Details for: GRB10

Gene ID: 2887

Symbol: GRB10

Ensembl ID: ENSG00000106070

Description: growth factor receptor bound protein 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.77
    Marker Score: 6077.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.71
    Marker Score: 1615
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.64
    Marker Score: 3286
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.51
    Marker Score: 10523
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.31
    Marker Score: 3356
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.23
    Marker Score: 1174
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.12
    Marker Score: 888
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.09
    Marker Score: 655
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.04
    Marker Score: 1137
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.01
    Marker Score: 76440
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.98
    Marker Score: 7666
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.91
    Marker Score: 14639
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.91
    Marker Score: 37967
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.89
    Marker Score: 33514
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.86
    Marker Score: 1084
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.84
    Marker Score: 7508.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.84
    Marker Score: 17323
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.83
    Marker Score: 18908
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.72
    Marker Score: 63268
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.71
    Marker Score: 105087
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.71
    Marker Score: 14662
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.7
    Marker Score: 16182
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.69
    Marker Score: 7013
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.66
    Marker Score: 3902
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.63
    Marker Score: 24344
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.58
    Marker Score: 431
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.58
    Marker Score: 498
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2353
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.52
    Marker Score: 481
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.48
    Marker Score: 1585
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.46
    Marker Score: 561
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.39
    Marker Score: 4928.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.39
    Marker Score: 405
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.38
    Marker Score: 630
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.37
    Marker Score: 763
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.35
    Marker Score: 3388
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.33
    Marker Score: 775
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.33
    Marker Score: 8564
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20451
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.31
    Marker Score: 2657
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.29
    Marker Score: 356
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.29
    Marker Score: 2713
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.25
    Marker Score: 2983
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.24
    Marker Score: 1427
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.23
    Marker Score: 5288
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.22
    Marker Score: 41287
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.21
    Marker Score: 6527
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.19
    Marker Score: 3391
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.15
    Marker Score: 344
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.15
    Marker Score: 5300
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.13
    Marker Score: 631
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.12
    Marker Score: 2162.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.11
    Marker Score: 549
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.1
    Marker Score: 985
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.09
    Marker Score: 1896
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.08
    Marker Score: 649
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.05
    Marker Score: 6328
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.05
    Marker Score: 741
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.05
    Marker Score: 381
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.01
    Marker Score: 376.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71768
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47993
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.98
    Marker Score: 357
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.97
    Marker Score: 234
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.97
    Marker Score: 236
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.96
    Marker Score: 633
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.96
    Marker Score: 721
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.95
    Marker Score: 1899
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.94
    Marker Score: 1574
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.91
    Marker Score: 866
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.9
    Marker Score: 3214
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.9
    Marker Score: 427
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5027
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.87
    Marker Score: 899
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.86
    Marker Score: 814
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.86
    Marker Score: 973
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.84
    Marker Score: 195
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 639
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.82
    Marker Score: 13203
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 262
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.81
    Marker Score: 305
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.81
    Marker Score: 212
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.79
    Marker Score: 978
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.79
    Marker Score: 1498
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.78
    Marker Score: 842
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.78
    Marker Score: 224
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.77
    Marker Score: 376
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.77
    Marker Score: 200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.76
    Marker Score: 521
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.76
    Marker Score: 366
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.76
    Marker Score: 684

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GRB10 is a cell surface protein that is expressed on the surface of cells in various tissues. * It is a member of the GRB family of cell surface receptors. * GRB10 is a high-priority candidate for a variety of human diseases, including cancer, diabetes, and cardiovascular disease. **Pathways and functions:** * GRB10 is a key regulator of cell growth, differentiation, and survival. * It is involved in a variety of cellular processes, including cell migration, proliferation, and differentiation. * GRB10 is also involved in the regulation of inflammation and cell death. **Clinical significance:** * Mutations in the GRB10 gene have been linked to a number of human diseases, including cancer, diabetes, and cardiovascular disease. * Targeting GRB10 with drugs is a promising new strategy for the treatment of these diseases. **Additional information:** * GRB10 is a highly conserved protein, with a similar gene found in mice and rats. * The GRB10 gene is located on chromosome 17q21. * GRB10 is a transmembrane protein that is composed of 12 extracellular domains and a single intracellular domain. * The extracellular domains of GRB10 are responsible for binding to growth factors. * The intracellular domain of GRB10 is responsible for signal transduction.

Genular Protein ID: 3980281467

Symbol: GRB10_HUMAN

Name: Growth factor receptor-bound protein 10

UniProtKB Accession Codes:

Q13322 A4D258 A7VJ95 A8K0E6 D3DVM9 O00427 O00701 O75222 Q92606 Q92907 Q92948

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 46 EPD 1 Ensembl 12 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 7 RefSeq 15 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7479769

Title: Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.

PubMed ID: 7479769

DOI: 10.1073/pnas.92.22.10287

PubMed ID: 8798417

Title: Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling.

PubMed ID: 8798417

DOI: 10.1074/jbc.271.37.22506

PubMed ID: 9006901

Title: Human GRB-IR-beta/GRB10: splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.

PubMed ID: 9006901

DOI: 10.1074/jbc.272.5.2659

PubMed ID: 9360986

Title: Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.

PubMed ID: 9360986

DOI: 10.1074/jbc.272.46.29104

PubMed ID: 9553107

Title: Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases.

PubMed ID: 9553107

DOI: 10.1074/jbc.273.17.10475

PubMed ID: 9753425

Title: Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase.

PubMed ID: 9753425

DOI: 10.1046/j.1365-2443.1998.00201.x

PubMed ID: 9881709

Title: Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease.

PubMed ID: 9881709

DOI: 10.1038/sj.onc.1202226

PubMed ID: 10861285

Title: Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion.

PubMed ID: 10861285

DOI: 10.1093/hmg/9.11.1587

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15952796

Title: Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites.

PubMed ID: 15952796

DOI: 10.1021/bi050413i

PubMed ID: 11527390

Title: Evidence against GRB10 as the gene responsible for Silver-Russell syndrome.

PubMed ID: 11527390

DOI: 10.1006/bbrc.2001.5500

PubMed ID: 12493740

Title: Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.

PubMed ID: 12493740

DOI: 10.1074/jbc.m208518200

PubMed ID: 12853971

Title: NIK is a component of the EGF/heregulin receptor signaling complexes.

PubMed ID: 12853971

DOI: 10.1038/sj.onc.1206532

PubMed ID: 15060076

Title: Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation.

PubMed ID: 15060076

DOI: 10.1074/jbc.m311802200

PubMed ID: 15722337

Title: Phosphorylation of grb10 regulates its interaction with 14-3-3.

PubMed ID: 15722337

DOI: 10.1074/jbc.m501477200

PubMed ID: 16434550

Title: Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation.

PubMed ID: 16434550

DOI: 10.1152/ajpendo.00609.2005

PubMed ID: 17376403

Title: GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway.

PubMed ID: 17376403

DOI: 10.1016/j.bbrc.2007.03.019

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19487367

Title: Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression.

PubMed ID: 19487367

DOI: 10.1093/hmg/ddp248

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21659604

Title: The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

PubMed ID: 21659604

DOI: 10.1126/science.1199498

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12551896

Title: Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.

PubMed ID: 12551896

DOI: 10.1074/jbc.m212026200

PubMed ID: 19648926

Title: Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.

PubMed ID: 19648926

DOI: 10.1038/nsmb.1642

PubMed ID: 10856193

Title: Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome.

PubMed ID: 10856193

DOI: 10.1086/302997

Sequence Information:

  • Length: 594
  • Mass: 67231
  • Checksum: 53A5F885E17C6C6B
  • Sequence:
    • MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV DLEALVNDMN 
ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ PQVSPRQRVQ RSQPVHILAV 
RRLQEEDQQF RTSSLPAIPN PFPELCGPGS PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK 
VVEILADMTA RDLCQLLVYK SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE 
SKFLFRKNYA KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK 
ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG RKQYNAPTDH 
GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG MLLYQNYRIP QQRKALLSPF 
STPVRSVSEN SLVAMDFSGQ TGRVIENPAE AQSAALEEGH AWRKRSTRMN ILGSQSPLHP 
STLSTVIHRT QHWFHGRISR EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK 
NFQILPCEDD GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.