Details for: GPER1

Gene ID: 2852

Symbol: GPER1

Ensembl ID: ENSG00000164850

Description: G protein-coupled estrogen receptor 1

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • G alpha (i) signalling events
    (R-HSA-418594)
  • G alpha (s) signalling events
    (R-HSA-418555)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Gper1 signaling
    (R-HSA-9634597)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0007189)
  • Apoptotic chromosome condensation
    (GO:0030263)
  • Axon
    (GO:0030424)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to estradiol stimulus
    (GO:0071392)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to mineralocorticoid stimulus
    (GO:0071389)
  • Cellular response to peptide hormone stimulus
    (GO:0071375)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Chromatin binding
    (GO:0003682)
  • Cytoplasm
    (GO:0005737)
  • Cytoplasmic vesicle membrane
    (GO:0030659)
  • Cytosol
    (GO:0005829)
  • Dendrite
    (GO:0030425)
  • Dendritic spine membrane
    (GO:0032591)
  • Early endosome
    (GO:0005769)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Golgi apparatus
    (GO:0005794)
  • Golgi membrane
    (GO:0000139)
  • G protein-coupled estrogen receptor activity
    (GO:0038054)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Mitochondrial membrane
    (GO:0031966)
  • Negative regulation of cell cycle process
    (GO:0010948)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of fat cell differentiation
    (GO:0045599)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of leukocyte activation
    (GO:0002695)
  • Negative regulation of lipid biosynthetic process
    (GO:0051055)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Nervous system development
    (GO:0007399)
  • Neuronal action potential
    (GO:0019228)
  • Nuclear envelope
    (GO:0005635)
  • Nuclear estrogen receptor activity
    (GO:0030284)
  • Nuclear fragmentation involved in apoptotic nuclear change
    (GO:0030264)
  • Nuclear receptor-mediated steroid hormone signaling pathway
    (GO:0030518)
  • Nucleolus
    (GO:0005730)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cardiac vascular smooth muscle cell differentiation
    (GO:2000724)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of endothelial cell apoptotic process
    (GO:2000353)
  • Positive regulation of epidermal growth factor receptor signaling pathway
    (GO:0045742)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of g protein-coupled receptor signaling pathway
    (GO:0045745)
  • Positive regulation of inositol trisphosphate biosynthetic process
    (GO:0032962)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of neurogenesis
    (GO:0050769)
  • Positive regulation of neurotransmitter secretion
    (GO:0001956)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein localization to plasma membrane
    (GO:1903078)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Positive regulation of release of sequestered calcium ion into cytosol
    (GO:0051281)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of uterine smooth muscle contraction
    (GO:0070474)
  • Postsynaptic density
    (GO:0014069)
  • Presynaptic membrane
    (GO:0042734)
  • Protein binding
    (GO:0005515)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of cytosolic calcium ion concentration
    (GO:0051480)
  • Steroid binding
    (GO:0005496)
  • Steroid hormone binding
    (GO:1990239)
  • Steroid hormone receptor signaling pathway
    (GO:0043401)
  • Trans-golgi network
    (GO:0005802)
  • Vasodilation
    (GO:0042311)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.2164
    Cell Significance Index: -4.8000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.7078
    Cell Significance Index: 17.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6034
    Cell Significance Index: 59.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4737
    Cell Significance Index: 427.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4576
    Cell Significance Index: 9.7500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3393
    Cell Significance Index: 2.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3140
    Cell Significance Index: 51.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3017
    Cell Significance Index: 59.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2923
    Cell Significance Index: 31.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2161
    Cell Significance Index: 5.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1852
    Cell Significance Index: 11.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1570
    Cell Significance Index: 10.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1171
    Cell Significance Index: 2.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1013
    Cell Significance Index: 11.8100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0877
    Cell Significance Index: 0.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0841
    Cell Significance Index: 3.8100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0785
    Cell Significance Index: 1.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0772
    Cell Significance Index: 14.6900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0750
    Cell Significance Index: 1.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0524
    Cell Significance Index: 7.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0502
    Cell Significance Index: 27.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0448
    Cell Significance Index: 1.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0431
    Cell Significance Index: 66.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0428
    Cell Significance Index: 29.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0344
    Cell Significance Index: 4.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0284
    Cell Significance Index: 5.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0274
    Cell Significance Index: 50.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0268
    Cell Significance Index: 0.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0256
    Cell Significance Index: 0.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0233
    Cell Significance Index: 2.9900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0137
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0122
    Cell Significance Index: 23.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0116
    Cell Significance Index: 0.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0021
    Cell Significance Index: 2.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0015
    Cell Significance Index: 0.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0003
    Cell Significance Index: 0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0019
    Cell Significance Index: -0.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0050
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0058
    Cell Significance Index: -4.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0068
    Cell Significance Index: -0.5200
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.0071
    Cell Significance Index: -0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0087
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0092
    Cell Significance Index: -5.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0093
    Cell Significance Index: -2.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0112
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0122
    Cell Significance Index: -2.0900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0158
    Cell Significance Index: -0.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0163
    Cell Significance Index: -0.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0172
    Cell Significance Index: -1.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0193
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0242
    Cell Significance Index: -2.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0261
    Cell Significance Index: -5.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0300
    Cell Significance Index: -0.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0325
    Cell Significance Index: -4.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0363
    Cell Significance Index: -4.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0375
    Cell Significance Index: -2.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0398
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0436
    Cell Significance Index: -4.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0451
    Cell Significance Index: -4.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0535
    Cell Significance Index: -3.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0547
    Cell Significance Index: -2.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0582
    Cell Significance Index: -4.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0592
    Cell Significance Index: -4.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0595
    Cell Significance Index: -3.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0619
    Cell Significance Index: -1.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0620
    Cell Significance Index: -3.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0644
    Cell Significance Index: -4.0600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0738
    Cell Significance Index: -0.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0780
    Cell Significance Index: -5.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0858
    Cell Significance Index: -4.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0896
    Cell Significance Index: -4.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0914
    Cell Significance Index: -1.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0984
    Cell Significance Index: -1.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0990
    Cell Significance Index: -1.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1002
    Cell Significance Index: -5.2600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1057
    Cell Significance Index: -1.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1067
    Cell Significance Index: -5.3900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1122
    Cell Significance Index: -3.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1185
    Cell Significance Index: -4.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1221
    Cell Significance Index: -3.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1223
    Cell Significance Index: -4.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1232
    Cell Significance Index: -3.6300
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1260
    Cell Significance Index: -1.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1265
    Cell Significance Index: -4.1400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1275
    Cell Significance Index: -0.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1316
    Cell Significance Index: -4.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1359
    Cell Significance Index: -3.2600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1412
    Cell Significance Index: -1.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1419
    Cell Significance Index: -3.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1427
    Cell Significance Index: -3.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1438
    Cell Significance Index: -3.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1479
    Cell Significance Index: -5.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1481
    Cell Significance Index: -2.3500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1517
    Cell Significance Index: -2.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1633
    Cell Significance Index: -3.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1650
    Cell Significance Index: -4.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Unique ligand-independent signaling:** GPER1 can activate its signaling pathways without the presence of estrogen, making it a key player in the regulation of estrogen-independent cellular processes. 2. **G protein-coupled receptor structure:** GPER1 belongs to the class A/1 rhodopsin-like receptors, which are characterized by their seven-transmembrane domain structure. 3. **Broad tissue expression:** GPER1 is widely expressed in various tissues, including the nervous system, cardiovascular system, immune cells, and reproductive tissues. 4. **Involvement in multiple signaling pathways:** GPER1 can interact with multiple signaling pathways, including the adenylate cyclase-activating G protein-coupled receptor signaling pathway, the phosphatidylinositol 3-kinase/protein kinase B signaling pathway, and the mitogen-activated protein kinase (MAPK) signaling pathway. **Pathways and Functions:** GPER1 is involved in a wide range of cellular processes, including: 1. **Cardiovascular regulation:** GPER1 is involved in the regulation of vascular tone, cardiac vascular smooth muscle cell proliferation, and cardiac endothelial cell function. 2. **Neurological functions:** GPER1 is involved in the regulation of neuronal action potentials, neurotransmitter secretion, and neurogenesis. 3. **Immune modulation:** GPER1 is involved in the regulation of innate and adaptive immune responses, including the activation of innate lymphoid cells and the regulation of leukocyte activation. 4. **Cell cycle regulation:** GPER1 can regulate cell cycle progression, including the promotion of cell proliferation and inhibition of apoptosis. 5. **Gene expression regulation:** GPER1 can regulate gene expression, including the promotion of estrogen-dependent and estrogen-independent gene expression. **Clinical Significance:** GPER1 has been implicated in various diseases and disorders, including: 1. **Hormone-sensitive cancers:** GPER1 expression has been found to be elevated in hormone-sensitive cancers, such as breast and prostate cancer. 2. **Cardiovascular disease:** GPER1 has been implicated in the regulation of cardiovascular disease, including hypertension and atherosclerosis. 3. **Neurological disorders:** GPER1 has been implicated in the regulation of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Immune-mediated disorders:** GPER1 has been implicated in the regulation of immune-mediated disorders, including multiple sclerosis and rheumatoid arthritis. In conclusion, GPER1 is a unique estrogen receptor that plays a critical role in mediating the effects of estrogen on various cellular processes. Its involvement in multiple signaling pathways and its expression in a wide range of tissues make it an important player in the regulation of physiological and pathological processes. Further research is needed to fully understand the mechanisms by which GPER1 regulates cellular processes and to explore its potential as a therapeutic target for various diseases and disorders.

Genular Protein ID: 3661182894

Symbol: GPER1_HUMAN

Name: Chemoattractant receptor-like 2

UniProtKB Accession Codes:

Q99527 A8K6C5 B5BUJ1 O00143 O43494 Q13631 Q6FHL1 Q96F42 Q99981

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 13 EMDB 5 Ensembl 4 ExpressionAtlas 1 GO 88 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8920907

Title: Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues.

PubMed ID: 8920907

DOI: 10.1006/bbrc.1996.1654

PubMed ID: 9070864

Title: Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors.

PubMed ID: 9070864

DOI: 10.1006/bbrc.1997.6161

PubMed ID: 9398636

Title: Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress.

PubMed ID: 9398636

DOI: 10.1006/bbrc.1997.7734

PubMed ID: 9141481

Title: A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue.

PubMed ID: 9141481

DOI: 10.1016/s0014-5793(97)00278-0

PubMed ID: 9367686

Title: Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer.

PubMed ID: 9367686

DOI: 10.1006/geno.1997.4972

PubMed ID: 9479505

Title: Discovery of three novel G-protein-coupled receptor genes.

PubMed ID: 9479505

DOI: 10.1006/geno.1998.5095

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11043579

Title: Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF.

PubMed ID: 11043579

DOI: 10.1210/mend.14.10.0532

PubMed ID: 12027886

Title: Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells.

PubMed ID: 12027886

DOI: 10.1046/j.1432-1033.2002.02912.x

PubMed ID: 15539556

Title: Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.

PubMed ID: 15539556

DOI: 10.1210/en.2004-1064

PubMed ID: 15705806

Title: A transmembrane intracellular estrogen receptor mediates rapid cell signaling.

PubMed ID: 15705806

DOI: 10.1126/science.1106943

PubMed ID: 16645038

Title: Nature of functional estrogen receptors at the plasma membrane.

PubMed ID: 16645038

DOI: 10.1210/me.2005-0525

PubMed ID: 17379646

Title: Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane.

PubMed ID: 17379646

DOI: 10.1210/en.2006-1605

PubMed ID: 18566127

Title: G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol.

PubMed ID: 18566127

DOI: 10.1210/en.2008-0269

PubMed ID: 19179659

Title: Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity.

PubMed ID: 19179659

DOI: 10.1161/circresaha.108.190892

PubMed ID: 19342448

Title: Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30.

PubMed ID: 19342448

DOI: 10.1210/me.2008-0262

PubMed ID: 19749156

Title: G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells.

PubMed ID: 19749156

DOI: 10.1210/me.2009-0120

PubMed ID: 20551055

Title: Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts.

PubMed ID: 20551055

DOI: 10.1158/0008-5472.can-10-0408

PubMed ID: 20203690

Title: Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest.

PubMed ID: 20203690

DOI: 10.1038/cdd.2010.20

PubMed ID: 19931550

Title: Conserved estrogen binding and signaling functions of the G protein-coupled estrogen receptor 1 (GPER) in mammals and fish.

PubMed ID: 19931550

DOI: 10.1016/j.steroids.2009.11.005

PubMed ID: 21427217

Title: G-1-activated membrane estrogen receptors mediate increased contractility of the human myometrium.

PubMed ID: 21427217

DOI: 10.1210/en.2010-0979

PubMed ID: 21242460

Title: GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone.

PubMed ID: 21242460

DOI: 10.1161/hypertensionaha.110.161653

PubMed ID: 21540189

Title: Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway.

PubMed ID: 21540189

DOI: 10.1074/jbc.m111.224071

PubMed ID: 21149639

Title: G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments.

PubMed ID: 21149639

DOI: 10.1124/mol.110.069500

PubMed ID: 21354433

Title: Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30/GPER) from the plasma membrane towards the nucleus.

PubMed ID: 21354433

DOI: 10.1016/j.steroids.2011.02.018

PubMed ID: 23135268

Title: G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17beta-estradiol in cancer cells and cancer-associated fibroblasts.

PubMed ID: 23135268

DOI: 10.1074/jbc.m112.417303

PubMed ID: 23285008

Title: G-protein coupled receptor 30 (GPR30): a novel regulator of endothelial inflammation.

PubMed ID: 23285008

DOI: 10.1371/journal.pone.0052357

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23283935

Title: Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation.

PubMed ID: 23283935

DOI: 10.1152/ajpcell.00203.2012

PubMed ID: 23674134

Title: G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection.

PubMed ID: 23674134

DOI: 10.1530/jme-13-0021

PubMed ID: 22521564

Title: Position paper: The membrane estrogen receptor GPER--Clues and questions.

PubMed ID: 22521564

DOI: 10.1016/j.steroids.2012.04.001

PubMed ID: 22495674

Title: Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology.

PubMed ID: 22495674

DOI: 10.1210/en.2012-1061

Sequence Information:

  • Length: 375
  • Mass: 42248
  • Checksum: 0A54EED8A698F075
  • Sequence:
    • MDVTSQARGV GLEMYPGTAQ PAAPNTTSPE LNLSHPLLGT ALANGTGELS EHQQYVIGLF 
LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN LAVADLILVA DSLIEVFNLH 
ERYYDIAVLC TFMSLFLQVN MYSSVFFLTW MSFDRYIALA RAMRCSLFRT KHHARLSCGL 
IWMASVSATL VPFTAVHLQH TDEACFCFAD VREVQWLEVT LGFIVPFAII GLCYSLIVRV 
LVRAHRHRGL RPRRQKALRM ILAVVLVFFV CWLPENVFIS VHLLQRTQPG AAPCKQSFRH 
AHPLTGHIVN LAAFSNSCLN PLIYSFLGET FRDKLRLYIE QKTNLPALNR FCHAALKAVI 
PDSTEQSDVR FSSAV

Genular Protein ID: 2510461461

Symbol: Q63ZY2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q63ZY2

Database IDs:

ARBA 38 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 18 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 407
  • Mass: 45342
  • Checksum: 1E13EDC0EA85E915
  • Sequence:
    • MDVTSQARGV GLEMYPGTAQ PAAPNTTSPE LNLSHPLLGT ALANGTGELS EHQQYVIGLF 
LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN LAVADLILVA DSLIEVFNLH 
ERYYDIAVLC TFMSLFLQVN MYSSVFFLTW MSFDRYIALA RAMRCSLFRT KHHARLSCGL 
IWMASVSATL VPFTAVHLQH TDEACFCFAD VREVQWLEVT LGFIVPFAII GLCYSLIVRV 
LVRAHRHRGL RPRRQKALRM ILAVVLVFFV CWLPENVFIS VHLLQRTQPG AAPCKQSFRH 
AHPLTGHVMS LNCGQMWLLA PRGLARVTLA WSPWGCLGNL TTGHLALLTQ NCYNPKALAP 
QGPKASGDQP VTQLLPANPA CRCTCLPLQE TFLTPSTRKA TRRGHCG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.