    Cell Significance Index: 13.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2799
    Cell Significance Index: 126.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0782
    Cell Significance Index: 23.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0166
    Cell Significance Index: 61.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9947
    Cell Significance Index: 24.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7630
    Cell Significance Index: 688.9400
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: 0.6994
    Cell Significance Index: 5.0100
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.4523
    Cell Significance Index: 3.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4128
    Cell Significance Index: 48.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4024
    Cell Significance Index: 27.8300
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.2267
    Cell Significance Index: 1.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2072
    Cell Significance Index: 5.9700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1553
    Cell Significance Index: 1.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1240
    Cell Significance Index: 90.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1052
    Cell Significance Index: 2.6300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0927
    Cell Significance Index: 1.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0501
    Cell Significance Index: 5.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0413
    Cell Significance Index: 0.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0205
    Cell Significance Index: 0.9300
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.0197
    Cell Significance Index: 0.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0159
    Cell Significance Index: 0.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0145
    Cell Significance Index: 0.3600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0101
    Cell Significance Index: 0.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.0048
    Cell Significance Index: 0.0600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0032
    Cell Significance Index: 0.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0026
    Cell Significance Index: 1.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0005
    Cell Significance Index: 0.0300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -3.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0024
    Cell Significance Index: -3.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0052
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0054
    Cell Significance Index: -3.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0055
    Cell Significance Index: -3.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0055
    Cell Significance Index: -1.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0085
    Cell Significance Index: -3.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0095
    Cell Significance Index: -0.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0098
    Cell Significance Index: -0.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0102
    Cell Significance Index: -2.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0107
    Cell Significance Index: -0.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0118
    Cell Significance Index: -0.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0120
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0124
    Cell Significance Index: -2.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0144
    Cell Significance Index: -2.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0145
    Cell Significance Index: -0.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0153
    Cell Significance Index: -0.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0157
    Cell Significance Index: -2.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0188
    Cell Significance Index: -0.9500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0200
    Cell Significance Index: -0.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0228
    Cell Significance Index: -3.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0255
    Cell Significance Index: -3.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0279
    Cell Significance Index: -3.8300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0338
    Cell Significance Index: -0.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0346
    Cell Significance Index: -3.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0346
    Cell Significance Index: -4.4700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0354
    Cell Significance Index: -0.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0401
    Cell Significance Index: -0.4600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0406
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0450
    Cell Significance Index: -0.7700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0493
    Cell Significance Index: -0.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0495
    Cell Significance Index: -3.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0498
    Cell Significance Index: -3.3500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0573
    Cell Significance Index: -0.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0583
    Cell Significance Index: -1.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0679
    Cell Significance Index: -3.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0688
    Cell Significance Index: -4.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0714
    Cell Significance Index: -3.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0738
    Cell Significance Index: -2.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0813
    Cell Significance Index: -3.8200
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0817
    Cell Significance Index: -0.8000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0834
    Cell Significance Index: -0.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0842
    Cell Significance Index: -2.9500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0882
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0898
    Cell Significance Index: -1.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0907
    Cell Significance Index: -4.2300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0925
    Cell Significance Index: -0.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0934
    Cell Significance Index: -4.8500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0973
    Cell Significance Index: -0.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1029
    Cell Significance Index: -3.3700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1035
    Cell Significance Index: -1.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1038
    Cell Significance Index: -4.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1058
    Cell Significance Index: -3.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1106
    Cell Significance Index: -3.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1115
    Cell Significance Index: -1.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1131
    Cell Significance Index: -3.0300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1158
    Cell Significance Index: -2.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1171
    Cell Significance Index: -3.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1178
    Cell Significance Index: -5.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1195
    Cell Significance Index: -3.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1209
    Cell Significance Index: -3.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1223
    Cell Significance Index: -3.2700
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1223
    Cell Significance Index: -1.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1233
    Cell Significance Index: -4.6700
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1258
    Cell Significance Index: -1.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GP2 is a glycoprotein that belongs to the ZAP-70 family of proteins. It is characterized by its ability to bind to various ligands, including antibodies, complement proteins, and other glycoproteins. GP2 is also known for its involvement in the regulation of immune cell functions, including the activation of T-cells and the regulation of cytokine production. Its expression is highly regulated, and its dysregulation has been implicated in various diseases. **Pathways and Functions:** GP2 is involved in several signaling pathways, including: 1. **Antigen binding:** GP2 binds to antigens, which triggers the activation of immune cells, such as T-cells and B-cells. 2. **Antigen transcytosis by m cells in mucosal-associated lymphoid tissue:** GP2 is involved in the transcytosis of antigens across the epithelial barrier, which is essential for the development of immune responses in mucosal tissues. 3. **Apical plasma membrane:** GP2 is involved in the regulation of cellular signaling at the apical plasma membrane, which is essential for the development of immune responses in epithelial tissues. 4. **Cell surface:** GP2 is expressed on the cell surface, where it interacts with other glycoproteins and receptors, regulating cellular signaling and immune responses. 5. **Endosome:** GP2 is also involved in the regulation of immune responses in endosomes, where it interacts with other glycoproteins and receptors, regulating the processing and presentation of antigens. **Functions:** GP2 plays several critical functions, including: 1. **Immune response:** GP2 is involved in the regulation of immune responses, including the activation of T-cells and the regulation of cytokine production. 2. **Cellular signaling:** GP2 is involved in the regulation of cellular signaling, including the regulation of cellular growth, differentiation, and survival. 3. **Protein modification:** GP2 is involved in the regulation of protein modification, including the synthesis of GPI-anchored proteins and the regulation of protein degradation. 4. **Neutrophil migration:** GP2 is involved in the regulation of neutrophil migration, which is essential for the development of immune responses in tissues. **Clinical Significance:** GP2 has been implicated in several diseases, including: 1. **Autoimmune disorders:** GP2 has been implicated in the development of autoimmune disorders, including rheumatoid arthritis and lupus. 2. **Cancer:** GP2 has been implicated in the development of cancer, including breast cancer and lung cancer. 3. **Neurological disorders:** GP2 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, GP2 is a multifunctional glycoprotein that plays a critical role in immune response, cellular signaling, and protein modification. Its dysregulation has been implicated in several diseases, including autoimmune disorders, cancer, and neurological disorders. Further research is needed to fully understand the functions and clinical significance of GP2.

Genular Protein ID: 2691943909

Symbol: GP2_HUMAN

Name: ZAP75

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8666297

Title: Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas.

PubMed ID: 8666297

DOI: 10.1016/0378-1119(96)00065-0

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10760606

Title: Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane-associated protein GP2.

PubMed ID: 10760606

DOI: 10.1016/s0167-4781(00)00057-9

PubMed ID: 19907495

Title: Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.

PubMed ID: 19907495

DOI: 10.1038/nature08529

PubMed ID: 35273390

Title: Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.

PubMed ID: 35273390

DOI: 10.1038/s41594-022-00729-3

Sequence Information:

  • Length: 537
  • Mass: 59480
  • Checksum: 8A6B6A0FC64F50B8
  • Sequence:
  • MPHLMERMVG SGLLWLALVS CILTQASAVQ RGYGNPIEAS SYGLDLDCGA PGTPEAHVCF 
    DPCQNYTLLD EPFRSTENSA GSQGCDKNMS GWYRFVGEGG VRMSETCVQV HRCQTDAPMW 
    LNGTHPALGD GITNHTACAH WSGNCCFWKT EVLVKACPGG YHVYRLEGTP WCNLRYCTVP 
    RDPSTVEDKC EKACRPEEEC LALNSTWGCF CRQDLNSSDV HSLQPQLDCG PREIKVKVDK 
    CLLGGLGLGE EVIAYLRDPN CSSILQTEER NWVSVTSPVQ ASACRNILER NQTHAIYKNT 
    LSLVNDFIIR DTILNINFQC AYPLDMKVSL QAALQPIVSS LNVSVDGNGE FIVRMALFQD 
    QNYTNPYEGD AVELSVESVL YVGAILEQGD TSRFNLVLRN CYATPTEDKA DLVKYFIIRN 
    SCSNQRDSTI HVEENGQSSE SRFSVQMFMF AGHYDLVFLH CEIHLCDSLN EQCQPSCSRS 
    QVRSEVPAID LARVLDLGPI TRRGAQSPGV MNGTPSTAGF LVAWPMVLLT VLLAWLF

Genular Protein ID: 1716391081

Symbol: B7Z1G2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 515
  • Mass: 57715
  • Checksum: B3B3AF0CE347F616
  • Sequence:
  • MKIKCEKSRT QSSAQHVQHS AHSTIVCRKH SHNAETAGRV DIVRGGPFFH HPLRKWLISP 
    PLNKPSVWPR TPIIPVHQLR RDTWVGNCNK KTAHSRLHSH GWPEEERFVF SSELHGKSAY 
    SKVTCMPHLM ERMVGSGLLW LALVSCILTQ ASAVQRVPRD PSTVEDKCEK ACRPEEECLA 
    LNSTWGCFCR QDLNSSDVHS LQPQLDCGPR EIKVKVDKCL LGGLGLGEEV IAYLRDPNCS 
    SILQTEERNW VSVTSPVQAS ACRNILERNQ THAIYKNTLS LVNDFIIRDT ILNINFQCAY 
    PLDMKVSLQA ALQPIVSSLN VSVDGNGEFI VRMALFQDQN YTNPYEGDAV ELSVESVLYV 
    GAILEQGDTS RFNLVLRNCY ATPTEDKADL VKYFIIRNSC SNQRDSTIHV EENGQSSESR 
    FSVQMFMFAG HYDLVFLHCE IHLCDSLNEQ CQPSCSRSQV RSEVPAIDLA RVLDLGPITR 
    RGAQSPGVMN GTPSTAGFLV AWPMVLLTVL LAWLF

Genular Protein ID: 1204423522

Symbol: Q68D34_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 530
  • Mass: 58650
  • Checksum: 5DDA60F600565F0D
  • Sequence:
  • MERMVGSGLL WLALVSCILT QASAVQRGYG NPIEASSYGL DLDCGAPGTP EAHVCFDPCQ 
    NYTLLDEPFR STENSAGSQG CDKNMSGWYR FVGEGGVRMS ETCVQVHRCQ TDAPMWLNGT 
    HPALGDGITN HTACAHWSGN CCFWKTEVLV KACPGGYHVY RLEGTPWCNL RYCTDPSTVE 
    DKCEKACRPE EECLALNSTW GCFCRQDLNS SDVHSLQPQL DCGPREIEVK VDKCLLGGLG 
    LGEEVIAYLR DPNCSSILQT EERNWVSVTS PVQASACRNI LERNQTHAIY KNTLSLVNDF 
    IIRDTILNIN FQCAYPLDMK VSLQAALQPI VSSLNVSVDG NGEFIVRMAL FQDQNYTNPY 
    EGDAVELSVE SVLYVGAILE QGDTSRFNLV LRNCYATPTE DKADLVKYFI IRNSCSNQRD 
    STIHVEENGQ SSESRFSVQM FMFAGHYDLV FLHCEIHLCD SLNEQCQPSC SRSQVRSEVP 
    AIDLARVLDL GPITRRGAQS PGVMNGTPST AGFLVAWPMV LLTVLLAWLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.