Details for: TRAV8 2

Gene ID: 28684

Symbol: TRAV8 2

Ensembl ID: ENSG00000211786

Description: T cell receptor alpha variable 8-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.8541
    Cell Significance Index: 10.1100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.3401
    Cell Significance Index: 10.8600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4589
    Cell Significance Index: 7.1000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.4201
    Cell Significance Index: 4.9700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3381
    Cell Significance Index: 3.3900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.1837
    Cell Significance Index: 0.5600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0170
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -3.0100
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0028
    Cell Significance Index: -0.0200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0097
    Cell Significance Index: -0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0136
    Cell Significance Index: -2.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0170
    Cell Significance Index: -0.4600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0186
    Cell Significance Index: -0.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0244
    Cell Significance Index: -3.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0267
    Cell Significance Index: -3.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0290
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0319
    Cell Significance Index: -3.6600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0359
    Cell Significance Index: -0.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0374
    Cell Significance Index: -3.8200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0449
    Cell Significance Index: -0.5300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0485
    Cell Significance Index: -0.6600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0485
    Cell Significance Index: -0.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0504
    Cell Significance Index: -2.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0586
    Cell Significance Index: -1.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0600
    Cell Significance Index: -3.8700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0608
    Cell Significance Index: -0.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0633
    Cell Significance Index: -3.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0841
    Cell Significance Index: -3.9200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1021
    Cell Significance Index: -0.8700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1094
    Cell Significance Index: -1.5000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1101
    Cell Significance Index: -1.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1171
    Cell Significance Index: -1.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1186
    Cell Significance Index: -1.1400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1218
    Cell Significance Index: -1.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1238
    Cell Significance Index: -3.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1309
    Cell Significance Index: -2.7400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1338
    Cell Significance Index: -3.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1365
    Cell Significance Index: -3.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1433
    Cell Significance Index: -3.3100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1454
    Cell Significance Index: -2.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1518
    Cell Significance Index: -1.5400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1559
    Cell Significance Index: -1.5200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1601
    Cell Significance Index: -2.7500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1630
    Cell Significance Index: -1.6900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1675
    Cell Significance Index: -1.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1695
    Cell Significance Index: -4.6100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1717
    Cell Significance Index: -1.7800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1747
    Cell Significance Index: -2.8300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1773
    Cell Significance Index: -1.5300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1819
    Cell Significance Index: -1.7300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1826
    Cell Significance Index: -3.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1836
    Cell Significance Index: -2.7100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1924
    Cell Significance Index: -2.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1930
    Cell Significance Index: -3.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1953
    Cell Significance Index: -3.6100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1955
    Cell Significance Index: -2.5300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1992
    Cell Significance Index: -2.8300
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2001
    Cell Significance Index: -1.8000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2072
    Cell Significance Index: -3.0200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2078
    Cell Significance Index: -2.4100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2115
    Cell Significance Index: -1.6500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2129
    Cell Significance Index: -3.6400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2183
    Cell Significance Index: -2.4600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2183
    Cell Significance Index: -2.0200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2206
    Cell Significance Index: -3.0600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2221
    Cell Significance Index: -2.2400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2238
    Cell Significance Index: -2.0700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2239
    Cell Significance Index: -3.3500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2241
    Cell Significance Index: -2.8000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2316
    Cell Significance Index: -2.9300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2324
    Cell Significance Index: -3.5300
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2328
    Cell Significance Index: -2.2800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2337
    Cell Significance Index: -2.5300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2348
    Cell Significance Index: -2.5300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2370
    Cell Significance Index: -3.1100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2382
    Cell Significance Index: -2.9600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2386
    Cell Significance Index: -3.0600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2401
    Cell Significance Index: -2.1000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2407
    Cell Significance Index: -3.8700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2415
    Cell Significance Index: -2.1800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2439
    Cell Significance Index: -3.2100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2465
    Cell Significance Index: -2.0800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2501
    Cell Significance Index: -2.5800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2505
    Cell Significance Index: -3.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2530
    Cell Significance Index: -2.7500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2537
    Cell Significance Index: -2.7400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2553
    Cell Significance Index: -2.9000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2554
    Cell Significance Index: -3.3400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2565
    Cell Significance Index: -3.3600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2579
    Cell Significance Index: -3.1400
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2582
    Cell Significance Index: -2.1400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.2588
    Cell Significance Index: -1.7800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2589
    Cell Significance Index: -2.9800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2600
    Cell Significance Index: -3.3400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2604
    Cell Significance Index: -3.3000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2618
    Cell Significance Index: -3.1900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2643
    Cell Significance Index: -2.1400
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2656
    Cell Significance Index: -2.2200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2677
    Cell Significance Index: -3.2100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2696
    Cell Significance Index: -3.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRAV8.2 is expressed in a wide range of cell types, including granulocyte-monocyte progenitors, goblet cells, and intestinal epithelial cells, suggesting its involvement in various physiological and pathological processes. 2. **T-Cell Receptor Complex:** As a member of the TRAV family, TRAV8.2 is part of the T-cell receptor complex, which is essential for recognizing and responding to antigens. 3. **Adaptive Immune Response:** TRAV8.2 plays a crucial role in the adaptive immune response, which is characterized by the specific recognition and elimination of pathogens and the maintenance of immune homeostasis. **Pathways and Functions:** 1. **T-Cell Receptor Signaling:** TRAV8.2 is involved in the signaling process of T-cell receptors, which triggers the activation of T-cells and the initiation of an immune response. 2. **Immunological Synapse:** TRAV8.2 is also involved in the formation of the immunological synapse, a critical structure that facilitates the interaction between T-cells and antigen-presenting cells. 3. **Regulation of Immune Response:** TRAV8.2 may play a role in regulating the immune response by modulating the activity of T-cells and other immune cells. **Clinical Significance:** 1. **Cancer Association:** The expression of TRAV8.2 in neoplastic and abnormal cells suggests its potential role in cancer development and progression. 2. **Autoimmune Diseases:** TRAV8.2 may also be involved in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where T-cell dysfunction and immune dysregulation play a key role. 3. **Immunological Disorders:** The expression of TRAV8.2 in goblet cells and intestinal epithelial cells may also be relevant to immunological disorders, such as inflammatory bowel disease and allergic reactions. In conclusion, TRAV8.2 is a complex gene with far-reaching implications in the adaptive immune response and disease. Further research is needed to fully understand its role in various physiological and pathological processes, and to explore its potential as a therapeutic target for immunological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.