Details for: GPR19

Gene ID: 2842

Symbol: GPR19

Ensembl ID: ENSG00000183150

Description: G protein-coupled receptor 19

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.52
    Marker Score: 1514.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.37
    Marker Score: 2840
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4816
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.94
    Marker Score: 1455
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5280
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.92
    Marker Score: 8777
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.9
    Marker Score: 3652
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1799
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.87
    Marker Score: 1647.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.8
    Marker Score: 6909
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8
    Marker Score: 3091
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.78
    Marker Score: 15588
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.75
    Marker Score: 7713
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.74
    Marker Score: 45698
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.74
    Marker Score: 27282
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.73
    Marker Score: 6888
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.73
    Marker Score: 439
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.69
    Marker Score: 5255
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.65
    Marker Score: 10240
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.65
    Marker Score: 24676
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.65
    Marker Score: 2678
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.61
    Marker Score: 193
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.6
    Marker Score: 8934
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.54
    Marker Score: 283
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.53
    Marker Score: 177
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.48
    Marker Score: 227
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.47
    Marker Score: 794
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.47
    Marker Score: 250
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.46
    Marker Score: 3072
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.46
    Marker Score: 207
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.46
    Marker Score: 453
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.44
    Marker Score: 496
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.44
    Marker Score: 158
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.42
    Marker Score: 250
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.4
    Marker Score: 128
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.35
    Marker Score: 7569
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.35
    Marker Score: 109
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.35
    Marker Score: 166
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.34
    Marker Score: 701
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.34
    Marker Score: 800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.34
    Marker Score: 290.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.33
    Marker Score: 142
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.32
    Marker Score: 145
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.29
    Marker Score: 841
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.29
    Marker Score: 288
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.28
    Marker Score: 136.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 123
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.26
    Marker Score: 1213
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.26
    Marker Score: 67
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.26
    Marker Score: 319
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.25
    Marker Score: 1060
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.23
    Marker Score: 145
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.21
    Marker Score: 78
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.21
    Marker Score: 197
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.2
    Marker Score: 83
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.19
    Marker Score: 208
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.19
    Marker Score: 96
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.19
    Marker Score: 124
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.18
    Marker Score: 440
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.18
    Marker Score: 48
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.17
    Marker Score: 905
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.17
    Marker Score: 111
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.17
    Marker Score: 93
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.16
    Marker Score: 154
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.16
    Marker Score: 66
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.16
    Marker Score: 93
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.16
    Marker Score: 76
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.15
    Marker Score: 54
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.15
    Marker Score: 149
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.15
    Marker Score: 185
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.15
    Marker Score: 5147
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.15
    Marker Score: 85
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.14
    Marker Score: 231

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Other Information

**Key characteristics:** * GPR19 is a single-pass transmembrane protein with a molecular weight of approximately 145 kDa. * It is a member of the GPCR superfamily, which are G protein-coupled receptors that are expressed in a variety of cell types. * GPR19 is a ligand-gated channel, which means that it opens or closes in response to the binding of a specific ligand. * It is expressed in high levels in the colon, where it is involved in the regulation of intestinal homeostasis. **Pathways and functions:** * GPR19 is involved in the regulation of intestinal homeostasis by binding to a variety of ligands, including gastrin, trefoil factor, and sphingomyelin. * It is also involved in the regulation of cell migration and differentiation in the colon. * It is a key regulator of the development of the intestinal epithelium. **Clinical significance:** * Mutations in GPR19 have been linked to a number of human diseases, including colorectal cancer and inflammatory bowel disease. * Targeting GPR19 has been shown to be a potential therapeutic strategy for these diseases. **Additional notes:** * GPR19 is a relatively new protein, and there is still much that is unknown about its function. * It is a promising target for cancer therapy due to its role in the development and progression of these diseases.

Genular Protein ID: 172024951

Symbol: GPR19_HUMAN

Name: Probable G-protein coupled receptor 19

UniProtKB Accession Codes:

Q15760

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8830667

Title: A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain.

PubMed ID: 8830667

DOI: 10.1016/0014-5793(96)00901-5

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 415
  • Mass: 47687
  • Checksum: D5DF78C1BFA401FD
  • Sequence:
    • MVFAHRMDNS KPHLIIPTLL VPLQNRSCTE TATPLPSQYL MELSEEHSWM SNQTDLHYVL 
KPGEVATASI FFGILWLFSI FGNSLVCLVI HRSRRTQSTT NYFVVSMACA DLLISVASTP 
FVLLQFTTGR WTLGSATCKV VRYFQYLTPG VQIYVLLSIC IDRFYTIVYP LSFKVSREKA 
KKMIAASWVF DAGFVTPVLF FYGSNWDSHC NYFLPSSWEG TAYTVIHFLV GFVIPSVLII 
LFYQKVIKYI WRIGTDGRTV RRTMNIVPRT KVKTIKMFLI LNLLFLLSWL PFHVAQLWHP 
HEQDYKKSSL VFTAITWISF SSSASKPTLY SIYNANFRRG MKETFCMSSM KCYRSNAYTI 
TTSSRMAKKN YVGISEIPSM AKTITKDSIY DSFDREAKEK KLAWPINSNP PNTFV

Genular Protein ID: 1661522448

Symbol: Q6IBH2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6IBH2

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 8 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 415
  • Mass: 47701
  • Checksum: 238619E007152ADF
  • Sequence:
    • MVFAHRMDNS KPHLIIPTLL VPLQNRSCTE TATPLPSQYL MELSEEHSWM SNQTDLHYVL 
KPGEVATASI FFGILWLFSI FGNSLVCLVI HRSRRTQSTT NYFVVSMACA DLLISVASTP 
FVLLQFTTGR WTLGSATCKV VRYFQYLTPG VQIYVLLSIC IDRFYTIVYP LSFKVSREKA 
KKMIAASWIF DAGFVTPVLF FYGSNWDSHC NYFLPSSWEG TAYTVIHFLV GFVIPSVLII 
LFYQKVIKYI WRIGTDGRTV RRTMNIVPRT KVKTIKMFLI LNLLFLLSWL PFHVAQLWHP 
HEQDYKKSSL VFTAITWISF SSSASKPTLY SIYNANFRRG MKETFCMSSM KCYRSNAYTI 
TTSSRMAKKN YVGISEIPSM AKTITKDSIY DSFDREAKEK KLAWPINSNP PNTFV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.