Details for: TRDJ1

Gene ID: 28522

Symbol: TRDJ1

Ensembl ID: ENSG00000211825

Description: T cell receptor delta joining 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.1971
    Cell Significance Index: 53.2200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.8480
    Cell Significance Index: 12.3600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.5548
    Cell Significance Index: 7.2800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.2463
    Cell Significance Index: 2.9900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0027
    Cell Significance Index: 0.0300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0015
    Cell Significance Index: 0.0100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0013
    Cell Significance Index: 0.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0049
    Cell Significance Index: -0.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0061
    Cell Significance Index: -0.1200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0085
    Cell Significance Index: -0.0700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0085
    Cell Significance Index: -0.1400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0085
    Cell Significance Index: -0.1700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0090
    Cell Significance Index: -0.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0099
    Cell Significance Index: -0.2500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0119
    Cell Significance Index: -0.1400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0120
    Cell Significance Index: -0.1600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0126
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0150
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0151
    Cell Significance Index: -0.2800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0153
    Cell Significance Index: -0.1900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0158
    Cell Significance Index: -0.1900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0160
    Cell Significance Index: -0.1800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0176
    Cell Significance Index: -0.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0188
    Cell Significance Index: -0.2000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0193
    Cell Significance Index: -0.1900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0195
    Cell Significance Index: -0.2600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0195
    Cell Significance Index: -0.2100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0198
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0204
    Cell Significance Index: -0.2100
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.0205
    Cell Significance Index: -0.2000
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0215
    Cell Significance Index: -0.2200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0220
    Cell Significance Index: -0.2200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0235
    Cell Significance Index: -0.2400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0246
    Cell Significance Index: -0.2800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0247
    Cell Significance Index: -0.2300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0258
    Cell Significance Index: -0.2300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0269
    Cell Significance Index: -0.3000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0286
    Cell Significance Index: -0.2900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0295
    Cell Significance Index: -0.2600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0301
    Cell Significance Index: -0.3300
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0303
    Cell Significance Index: -0.2700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0310
    Cell Significance Index: -0.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0323
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0335
    Cell Significance Index: -0.2800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0391
    Cell Significance Index: -0.3900
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0396
    Cell Significance Index: -0.3600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0404
    Cell Significance Index: -0.4700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0425
    Cell Significance Index: -0.4000
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0436
    Cell Significance Index: -0.3600
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0460
    Cell Significance Index: -0.3700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0469
    Cell Significance Index: -0.4100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0475
    Cell Significance Index: -0.4100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0491
    Cell Significance Index: -0.4100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0493
    Cell Significance Index: -0.5000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0499
    Cell Significance Index: -0.5900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0594
    Cell Significance Index: -0.6000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0596
    Cell Significance Index: -0.6000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0711
    Cell Significance Index: -0.6000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0713
    Cell Significance Index: -0.5700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0716
    Cell Significance Index: -0.5800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0758
    Cell Significance Index: -0.5900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0793
    Cell Significance Index: -0.5900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0869
    Cell Significance Index: -1.0000
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1104
    Cell Significance Index: -1.0200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.3248
    Cell Significance Index: -0.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRDJ1 is a gene that codes for a protein involved in the assembly and function of the gamma-delta T cell receptor (γδ TCR). The γδ TCR is a unique T cell receptor that recognizes non-peptide antigens, such as lipid antigens and stress-induced antigens. TRDJ1 is specifically involved in the joining of the gamma and delta chains of the γδ TCR, which is essential for the proper assembly and function of the receptor. The expression of TRDJ1 is highly regulated and is restricted to cells that express the γδ TCR, such as mature gamma-delta T cells and natural killer T cells. **Pathways and Functions:** TRDJ1 is involved in the adaptive immune response and plays a crucial role in the functioning of gamma-delta T cells. The γδ TCR recognizes non-peptide antigens and triggers an immune response through the activation of various signaling pathways. The assembly and function of the γδ TCR are dependent on TRDJ1, which interacts with other proteins to form the functional receptor. TRDJ1 also regulates the expression of other genes involved in the immune response, including cytokine genes and genes involved in the activation of immune cells. **Clinical Significance:** Dysregulation of TRDJ1 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For example, TRDJ1 has been shown to be overexpressed in certain types of cancer, such as leukemia and lymphoma, where it may contribute to the development and progression of the disease. Additionally, TRDJ1 has been implicated in autoimmune diseases, such as type 1 diabetes and rheumatoid arthritis, where it may contribute to the dysregulation of the immune response. Understanding the function and regulation of TRDJ1 is essential for the development of new therapeutic strategies for these diseases. In conclusion, TRDJ1 is a key player in the adaptive immune response, particularly in the functioning of gamma-delta T cells. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of understanding its function and regulation. Further research on TRDJ1 is necessary to elucidate its role in the immune system and to develop new therapeutic strategies for the treatment of immune-related diseases. **Recommendations for Future Research:** 1. Elucidate the mechanisms of TRDJ1 regulation and its interaction with other proteins involved in the immune response. 2. Investigate the role of TRDJ1 in autoimmune diseases and cancer. 3. Develop new therapeutic strategies targeting TRDJ1 for the treatment of immune-related disorders. 4. Examine the expression of TRDJ1 in different cell types and its role in the immune response. By addressing these research gaps, we can gain a deeper understanding of the function and clinical significance of TRDJ1 and develop new therapeutic strategies for the treatment of immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.