Details for: GPER1

Gene ID: 2852

Symbol: GPER1

Ensembl ID: ENSG00000164850

Description: G protein-coupled estrogen receptor 1

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • G alpha (i) signalling events
    (R-HSA-418594)
  • G alpha (s) signalling events
    (R-HSA-418555)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Gper1 signaling
    (R-HSA-9634597)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0007189)
  • Apoptotic chromosome condensation
    (GO:0030263)
  • Axon
    (GO:0030424)
  • Cell cycle
    (GO:0007049)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to estradiol stimulus
    (GO:0071392)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to mineralocorticoid stimulus
    (GO:0071389)
  • Cellular response to peptide hormone stimulus
    (GO:0071375)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Chromatin binding
    (GO:0003682)
  • Cytoplasm
    (GO:0005737)
  • Cytoplasmic vesicle membrane
    (GO:0030659)
  • Cytosol
    (GO:0005829)
  • Dendrite
    (GO:0030425)
  • Dendritic spine membrane
    (GO:0032591)
  • Early endosome
    (GO:0005769)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Golgi apparatus
    (GO:0005794)
  • Golgi membrane
    (GO:0000139)
  • G protein-coupled estrogen receptor activity
    (GO:0038054)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Intracellular steroid hormone receptor signaling pathway
    (GO:0030518)
  • Mitochondrial membrane
    (GO:0031966)
  • Negative regulation of cell cycle process
    (GO:0010948)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of fat cell differentiation
    (GO:0045599)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of leukocyte activation
    (GO:0002695)
  • Negative regulation of lipid biosynthetic process
    (GO:0051055)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Nervous system development
    (GO:0007399)
  • Neuronal action potential
    (GO:0019228)
  • Nuclear envelope
    (GO:0005635)
  • Nuclear estrogen receptor activity
    (GO:0030284)
  • Nuclear fragmentation involved in apoptotic nuclear change
    (GO:0030264)
  • Nucleolus
    (GO:0005730)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cardiac vascular smooth muscle cell differentiation
    (GO:2000724)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of endothelial cell apoptotic process
    (GO:2000353)
  • Positive regulation of epidermal growth factor receptor signaling pathway
    (GO:0045742)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of g protein-coupled receptor signaling pathway
    (GO:0045745)
  • Positive regulation of inositol trisphosphate biosynthetic process
    (GO:0032962)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of neurogenesis
    (GO:0050769)
  • Positive regulation of neurotransmitter secretion
    (GO:0001956)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein localization to plasma membrane
    (GO:1903078)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Positive regulation of release of sequestered calcium ion into cytosol
    (GO:0051281)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of uterine smooth muscle contraction
    (GO:0070474)
  • Postsynaptic density
    (GO:0014069)
  • Protein binding
    (GO:0005515)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of cytosolic calcium ion concentration
    (GO:0051480)
  • Steroid binding
    (GO:0005496)
  • Steroid hormone binding
    (GO:1990239)
  • Steroid hormone mediated signaling pathway
    (GO:0043401)
  • Trans-golgi network
    (GO:0005802)
  • Vasodilation
    (GO:0042311)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.8
    Marker Score: 10906
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.11
    Marker Score: 2979
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.11
    Marker Score: 9213.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.64
    Marker Score: 22338
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.41
    Marker Score: 590
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 847
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2
    Marker Score: 2281
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.2
    Marker Score: 1384
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.1
    Marker Score: 2243
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16417
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5332
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.93
    Marker Score: 2196
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.85
    Marker Score: 353
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.8
    Marker Score: 1108
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 680
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.66
    Marker Score: 804
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.66
    Marker Score: 398
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.66
    Marker Score: 316
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.65
    Marker Score: 1642
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 344
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.5
    Marker Score: 223
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.5
    Marker Score: 676
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.45
    Marker Score: 551
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.44
    Marker Score: 381
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 185
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.42
    Marker Score: 131.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.37
    Marker Score: 530
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.34
    Marker Score: 1256
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.33
    Marker Score: 929
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.29
    Marker Score: 116
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.29
    Marker Score: 111
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.27
    Marker Score: 276
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.26
    Marker Score: 98
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 150
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.26
    Marker Score: 83
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.25
    Marker Score: 167
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.25
    Marker Score: 118
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.24
    Marker Score: 98
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.22
    Marker Score: 140
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.22
    Marker Score: 52
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.21
    Marker Score: 208
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.21
    Marker Score: 858
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.2
    Marker Score: 463
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.2
    Marker Score: 406
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2
    Marker Score: 92
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.2
    Marker Score: 201
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.2
    Marker Score: 67
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2
    Marker Score: 142
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.19
    Marker Score: 87
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.19
    Marker Score: 178
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 169
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.18
    Marker Score: 108
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.18
    Marker Score: 781
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.18
    Marker Score: 258
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.17
    Marker Score: 123
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.17
    Marker Score: 37
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.16
    Marker Score: 48
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.16
    Marker Score: 231
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.16
    Marker Score: 104
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.16
    Marker Score: 169
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.15
    Marker Score: 992
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.15
    Marker Score: 173
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.15
    Marker Score: 103
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.15
    Marker Score: 58
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.15
    Marker Score: 138
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.15
    Marker Score: 88
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.15
    Marker Score: 119
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.14
    Marker Score: 69
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.14
    Marker Score: 152
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.14
    Marker Score: 96
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.14
    Marker Score: 75
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.14
    Marker Score: 105
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.14
    Marker Score: 27
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.13
    Marker Score: 30
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 170
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 47

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Other Information

**Key characteristics:** - GPER1 is a single-pass membrane protein with a molecular weight of approximately 140 kDa. - It is a ligand-gated ion channel that is expressed in the plasma membrane of cells. - It is a G protein-coupled receptor, which means that it is activated by the binding of a specific ligand. - GPER1 is a nuclear protein that is regulated by a variety of hormones, including estrogen. **Pathways and functions:** - GPER1 is involved in a variety of cellular processes, including: - Regulation of neurotransmitter secretion - Regulation of protein phosphorylation - Regulation of cell growth and differentiation - Regulation of inflammation - In the retina, GPER1 is expressed in retinal cone cells, which are responsible for color vision. - In the uterus, GPER1 is expressed in luminal cells, which are responsible for the production of estrogen. - In the heart, GPER1 is expressed in cardiac endothelial cells, which are responsible for the regulation of blood pressure and heart rate. **Clinical significance:** - Mutations in GPER1 have been linked to a number of human diseases, including: - Breast cancer - Ovarian cancer - Heart disease - Diabetes - Infertility - GPER1 is a potential therapeutic target for a variety of diseases that are characterized by abnormal neurotransmitter secretion or cell growth.

Genular Protein ID: 3661182894

Symbol: GPER1_HUMAN

Name: Chemoattractant receptor-like 2

UniProtKB Accession Codes:

Q99527 A8K6C5 B5BUJ1 O00143 O43494 Q13631 Q6FHL1 Q96F42 Q99981

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 13 Ensembl 4 ExpressionAtlas 1 GO 89 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8920907

Title: Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues.

PubMed ID: 8920907

DOI: 10.1006/bbrc.1996.1654

PubMed ID: 9070864

Title: Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors.

PubMed ID: 9070864

DOI: 10.1006/bbrc.1997.6161

PubMed ID: 9398636

Title: Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress.

PubMed ID: 9398636

DOI: 10.1006/bbrc.1997.7734

PubMed ID: 9141481

Title: A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue.

PubMed ID: 9141481

DOI: 10.1016/s0014-5793(97)00278-0

PubMed ID: 9367686

Title: Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer.

PubMed ID: 9367686

DOI: 10.1006/geno.1997.4972

PubMed ID: 9479505

Title: Discovery of three novel G-protein-coupled receptor genes.

PubMed ID: 9479505

DOI: 10.1006/geno.1998.5095

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11043579

Title: Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF.

PubMed ID: 11043579

DOI: 10.1210/mend.14.10.0532

PubMed ID: 12027886

Title: Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells.

PubMed ID: 12027886

DOI: 10.1046/j.1432-1033.2002.02912.x

PubMed ID: 15539556

Title: Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.

PubMed ID: 15539556

DOI: 10.1210/en.2004-1064

PubMed ID: 15705806

Title: A transmembrane intracellular estrogen receptor mediates rapid cell signaling.

PubMed ID: 15705806

DOI: 10.1126/science.1106943

PubMed ID: 16645038

Title: Nature of functional estrogen receptors at the plasma membrane.

PubMed ID: 16645038

DOI: 10.1210/me.2005-0525

PubMed ID: 17379646

Title: Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane.

PubMed ID: 17379646

DOI: 10.1210/en.2006-1605

PubMed ID: 18566127

Title: G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol.

PubMed ID: 18566127

DOI: 10.1210/en.2008-0269

PubMed ID: 19179659

Title: Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity.

PubMed ID: 19179659

DOI: 10.1161/circresaha.108.190892

PubMed ID: 19342448

Title: Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30.

PubMed ID: 19342448

DOI: 10.1210/me.2008-0262

PubMed ID: 19749156

Title: G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells.

PubMed ID: 19749156

DOI: 10.1210/me.2009-0120

PubMed ID: 20551055

Title: Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts.

PubMed ID: 20551055

DOI: 10.1158/0008-5472.can-10-0408

PubMed ID: 20203690

Title: Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest.

PubMed ID: 20203690

DOI: 10.1038/cdd.2010.20

PubMed ID: 19931550

Title: Conserved estrogen binding and signaling functions of the G protein-coupled estrogen receptor 1 (GPER) in mammals and fish.

PubMed ID: 19931550

DOI: 10.1016/j.steroids.2009.11.005

PubMed ID: 21427217

Title: G-1-activated membrane estrogen receptors mediate increased contractility of the human myometrium.

PubMed ID: 21427217

DOI: 10.1210/en.2010-0979

PubMed ID: 21242460

Title: GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone.

PubMed ID: 21242460

DOI: 10.1161/hypertensionaha.110.161653

PubMed ID: 21540189

Title: Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway.

PubMed ID: 21540189

DOI: 10.1074/jbc.m111.224071

PubMed ID: 21149639

Title: G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments.

PubMed ID: 21149639

DOI: 10.1124/mol.110.069500

PubMed ID: 21354433

Title: Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30/GPER) from the plasma membrane towards the nucleus.

PubMed ID: 21354433

DOI: 10.1016/j.steroids.2011.02.018

PubMed ID: 23135268

Title: G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17beta-estradiol in cancer cells and cancer-associated fibroblasts.

PubMed ID: 23135268

DOI: 10.1074/jbc.m112.417303

PubMed ID: 23285008

Title: G-protein coupled receptor 30 (GPR30): a novel regulator of endothelial inflammation.

PubMed ID: 23285008

DOI: 10.1371/journal.pone.0052357

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23283935

Title: Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation.

PubMed ID: 23283935

DOI: 10.1152/ajpcell.00203.2012

PubMed ID: 23674134

Title: G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection.

PubMed ID: 23674134

DOI: 10.1530/jme-13-0021

PubMed ID: 22521564

Title: Position paper: The membrane estrogen receptor GPER--Clues and questions.

PubMed ID: 22521564

DOI: 10.1016/j.steroids.2012.04.001

PubMed ID: 22495674

Title: Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology.

PubMed ID: 22495674

DOI: 10.1210/en.2012-1061

Sequence Information:

  • Length: 375
  • Mass: 42248
  • Checksum: 0A54EED8A698F075
  • Sequence:
    • MDVTSQARGV GLEMYPGTAQ PAAPNTTSPE LNLSHPLLGT ALANGTGELS EHQQYVIGLF 
LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN LAVADLILVA DSLIEVFNLH 
ERYYDIAVLC TFMSLFLQVN MYSSVFFLTW MSFDRYIALA RAMRCSLFRT KHHARLSCGL 
IWMASVSATL VPFTAVHLQH TDEACFCFAD VREVQWLEVT LGFIVPFAII GLCYSLIVRV 
LVRAHRHRGL RPRRQKALRM ILAVVLVFFV CWLPENVFIS VHLLQRTQPG AAPCKQSFRH 
AHPLTGHIVN LAAFSNSCLN PLIYSFLGET FRDKLRLYIE QKTNLPALNR FCHAALKAVI 
PDSTEQSDVR FSSAV

Genular Protein ID: 2510461461

Symbol: Q63ZY2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q63ZY2

Database IDs:

ARBA 34 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 1 RefSeq 2 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 407
  • Mass: 45342
  • Checksum: 1E13EDC0EA85E915
  • Sequence:
    • MDVTSQARGV GLEMYPGTAQ PAAPNTTSPE LNLSHPLLGT ALANGTGELS EHQQYVIGLF 
LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN LAVADLILVA DSLIEVFNLH 
ERYYDIAVLC TFMSLFLQVN MYSSVFFLTW MSFDRYIALA RAMRCSLFRT KHHARLSCGL 
IWMASVSATL VPFTAVHLQH TDEACFCFAD VREVQWLEVT LGFIVPFAII GLCYSLIVRV 
LVRAHRHRGL RPRRQKALRM ILAVVLVFFV CWLPENVFIS VHLLQRTQPG AAPCKQSFRH 
AHPLTGHVMS LNCGQMWLLA PRGLARVTLA WSPWGCLGNL TTGHLALLTQ NCYNPKALAP 
QGPKASGDQP VTQLLPANPA CRCTCLPLQE TFLTPSTRKA TRRGHCG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.