Details for: GRB10

Gene ID: 2887

Symbol: GRB10

Ensembl ID: ENSG00000106070

Description: growth factor receptor bound protein 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 304.3488
    Cell Significance Index: -47.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 186.2260
    Cell Significance Index: -47.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 96.7122
    Cell Significance Index: -39.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.2991
    Cell Significance Index: -39.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.0930
    Cell Significance Index: -48.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.9069
    Cell Significance Index: -47.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.5185
    Cell Significance Index: -31.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.2477
    Cell Significance Index: -48.3300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 7.2518
    Cell Significance Index: 104.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 7.0323
    Cell Significance Index: 394.6200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 4.0261
    Cell Significance Index: 41.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.2457
    Cell Significance Index: 83.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.2339
    Cell Significance Index: 29.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.5476
    Cell Significance Index: 96.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.4634
    Cell Significance Index: 108.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1507
    Cell Significance Index: 431.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8585
    Cell Significance Index: 666.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2401
    Cell Significance Index: 33.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1560
    Cell Significance Index: 13.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1479
    Cell Significance Index: 133.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0964
    Cell Significance Index: 208.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.0531
    Cell Significance Index: 17.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9276
    Cell Significance Index: 58.4700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.8955
    Cell Significance Index: 21.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8953
    Cell Significance Index: 68.7100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8120
    Cell Significance Index: 561.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7679
    Cell Significance Index: 22.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7160
    Cell Significance Index: 44.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5946
    Cell Significance Index: 118.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5550
    Cell Significance Index: 37.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5237
    Cell Significance Index: 13.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5149
    Cell Significance Index: 233.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4914
    Cell Significance Index: 925.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4530
    Cell Significance Index: 9.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4134
    Cell Significance Index: 373.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3250
    Cell Significance Index: 32.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3207
    Cell Significance Index: 6.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2910
    Cell Significance Index: 6.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2797
    Cell Significance Index: 50.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2480
    Cell Significance Index: 6.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2386
    Cell Significance Index: 12.4300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2288
    Cell Significance Index: 3.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1979
    Cell Significance Index: 125.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1855
    Cell Significance Index: 31.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1837
    Cell Significance Index: 1.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1741
    Cell Significance Index: 21.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1635
    Cell Significance Index: 26.5900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1170
    Cell Significance Index: 1.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0912
    Cell Significance Index: 9.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0554
    Cell Significance Index: 30.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0327
    Cell Significance Index: 1.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0253
    Cell Significance Index: 0.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0247
    Cell Significance Index: 1.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -12.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0090
    Cell Significance Index: -1.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0103
    Cell Significance Index: -4.5400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0112
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0170
    Cell Significance Index: -10.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0255
    Cell Significance Index: -18.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0296
    Cell Significance Index: -45.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0379
    Cell Significance Index: -0.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0413
    Cell Significance Index: -56.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0532
    Cell Significance Index: -30.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0576
    Cell Significance Index: -42.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0611
    Cell Significance Index: -46.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0722
    Cell Significance Index: -4.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1213
    Cell Significance Index: -25.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1320
    Cell Significance Index: -37.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1535
    Cell Significance Index: -21.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2061
    Cell Significance Index: -21.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2076
    Cell Significance Index: -23.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2123
    Cell Significance Index: -9.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2173
    Cell Significance Index: -22.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2260
    Cell Significance Index: -25.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2268
    Cell Significance Index: -11.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2645
    Cell Significance Index: -34.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2967
    Cell Significance Index: -38.0400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3106
    Cell Significance Index: -3.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3306
    Cell Significance Index: -4.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3352
    Cell Significance Index: -7.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3830
    Cell Significance Index: -18.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3883
    Cell Significance Index: -28.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4110
    Cell Significance Index: -48.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4204
    Cell Significance Index: -25.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4391
    Cell Significance Index: -12.5300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4549
    Cell Significance Index: -6.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4932
    Cell Significance Index: -13.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5557
    Cell Significance Index: -44.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5655
    Cell Significance Index: -40.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6060
    Cell Significance Index: -39.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6566
    Cell Significance Index: -21.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6796
    Cell Significance Index: -22.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7025
    Cell Significance Index: -14.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7128
    Cell Significance Index: -14.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7206
    Cell Significance Index: -22.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7365
    Cell Significance Index: -38.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7682
    Cell Significance Index: -15.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7882
    Cell Significance Index: -22.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8173
    Cell Significance Index: -17.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8644
    Cell Significance Index: -30.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Interactions with Receptor Tyrosine Kinases (RTKs):** GRB10 binds to RTKs, such as insulin receptor, Flt3, and Scf-kit, modulating their signaling activity. 2. **Regulation of Insulin Signaling:** GRB10 negatively regulates insulin receptor signaling, which is crucial for glucose metabolism and energy homeostasis. 3. **Immune System Modulation:** GRB10 influences immune responses by interacting with cytokine signaling pathways, such as those involved in the immune system and vascular endothelial growth factor receptor signaling. 4. **Developmental Biology:** GRB10 is expressed in various tissues, including the nervous system, cardiovascular system, and kidney, highlighting its role in developmental processes. 5. **Cellular Stress Response:** GRB10 modulates cellular responses to stress, including negative regulation of phosphorylation and wnt signaling. **Pathways and Functions:** 1. **Insulin Receptor Signaling Pathway:** GRB10 negatively regulates insulin receptor signaling, which is essential for glucose metabolism and energy homeostasis. 2. **Cytokine Signaling in Immune System:** GRB10 interacts with cytokine signaling pathways, modulating immune responses and inflammation. 3. **Erk1 and Erk2 Cascade:** GRB10 influences the Erk1 and Erk2 signaling pathway, which is involved in cell proliferation, differentiation, and survival. 4. **Negative Regulation of Phosphorylation:** GRB10 negatively regulates phosphorylation, which is essential for various cellular processes, including protein function and signaling. 5. **Vascular Associated Smooth Muscle Cell Migration:** GRB10 modulates vascular associated smooth muscle cell migration, which is critical for vascular development and disease. **Clinical Significance:** 1. **Diabetes and Metabolic Disorders:** GRB10's negative regulation of insulin signaling pathway makes it a potential therapeutic target for treating diabetes and metabolic disorders. 2. **Autoimmune Disorders:** GRB10's involvement in immune system modulation and cytokine signaling pathways suggests its potential role in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** GRB10's interactions with RTKs and signaling pathways make it a potential target for cancer therapy, particularly in tumors with altered insulin signaling. 4. **Neurological Disorders:** GRB10's expression in the nervous system and involvement in developmental biology and cellular stress response make it a potential target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, GRB10 is a multifunctional gene that plays a critical role in regulating various biological processes, including immune responses, development, and metabolic homeostasis. Its involvement in these processes has significant implications for understanding human diseases and developing novel therapeutic strategies.

Genular Protein ID: 3980281467

Symbol: GRB10_HUMAN

Name: Growth factor receptor-bound protein 10

UniProtKB Accession Codes:

Q13322 A4D258 A7VJ95 A8K0E6 D3DVM9 O00427 O00701 O75222 Q92606 Q92907 Q92948

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 46 Ensembl 12 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 7 RefSeq 15 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7479769

Title: Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.

PubMed ID: 7479769

DOI: 10.1073/pnas.92.22.10287

PubMed ID: 8798417

Title: Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling.

PubMed ID: 8798417

DOI: 10.1074/jbc.271.37.22506

PubMed ID: 9006901

Title: Human GRB-IR-beta/GRB10: splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.

PubMed ID: 9006901

DOI: 10.1074/jbc.272.5.2659

PubMed ID: 9360986

Title: Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.

PubMed ID: 9360986

DOI: 10.1074/jbc.272.46.29104

PubMed ID: 9553107

Title: Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases.

PubMed ID: 9553107

DOI: 10.1074/jbc.273.17.10475

PubMed ID: 9753425

Title: Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase.

PubMed ID: 9753425

DOI: 10.1046/j.1365-2443.1998.00201.x

PubMed ID: 9881709

Title: Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease.

PubMed ID: 9881709

DOI: 10.1038/sj.onc.1202226

PubMed ID: 10861285

Title: Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion.

PubMed ID: 10861285

DOI: 10.1093/hmg/9.11.1587

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15952796

Title: Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites.

PubMed ID: 15952796

DOI: 10.1021/bi050413i

PubMed ID: 11527390

Title: Evidence against GRB10 as the gene responsible for Silver-Russell syndrome.

PubMed ID: 11527390

DOI: 10.1006/bbrc.2001.5500

PubMed ID: 12493740

Title: Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.

PubMed ID: 12493740

DOI: 10.1074/jbc.m208518200

PubMed ID: 12853971

Title: NIK is a component of the EGF/heregulin receptor signaling complexes.

PubMed ID: 12853971

DOI: 10.1038/sj.onc.1206532

PubMed ID: 15060076

Title: Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation.

PubMed ID: 15060076

DOI: 10.1074/jbc.m311802200

PubMed ID: 15722337

Title: Phosphorylation of grb10 regulates its interaction with 14-3-3.

PubMed ID: 15722337

DOI: 10.1074/jbc.m501477200

PubMed ID: 16434550

Title: Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation.

PubMed ID: 16434550

DOI: 10.1152/ajpendo.00609.2005

PubMed ID: 17376403

Title: GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway.

PubMed ID: 17376403

DOI: 10.1016/j.bbrc.2007.03.019

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19487367

Title: Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression.

PubMed ID: 19487367

DOI: 10.1093/hmg/ddp248

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21659604

Title: The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

PubMed ID: 21659604

DOI: 10.1126/science.1199498

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12551896

Title: Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.

PubMed ID: 12551896

DOI: 10.1074/jbc.m212026200

PubMed ID: 19648926

Title: Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.

PubMed ID: 19648926

DOI: 10.1038/nsmb.1642

PubMed ID: 10856193

Title: Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome.

PubMed ID: 10856193

DOI: 10.1086/302997

Sequence Information:

  • Length: 594
  • Mass: 67231
  • Checksum: 53A5F885E17C6C6B
  • Sequence:
    • MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV DLEALVNDMN 
ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ PQVSPRQRVQ RSQPVHILAV 
RRLQEEDQQF RTSSLPAIPN PFPELCGPGS PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK 
VVEILADMTA RDLCQLLVYK SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE 
SKFLFRKNYA KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK 
ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG RKQYNAPTDH 
GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG MLLYQNYRIP QQRKALLSPF 
STPVRSVSEN SLVAMDFSGQ TGRVIENPAE AQSAALEEGH AWRKRSTRMN ILGSQSPLHP 
STLSTVIHRT QHWFHGRISR EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK 
NFQILPCEDD GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.