Details for: GRB10
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 304.3488
Cell Significance Index: -47.3400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 186.2260
Cell Significance Index: -47.2400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 96.7122
Cell Significance Index: -39.2900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 41.2991
Cell Significance Index: -39.4300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 39.0930
Cell Significance Index: -48.2000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.9069
Cell Significance Index: -47.9700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 14.5185
Cell Significance Index: -31.7800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.2477
Cell Significance Index: -48.3300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 7.2518
Cell Significance Index: 104.3000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 7.0323
Cell Significance Index: 394.6200 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 4.0261
Cell Significance Index: 41.7000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 3.2457
Cell Significance Index: 83.4300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 3.2339
Cell Significance Index: 29.7800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.5476
Cell Significance Index: 96.4700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.4634
Cell Significance Index: 108.9600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.1507
Cell Significance Index: 431.4300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.8585
Cell Significance Index: 666.6300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.2401
Cell Significance Index: 33.2300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.1560
Cell Significance Index: 13.7800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.1479
Cell Significance Index: 133.7800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0964
Cell Significance Index: 208.6600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.0531
Cell Significance Index: 17.7400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.9276
Cell Significance Index: 58.4700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.8955
Cell Significance Index: 21.8500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.8953
Cell Significance Index: 68.7100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.8120
Cell Significance Index: 561.6200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7679
Cell Significance Index: 22.1300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.7160
Cell Significance Index: 44.0100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5946
Cell Significance Index: 118.0000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.5550
Cell Significance Index: 37.3200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5237
Cell Significance Index: 13.0900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.5149
Cell Significance Index: 233.7000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4914
Cell Significance Index: 925.1800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4530
Cell Significance Index: 9.8200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4134
Cell Significance Index: 373.3100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3250
Cell Significance Index: 32.1500 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3207
Cell Significance Index: 6.2600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.2910
Cell Significance Index: 6.9800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2797
Cell Significance Index: 50.4200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2480
Cell Significance Index: 6.9300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2386
Cell Significance Index: 12.4300 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.2288
Cell Significance Index: 3.7700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1979
Cell Significance Index: 125.7100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1855
Cell Significance Index: 31.6700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1837
Cell Significance Index: 1.1100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1741
Cell Significance Index: 21.4100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1635
Cell Significance Index: 26.5900 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1170
Cell Significance Index: 1.6800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0912
Cell Significance Index: 9.9200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0554
Cell Significance Index: 30.2500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0327
Cell Significance Index: 1.4800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0253
Cell Significance Index: 0.8900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0247
Cell Significance Index: 1.4900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0065
Cell Significance Index: -12.0200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0090
Cell Significance Index: -1.3100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0103
Cell Significance Index: -4.5400 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0112
Cell Significance Index: -0.1400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0170
Cell Significance Index: -10.6500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0255
Cell Significance Index: -18.8700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0296
Cell Significance Index: -45.5200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0379
Cell Significance Index: -0.6500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0413
Cell Significance Index: -56.2100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0532
Cell Significance Index: -30.0100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0576
Cell Significance Index: -42.2500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0611
Cell Significance Index: -46.2200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0722
Cell Significance Index: -4.9900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1213
Cell Significance Index: -25.5400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1320
Cell Significance Index: -37.9700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1535
Cell Significance Index: -21.0800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2061
Cell Significance Index: -21.0600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2076
Cell Significance Index: -23.7800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2123
Cell Significance Index: -9.9000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2173
Cell Significance Index: -22.6300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2260
Cell Significance Index: -25.8000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2268
Cell Significance Index: -11.7800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2645
Cell Significance Index: -34.1700 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2967
Cell Significance Index: -38.0400 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.3106
Cell Significance Index: -3.9200 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3306
Cell Significance Index: -4.8800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3352
Cell Significance Index: -7.3400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3830
Cell Significance Index: -18.0000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3883
Cell Significance Index: -28.9400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4110
Cell Significance Index: -48.4700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4204
Cell Significance Index: -25.7800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4391
Cell Significance Index: -12.5300 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.4549
Cell Significance Index: -6.9200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4932
Cell Significance Index: -13.1700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5557
Cell Significance Index: -44.0100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5655
Cell Significance Index: -40.0000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.6060
Cell Significance Index: -39.1000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6566
Cell Significance Index: -21.0300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6796
Cell Significance Index: -22.2500 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.7025
Cell Significance Index: -14.9100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.7128
Cell Significance Index: -14.3100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7206
Cell Significance Index: -22.9500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7365
Cell Significance Index: -38.6700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.7682
Cell Significance Index: -15.1900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.7882
Cell Significance Index: -22.6000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.8173
Cell Significance Index: -17.4700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.8644
Cell Significance Index: -30.2800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3980281467
Symbol: GRB10_HUMAN
Name: Growth factor receptor-bound protein 10
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7479769
Title: Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.
PubMed ID: 7479769
PubMed ID: 8798417
Title: Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling.
PubMed ID: 8798417
PubMed ID: 9006901
Title: Human GRB-IR-beta/GRB10: splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.
PubMed ID: 9006901
PubMed ID: 9360986
Title: Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.
PubMed ID: 9360986
PubMed ID: 9553107
Title: Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases.
PubMed ID: 9553107
PubMed ID: 9753425
Title: Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase.
PubMed ID: 9753425
PubMed ID: 9881709
Title: Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease.
PubMed ID: 9881709
PubMed ID: 10861285
Title: Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion.
PubMed ID: 10861285
PubMed ID: 9039502
Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
PubMed ID: 9039502
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12853948
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15952796
Title: Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites.
PubMed ID: 15952796
DOI: 10.1021/bi050413i
PubMed ID: 11527390
Title: Evidence against GRB10 as the gene responsible for Silver-Russell syndrome.
PubMed ID: 11527390
PubMed ID: 12493740
Title: Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
PubMed ID: 12493740
PubMed ID: 12853971
Title: NIK is a component of the EGF/heregulin receptor signaling complexes.
PubMed ID: 12853971
PubMed ID: 15060076
Title: Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation.
PubMed ID: 15060076
PubMed ID: 15722337
Title: Phosphorylation of grb10 regulates its interaction with 14-3-3.
PubMed ID: 15722337
PubMed ID: 16434550
Title: Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation.
PubMed ID: 16434550
PubMed ID: 17376403
Title: GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway.
PubMed ID: 17376403
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19487367
Title: Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression.
PubMed ID: 19487367
DOI: 10.1093/hmg/ddp248
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21659604
Title: The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
PubMed ID: 21659604
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 12551896
Title: Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.
PubMed ID: 12551896
PubMed ID: 19648926
Title: Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
PubMed ID: 19648926
DOI: 10.1038/nsmb.1642
PubMed ID: 10856193
Title: Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome.
PubMed ID: 10856193
DOI: 10.1086/302997
Sequence Information:
- Length: 594
- Mass: 67231
- Checksum: 53A5F885E17C6C6B
- Sequence:
MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV DLEALVNDMN ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ PQVSPRQRVQ RSQPVHILAV RRLQEEDQQF RTSSLPAIPN PFPELCGPGS PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK VVEILADMTA RDLCQLLVYK SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE SKFLFRKNYA KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG RKQYNAPTDH GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG MLLYQNYRIP QQRKALLSPF STPVRSVSEN SLVAMDFSGQ TGRVIENPAE AQSAALEEGH AWRKRSTRMN ILGSQSPLHP STLSTVIHRT QHWFHGRISR EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK NFQILPCEDD GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.