Details for: TRBV6 8

Gene ID: 28599

Symbol: TRBV6 8

Ensembl ID: ENSG00000253534

Description: T cell receptor beta variable 6-8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 6.7262
    Cell Significance Index: 131.5100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2511
    Cell Significance Index: 30.3100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3684
    Cell Significance Index: 5.3700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3479
    Cell Significance Index: 4.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2244
    Cell Significance Index: 3.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0019
    Cell Significance Index: -0.3800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0058
    Cell Significance Index: -0.0600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0062
    Cell Significance Index: -0.1000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0090
    Cell Significance Index: -0.1200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0091
    Cell Significance Index: -0.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0135
    Cell Significance Index: -0.1600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0156
    Cell Significance Index: -0.1800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0174
    Cell Significance Index: -0.1600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0177
    Cell Significance Index: -0.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0184
    Cell Significance Index: -0.3400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0206
    Cell Significance Index: -0.2600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0232
    Cell Significance Index: -0.1500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0247
    Cell Significance Index: -0.2500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0260
    Cell Significance Index: -0.1400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0260
    Cell Significance Index: -0.2400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0267
    Cell Significance Index: -0.2500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0269
    Cell Significance Index: -0.2900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0273
    Cell Significance Index: -0.2800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0280
    Cell Significance Index: -0.3500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0282
    Cell Significance Index: -0.2400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0284
    Cell Significance Index: -0.3200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0284
    Cell Significance Index: -0.3300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0286
    Cell Significance Index: -0.2900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0287
    Cell Significance Index: -0.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0291
    Cell Significance Index: -0.2800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0299
    Cell Significance Index: -0.3400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0306
    Cell Significance Index: -0.3300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0316
    Cell Significance Index: -0.3000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0316
    Cell Significance Index: -0.3500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0316
    Cell Significance Index: -0.3500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0319
    Cell Significance Index: -0.2800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0323
    Cell Significance Index: -0.3400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0325
    Cell Significance Index: -0.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0327
    Cell Significance Index: -0.8200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0331
    Cell Significance Index: -0.3300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0335
    Cell Significance Index: -0.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0337
    Cell Significance Index: -0.3500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0339
    Cell Significance Index: -0.3300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0340
    Cell Significance Index: -0.3500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0347
    Cell Significance Index: -0.3800
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0348
    Cell Significance Index: -0.3100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0349
    Cell Significance Index: -0.3100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0349
    Cell Significance Index: -0.3700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0349
    Cell Significance Index: -0.3800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0352
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0352
    Cell Significance Index: -0.3300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0365
    Cell Significance Index: -0.3400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0366
    Cell Significance Index: -0.3400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0367
    Cell Significance Index: -0.3800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0371
    Cell Significance Index: -0.3300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0377
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0379
    Cell Significance Index: -0.3500
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.0380
    Cell Significance Index: -0.3500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0383
    Cell Significance Index: -0.3100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0387
    Cell Significance Index: -0.3300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0398
    Cell Significance Index: -0.3100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0403
    Cell Significance Index: -0.3000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0407
    Cell Significance Index: -0.3500
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0417
    Cell Significance Index: -0.3400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0427
    Cell Significance Index: -0.3600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0432
    Cell Significance Index: -0.3500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0440
    Cell Significance Index: -0.4700
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.0450
    Cell Significance Index: -0.5000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0480
    Cell Significance Index: -0.3300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0494
    Cell Significance Index: -0.3800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0605
    Cell Significance Index: -0.3300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0650
    Cell Significance Index: -1.1200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0886
    Cell Significance Index: -0.2700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0892
    Cell Significance Index: -1.0500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1204
    Cell Significance Index: -1.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** TRBV6-8 is situated within the TCR complex, specifically within the variable region of the beta chain. Its expression is widespread across multiple cell types, including hematopoietic cells, alpha-beta T cells, and intestinal epithelial cells. 2. **Pathways and Signaling:** The TCR complex, including TRBV6-8, is involved in cell surface receptor signaling pathways, which regulate immune responses to antigens. 3. **Cellular Context:** TRBV6-8 is expressed in various cell types, including hematopoietic cells, alpha-beta T cells, goblet cells, absorptive cells, and intestinal epithelial cells, highlighting its diverse roles in different tissues. 4. **Disease Association:** Alterations in TRBV6-8 have been linked to various diseases, including cancer, emphasizing the importance of this gene in immune function and disease. **Pathways and Functions:** The TRBV6-8 gene is integral to the adaptive immune response, which involves a complex interplay between T cells, antigen-presenting cells, and cytokines. The TCR complex, including TRBV6-8, recognizes and binds to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells. This recognition triggers a signaling cascade that leads to T cell activation, proliferation, and differentiation. The specific functions of TRBV6-8 involve: 1. **Antigen Recognition:** TRBV6-8 plays a crucial role in recognizing and binding to antigens, which is essential for the initiation of the adaptive immune response. 2. **T Cell Activation:** The TCR complex, including TRBV6-8, triggers a signaling cascade that leads to T cell activation, proliferation, and differentiation. 3. **Immune Regulation:** TRBV6-8 is involved in regulating immune responses, including the production of cytokines and the activation of immune cells. **Clinical Significance:** The TRBV6-8 gene has significant implications for various diseases, including: 1. **Cancer:** Alterations in TRBV6-8 have been linked to cancer, highlighting the importance of this gene in immune function and tumor development. 2. **Autoimmune Diseases:** Dysregulation of TRBV6-8 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Infectious Diseases:** TRBV6-8 plays a crucial role in recognizing and responding to pathogens, making it a target for developing novel therapies against infectious diseases. In conclusion, the TRBV6-8 gene is a critical component of the adaptive immune system, involved in recognizing and binding to antigens, regulating immune responses, and maintaining immune homeostasis. Its significance extends beyond its role in immune function, as alterations in TRBV6-8 have been implicated in various diseases, including cancer, autoimmune diseases, and infectious diseases. Further research is needed to fully understand the complexities of TRBV6-8 and its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.