Details for: GP2

Gene ID: 2813

Symbol: GP2

Ensembl ID: ENSG00000169347

Description: glycoprotein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 7.94
    Marker Score: 5603
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 6.72
    Marker Score: 3789
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.47
    Marker Score: 11539
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.11
    Marker Score: 2121
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.04
    Marker Score: 5477
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.92
    Marker Score: 1997
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1
    Marker Score: 580
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.88
    Marker Score: 199
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.86
    Marker Score: 214
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1598
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.84
    Marker Score: 527
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.81
    Marker Score: 469
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 677
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2798.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.59
    Marker Score: 249
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1204
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 370.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 455
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.5
    Marker Score: 794
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.49
    Marker Score: 270
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.46
    Marker Score: 1055
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.45
    Marker Score: 1060
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.44
    Marker Score: 488
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.43
    Marker Score: 111
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6544
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.4
    Marker Score: 149
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.36
    Marker Score: 252
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 214
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.35
    Marker Score: 347
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.33
    Marker Score: 104
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.32
    Marker Score: 167
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.3
    Marker Score: 84
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.29
    Marker Score: 77
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.28
    Marker Score: 288
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 127
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.25
    Marker Score: 134
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.25
    Marker Score: 74
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.23
    Marker Score: 82
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.23
    Marker Score: 370
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.21
    Marker Score: 95
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.21
    Marker Score: 139.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.19
    Marker Score: 111
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.19
    Marker Score: 183
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 84
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.18
    Marker Score: 198
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.18
    Marker Score: 178
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.18
    Marker Score: 2389
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.17
    Marker Score: 179
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.17
    Marker Score: 73
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.16
    Marker Score: 187.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.15
    Marker Score: 245
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.14
    Marker Score: 52
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.14
    Marker Score: 339
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.14
    Marker Score: 35
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.13
    Marker Score: 50
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.13
    Marker Score: 52
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 111
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.12
    Marker Score: 236
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.12
    Marker Score: 172
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.11
    Marker Score: 548
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.11
    Marker Score: 156
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 103
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.11
    Marker Score: 96
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.09
    Marker Score: 141.5
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.09
    Marker Score: 21

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Other Information

**Key characteristics:** - GP2 is a cell surface glycoprotein that is expressed in mucosal-associated lymphoid tissue, epithelial cells of the pancreas, blood vessel endothelial cells, kidney loop of Henle, and other cell types. - It is a member of the immunoglobulin superfamily and is expressed in high levels on epithelial cells. - GP2 is a transmembrane protein that is involved in cell adhesion, signaling, and immune responses. **Pathways and functions:** - GP2 is involved in the regulation of epithelial cell adhesion to extracellular matrix proteins. - It is also involved in the regulation of immune responses, including the activation of dendritic cells and the inhibition of T cells. - GP2 is a key regulator of the epithelial-mesenchymal transition, which is a process by which epithelial cells lose their epithelial characteristics and become mesenchymal cells. **Clinical significance:** - Mutations in GP2 have been linked to a number of human diseases, including cancer, autoimmune disorders, and kidney disease. - GP2 inhibitors are being investigated as a potential treatment for these diseases. **Additional information:** - GP2 is a highly conserved protein, with a similar protein found in mice named gp2. - It is a transmembrane protein that is composed of 17 transmembrane domains, each of which is responsible for a different cell adhesion molecule. - GP2 is a relatively promiscuous receptor, meaning that it can bind to a variety of different ligands. - It is a key regulator of epithelial cell adhesion, migration, and signaling.

Genular Protein ID: 2691943909

Symbol: GP2_HUMAN

Name: ZAP75

UniProtKB Accession Codes:

P55259 A6NFM9 A6NJA8 Q13338 Q9UIF1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8666297

Title: Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas.

PubMed ID: 8666297

DOI: 10.1016/0378-1119(96)00065-0

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10760606

Title: Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane-associated protein GP2.

PubMed ID: 10760606

DOI: 10.1016/s0167-4781(00)00057-9

PubMed ID: 19907495

Title: Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.

PubMed ID: 19907495

DOI: 10.1038/nature08529

PubMed ID: 35273390

Title: Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.

PubMed ID: 35273390

DOI: 10.1038/s41594-022-00729-3

Sequence Information:

  • Length: 537
  • Mass: 59480
  • Checksum: 8A6B6A0FC64F50B8
  • Sequence:
    • MPHLMERMVG SGLLWLALVS CILTQASAVQ RGYGNPIEAS SYGLDLDCGA PGTPEAHVCF 
DPCQNYTLLD EPFRSTENSA GSQGCDKNMS GWYRFVGEGG VRMSETCVQV HRCQTDAPMW 
LNGTHPALGD GITNHTACAH WSGNCCFWKT EVLVKACPGG YHVYRLEGTP WCNLRYCTVP 
RDPSTVEDKC EKACRPEEEC LALNSTWGCF CRQDLNSSDV HSLQPQLDCG PREIKVKVDK 
CLLGGLGLGE EVIAYLRDPN CSSILQTEER NWVSVTSPVQ ASACRNILER NQTHAIYKNT 
LSLVNDFIIR DTILNINFQC AYPLDMKVSL QAALQPIVSS LNVSVDGNGE FIVRMALFQD 
QNYTNPYEGD AVELSVESVL YVGAILEQGD TSRFNLVLRN CYATPTEDKA DLVKYFIIRN 
SCSNQRDSTI HVEENGQSSE SRFSVQMFMF AGHYDLVFLH CEIHLCDSLN EQCQPSCSRS 
QVRSEVPAID LARVLDLGPI TRRGAQSPGV MNGTPSTAGF LVAWPMVLLT VLLAWLF

Genular Protein ID: 1204423522

Symbol: Q68D34_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68D34

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2 SMART 1

Sequence Information:

  • Length: 530
  • Mass: 58650
  • Checksum: 5DDA60F600565F0D
  • Sequence:
    • MERMVGSGLL WLALVSCILT QASAVQRGYG NPIEASSYGL DLDCGAPGTP EAHVCFDPCQ 
NYTLLDEPFR STENSAGSQG CDKNMSGWYR FVGEGGVRMS ETCVQVHRCQ TDAPMWLNGT 
HPALGDGITN HTACAHWSGN CCFWKTEVLV KACPGGYHVY RLEGTPWCNL RYCTDPSTVE 
DKCEKACRPE EECLALNSTW GCFCRQDLNS SDVHSLQPQL DCGPREIEVK VDKCLLGGLG 
LGEEVIAYLR DPNCSSILQT EERNWVSVTS PVQASACRNI LERNQTHAIY KNTLSLVNDF 
IIRDTILNIN FQCAYPLDMK VSLQAALQPI VSSLNVSVDG NGEFIVRMAL FQDQNYTNPY 
EGDAVELSVE SVLYVGAILE QGDTSRFNLV LRNCYATPTE DKADLVKYFI IRNSCSNQRD 
STIHVEENGQ SSESRFSVQM FMFAGHYDLV FLHCEIHLCD SLNEQCQPSC SRSQVRSEVP 
AIDLARVLDL GPITRRGAQS PGVMNGTPST AGFLVAWPMV LLTVLLAWLF

Genular Protein ID: 1716391081

Symbol: B7Z1G2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1G2

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 5 SAM 2 SMART 1

Sequence Information:

  • Length: 515
  • Mass: 57715
  • Checksum: B3B3AF0CE347F616
  • Sequence:
    • MKIKCEKSRT QSSAQHVQHS AHSTIVCRKH SHNAETAGRV DIVRGGPFFH HPLRKWLISP 
PLNKPSVWPR TPIIPVHQLR RDTWVGNCNK KTAHSRLHSH GWPEEERFVF SSELHGKSAY 
SKVTCMPHLM ERMVGSGLLW LALVSCILTQ ASAVQRVPRD PSTVEDKCEK ACRPEEECLA 
LNSTWGCFCR QDLNSSDVHS LQPQLDCGPR EIKVKVDKCL LGGLGLGEEV IAYLRDPNCS 
SILQTEERNW VSVTSPVQAS ACRNILERNQ THAIYKNTLS LVNDFIIRDT ILNINFQCAY 
PLDMKVSLQA ALQPIVSSLN VSVDGNGEFI VRMALFQDQN YTNPYEGDAV ELSVESVLYV 
GAILEQGDTS RFNLVLRNCY ATPTEDKADL VKYFIIRNSC SNQRDSTIHV EENGQSSESR 
FSVQMFMFAG HYDLVFLHCE IHLCDSLNEQ CQPSCSRSQV RSEVPAIDLA RVLDLGPITR 
RGAQSPGVMN GTPSTAGFLV AWPMVLLTVL LAWLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.